Associated with Idiopathic Generalized Epilepsy: Causes & Reasons

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Possible Causes for Associated with Idiopathic Generalized Epilepsy

Idiopathic Generalized Epilepsy

IDO activity appeared to be associated with idiopathic generalized epilepsies such as unclassified IGE and JME, two of the most common types of primary generalized epilepsy [ncbi.nlm.nih.gov]

PURPOSE: Photosensitivity or photoparoxysmal response (PPR) is an electroencephalography trait that is highly associated with idiopathic generalized epilepsies (IGEs) and [ncbi.nlm.nih.gov]

In patients with idiopathic (but not cryptogenic or symptomatic) etiology of epilepsy, IDO activity was increased compared to the control subjects (p CONCLUSIONS: Increased [ncbi.nlm.nih.gov]

15q13.3 Microdeletion Syndrome

We screened 570 patients with pediatric epilepsies including idiopathic generalized epilepsies, focal epilepsies and fever-associated epilepsy syndromes for microdeletions [ikmb.uni-kiel.de]

In our pediatric cohort, recurrent microdeletions at 15q11.2, 15q13.3 and 16p13.11 are mainly associated with phenotypes related to idiopathic generalized epilepsies or related [ikmb.uni-kiel.de]

generalized epilepsies and other neurodevelopmental disorders. [ikmb.uni-kiel.de]

Familial Febrile Seizures Type 5

[…] with idiopathic generalized epilepsies. [link.springer.com]

Lack of an association between candidate gene loci and idiopathic generalized epilepsy in Kuwaiti Arab children. J. Biomed. Sci. 12, 815–818. [degruyter.com]

Mutations in SCN1B have been associated with Brugada syndrome (5/20), generalized epilepsy with febrile seizures (5/20), atrial fibrillation (2/20), idiopathic and generalized [centogene.com]

Childhood Absence Epilepsy

generalized epilepsy. [doi.org]

Zamponi, Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants, Annals of Neurology, 62, 6, (560-568), (2007). [doi.org]

CONCLUSION: The association of two different idiopathic focal and generalized epilepsies in the same patient may be merely coincidental, but a close genetic relationship between [ncbi.nlm.nih.gov]

Familial Febrile Seizures Type 9

GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. [id-press.eu]

[…] with idiopathic generalized epilepsies. [link.springer.com]

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Familial Febrile Seizures Type 1

GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. [id-press.eu]

GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. 2009 ). [flipper.diff.org]

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Idiopathic Hemiconvulsion-Hemiplegia Syndrome

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [eng.ichacha.net]

Classification of epilepsies and particularly of epilepsy syndromes will change with advances in research. [eng.ichacha.net]

Familial Febrile Seizures Type 4

GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. [id-press.eu]

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Generalized Epilepsy with Febrile Seizures plus Type 7

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Although a few candidate disease alleles were identified, the patient survey suggests that SCN1A is nota major contributor to idiopathic generalized epilepsy. [experts.umich.edu]

Generalized Epilepsy with Febrile Seizures plus Type 2

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Although a few candidate disease alleles were identified, the patient survey suggests that SCN1A is nota major contributor to idiopathic generalized epilepsy. [experts.umich.edu]

Juvenile Myoclonic Epilepsy

Gallagher and Hua-Jun Feng, GABAA-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures, The GABA Receptors, 10.1007/978-1-59745-465-0_ [dx.doi.org]

JME is a relatively benign form of idiopathic generalized epilepsy and typically occurs in adolescence. [dergipark.org.tr]

JME syndrome is characterized by myoclonic jerks often associated with generalized tonic clonic seizures and typical absence seizures. [dergipark.org.tr]

Generalized Epilepsy with Febrile Seizures plus Type 3

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Several genes, which encode sodium or GABA receptor subunits, have been associated with febrile seizures phenotypes (see table): Idiopathic generalized epilepsy 10, generalized [centogene.com]

Absence Seizure

generalized epilepsy. [doi.org]

Zamponi, Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants, Annals of Neurology, 62, 6, (560-568), (2007). [doi.org]

Myoclonic and tonic-clonic seizures may be associated with these idiopathic generalized epilepsies, but are seldom observed in forms with an early onset. [symptoma.com]

Generalized Epilepsy with Febrile Seizures Plus

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Familial Infantile Myoclonic Epilepsy

[…] with idiopathic generalized epilepsies. [genome.jp]

Haug K, Warnstedt M, Alekov AK, Sander T, Ramírez A, et al: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies [karger.com]

