Create issue ticket

209 Possible Causes for Aspartate Transaminase Increased, Muscle Biopsy showing Presence of Vacuoles

  • Glycogen Storage Disease Type 2

    Muscle biopsy in Pompe disease shows the presence of vacuoles that stain positively for glycogen.[dx.doi.org] Biochemical investigations include serum creatine kinase (typically increased 10 fold) with lesser elevations of the serum aldolase, aspartate transaminase, alanine transaminase[en.wikipedia.org] Quantitatively, muscle glycogen content is elevated up to tenfold above normal in infantile Pompe disease and to a lesser extent in late onset patients.[dx.doi.org]

  • Myositis

    In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com] The T-cell receptor repertoire observed in lymphocytes that have been isolated from the muscles of these patients shows restriction when compared to the lymphocytes of the[rheumatologyadvisor.com]

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Myocardial Infarction

    The level of serum aspartate transaminase (AST) increases rapidly in 4 to 6 hours, reaches its peak in 24 to 48 hours, and returns to normal in five days.[medical-dictionary.thefreedictionary.com] Enzymes such as glutamine oxaloacetic transaminase (aspartate aminotransferase) and lactate dehydrogenase are still being used for diagnosis of MI in some laboratories.[dx.doi.org] Within 2 to 4 hours after infarction the level of creatine kinase (CK) is increased; it reaches its peak within 24 hours and subsides to normal level within 48 hours.[medical-dictionary.thefreedictionary.com]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Liver Cirrhosis

    During liver injury, ALT released from damaged cells can rapidly increase ALT activity in the serum. 11 Aspartate transaminase (AST) is present not only in the liver but also[doi.org] Therefore, AST activity increases in the case of hepatic injury but is less specific for hepatic injury than ALT. 11, 12 The aim of this study was 2-fold.[doi.org]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Infectious Mononucleosis

    Infectious mononucleosis should be suspected in patients 10 to 30 years of age who present with sore throat and significant fatigue, palatal petechiae, posterior cervical or auricular adenopathy, marked adenopathy, or inguinal adenopathy. An atypical lymphocytosis of at least 20 percent or atypical lymphocytosis of[…][ncbi.nlm.nih.gov]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Cholangitis

    Clin J Gastroenterol. 2018 Feb;11(1):62-68. doi: 10.1007/s12328-017-0787-3. Epub 2017 Nov 1. Ohno Y 1 , Kumagi T 2 , Imamura Y 1 , Kuroda T 1 , Koizumi M 1 , Watanabe T 1 , Yoshida O 1 , Tokumoto Y 1 , Takeshita E 1 , Abe M 1 , Harada K 3 , Hiasa Y 1 . Author information 1 Gastroenterology and Metabology, Ehime University[…][ncbi.nlm.nih.gov]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Pulmonary Embolism

    AIM: To assess the prognostic value of lactate level for mortality in patients with pulmonary embolism (PE) and Pulmonary Embolism Severity Index (PESI) I-III and its independence of gas-analysis parameters and acid-base status. METHODS: This prospective observational study was conducted at the University Clinical[…][ncbi.nlm.nih.gov]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Cholestasis

    Elevated aspartate transaminase (AST) and alanine aminotransferase (ALT) suggest a more hepatocellular picture.[patient.info] At 34 weeks she gave a history of occasional right upper quadrant abdominal pain and her biochemistry revealed raised serum aspartate transaminase ,alanine transaminase, fasting[casesjournal.biomedcentral.com] Serum albumin and globulin will change little in the acute phase but albumin will decrease and globulin increase in chronic disease.[patient.info]

    Missing: Muscle Biopsy showing Presence of Vacuoles
  • Cholecystitis

    Song et al demonstrated that 424 of 1178 patients with ACC had increased liver tests (alanine transaminase (ALT), aspartate transaminase (AST) greater than twice normal levels[doi.org]

    Missing: Muscle Biopsy showing Presence of Vacuoles

Further symptoms