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449 Possible Causes for Asthenia, Vacuolization

  • Inclusion Body Myositis

    The coexistence of ring fibres, rimmed vacuoles and inclusion-body myositis-type inclusions in a child with congenital myopathy has not been previously reported.[] Abstract OBJECTIVE: Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature.[] Rimmed vacuoles were found in 49 patients (60.5%).[]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[] Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[] Muscle biopsy showed dystrophic features with many rimmed vacuoles in the fibers.[]

  • Lumbar Disk Herniation

    The nucleus pulposus consists of large vacuolated notochord cells, small chondrocyte-like cells, collagen fibrils, and aggrecan, a proteoglycan that aggregates by binding[]

  • Acute Kidney Failure

    We discuss the pathophysiologic process of both acute and chronic tubular injury from heme and heme proteins, including injury to organelles resulting in autophagic vacuoles[] Renal biopsy findings The predominant lesion seen on biopsy was extensive vacuolization of the proximal convoluted tubular epithelial cells.[] Photomicrograph demonstrating marked coarse and subnuclear vacuolation (arrow) of proximal convoluted tubular cell cytoplasm, typical of hypokalaemia.[]

  • Stroke

    Microscopic evaluation during the first 24 to 48 hours discloses anoxic neurons, vacuolization of the white matter due to disentanglement of swellings of myelin and axon.[]

  • Polymyositis

    KEYWORDS: anti-Ku antibody; dropped head syndrome; rimmed vacuole; scleroderma-polymyositis overlap syndrome[] CASE REPORT A male patient, 37 years old, was admitted with signs of anasarca, progressive muscle weakness, dysphagia to solids, and development of asthenia for 45 days.[] Arahata and Engel state that all their patients with a diagnosis of inclusion body myositis had the typical histological findings, including vacuoles and filamentous inclusions[]

  • Cyanogenic Glycoside

    Cyanogenic glycosides are stored in inactive forms in plant vacuoles.[] In young sorghum leaves, dhurrin is localized in vacuoles of plants and the enzymes responsible for its hydrolysis to hydrogen cyanide is located in cytoplasm.[]

  • Muscular Dystrophy

    Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation . J Neurol Sci, 1981; 51: 141–155.[] Autosomal recessive distal muscular dystrophy: a comparative study with distal myopathy with rimmed vacuole formation . Ann Neurol, 1985; 17: 51–59.[] […] disorders are considered to be definitive entities: Miyoshi's myopathy, which has an early adult onset and first involves the calf muscles, and distal myopathy with rimmed vacuoles[]

  • Graves Disease

    […] and basal nuclei Nuclei are enlarged, vesicular and show prominent nucleoli Background may show lymphocytes and oncocytes Flame cells represented by marginal cytoplasmic[] Hyperplastic follicles are lined by tall columnar cells Cytology Description Follicular cells in clusters and sheets Cells are tall with finely granular cytoplasm, marginal vacuoles[] vacuoles with pink red frayed edges may be prominent, however not specific for Graves disease After radioactive therapy: prominent microfollicular architecture with significant[]

  • Hypoxia

    However, in balanced nutrient conditions, Arabidopsis mesophyll vacuoles contain Zn in the micromolar range ( Lanquar et al., 2010 ).[] […] achieved through Zn high-affinity binding to phytochelatins, metallothioneins, and organic acids in the cytosol and through compartmentalization of this metal into cell vacuoles[] […] waterlogging, the plants reduced root Zn accumulation by decreasing the Zn uptake (via Pop_ZIP4.2 and nicotianamine chelation) and limiting its compartmentalization into the vacuole[]

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