Pflugers Arch 460:495–503 CrossRef PubMed Google Scholar Stogmann E, Lichtner P, Baumgartner C et al (2006) Idiopathic generalized epilepsy phenotypes associated with different [link.springer.com]

Febrile Seizures

Pure FCs and febrile convulsions associated with idiopathic generalized epilepsy may not share a common genetic etiology. [ncbi.nlm.nih.gov]

GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. 2009). [flipper.diff.org]

Generalized Epilepsy with Febrile Seizures plus Type 4

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Autosomal Dominant Lateral Temporal Lobe Epilepsy

Genes associated with idiopathic generalized epilepsies remain within the ion channel family. [journals.lww.com]

Mutations in the chloride channel gene CLCN2 have been associated with the most common forms of idiopathic generalized epilepsies. [journals.lww.com]

Myoclonic-Astatic Epilepsy

CONCLUSIONS: In addition to the thalamocortical network, which is commonly found in idiopathic generalized epilepsies, GSW in patients with MAE are characterized by BOLD signal [ncbi.nlm.nih.gov]

Based on an extensive evaluation, these patients were stratified into idiopathic partial, idiopathic generalized, symptomatic partial or symptomatic generalized epilepsies [ncbi.nlm.nih.gov]

Myoclonic-astatic epilepsy is perhaps more a conceptual category of idiopathic myoclonic epilepsy than a discrete syndrome. [ncbi.nlm.nih.gov]

Myoclonic Epilepsy of Infancy

Myoclonic-astatic epilepsy is perhaps more a conceptual category of idiopathic myoclonic epilepsy than a discrete syndrome. [journals.lww.com]

The electroclinical features of these patients resemble those of children with idiopathic generalized epilepsy. [onlinelibrary.wiley.com]

Childhood-onset myoclonic-astatic attacks are the characteristic seizures associated in most with episodes of nonconvulsive status and generalized tonic-clonic seizures. [journals.lww.com]

Focal Epilepsy - Speech Disorder - Mental Retardation

Photosensitive seizures are usually associated with idiopathic generalized epilepsy, but may also occur with focal or symptomatic epilepsies. [euroformhealthcare.biz]

The term photoparox-ysmal is used if there is only an electrographic discharge, whereas photoconvulsive is used if there is an actual clinical event associated with the discharge [euroformhealthcare.biz]

Familial Febrile Seizures Type 6

GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci 2006;26:2590–7. 3. [jcomjournal.com]

Kallmann Syndrome Type 3

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance CentoMD® exclusive variant numbers (++) GABRD 137163 Epilepsy, idiopathic generalized, 10 AD 12 GABRG2 137164 Epilepsy [centogene.com]

Cardiodysrhythmic Potassium-Sensitive Periodic Paralysis

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nat Genet 2003 ; 33 : 527 –532. 75. [cambridge.org]

Frequent mutations of SCN1A in severe myoclonic epilepsy in infancy. Neurology 2002 ; 58 : 1122 –1124. 74. Haug K, Warnstedt M, Alekov AK, et al. [cambridge.org]

Hypogonadotropic Hypogonadism Type 8

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance CentoMD® exclusive variant numbers (++) GABRD 137163 Epilepsy, idiopathic generalized, 10 AD 12 GABRG2 137164 Epilepsy [centogene.com]

Hypogonadotropic Hypogonadism Type 18

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance CentoMD® exclusive variant numbers (++) GABRD 137163 Epilepsy, idiopathic generalized, 10 AD 12 GABRG2 137164 Epilepsy [centogene.com]

Hypogonadotropic Hypogonadism Type 22

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance CentoMD® exclusive variant numbers (++) GABRD 137163 Epilepsy, idiopathic generalized, 10 AD 12 GABRG2 137164 Epilepsy [centogene.com]

Kallmann Syndrome Type 4

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance CentoMD® exclusive variant numbers (++) GABRD 137163 Epilepsy, idiopathic generalized, 10 AD 12 GABRG2 137164 Epilepsy [centogene.com]

Hypogonadotropic Hypogonadism Type 21

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance CentoMD® exclusive variant numbers (++) GABRD 137163 Epilepsy, idiopathic generalized, 10 AD 12 GABRG2 137164 Epilepsy [centogene.com]

Narcolepsy

Narcolepsy type 1 may occur in association with idiopathic generalized epilepsy, leading to remarkable diagnostic and therapeutic challenges. [ncbi.nlm.nih.gov]