Possible Causes for aspartate aminotransferase increased Chronic Alcoholism Increased serum globulin levels Metabolic Elevated blood ammonia level Hyperglycemia Respiratory alkalosis Hypomagnesemia Hypophosphatemia Hyponatremia Hypokalemia Back to [clevelandclinicmeded.com] aminotransferase (AST) and alanine aminotransferase (ALT) levels elevated, usually 300 U/L; AST/ALT ratio 2:1 Hematologic Anemia Leukocytosis or leukopenia Thrombocytopenia [clevelandclinicmeded.com] Asterixis Confusion, stupor Laboratory Findings Liver synthetic function Hyperbilirubinemia (usually conjugated) Prolonged prothrombin time Hypoalbuminemia Liver enzyme levels Aspartate [clevelandclinicmeded.com] COVID-19 The Government of Estonia decided to close all educational institutions, except kindergartens, and will apply only digital learning solutions from Monday, 16 March due to the spread of the coronavirus in Estonia. The situation will be reassessed every 14 days and, if necessary, a decision will be taken on the need to[…] [hm.ee] Myocardial Infarction Enzymes such as glutamine oxaloacetic transaminase (aspartate aminotransferase) and lactate dehydrogenase are still being used for diagnosis of MI in some laboratories. [dx.doi.org] Raised troponin levels are associated with increased risks of death and recurrent MI. [dx.doi.org] Liver Cirrhosis Reference range: 4 to 43IU/L AST (GOT) This test detects the presence of the enzyme aspartate aminotransferase in the bloodstream. [otsuka.co.jp] […] enzyme related to the bile ducts; often increased if ducts are blocked Aspartate aminotransferase (AST) – an enzyme found in the liver and a few other places, particularly [labtestsonline.org] This enzyme is also usually only found in the liver, so an increased amount in the bloodstream indicates liver damage. [otsuka.co.jp] Infectious Mononucleosis The objective is to report a case of atypical acute infectious mononucleosis in a juvenile ankylosing spondylitis patient who was treated with infliximab. A 20-year-old man was hospitalized for the evaluation of lymphadenopathy and systemic symptoms. His symptoms developed at the eighth week of the infliximab[…] [ncbi.nlm.nih.gov] Cholangitis […] slightly, such as aspartate aminotransferase (AST) at106 IU/L, alanine aminotransferase (ALT) at 76 IU/L and albumin was 24g/L. [omicsonline.org] […] cholestatic picture with elevated Alkaline Phospatase (ALP) at 176 IU/L, γ-Glutamyl Transpeptidase (γ-GT) at137 IU/L and bilirubin at 32 µmol/L, but the synthetic liver function increased [omicsonline.org] Pulmonary Embolism Although the advent of multi-detector row computed tomography (CT) has enabled better visualization of subsegmental pulmonary (SSP) arteries, SSP embolism is of uncertain clinical significance. We aimed at answering the following questions: Is spiral CT an accurate method to detect SSP embolism? How are[…] [ncbi.nlm.nih.gov] Cholestasis Rats treated with 30 mg/kg/day ANIT for 3 weeks exhibited a time-dependent increase in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin [ncbi.nlm.nih.gov] RESULTS: After BDL, plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and total bile acids (TBA) were increased and [ncbi.nlm.nih.gov] Elevated aspartate transaminase (AST) and alanine aminotransferase (ALT) suggest a more hepatocellular picture. [patient.info] Hepatocellular Carcinoma The most commonly reported adverse events included aspartate aminotransferase increase (19%); rash (17%); elevation of alanine aminotransferase (15%), lipase (17%) and amylase [healio.com] Also the aspartate aminotransferease, alanine aminotransferase and gamma-glutamyltransferase levels were drastically increased. [jbiomeds.com] The most common grade 3 or grade 4 adverse events included aspartate aminotransferase increase (11%), alanine aminotransferase increase (9%) and lipase increase (9%). [healio.com] Viral Hepatitis Laboratory analyses reveal increased amounts of aspartate aminotransferase (AST) and bilirubin and an abnormal coagulation of the blood. [medical-dictionary.thefreedictionary.com] Serum ALT is usually increased more than serum aspartate aminotransferase. [academic.oup.com] Acute hepatitis can usually be differentiated from other causes of jaundice by Its marked elevations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) [msdmanuals.com] Liver Metastasis BACKGROUND: Liver metastasis is common in patients with colorectal cancer (CRC), and is correlated with poor outcome. MicroRNAs (miRNAs) are small non-coding RNAs involved in cancer development and progression, but their role in CRC liver metastasis has not been extensively investigated. RESULTS: Thirteen miRNAs[…] [ncbi.nlm.nih.gov] Cholecystitis • To determine the sensitivity of hepatobiliary imaging (HBI) and strict- and liberal-criteria real-time ultrasonography (RTUS), we retrospectively analyzed 100 cases of pathologically proved acute cholecystitis (AC). A positive HBI was one in which there was nonvisualization of the gallbladder up to four hours after[…] [doi.org] Angiomyolipoma Angiomyolipoma is a common benign renal tumor. It is typically composed of adipose tissue and hence is easily diagnosed by using imaging methods such as ultrasonography, computed tomography, and magnetic resonance imaging. However, it is difficult to differentiate an atypical angiomyolipoma such as a fat-poor[…] [ncbi.nlm.nih.gov] Primary Biliary Cirrhosis In the outpatient clinic, when the aspartate and alanine aminotransferase level exceeded the upper limit of the normal range, the dose of methylprednisolone was increased [ncbi.nlm.nih.gov] […] alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels Increased lipid and cholesterol levels, with an increased HDL fraction Increased erythrocyte sedimentation [emedicine.medscape.com] […] elevations of the alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGTP), and