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103 Possible Causes for Astrocytic Gliosis, Failure to Thrive

  • Leigh's Disease

    In addition, there was severe leukoencephalopathy of the cerebral hemispheres with sudanophilic tissue degregation, advanced axonal loss and reactive astrocytic gliosis.[ncbi.nlm.nih.gov] Constitutional symptoms, such as malaise, fatigue, anorexia and failure to thrive are present in many patients, while respiratory and gastrointestinal disturbances such as[symptoma.com] Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary[ncbi.nlm.nih.gov]

  • Neonatal Adrenoleukodystrophy

    gliosis Metachromatic leukodystrophy: accumulation of PAS and Luxol fast blue / LFB macrophages that show brown metachromasia with acidified cresyl violet, toluidine blue[pathologyoutlines.com] Abnormal clinical features in neonatal adrenoleukodystrophy are generally present at birth, and include muscle hypotonia, severe psychomotor retardation, and failure to thrive[ncbi.nlm.nih.gov] […] to thrive and severely delayed psychomotor development.[orpha.net]

  • Alpers Syndrome

    The neuropathology of vCJD is characteristic with grey matter spongiform degeneration, reactive astrocytic gliosis, and “florid plaques” which are pathognomonic of vCJD.[jnnp.bmj.com] Mangalat, N, Tatevian, N, Bhattacharjee, MB & Rhoads, JM 2012, ' Alpers syndrome: An unusual etiology of failure to thrive ', Ultrastructural Pathology, vol. 36, no. 4, pp[uthealth.influuent.utsystem.edu] The first symptoms of the disorder are usually nonspecific and may include hypoglycemia secondary to underlying liver disease, failure to thrive, infection-associated encephalopathy[ninds.nih.gov]

  • Hawkinsinuria

    Marked astrocytic gliosis and generalized cystic degeneration occur ( 111 ).[neupsykey.com] Metabolic acidosis and failure to thrive appear to be confined to infancy.[ncbi.nlm.nih.gov] Herein we describe clinical and laboratory findings in two fraternal twins with hawkinsinuria who presented with failure to thrive and metabolic acidosis.[ncbi.nlm.nih.gov]

  • Globoid Cell Leukodystrophy

    The classic presentation includes excessive irritability, muscle hypertonicity, developmental delay, failure to thrive, peripheral neuropathy, seizures, and optic nerve atrophy[ncbi.nlm.nih.gov] ] a metabolic disorder of infancy or early childhood characterized by spasticity, seizures, and rapidly progressive cerebral degeneration, massive loss of myelin, severe astrocytic[medical-dictionary.thefreedictionary.com] […] to thrive, and an increase in life span.[ncbi.nlm.nih.gov]

  • Alexander Disease

    KEYWORDS: Alexander disease; Rosenthal fibers; astrocyte; glia; gliosis; neurodegenerative diseases[ncbi.nlm.nih.gov] The child was born after an uneventful pregnancy, presented initially only as a failure to thrive.[ncbi.nlm.nih.gov] […] to thrive, episodic deterioration, abnormal eye movements, pyramidal and cerebellar signs), urinary excretion of 3-methyl-glutaconic acid and imaging findings (extensive[ncbi.nlm.nih.gov]

  • Phosphoenolpyruvate Carboxykinase Deficiency

    Central nervous system neuropathology may include poor myelination, paucity of cerebral cortex neurons, gliosis, and proliferation of astrocytes.[emedicine.medscape.com] Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia.[uniprot.org] In severe cases symptoms may include persistent and very low levels of blood's sugar in newborns (neonatal hypoglycemia ), failure to thrive, build-up of lactic acid in the[rarediseases.info.nih.gov]

  • Abetalipoproteinemia

    Neuronal loss and mild gliosis can be seen in the thalamus, substantia nigra, and anterior horn of the spinal cord. Acanthocytes are seen in peripheral blood smears.[emedicine.medscape.com] Diarrhea, failure to thrive, acanthocytosis and central nervous system complications are most important features.[symptoma.com] Typically, patients present with failure to thrive, acanthocytosis, pigmented retinopathy and neurological features.[ncbi.nlm.nih.gov]

  • Pyruvate Carboxylase Deficiency

    Central nervous system neuropathology may include poor myelination, paucity of cerebral cortex neurons, gliosis, and proliferation of astrocytes.[emedicine.com] Diagnosis PC deficiency is suspected in individuals with failure to thrive, developmental delay, recurrent seizures, and metabolic acidosis.[rarediseases.org] Also periodic hypoglicemia, failure to thrive, vomiting and hypotonia and ataxia. i don't know why ataxia but that's it. drpkaur Forum Junior Topics: 197 Posts: 813 Aug 15[prep4usmle.com]

  • Cockayne Syndrome

    (a) Hematoxylin-eosin–stained section of white matter shows fibrillary gliosis and rare binucleated astrocytes (arrow).[ncbi.nlm.nih.gov] Of these, failure to thrive, photosensitivity, and intellectual disability (language delays) developed before 2 or 3 years of age, whereas deafness, sunken eyes, and basal[ncbi.nlm.nih.gov] CAMFAK syndrome is an inherited disease characterized by congenital cataracts, microcephaly, failure to thrive, and kyphoscoliosis with onset in early infancy.[ncbi.nlm.nih.gov]

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