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91 Possible Causes for Asthenia, Limb Weakness, Spasticity - Hyperreflexia

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com] Symptoms can include: Pain (for example, headaches, pain in the legs and feet, back pain, and muscle spasms) Electric-shock sensations that run down the back and limbs when[hopkinsmedicine.org] Typical symptoms associated with PML are diverse, progress over days to weeks, and include progressive weakness on one side of the body or clumsiness of limbs, disturbance[ocrevus.com]

  • Motor Neuron Disease

    Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal[en.wikipedia.org] Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[ncbi.nlm.nih.gov] , hyperreflexia and atrophy in later stages of disease, but fasciculations are absent.[symptoma.com]

  • Radiculomyelopathy

    Myelopathic features are characterized by a more abrupt onset and include spastic paraplegia or quadriplegia, hyperreflexia, Babinski reflex, clonus, or a variety of sensory[fluoridealert.org] Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb.[patient.info] weakness or may not be able to give full effort on muscle strength testing because of limb pain.[consultant360.com]

  • Mononeuritis Multiplex

    CNS Upper motor neuron signs (spasticity, hyperreflexia, upgoing plantar reflexes) are usually seen distal to the lesion.[clinicaladvisor.com] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[clevelandclinicmeded.com] weakness from mononeuritis multiplex. ( 27728172 ) 2016 19 Mononeuritis multiplex in acquired amegakaryocytic thrombocytopenia. ( 26752909 ) Khan F....Mukundan L. 2015 20[malacards.org]

  • Lumbosacral Plexus Disorder

    The disorder affects men exclusively and is characterized by muscle wasting and weakness, without signs of upper motor neuron dysfunction such as spasticity or hyperreflexia[neupsykey.com] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[clevelandclinicmeded.com] After infections, surgery or stress Few episodes after 50 years Non-penetrance: Rare Pain Precedes weakness Increased by limb movement Weakness: Multifocal Course: Maximum[neuromuscular.wustl.edu]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    , weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[6],[4].[explainmedicine.com] In family A the pathological findings and the clinical presentation with symmetrical proximal limb weakness show similarities with autosomal dominant SMA.[link.springer.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us]

  • Peripheral Motor Neuropathy

    However, hyperreflexia and spasticity typical of ALS never occur in MMN. Conduction block Amount of block increases with more proximal stimulation. B.[neuromuscular.wustl.edu] weakness in individual motor nerve distribution with or without persistent conduction block preferentially affecting young man.[neurology.org] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[clevelandclinicmeded.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    , spasticity -muscle atrophy (fasciculations), fasciculations, tongue atrophy, rapidly progressive (lethal) -upper & lower motor neurons, bulbar weakness -normal sensation[brainscape.com] In family A the pathological findings and the clinical presentation with symmetrical proximal limb weakness show similarities with autosomal dominant SMA.[link.springer.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us]

  • Infantile Neuroaxonal Dystrophy

    Clinical Onset before age three years Psychomotor regression (most common presenting feature) Early truncal hypotonia followed by spastic tetraparesis (usually with hyperreflexia[ncbi.nlm.nih.gov] Lower limb weakness within several months developed into complete paraparesis, and dysphagia occurred.[thieme-connect.com] (truncal hypotonia) -Later development of muscle tightness and weakness in both arms and legs (spastic tetraparesis) -Abnormal reflexes Common eye features include: -Crossed[rarediseases.org]

  • Neuromuscular Junction Disorder

    Upper motor neuronal dysfunction lead to spasticity and hyperreflexia while lower motor neuronal lesions lead to paralysis with muscle fasciculations.[lecturio.com] Diagnosis  Clinical Features:  Proximal Distal limb weakness  Initial presentation with difficulties to walk.[slideshare.net] In NMJD breathiness and asthenia are frequently present with variable degree and fluctuating pattern during the day.[medcraveonline.com]

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