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209 Possible Causes for Astrocytic Gliosis, Muscle Weakness

  • Leigh's Disease

    NARP is characterized by proximal neurogenic muscle weakness with sensory neuropathy, ataxia, and pigmentary retinopathy.[ncbi.nlm.nih.gov] In addition, there was severe leukoencephalopathy of the cerebral hemispheres with sudanophilic tissue degregation, advanced axonal loss and reactive astrocytic gliosis.[ncbi.nlm.nih.gov] Longstanding chronic lesions involved the optic chiasma and the cerebral peduncles and consisted of myelin loss, status spongiosus, astrocytic gliosis and marked capillary[ncbi.nlm.nih.gov]

  • Chronic Fatigue Syndrome

    In all three groups, a majority of patients exhibited muscle weakness in the lower limbs, and significant numbers of patients had absent or abnormal reflexes.[ncbi.nlm.nih.gov] PubMed Google Scholar Hwang SY, Jung JS, Kim TH, Lim SJ, Oh ES, Kim JY, Ji KA, Joe EH, Cho KH, Han IO: Ionizing radiation induces astrocyte gliosis through microglia activation[doi.org] Other symptoms include sore throat, fever, muscle weakness, headache, and joint pain A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain[icd9data.com]

  • McLeod Neuroacanthocytosis Syndrome

    Neuromuscular manifestations include a (mostly subclinical) sensorimotor axonopathy and clinically relevant muscle weakness or atrophy.[rareconnect.org] Marked neuronal loss and astrocytic gliosis were observed on histologic examination.[ncbi.nlm.nih.gov] People with McLeod neuroacanthocytosis syndrome also have problems with their muscles, including muscle weakness (myopathy) and muscle degeneration (atrophy).[ghr.nlm.nih.gov]

  • Classic Progressive Supranuclear Palsy Syndrome

    However, muscle atrophy, weakness, evidence of denervation on electromyography, vertical gaze palsy, parkinsonism, gait freezing, aphasia, speech apraxia, or dementia was[okayama.pure.elsevier.com] Neuropathologically, all forms are characterized by neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific[orpha.net] The disease is characterized neuropathologically by gliosis with astrocytic plaques, accumulation of tau-immunoreactive neurofibrillary tangles and neuronal loss in specific[orpha.net]

  • Motor Neuron Disease

    […] wasting and weakness, absent reflexes, loss of weight and muscle twitching.[mndnsw.asn.au] In the frontal and temporal lobes, microscopic changes include loss of pyramidal cells, spongiform neuropil change, and astrocytic gliosis.[emedicine.medscape.com] Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles.[ncbi.nlm.nih.gov]

  • Globoid Cell Leukodystrophy

    Initial signs and symptoms typically include irritability, muscle weakness, feeding difficulties, episodes of fever without any sign of infection, stiff posture, and delayed[ghr.nlm.nih.gov] ] a metabolic disorder of infancy or early childhood characterized by spasticity, seizures, and rapidly progressive cerebral degeneration, massive loss of myelin, severe astrocytic[medical-dictionary.thefreedictionary.com] Other symptoms include muscle weakness, spasticity, deafness, optic atrophy, optic nerve enlargement, blindness, paralysis, and difficulty when swallowing.[en.wikipedia.org]

  • Amyotrophic Lateral Sclerosis Type 1

    Signs and symptoms include muscle weakness, atrophy, and fasciculation.[icd10data.com] Pathology Atrophy of the anterior horn cells and replacement of the large motor neurons by fibrous astrocytes (gliosis) causes the affected anterior and lateral columns of[aafp.org] Muscle weakness can have many causes.[msdmanuals.com]

  • Neonatal Adrenoleukodystrophy

    Other side effects of corticosteroids include muscle weakness, osteoporosis, high blood pressure, depression, and weight gain.[livingnaturallyonline.com] gliosis Metachromatic leukodystrophy: accumulation of PAS and Luxol fast blue / LFB macrophages that show brown metachromasia with acidified cresyl violet, toluidine blue[pathologyoutlines.com] XALD: gliosis and inflammation XALD. Lipid macrophages, lymphocytes, and reactive astrocytes in the white matter.[neuropathology-web.org]

  • Progressive Bulbar Palsy

    A 12-month-old boy with progressive cranial nerve palsies followed by ventilatory failure demanding artificial ventilation, generalized muscle weakness, and rapid progression[ncbi.nlm.nih.gov] PSP is characterized neuropathologically by neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain[orpha.net] Symptoms muscle weakness (especially pharyngeal, facial and masticatory muscles) loss of speech emotial lability – rapid alternation of laughing and crying tongue muscle atrophy[wikilectures.eu]

  • Amyotrophic Lateral Sclerosis

    weakness.[ncbi.nlm.nih.gov] Pathology Atrophy of the anterior horn cells and replacement of the large motor neurons by fibrous astrocytes (gliosis) causes the affected anterior and lateral columns of[aafp.org] Upper motor neurone pathology in ALS is indicated by depopulation of the Betz cells in the motor cortex (Brodmann area 4), variable astrocytic gliosis affecting both the grey[doi.org]

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