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126 Possible Causes for Astrocytic Gliosis, Hearing Impairment

  • Globoid Cell Leukodystrophy

    ] a metabolic disorder of infancy or early childhood characterized by spasticity, seizures, and rapidly progressive cerebral degeneration, massive loss of myelin, severe astrocytic[medical-dictionary.thefreedictionary.com] The presence of numerous, often multinucleated, globoid cells, the almost total loss of myelin and oligodendroglia, and astrocytic gliosis in the white matter are the morphologic[mhmedical.com] gliosis through astrocytic PGD2 receptors (DP1).[emedicine.com]

  • Demyelinating Disease

    As lesions evolve, there is prominent astrocytic proliferation (gliosis).[accessmedicine.mhmedical.com] Vision impairment. Loss of sensation. Unsteady gait. Impaired muscle coordination Neurological symptoms. Spastic paraparesis. Problems with hearing. Incontinence.[epainassist.com] Astrocytic gliosis in plaques is usually evident in sections stained with haematoxylin and eosin, but can be observed more obviously by immunolabelling the astrocytes—for[ncbi.nlm.nih.gov]

  • Neonatal Adrenoleukodystrophy

    gliosis Metachromatic leukodystrophy: accumulation of PAS and Luxol fast blue / LFB macrophages that show brown metachromasia with acidified cresyl violet, toluidine blue[pathologyoutlines.com] Hearing aids are provided to those with hearing impairment, and cochlear implants considered when hearing loss is profound.[orpha.net] XALD: gliosis and inflammation XALD. Lipid macrophages, lymphocytes, and reactive astrocytes in the white matter.[neuropathology-web.org]

  • Leukodystrophy

    It is characterized histologically by a paucity of myelin and oligodendroglia, severe astrocytic gliosis, and massive infiltration with unique multinucleated globoid cells[ucl.ac.uk] There was no history of impaired cognition, seizures, impaired vision or hearing, night blindness, malabsorption, headache, vomiting, or episodic deterioration.[annalsofian.org] gliosis Metachromatic leukodystrophy: accumulation of PAS and Luxol fast blue / LFB macrophages that show brown metachromasia with acidified cresyl violet, toluidine blue[pathologyoutlines.com]

  • Parkinson's Disease

    Because Ret is not genetically ablated in astrocytes, these results suggest that the gliosis in the striatum of DAT-Ret lx/lx mice is non-cell autonomously caused by degenerating[ncbi.nlm.nih.gov] In other words, they realize that what they’re seeing (or hearing) isn’t actually there. But this may worsen over time.[psychcentral.com] […] by invading reactive astrocytes.[ncbi.nlm.nih.gov]

  • Cerebral Palsy

    The cerebellar white matter showed astrocytic gliosis, vacuolation of the neuropil and a diffuse infiltrate mainly of T-lymphocytes.[dx.doi.org] impairment, gastro-oesophageal reflux and constipation, learning and behavioural difficulties) which require close multi-disciplinary teamwork.[discovery.ucl.ac.uk] Because children with CP may have associated deficits of mental retardation, ophthalmologic and hearing impairments, speech and language disorders, and oral-motor dysfunction[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 1

    , 16, 18, 21, 32, 33 leading to neuronal loss, gliosis, delayed myelination, or/and demyelination. 9, 10, 18, 21, 26, 32 Among other theories, increase of fluid content in[ajnr.org] Hearing impairment. Umbilical hernias and inguinal hernias. Joint stiffness and skeletal deformities. Cardiomyopathy and coronary heart disease. Hepatosplenomegaly.[patient.info] impairment – Deafness Musculoskeletal disease – Short stature; joint stiffness; symptoms of peripheral nerve entrapment Findings from examination may include the following[emedicine.medscape.com]

  • Canavan Disease

    No fibrous gliosis is present but there are Alzheimer type 2 astrocytes in the cortex. CD is caused by mutations of ASPA , which encodes the enzyme Aspartoacylase.[neuropathology-web.org] impairment Multifocal cystic and calcified white matter lesions, temporal cysts Genetic analysis None Mitochondrial DNA Depletion Syndrome MT-TK2, POLG1 Seizures, hepatorenal[ncbi.nlm.nih.gov] Usher Syndrome Type 1F is characterized by profound hearing loss which is present at birth, and adolescent-onset retinitis pigmentosa, a disorder that significantly impairs[kveller.com]

  • Phakomatosis Pigmentokeratotica

    Disorganization of cortical neuronal migration and organization, polymicrogyria, heterotopia, white matter gliosis, increased neuronal size, and/or excessive neuron and astrocyte[dermaamin.com] PubMed CrossRef Google Scholar Onsun N, Inandirici A, Kural Y, Teker C, Atilganoglu U (2007) Phakomatosis pigmentovascularis type II b with bilateral hearing impairment.[link.springer.com] […] loss due to an impaired ability of the auditory nerves to transmit sensory input to the brain (sensorineural hearing loss).[rarediseases.org]

  • Cockayne Syndrome

    (a) Hematoxylin-eosin–stained section of white matter shows fibrillary gliosis and rare binucleated astrocytes (arrow).[ncbi.nlm.nih.gov] Clinical features included short stature, cachectic senile look, neurological deterioration, photosensitivity, mental retardation, hearing impairment and carious teeth.[ncbi.nlm.nih.gov] We describe a premature, small for gestational age infant girl with micropthalmia, bilateral congenital cataracts, hearing impairment, progressive somatic and neurodevelopmental[ncbi.nlm.nih.gov]

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