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11 Possible Causes for Ascites, Mutation in the CDK6 Gene, Personality Change

  • Malignant Gastric Neoplasm

    Most cancers are caused by gene changes that happen during a person’s lifetime, but a person’s cancer risk can be higher if they have one of these rare inherited mutations[debbiesdream.org] Imaging studies showed massive ascites and tumor infiltration in the omentum and peritoneal wall.[ncbi.nlm.nih.gov] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com]

  • Gastric Cancer

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] A provisional diagnosis of gastric carcinoma with cirrhosis and ascites was made.[ncbi.nlm.nih.gov] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Glioblastoma Multiforme

    General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org] T Wakabayashi , J Yoshida , N Kageyama , etal: Extraneural metastasis of malignant glioma through a ventriculo-peritoneal shunt: Growth in peritoneal cavity as ascitic form[jco.ascopubs.org]

  • Pancreatic Neoplasm

    Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] US is used for diagnosis rather than staging, although liver metastasis and ascites may be seen. Ultrasound normal anatomy 23.[slideshare.net] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov]

  • Biliary Carcinoma

    If you are concerned about any changes you experience, please talk with your doctor.[cancer.net] The patient also underwent a chest X-ray and a thoraco-abdominopelvic CT scan, which revealed associated pulmonary metastases and large ascites.[em-consulte.com] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org]

  • Gastric Adenocarcinoma

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] We present a quite rare case of chylous ascites associated with signet ring cell gastric adenocarcinoma.[ncbi.nlm.nih.gov] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org]

  • Rhabdomyosarcoma

    Shrieve, Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas, Cancer Medicine, 7, 12, (6030[doi.org] Intraoperatively, about 1000 mL of cloudy hemorrhagic ascites was found in the abdominal cavity.[journals.lww.com] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov]

  • Medulloblastoma

    […] in sensation on one side of the body Seizures Unusual sleepiness or change in energy level Change in personality or behavior Unexplained weight loss or weight gain More advanced[columbianeurosurgery.org] Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org] In two of six patients with a ventriculoperitoneal shunt, abdominal ascites developed (no infectious agent was identified); in one child, episodes of ascites did not recur[content.nejm.org]

  • Acute Myelomonocytic Leukemia

    CML is an acquired leukemia, resulting from a change in a person's DNA. This change results in an uncontrolled growth of white cells.[nationalcmlsociety.org] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com] […] neutrophils blue, and nonspecific esterase stains monocytes red-brown Images hosted on other servers: Bone marrow biopsy: Resembling sarcomatoid carcinoma Other sites: Leukemic ascites[pathologyoutlines.com]

  • Neuroectodermal Tumor

    changes.[knowcancer.com] In two of six patients with a ventriculoperitoneal shunt, abdominal ascites developed (no infectious agent was identified); in one child, episodes of ascites did not recur[content.nejm.org] Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org]

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