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47 Possible Causes for Asthenia, Cognitive Defect, Spasticity - Hyperreflexia

  • Hyponatremia

    They are primarily central nervous system (CNS) manifestations, such as irritability, restlessness, lethargy, muscular twitching, spasticity and hyperreflexia, all of which[aafp.org] CASE: A 17-year-old boy was admitted to the emergency department with abdominal pain, nausea and vomiting, asthenia, and weight loss.[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com]

  • Hypernatremia

    Muscle twitching, tremor, spasticity, hyperreflexia, and lethargy may also be seen. Coma, seizures, and muscle weakness are later signs.[aneskey.com] […] of hypernatremic patients and risk factors for death occurrence during hospitalization Age (years) 79.7   14 85.3   10.7 77.2   14.7 Male 44% 63% 41% Cause of admission Asthenia[bmcnephrol.biomedcentral.com] , twitching, spasticity 430: seizures and death Urine osmolarity (Uosm) Can be used to determine cause when etiology unclear (not usually in ED, part of inpatient workup)[fprmed.com]

  • Motor Neuron Disease

    Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal[en.wikipedia.org] , hyperreflexia and atrophy in later stages of disease, but fasciculations are absent.[symptoma.com] The essential clinical findings are slowly progressive and often include severe spasticity, hyperreflexia, and weakness in a pyramidal distribution, noticeably in both lower[emedicine.medscape.com]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    , weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[6],[4].[explainmedicine.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us] : strabismus , nystagmus , oculomotor apraxia Cognitive defects Life expectancy 1 year Diagnostics Genetic testing : best initial and confirmatory test Further tests Laboratory[amboss.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    , spasticity -muscle atrophy (fasciculations), fasciculations, tongue atrophy, rapidly progressive (lethal) -upper & lower motor neurons, bulbar weakness -normal sensation[brainscape.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us] Sensory, visual, and cognitive defects may be detected later in life.[britannica.com]

  • Neurogenic Arthrogryposis Multiplex Congenita

    Dysarthria Hyperreflexia Enlarged cisterna magna Abnormality of the skeletal system Vomiting Babinski sign Clinodactyly Dementia Gastroesophageal reflux Pes cavus Microcornea[mendelian.co] Claude Stoll, Marie‐Christine Ehret‐Mentre, Alain Treisser and Christine Tranchant, Prenatal diagnosis of congenital my asthenia with arthrogryposis in a myasthenic mother[doi.org] In some cases, however, their lifespan may be altered by issues with central nervous system or heart defects.[primehealthchannel.com]

  • Ataxia

    Typical clinical signs and symptoms of autosomal dominant ataxias (ADCA) include the following: Limb and truncal ataxia Hyperreflexia and spasticity (pyramidal signs) are[centogene.com] This results in a characteristic type of irregular, uncoordinated movement that can manifest itself in many possible ways, such as asthenia, asynergy, delayed reaction time[en.wikipedia.org] defects: SCA 1, 2, 3, 12, 13, 19, 21 Seizures Adult: SCA 10 Childhood onset: DRPLA, SCA 7 Dementia Common: DRPLA ; SCA 17 Early onset patients: SCA 2, 7 Oldest patients:[neuromuscular.wustl.edu]

  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    Spasticity and hyperreflexia are often present but some newborn infants are hypotonic.[disorders.eyes.arizona.edu] One case with recurrent pharyngitis. [101] Recurrent fevers with flares, plus headaches, asthenia and pain.[autoinflammatory-search.org] Clinically, affected individuals show an L-DOPA-responsive, diurnally fluctuating movement disorder usually associated with cognitive delay and severe neurologic dysfunction[mendelian.co]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    , and spasticity; mental retardation, cognitive impairment, or both; and epilepsy.[blogs.nejm.org] (appendicular or axial)  Dysmetria  Dyssynergia  Dysdiadochokinesia  Rebound Phenomenon  Dysarthria  Tremor  Titubation and increased postural sway  Hypotonia  Asthenia[slideshare.net] Typical clinical signs and symptoms of autosomal dominant ataxias (ADCA) include the following: Limb and truncal ataxia Hyperreflexia and spasticity (pyramidal signs) are[centogene.com]

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