Aspartate Aminotransferase Increased: Causes & Reasons

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Possible Causes for Aspartate Aminotransferase Increased

Malignant Neoplasm of the Liver

The patient developed the following symptoms/conditions: aspartate aminotransferase increased, musculoskeletal pain ,decreased appetite,prophylaxis,abdominal pain upper,hepatitis [patientsville.com]

aminotransferase (AST) increase) in order to facilitate the selection of patients who might benefit from repeated TACE treatment. 83, 84 The authors reported that even discrete [esmoopen.bmj.com]

The Assessment for Retreatment with TACE (ART) score was developed based on radiological tumour response and impairment of liver function (Child-Pugh score and serum aspartate [esmoopen.bmj.com]

Chronic Alcoholism

Increased serum globulin levels Metabolic Elevated blood ammonia level Hyperglycemia Respiratory alkalosis Hypomagnesemia Hypophosphatemia Hyponatremia Hypokalemia Back to [clevelandclinicmeded.com]

aminotransferase (AST) and alanine aminotransferase (ALT) levels elevated, usually < 300 U/L; AST/ALT ratio ~ 2:1 Hematologic Anemia Leukocytosis or leukopenia Thrombocytopenia [clevelandclinicmeded.com]

Asterixis Confusion, stupor Laboratory Findings Liver synthetic function Hyperbilirubinemia (usually conjugated) Prolonged prothrombin time Hypoalbuminemia Liver enzyme levels Aspartate [clevelandclinicmeded.com]

Hepatocellular Carcinoma

The most commonly reported adverse events included aspartate aminotransferase increase (19%); rash (17%); elevation of alanine aminotransferase (15%), lipase (17%) and amylase [healio.com]

Also the aspartate aminotransferease, alanine aminotransferase and gamma-glutamyltransferase levels were drastically increased. [jbiomeds.com]

The most common grade 3 or grade 4 adverse events included aspartate aminotransferase increase (11%), alanine aminotransferase increase (9%) and lipase increase (9%). [healio.com]

Primary Biliary Cirrhosis

In the outpatient clinic, when the aspartate and alanine aminotransferase level exceeded the upper limit of the normal range, the dose of methylprednisolone was increased [ncbi.nlm.nih.gov]

Aspartate, alanine aminotransferase, and bilirubin values were normal. [care.diabetesjournals.org]

[…] alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels Increased lipid and cholesterol levels, with an increased HDL fraction Increased erythrocyte sedimentation [emedicine.com]

Liver Cirrhosis

Reference range: 4 to 43IU/L AST (GOT) This test detects the presence of the enzyme aspartate aminotransferase in the bloodstream. [otsuka.co.jp]

[…] enzyme related to the bile ducts; often increased if ducts are blocked Aspartate aminotransferase (AST) – an enzyme found in the liver and a few other places, particularly [labtestsonline.org]

This enzyme is also usually only found in the liver, so an increased amount in the bloodstream indicates liver damage. [otsuka.co.jp]

Myocardial Infarction

Enzymes such as glutamine oxaloacetic transaminase (aspartate aminotransferase) and lactate dehydrogenase are still being used for diagnosis of MI in some laboratories. [dx.doi.org]

Raised troponin levels are associated with increased risks of death and recurrent MI. [dx.doi.org]

Cholestasis

RESULTS: After BDL, plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and total bile acids (TBA) were increased and [ncbi.nlm.nih.gov]

Elevated aspartate transaminase (AST) and alanine aminotransferase (ALT) suggest a more hepatocellular picture. [patient.info]

Laboratory findings show increased fasting total serum bile salts (>10 μmol/L) and mild abnormalities of aminotransaminases, with alanine aminotransferase (ALT) and aspartate [worldgastroenterology.org]

Cholangitis

[…] slightly, such as aspartate aminotransferase (AST) at106 IU/L, alanine aminotransferase (ALT) at 76 IU/L and albumin was 24g/L. [omicsonline.org]

