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61 Possible Causes for Asthenia, Slurred Speech, Spasticity - Hyperreflexia

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[]

  • Motor Neuron Disease

    Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal[] The early symptoms are slurred speech and stumbling.[] , hyperreflexia and atrophy in later stages of disease, but fasciculations are absent.[]

  • Hyponatremia

    They are primarily central nervous system (CNS) manifestations, such as irritability, restlessness, lethargy, muscular twitching, spasticity and hyperreflexia, all of which[] CASE: A 17-year-old boy was admitted to the emergency department with abdominal pain, nausea and vomiting, asthenia, and weight loss.[] On admission, the patient was agitated and had slurred speech. Treatment with hypertonic saline lead to full recovery.[]

  • Amyotrophic Lateral Sclerosis

    The upper motor signs include spasticity, hyperreflexia and weakness. The lower motor signs include amyotrophy, weakness and fasciculations.[] Asthenia There was a trend toward more asthenia among the treated participants in each trial, and this became statistically significant when the data from the three trials[] speech, stumbling, and muscle twitching for 3 years.[]

  • Radiculomyelopathy

    Myelopathic features are characterized by a more abrupt onset and include spastic paraplegia or quadriplegia, hyperreflexia, Babinski reflex, clonus, or a variety of sensory[] Bulbar onset: The first sign is usually slurring of the speech (impaired tongue movement). Wasting and fasciculation of the tongue.[]

  • Amyotrophic Lateral Sclerosis Type 1

    hyperreflexia ( ) Hoffman's ( ) Babinski's spastic dysarthria lower motor neuron (LMN) signs muscular atrophy weakness clinical fasciculations clumsiness Evaluation Diagnosis[] […] positive effect on functional abilities from the use of riluzole is unclear, and no studies have reported that the drug halts the disease process. 21 Adverse effects include asthenia[] Early symptoms can include: weakness in your ankle or leg – you might trip, or find it harder to climb stairs slurred speech, which may develop into difficulty swallowing[]

  • Ataxia

    Typical clinical signs and symptoms of autosomal dominant ataxias (ADCA) include the following: Limb and truncal ataxia Hyperreflexia and spasticity (pyramidal signs) are[] This results in a characteristic type of irregular, uncoordinated movement that can manifest itself in many possible ways, such as asthenia, asynergy, delayed reaction time[] Many symptoms of Ataxia can mimic those of being drunk – slurred speech, stumbling, falling, and incoordination.[]

  • Friedreich Ataxia

    His examination was significant for spastic gait, hyperreflexia, and sensory neuropathy. Genetic testing revealed a compound heterozygous mutation in the FXN gene.[] Adverse effects One participant in Zannolli 2012 (total of 13 enrolled participants) experienced asthenia during drug tapering, which did not require medical intervention.[] Other difficulties include constant tremor, slurred speech, difficulty swallowing, scoliosis, heart abnormalities and diabetes.[]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    , spasticity -muscle atrophy (fasciculations), fasciculations, tongue atrophy, rapidly progressive (lethal) -upper & lower motor neurons, bulbar weakness -normal sensation[] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[] speech Drooling Difficulty swallowing and breathing in more advanced stages Less commonly, symptoms firstly appear in the tongue or hands and progresses downwards to the[]

  • Infantile Neuroaxonal Dystrophy

    Clinical Onset before age three years Psychomotor regression (most common presenting feature) Early truncal hypotonia followed by spastic tetraparesis (usually with hyperreflexia[] […] problems Dysarthria (poor articulation or slurring) Dysphonia (defective use of the voice) Dysphasia (difficulty in using or understanding words) Causes nutritional problems[] […] of the nerve that connects the eye to the brain) Seen later in the disease Bulbar dysfunction (impairment of the function of cranial nerves IX, X, XI and XII) Results in speech[]

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