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232 Possible Causes for Ascites, Massive Splenomegaly

  • Primary Myelofibrosis

    Here we report a rare case of PMF with anemia, small bowel obstruction and ascites due to extramedullary hematopoiesis and portal hypertension.[ncbi.nlm.nih.gov] She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] Severe acute liver dysfunction occurred following transjugular intrahepatic portosystemic shunt (TIPS) creation in a patient with massive ascites due to portal hypertension[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] A PVS is a treatment option for ascites due to BCS.[ncbi.nlm.nih.gov] Depending on their localization, thromboses (which affect 30-40 % of untreated patients) may manifest as abdominal pain, hepatomegaly, ascites and headaches.[orpha.net]

  • Portal Vein Thrombosis

    Peritoneal tuberculosis can present with unusual manifestations such as portal vein thrombosis and transudative ascites causing a diagnostic dilemma.[ncbi.nlm.nih.gov] The splenectomy was performed in other services, before the PVT diagnosis, due to the massive splenomegaly and severe hypersplenism.[scielo.br] On examination she had pallor and massive splenomegaly.[jpgo.org]

  • Presinusoidal Portal Hypertension

    […] stage characterized by ascites, together with increasing jaundice and anemia.[annals.org] Massive splenomegaly ( 10 cm below the left subcostal margin)-present in 95 % of patients. Dilated superficial abdominal veins- in15 %.[gastroenterologybook.com] Portal hypertension may also occur in massive splenomegaly or AV fistulas due to increased blood flow.[medicscientist.com]

  • Hepatosplenic Amyloidosis

    Splenectomy may be justified in the case of massive splenomegaly, infarction, or disabling symptoms of pain and compression of neighboring structures.[accessmedicine.mhmedical.com] Ascitic fluid may be tapped and drawn for differential analysis.[medical-dictionary.thefreedictionary.com] Computed tomography demonstrates characteristic massive splenomegaly.[ctisus.com]

  • Budd-Chiari Syndrome

    A PVS is a treatment option for ascites due to BCS.[ncbi.nlm.nih.gov] Causes of Portal Hypertension Prehepatic Portal vein thrombosis Splenic vein thrombosis Massive splenomegaly Intrahepatic Schistosomiasis Congenital hepatic fibrosis Cirrhosis[uscmedicine.blog] CLINICAL FEATURES SYMPTOMS  ABDOMINAL PAIN & DISTENTION  ANOREXIA  JAUNDICE SIGNS  MASSIVE ASCITES (83- 100%)  HEPATOMEGALY  COLLATERALS  SPLENOMEGALY  JAUNDICE [slideshare.net]

  • Portal Hypertension

    The serum-ascites albumin gradient value of 1.9 g/dL and the total protein level in the ascites of 3.1 g/dL indicated the ascites to have been caused by portal hypertension[ncbi.nlm.nih.gov] We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] IPH and EHPVO are both characterized by normal hepatic venous pressure gradient, moderate to massive splenomegaly with preserved liver synthetic functions.[ncbi.nlm.nih.gov]

  • Gaucher Disease

    Large volume lymphadenopathy inevitably provokes concern about the possibility of malignancy, but in a patient with Gaucher disease-particularly with significant ascites and[ncbi.nlm.nih.gov] HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] The gastrointestinal features include hepatosplenomegaly, jaundice , hepatic (liver) failure, and ascites (fluid in the abdomen).[medicinenet.com]

  • Hypersplenism

    Left-sided pleural effusion and increase in amount or new development of ascites occurred in six and five patients, respectively.[ncbi.nlm.nih.gov] Our results demonstrate that shunt surgery with partial resection of the spleen is effective and safe for pediatric patients with massive splenomegaly and severe hypersplenism[ncbi.nlm.nih.gov] […] with many complications, including intermittent fever, abdominal pain, nausea, vomiting, post-embolization syndrome, splenic abscess, splenic rupture, pneumonia, refractory ascites[clinicaltrials.gov]

  • Waldenstrom Macroglobulinemia

    Adenosine deaminase of ascitic fluid was 19 IU/L.[pancreas.imedpub.com] Case report. 41M with WM, massive splenomegaly.[en.wikibooks.org] There was also mild hepatomegaly but no splenomegaly or ascites. Rest of the abdominal exam was unremarkable. Also, examination of other systems was unremarkable.[pancreas.imedpub.com]

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