[…] cholestatic picture with elevated Alkaline Phospatase (ALP) at 176 IU/L, γ-Glutamyl Transpeptidase (γ-GT) at137 IU/L and bilirubin at 32 µmol/L, but the synthetic liver function increased [omicsonline.org]

Viral Hepatitis

Laboratory analyses reveal increased amounts of aspartate aminotransferase (AST) and bilirubin and an abnormal coagulation of the blood. [medical-dictionary.thefreedictionary.com]

Serum ALT is usually increased more than serum aspartate aminotransferase. [academic.oup.com]

The most striking laboratory findings include increases of serum aminotransferase activities, serum bilirubin (both total and direct), and serum alkaline phosphatase activity [academic.oup.com]

Wolman Disease

While alanine aminotransferase levels did not change by week 48, median aspartate aminotransferase levels decreased from 99.5 U/L by 35.3% in six patients. [healio.com]

Regarding liver enzymes, we can observe that patients 1 to 4 had moderately increased aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, and [hindawi.com]

Additionally, LDL decreased in two patients from 118.8 mg/dL at baseline by a median 47.5% at 48 weeks and HDL increased in three other patients from 9.4 mg/dL at baseline [healio.com]

Cytomegalovirus Infection

Liver function test abnormalities are characterized by mild transaminitis with increases in aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase, [karger.com]

Erythropoietic Protoporphyria

One or more of these was increased in 17 (25%) patients; sFn correlated with γ-glutamyl transpeptidase (r s = 0.507; P < .001) and alanine aminotransferase (r s = 0.392; P [doi.org]

< .001) but not with aspartate aminotransferase. [doi.org]

Chronic Hepatitis

The treatment efficacy is measured either by the fall in viraemia (level of HDV RNA) or the normalisation of alanine aminotransferase (ALT) or aspartate aminotransferase [doi.org]

Laboratory studies characteristically reveal serum levels of aspartate aminotransferase (AST) that are more than twice the upper limit of the normal range, although rarely [doi.org]

In terms of laboratory chemistry, pathological values of glutamate-oxalacetate-transaminase (GOT) (aspartate-aminotransferase [ASAT]) and glutamate-pyruvate-transaminase [doi.org]

Q Fever

The liver transaminases were mildly increased (alanine aminotransferase, 184 IU/L [41 IU/L, upper limit of normal]; aspartate aminotransferase [AST], 161 IU/L [42 IU/L, upper [academic.oup.com]

The erythrocyte sedimentation rate (ESR) was normal at 5 mm/h; however, his C-reactive protein was mildly increased to 18.5 mg/L (8 mg/L, limit of normal). [academic.oup.com]

Histoplasmosis

At this time, there was a substantial drop in the hemoglobin level (from 7.8 to 4.6 g per deciliter), an increase in the aspartate aminotransferase level (to 626 U per liter [doi.org]

COVID-19

SARS-CoV-2 Variant Classifications and Definitions SARS-CoV-2 Variant Classifications and Definitions Key Definitions Key Points How Variants Are Classified Variants Being Monitored (VBM) Variant of Interest (VOI) Variant of Concern (VOC) Variant of High Consequence (VOHC) References Viruses like SARS-CoV-2[…] [cdc.gov]

Infectious Mononucleosis

Infectious mononucleosis is usually a self-limiting illness, but can be rarely associated with complications. A 17-year-old boy with Epstein-Barr virus related infectious mononucleosis and cold antibody-mediated autoimmune hemolytic anemia with incidentally noted multiple pulmonary nodules. Nodules regressed over the next[…] [ncbi.nlm.nih.gov]

Pulmonary Embolism

Pulmonary embolism (PE) can be a severe disease and is difficult to diagnose, given its nonspecific signs and symptoms. Because of this, testing patients with suspected acute PE has increased dramatically. However, the overuse of some tests, particularly computed tomography (CT) and plasma d-dimer measurement, may[…] [ncbi.nlm.nih.gov]

