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69 Possible Causes for Astrocytic Gliosis, Generalized Motor Seizure

  • Leigh's Disease

    […] continuous crying, and seizures.[ninds.nih.gov] In addition, there was severe leukoencephalopathy of the cerebral hemispheres with sudanophilic tissue degregation, advanced axonal loss and reactive astrocytic gliosis.[ncbi.nlm.nih.gov] Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary[ncbi.nlm.nih.gov]

  • Alzheimer Disease

    Multifocal spongiform encephalopathic changes, mononuclear perivascular infiltrates, subcortical demyelination and gliosis were also found.[ncbi.nlm.nih.gov] Of particular interest were well-defined neuronal and astrocytic intranuclear inclusion bodies (Cowdry type I and I), suggestive of viral disease.[ncbi.nlm.nih.gov]

  • Epilepsy

    A variety of seizure types were reported: generalized tonic-clonic seizures in 511 PWE (69.4%), absences in 15 (2.0%), focal motor seizures with full awareness in 7 (1.0%)[ncbi.nlm.nih.gov] Astrocyte reactivity Evidence suggests that the BBB disruption contributes to astrocyte activation and gliosis.[doi.org] Generalized seizures have both motor (movement) and nonmotor (absence) symptoms.[everydayhealth.com]

  • Creutzfeldt Jakob Disease

    Creutzfeldt Jakob disease is characterized by dementia, motor dysfunction, twitches, seizures, psychosis, and hallucinations.The duration of the disease is generally less[symptoma.com] gliosis; however, a reduction of ADCs correlated with astrocytic gliosis and also with spongiform changes and nerve cell loss.[ajnr.org] gliosis.[ajnr.org]

  • Alpers Syndrome

    Children present with seizures in half of the cases. Seizures may be focal, generalized or myoclonic.[symptoma.com] The neuropathology of vCJD is characteristic with grey matter spongiform degeneration, reactive astrocytic gliosis, and “florid plaques” which are pathognomonic of vCJD.[jnnp.bmj.com] After a squint operation, the patient developed headache and nausea and then presented with a generalized tonic-clonic seizure.[ajnr.org]

  • Hypoxia

    After 20 weeks' gestation, hypoxic-ischemic insults result in astrocyte activation with subsequent gliosis.[emedicine.medscape.com] GFAP is a useful marker to study astrocytic response to injury.[emedicine.medscape.com] The 3 major features of status marmoratus include neuronal loss, gliosis and hypermyelination.[emedicine.medscape.com]

  • Binswanger Disease

    gliosis. 18 19 20 État Lacunaire Lacunes, small cavitary lesions that result from ischemic strokes due to occlusion of penetrating cerebral arterioles, are also a common[stroke.ahajournals.org] WHO grade IV astrocytoma characterized by hemorrhagic necrosis, endothelial proliferation, crossing of the corpus callosum , ring-enhancement on imaging, and poor survival gliosis[strokecenter.org] There is perivascular leakage of serum proteins. 21 Increased MRI signal intensity probably results from the combination of dilated, fluid-filled perivascular spaces and astrocytic[stroke.ahajournals.org]

  • Fat Embolism

    In addition, occasional focal areas of ischemic injury showing filiform neurons with reactive astrocytic gliosis background consistent with acute lesions were observed in[ncbi.nlm.nih.gov]

  • Diffuse Cerebral Sclerosis of Schilder

    […] and scattered astrocytes with absence of oligodendroglia, axons, myelin, and inflammatory cells (, 2 ).[doi.org] […] middle layer zone (Schaumburg zone 2), showing perivascular inflammatory cells and demyelination with preservation of axons; and a central zone (Schaumburg zone 3), showing gliosis[doi.org]

  • Subacute Sclerosing Panencephalitis

    Cognitive and behavioral decline was preceeded by 6-18 months in two children with intractable focal motor seizures with secondary generalization, one child with complex partial[ncbi.nlm.nih.gov] There is often evidence of neuronal degeneration, gliosis, proliferation of astrocytes, perivascular cuffing, lymphocytic and plasma cell infiltration, and demyelination.[doi.org] Motor regression, cognition decline and seizures (focal, generalized tonic-clonic or myoclonic) are the major clinical manifestations.[orpha.net]

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