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91 Possible Causes for Asthenia, Muscular Atrophy, Spasticity - Hyperreflexia

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com] In late-stage Roche, they have treatments that are being tested for Alzheimer’s disease, Autism, and for Spinal Muscular Atrophy.[mdmag.com] Roche has more than a dozen investigational medicines in clinical development for diseases that include multiple sclerosis, Alzheimer’s disease, spinal muscular atrophy, Parkinson[finance.yahoo.com]

  • Motor Neuron Disease

    Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal[en.wikipedia.org] Some MNDs, such as ALS and some forms of spinal muscular atrophy, are fatal.[ninds.nih.gov] , hyperreflexia and atrophy in later stages of disease, but fasciculations are absent.[symptoma.com]

  • Amyotrophic Lateral Sclerosis

    The upper motor signs include spasticity, hyperreflexia and weakness. The lower motor signs include amyotrophy, weakness and fasciculations.[symptoma.com] Asthenia There was a trend toward more asthenia among the treated participants in each trial, and this became statistically significant when the data from the three trials[doi.org] The patients were a 54-year-old man with progressive muscular atrophy who underwent removal of internal fixators in the arm and leg, and a 66-year-old woman with amyotrophic[ncbi.nlm.nih.gov]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    , spasticity -muscle atrophy (fasciculations), fasciculations, tongue atrophy, rapidly progressive (lethal) -upper & lower motor neurons, bulbar weakness -normal sensation[brainscape.com] muscular atrophy, but have different genetic causes.[togetherinsma.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us]

  • Radiculomyelopathy

    Myelopathic features are characterized by a more abrupt onset and include spastic paraplegia or quadriplegia, hyperreflexia, Babinski reflex, clonus, or a variety of sensory[fluoridealert.org] With pure LMN features (progressive muscular atrophy).[patient.info] There are rare disease variants that are either pure upper motor neuron in form (primary lateral sclerosis) or pure lower motor neuron (progressive muscular atrophy).[consultant360.com]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    , weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[6],[4].[explainmedicine.com] […] are not associated with a defect in the SMN1 gene on chromosome 5q X-linked spinal muscular atrophy X-linked spinal muscular atrophy is seen only among males![amboss.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us]

  • Syringomyelia

    Upper extremity reflexes are diminished or absent, whereas weakness, altered gait, spasticity, and hyperreflexia may be noted in the lower extremities.[medical-dictionary.thefreedictionary.com] PATIENTS CONCERNS: A 52-year-old non-diabetic female presented with progressive swelling, pain and limited movement in her left shoulder joint combined with asthenia of her[ncbi.nlm.nih.gov] Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile[fpnotebook.com]

  • Amyotrophic Lateral Sclerosis Type 1

    hyperreflexia ( ) Hoffman's ( ) Babinski's spastic dysarthria lower motor neuron (LMN) signs muscular atrophy weakness clinical fasciculations clumsiness Evaluation Diagnosis[orthobullets.com] atrophy and related syndromes G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman] G12.1 Other inherited spinal muscular atrophy G12.2 Motor neuron disease G12.21[icd10data.com] […] positive effect on functional abilities from the use of riluzole is unclear, and no studies have reported that the drug halts the disease process. 21 Adverse effects include asthenia[aafp.org]

  • Muscular Fasciculation

    Upper motor neuron lesions are characterized by weakness, spasticity, hyperreflexia, primitive reflexes and the Babinski sign.[informatics.med.nyu.edu] […] positive effect on functional abilities from the use of riluzole is unclear, and no studies have reported that the drug halts the disease process. 21 Adverse effects include asthenia[aafp.org] March 10, 2015 ; 84 (10) Resident and Fellow Section First published March 9, 2015, DOI: Spinal muscular atrophy (SMA) is a heterogeneous, autosomal-recessive neuromuscular[n.neurology.org]

  • Neuromuscular Junction Disorder

    Upper motor neuronal dysfunction lead to spasticity and hyperreflexia while lower motor neuronal lesions lead to paralysis with muscle fasciculations.[lecturio.com] Spinal muscular atrophies: Amyotrophic lateral sclerosis (ALS), or motor neuron disease Infantile progressive spinal muscular atrophy Intermediate spinal muscular atrophy[hopkinsmedicine.org] In NMJD breathiness and asthenia are frequently present with variable degree and fluctuating pattern during the day.[medcraveonline.com]

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