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103 Possible Causes for Astrocytic Gliosis, Failure to Thrive

  • Leigh's Disease

    In addition, there was severe leukoencephalopathy of the cerebral hemispheres with sudanophilic tissue degregation, advanced axonal loss and reactive astrocytic gliosis.[] Constitutional symptoms, such as malaise, fatigue, anorexia and failure to thrive are present in many patients, while respiratory and gastrointestinal disturbances such as[] Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary[]

  • Neonatal Adrenoleukodystrophy

    gliosis Metachromatic leukodystrophy: accumulation of PAS and Luxol fast blue / LFB macrophages that show brown metachromasia with acidified cresyl violet, toluidine blue[] Abnormal clinical features in neonatal adrenoleukodystrophy are generally present at birth, and include muscle hypotonia, severe psychomotor retardation, and failure to thrive[] […] to thrive and severely delayed psychomotor development.[]

  • Alpers Syndrome

    The neuropathology of vCJD is characteristic with grey matter spongiform degeneration, reactive astrocytic gliosis, and “florid plaques” which are pathognomonic of vCJD.[] Mangalat, N, Tatevian, N, Bhattacharjee, MB & Rhoads, JM 2012, ' Alpers syndrome: An unusual etiology of failure to thrive ', Ultrastructural Pathology, vol. 36, no. 4, pp[] The first symptoms of the disorder are usually nonspecific and may include hypoglycemia secondary to underlying liver disease, failure to thrive, infection-associated encephalopathy[]

  • Hawkinsinuria

    Marked astrocytic gliosis and generalized cystic degeneration occur ( 111 ).[] Metabolic acidosis and failure to thrive appear to be confined to infancy.[] Herein we describe clinical and laboratory findings in two fraternal twins with hawkinsinuria who presented with failure to thrive and metabolic acidosis.[]

  • Globoid Cell Leukodystrophy

    The classic presentation includes excessive irritability, muscle hypertonicity, developmental delay, failure to thrive, peripheral neuropathy, seizures, and optic nerve atrophy[] ] a metabolic disorder of infancy or early childhood characterized by spasticity, seizures, and rapidly progressive cerebral degeneration, massive loss of myelin, severe astrocytic[] […] to thrive, and an increase in life span.[]

  • Alexander Disease

    KEYWORDS: Alexander disease; Rosenthal fibers; astrocyte; glia; gliosis; neurodegenerative diseases[] The child was born after an uneventful pregnancy, presented initially only as a failure to thrive.[] […] to thrive, episodic deterioration, abnormal eye movements, pyramidal and cerebellar signs), urinary excretion of 3-methyl-glutaconic acid and imaging findings (extensive[]

  • Phosphoenolpyruvate Carboxykinase Deficiency

    Central nervous system neuropathology may include poor myelination, paucity of cerebral cortex neurons, gliosis, and proliferation of astrocytes.[] Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia.[] In severe cases symptoms may include persistent and very low levels of blood's sugar in newborns (neonatal hypoglycemia ), failure to thrive, build-up of lactic acid in the[]

  • Abetalipoproteinemia

    Neuronal loss and mild gliosis can be seen in the thalamus, substantia nigra, and anterior horn of the spinal cord. Acanthocytes are seen in peripheral blood smears.[] Diarrhea, failure to thrive, acanthocytosis and central nervous system complications are most important features.[] Typically, patients present with failure to thrive, acanthocytosis, pigmented retinopathy and neurological features.[]

  • Pyruvate Carboxylase Deficiency

    Central nervous system neuropathology may include poor myelination, paucity of cerebral cortex neurons, gliosis, and proliferation of astrocytes.[] Diagnosis PC deficiency is suspected in individuals with failure to thrive, developmental delay, recurrent seizures, and metabolic acidosis.[] Also periodic hypoglicemia, failure to thrive, vomiting and hypotonia and ataxia. i don't know why ataxia but that's it. drpkaur Forum Junior Topics: 197 Posts: 813 Aug 15[]

  • Cockayne Syndrome

    (a) Hematoxylin-eosin–stained section of white matter shows fibrillary gliosis and rare binucleated astrocytes (arrow).[] Of these, failure to thrive, photosensitivity, and intellectual disability (language delays) developed before 2 or 3 years of age, whereas deafness, sunken eyes, and basal[] CAMFAK syndrome is an inherited disease characterized by congenital cataracts, microcephaly, failure to thrive, and kyphoscoliosis with onset in early infancy.[]

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