Liver Metastasis

BACKGROUND: Liver metastasis is common in patients with colorectal cancer (CRC), and is correlated with poor outcome. MicroRNAs (miRNAs) are small non-coding RNAs involved in cancer development and progression, but their role in CRC liver metastasis has not been extensively investigated. RESULTS: Thirteen miRNAs[…] [ncbi.nlm.nih.gov]

Cholecystitis

Cholecystitis is the inflammation of the gallbladder, most commonly caused by the presence of gallstones. Patients with acute cholecystitis usually present with the following symptoms: Pain: Patients with cholecystitis usually present with right upper quadrant pain which radiates to the tip of right shoulder. There[…] [symptoma.com]

Angiomyolipoma

Record: found Abstract: found Article: found Is Open Access Angiomyolipome rénal agressif avec extension à la veine rénale: à propos d'un cas et une revue de la littérature Translated title: Aggressive renal angiomyolipoma extending to the renal vein: about a case and literature review Publication date[…] [scienceopen.com]

Myositis

Purulent myositis is an acute, intramuscular bacterial infection involving abscess formation most commonly affecting the quadriceps, hamstring and gluteal muscles. We present a case of extensive purulent myositis of the thigh and lower leg caused by bowel perforation below the peritoneal reflection secondary to[…] [ncbi.nlm.nih.gov]

Myocarditis

Myocarditis is a condition characterized by inflammation of the myocardium. Viral infection is the major causative factor. Mild cases of myocarditis seldom produce any symptoms. In severe cases, the following symptoms are experienced: Pain in the chest Onset of arrhythmia Feeling of shortness of breath, during[…] [symptoma.com]

Gaucher Disease

Summary Epidemiology The prevalence is approximately 1/100,000. The annual incidence of GD in the general population is about 1/60,000, but it can reach up to 1/1,000 in Ashkenazi Jewish populations. Clinical description The clinical manifestations of this disease are highly variable. GD type 1 (90% of cases) is the chronic[…] [orpha.net]

Pompe Disease

Pompe disease is an inherited disorder caused by the buildup of a complex sugar called glycogen in the body's cells. The accumulation of glycogen in certain organs and tissues, especially muscles, impairs their ability to function normally. Researchers have described three types of Pompe disease, which differ in[…] [ghr.nlm.nih.gov]

Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome

Overview Background Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, also called ornithine translocase deficiency, is a very rare inborn error of metabolism; the age at presentation and long-term prognosis widely vary among affected individuals. Growth and developmental delays, learning disabilities[…] [emedicine.medscape.com]

Aggressive Systemic Mastocytosis

Summary Epidemiology It represents less than 10% of cases of SM and the global prevalence is estimated in the order of between 1/400,000 and 1/250,000. Clinical description ASM doesn't usually develop in children. Cutaneous involvement is normally absent. Patients present with severe symptoms related to mast cell[…] [orpha.net]

Disseminated Histoplasmosis

Histoplasmosis is considered to be the most prevalent endemic mycosis in United States that can present as a disseminated infection. The initial presentation of Disseminated Histoplasmosis (DH) can be atypical. We report three cases with such atypical presentation. Our first patient presented with bowel perforation,[…] [ncbi.nlm.nih.gov]

3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

Brief Article Open Access Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved. World J Gastroenterol. Mar 14, 2012; 18(10): 1067-1076 Published online Mar 14, 2012. doi: 10.3748/wjg.v18.i10.1067 Differential diagnosis in patients with suspected bile acid synthesis defects Dorothea Haas, Hongying[…] [wjgnet.com]

Chlorphenol Poisoning

Abstract Experimental studies proved that ortho-chlorophenol intoxication is manifested by increased serum markers of cytolysis (alanine aminotransferase, aspartate aminotransferase [pubmed.ncbi.nlm.nih.gov]