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16 Possible Causes for Aspiration Pneumonia, Compound Muscle Action Potential with Low Amplitude, Muscle Biopsy Abnormal

  • Dermatomyositis

    Muscle biopsy abnormalities at some time during their disease: i. degeneration and regeneration of muscle fibers ii. necrosis iii. phagocytosis iv. interstitial mononuclear[] Pulmonary manifestations range from aspiration pneumonia to interstitial lung disease (ILD), sometimes with complications such as pulmonary arterial hypertension (see these[] Low compound muscle action potentials (CMAP) amplitudes may not necessarily indicate a neuropathic process, as it may reflect muscle atrophy and fibrosis.[]

  • Inclusion Body Myositis

    Muscle biopsy may display several common findings including; inflammatory cells invading muscle cells, vacuolar degeneration, inclusions or plaques of abnormal proteins.[] The incidence of dysphagia, rate of aspirations, rate of aspiration pneumonias and treatment results of dysphagia were analyzed.[] However, the low compound muscle action potential amplitudes could be explained by the loss of excitable muscle tissue that occurs in myopathies.[]

  • Guillain-Barré Syndrome

    Other Studies Muscle biopsy may help to distinguish GBS from a primary myopathy in unclear cases.[] Thromboembolism, pneumonia, skin breakdown. Cardiac arrhythmia. Ileus. Aspiration pneumonia. Urinary retention. Psychiatric problems - eg, depression, anxiety.[] muscle action potentials reduced amplitude with relatively preserved conduction velocity implicates axonal neuropathy delayed/absent F waves implicates nerve root involvement[]

  • Myasthenia Gravis

    Muscle biopsies in these patients show myopathic signs with prominent mitochondrial abnormalities, as opposed to the neurogenic features and atrophy frequently found in MG[] Complications Aspiration pneumonia due to throat muscle weakness. Acute respiratory failure during an exacerbation.[] Distinguishing features of the RNS test in LEMS and MG are confirmed in this direct comparison study: the low compound muscle action potential amplitude, decrement at LRS,[]

  • Neuropathy

    In peripheral neuropathy, the electrical activity will be abnormal.[] Compounding the problem of aspiration pneumonias and chronic lung disease is the presence of relative insensitivity to hypoxemia [ 23 - 26 ], which limits ability to cope[] Patients have relatively normal nerve conduction velocities but low amplitude sensory nerve action potentials and compound muscle action potentials.[]

  • Lambert Eaton Myasthenic Syndrome

    QEMG, nerve conduction studies and muscle biopsy were performed in four consecutive LEMS patients.[] Approximately 2 months after the operation, he had aspiration pneumonia with respiratory failure.[] Distinguishing features of the RNS test in LEMS and MG are confirmed in this direct comparison study: the low compound muscle action potential amplitude, decrement at LRS,[]

  • Neuromuscular Junction Disorder

    Electromyography shows fibrillation in abnormal spontaneous activity in the muscles while a muscle biopsy shows atrophic and hypertrophied muscle fibers.[] Aspiration pneumonia is clearly an undesirable outcome in someone with already compromised respiratory function.[] EMNG showed signs of myopathy and low compound muscle action potential (CMAP) amplitude (0,15 mV) on lower extremities. Muscle and nerve biopsy were normal.[]

  • Congenital Merosin-Positive Muscular Dystrophy

    We studied expression of the skeletal muscle isoforms of alpha-actinin (alpha-actinin-2 and alpha-actinin-3) in muscle biopsies from 12 patients with pure CMD (including one[] Aspiration pneumonia and/or respiratory insufficiency may require assisted cough devices, supplemental oxygen, noninvasive ventilation, and/or mechanical ventilation via tracheostomy[] Myopathic findings include low amplitude compound muscle action potentials (CMAPs) and small polyphasic motor unit potentials that are rapidly recruited.[]

  • Acute Pandysautonomia

    Surprisingly, limb or intercostal muscle biopsies exhibit no reduction in AChR numbers or complement deposition.[] The patients are at risk for sustaining injury during falls and developing urinary tract infection or aspiration pneumonia.[] In cases of suspected neuromuscular transmission defect, such as with botulism or LEMS, a typical electrophysiologic pattern of low-amplitude compound muscle action potentials[]

  • Charcot-Marie-Tooth Disease Type 2S

    Tests that measure electrical activity while muscles are relaxed and contracted ( electromyography ). Lab tests of a small piece of the nerve (nerve biopsy).[] Laryngeal dysfunction with aspiration pneumonia.[] Electrodiagnostic studies showed normal or moderately slowed motor nerve conduction velocities (MNCVs) but very low motor compound muscle action potential (CMAP) amplitudes[]

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