immunoglobulin levels (mainly IgM): Usually the most prominent findings Elevation of the aminotransferases [emedicine.medscape.com] Cytomegalovirus Infection Liver function test abnormalities are characterized by mild transaminitis with increases in aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase, [karger.com] Myositis The benign acute childhood myositis presents as a marked and painful oedema of leg muscles in the days following a viral illness. This disease is often considered as occurring only in children. We report the case of a 32-year-old patient who presented with severe pain and oedema of both legs associated with motor[…] [ncbi.nlm.nih.gov] Myocarditis Definition The term myocarditis refers to an inflammatory response within the myocardium that is not secondary to ischemic events or cardiac rejection in the setting of transplantation. The presence of myocyte necrosis is required for certain types of myocarditis — specifically, lymphocytic myocarditis that is[…] [emedicine.medscape.com] Malignant Neoplasm of the Liver The patient developed the following symptoms/conditions: aspartate aminotransferase increased, musculoskeletal pain ,decreased appetite,prophylaxis,abdominal pain upper,hepatitis [patientsville.com] aminotransferase (AST) increase) in order to facilitate the selection of patients who might benefit from repeated TACE treatment. 83, 84 The authors reported that even discrete [esmoopen.bmj.com] The Assessment for Retreatment with TACE (ART) score was developed based on radiological tumour response and impairment of liver function (Child-Pugh score and serum aspartate [esmoopen.bmj.com] Wolman Disease While alanine aminotransferase levels did not change by week 48, median aspartate aminotransferase levels decreased from 99.5 U/L by 35.3% in six patients. [healio.com] Regarding liver enzymes, we can observe that patients 1 to 4 had moderately increased aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, and [hindawi.com] Additionally, LDL decreased in two patients from 118.8 mg/dL at baseline by a median 47.5% at 48 weeks and HDL increased in three other patients from 9.4 mg/dL at baseline [healio.com] Glycogen Storage Disease Type 2 Serum enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), or lactate dehydrogenase (LDH) may be elevated and may reflect enzymes released from [dx.doi.org] […] muscle. 24 There is increasing evidence of the value of a specific glucose tetrasaccharide in urine [Glc 4 (Glcα1-6Glcα1-4Glcα1-4Glc)] in the evaluation of Pompe disease. [dx.doi.org] Erythropoietic Protoporphyria One or more of these was increased in 17 (25%) patients; sFn correlated with γ-glutamyl transpeptidase (r s 0.507; P .001) and alanine aminotransferase (r s 0.392; P .001) [doi.org] […] but not with aspartate aminotransferase. [doi.org] Gaucher Disease Gaucher disease is the commonest lysosomal storage disease seen in India and worldwide. It should be considered in any child or adult with an unexplained splenohepatomegaly and cytopenia which are seen in the three types of Gaucher disease. Type 1 is the non-neuronopathic form and type 2 and 3 are the[…] [ncbi.nlm.nih.gov] Chronic Hepatitis DIAGNOSIS OF TOXIC HEPATITIS Laboratory Liver damage can be of two types: hepatocellular damage (death of liver cells), in which alanine aminotransferase and aspartate aminotransferase [doi.org] The control of HBV DNA was associated with a modest, intermittent increase in levels of serum aspartate aminotransferase and alanine aminotransferase that may indicate hepatocyte [doi.org] The treatment efficacy is measured either by the fall in viraemia (level of HDV RNA) or the normalisation of alanine aminotransferase (ALT) or aspartate aminotransferase [doi.org] Q Fever The liver transaminases were mildly increased (alanine aminotransferase, 184 IU/L [41 IU/L, upper limit of normal]; aspartate aminotransferase [AST], 161 IU/L [42 IU/L, upper [academic.oup.com] The erythrocyte sedimentation rate (ESR) was normal at 5 mm/h; however, his C-reactive protein was mildly increased to 18.5 mg/L (8 mg/L, limit of normal). [academic.oup.com] Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a rare inherited urea cycle disorder, can remain undiagnosed for decades and suddenly turn into an acute life-threatening state. Adult presentation of hyperornithinemia-hyperammonemia-homocitrullinuria syndrome has rarely been described, but is potentially[…] [ncbi.nlm.nih.gov] Aggressive Systemic Mastocytosis Aggressive systemic mastocytosis (ASM) is a subtype of systemic mastocytosis, which comprises a heterogenous group of disorders characterized by infiltration of bone marrow, skin, liver, spleen, lymph nodes and gastrointestinal tract by neoplastic mast cells. There is lack of data on the association of ASM with[…] [ncbi.nlm.nih.gov] Histoplasmosis At this time, there was a substantial drop in the hemoglobin level (from 7.8 to 4.6 g per deciliter), an increase in the aspartate aminotransferase level (to 626 U per liter [doi.org] Disseminated Histoplasmosis Histoplasmosis is considered to be the most prevalent endemic mycosis in United States that can present as a disseminated infection. The initial presentation of Disseminated Histoplasmosis (DH) can be atypical. We report three cases with such atypical presentation. Our first patient presented with bowel perforation,[…] [ncbi.nlm.nih.gov] Common Cold […] of alanine aminotransferase, aspartate aminotransferase, or ammonia in serum. [nejm.org] The encephalopathy must be associated with either fatty metamorphosis of the liver, diagnosed by biopsy or at autopsy, or a tripling (or a greater increase) in the levels [nejm.org] Bronchitis Then in 1976, in a double-blind randomized controlled trial, Rawles and Kenmure reported greater serum aspartate aminotransferase levels, indicating increased infarct size [doi.org]
