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59 Possible Causes for Asthenia, Peripheral Paralysis, Spasticity - Hyperreflexia

  • Hyponatremia

    They are primarily central nervous system (CNS) manifestations, such as irritability, restlessness, lethargy, muscular twitching, spasticity and hyperreflexia, all of which[] Sarcoidosis may affect brain, spinal cord, and any part of the central or peripheral nervous system.[] CASE: A 17-year-old boy was admitted to the emergency department with abdominal pain, nausea and vomiting, asthenia, and weight loss.[]

  • Amyotrophic Lateral Sclerosis Type 1

    hyperreflexia ( ) Hoffman's ( ) Babinski's spastic dysarthria lower motor neuron (LMN) signs muscular atrophy weakness clinical fasciculations clumsiness Evaluation Diagnosis[] […] positive effect on functional abilities from the use of riluzole is unclear, and no studies have reported that the drug halts the disease process. 21 Adverse effects include asthenia[] On physical exam, signs of hyperreflexia, spasticity, fasciculations, and muscle atrophy are present in an asymmetric fashion. Tongue fasciculations are also present.[]

  • Amyotrophic Lateral Sclerosis

    The upper motor signs include spasticity, hyperreflexia and weakness. The lower motor signs include amyotrophy, weakness and fasciculations.[] ., 1990 ), stroke ( Holroyd and Hill, 1989 ), peripheral nerve lesions ( Pajntar et al., 1980 ), cases of organic paralysis ( Lucas et al., 1981 ), various type of dystonia[] Asthenia There was a trend toward more asthenia among the treated participants in each trial, and this became statistically significant when the data from the three trials[]

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[] […] and optic nerves causing paralysis, tremor, disturbance of speech, nystagmus, diplopia due to involvement of the extraocular muscles, and frequently retrobulbar optic neuritis[] (MS). sclerosis, multiple (MS) An autoimmune disease in which there are disseminated patches of demyelination and sclerosis (or hardening) of the brain, spinal cord and peripheral[]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    , spasticity -muscle atrophy (fasciculations), fasciculations, tongue atrophy, rapidly progressive (lethal) -upper & lower motor neurons, bulbar weakness -normal sensation[] Periodic paralysis with later-onset distal motor neuropathy Periodic paralysis with transient compartment-like syndrome Peripheral demyelinating neuropathy-central dysmyelinating[] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[]

  • Paraneoplastic Neurologic Syndrome

    Given that the index patient presented with hyperreflexia and a positive Babinski reflex, it is of note that mutations in beta-NAP have been proposed to play a role in spastic[] Neurological signs may include dementia with or without brain stem signs, rapid and irregular eye movements, and ophthalmoplegia (weakness or paralysis in muscles that move[] A 49-year-old woman presented with a history of progressive asthenia of the lower extremities persisting for 2 months.[]

  • Neuromuscular Junction Disorder

    Upper motor neuronal dysfunction lead to spasticity and hyperreflexia while lower motor neuronal lesions lead to paralysis with muscle fasciculations.[] Nerve Paresis/paralysis Weak, breathy voice, hypernasal speech, dysphagia, aspirations, pitch abnormalities Vagal nerve, SLN, RLN injury Myopathy Paresis, flaccidity Weak[] These central lesions are most commonly bilateral and may have associated upper motor neuron signs such as spasticity, hyperreflexia, and clonus.[]

  • Myositis

    Upper motor neurons disease may be associated with hyperreflexia, a positive Babinski’s sign, distal more than proximal weakness or spasticity.[] The signs were most consistent with masticatory myositis and a peripheral neuropathy; the differential diagnoses included polyradiculoneuritis (Coonhound paralysis), metabolic[] However, the correct term for this symptom is asthenia. Asthenia is a lack of energy that may exist in the absence of true weakness.[]

  • Neurogenic Arthrogryposis Multiplex Congenita

    Dysarthria Hyperreflexia Enlarged cisterna magna Abnormality of the skeletal system Vomiting Babinski sign Clinodactyly Dementia Gastroesophageal reflux Pes cavus Microcornea[] Claude Stoll, Marie‐Christine Ehret‐Mentre, Alain Treisser and Christine Tranchant, Prenatal diagnosis of congenital my asthenia with arthrogryposis in a myasthenic mother[] Recurrent pneumonia Tetraparesis EMG: neuropathic changes Abnormality of the upper limb Decreased number of large peripheral myelinated nerve fibers Proximal muscle weakness[]

  • Mononeuritis

    CNS Upper motor neuron signs (spasticity, hyperreflexia, upgoing plantar reflexes) are usually seen distal to the lesion.[] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[] More severe neuropathy symptoms may include burning pain, muscle wasting, paralysis, or gland dysfunction.[]

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