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79 Possible Causes for Astrocytic Gliosis, Myoclonic Jerking

  • Alzheimer Disease

    After 36 hours of donepezil remission, the frequency of the myoclonic jerks was sharply reduced. The patient remains asymptomatic after 6 months of follow-up.[ncbi.nlm.nih.gov] Multifocal spongiform encephalopathic changes, mononuclear perivascular infiltrates, subcortical demyelination and gliosis were also found.[ncbi.nlm.nih.gov] Of particular interest were well-defined neuronal and astrocytic intranuclear inclusion bodies (Cowdry type I and I), suggestive of viral disease.[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    During the patient's hospital course, his clinical condition deteriorated with myoclonic jerks, fevers and severe encephalopathy.[ncbi.nlm.nih.gov] gliosis; however, a reduction of ADCs correlated with astrocytic gliosis and also with spongiform changes and nerve cell loss.[ajnr.org] Further progression usually affected more than one neurological domain, with all patients eventually developing cognitive decline and myoclonic jerks.[ncbi.nlm.nih.gov]

  • Epilepsy

    So the jerks were considered as cortical origin and generalized myoclonic seizure was confirmed.[ncbi.nlm.nih.gov] Astrocyte reactivity Evidence suggests that the BBB disruption contributes to astrocyte activation and gliosis.[doi.org] , like EPC, presented with myoclonic jerks. [7] This thought process was later proven inconclusive after considering subsequent literature.[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    Pathology Atrophy of the anterior horn cells and replacement of the large motor neurons by fibrous astrocytes (gliosis) causes the affected anterior and lateral columns of[aafp.org] Upper motor neurone pathology in ALS is indicated by depopulation of the Betz cells in the motor cortex (Brodmann area 4), variable astrocytic gliosis affecting both the grey[doi.org] Histopathological features The pathological hallmarks of ALS are the degeneration and loss of motor neurones with astrocytic gliosis and the presence of intraneuronal inclusions[doi.org]

  • Lafora Disease

    The patient had photosensitivity, a few episodes of sudden transient blindness, and infrequent complex visual auras, dysarthria and mild ataxia, frequent myoclonic jerks prominently[ncbi.nlm.nih.gov] As shown in Figure 4A, immunostaining showed a significant reduction in the number of Gfap-positive astrocytes in the brains sections of the double mutants as compared to[doi.org] Until the age of 48, the patient did not have myoclonic jerks or ataxia clinically, but had well controlled seizures.[ncbi.nlm.nih.gov]

  • Subacute Sclerosing Panencephalitis

    Typical initial symptoms consist of intellectual decline, deterioration in school performance, and myoclonic jerks.[ncbi.nlm.nih.gov] There is often evidence of neuronal degeneration, gliosis, proliferation of astrocytes, perivascular cuffing, lymphocytic and plasma cell infiltration, and demyelination.[doi.org] Features like myoclonic jerks, cognitive decline and typical EEG findings lead to a strong suspicion of SSPE.[ncbi.nlm.nih.gov]

  • Aicardi's Syndrome

    Asymmetric myoclonic jerks developed at one month of age.[ncbi.nlm.nih.gov] As the most recent immunohistochemical studies, too, have shown, 24 astrocytes produce the INF-α, responsible for the cascade of events leading to the autoimmune inflammatory[ajnr.org] 20 – 22 AGS is, to all intents and purposes, a leukoencephalopathy, characterized by the presence of mixed features attributable to hypomyelination, dysmyelination, and gliosis[ajnr.org]

  • Juvenile Absence Epilepsy

    A total of 33 patients (47%) also had myoclonic jerks with a mean age at onset of 16 years.[medlink.com] B, Glial fibrillary acid protein stain (original magnification 40) of the patient's cerebral cortex showing activated astrocytes, a sign of gliosis.[jamanetwork.com] Myoclonic jerks are infrequent, mild and of random distribution.[pennsw.com.au]

  • Wilson Disease

    jerking similar to that seen in progressive myoclonic syndrome.[web.archive.org] In the early stages of the disease, proliferation of large protoplasmic astrocytes such as Opalski cells and Alzheimer cells occurs.[web.archive.org] Autonomic disturbances including postural hypotension, abnormal sweating, and sphincter and sexual dysfunction are frequently present. 33 Very rarely, teenage patients exhibit myoclonic[web.archive.org]

  • Fatal Familial Insomnia

    Overall, 20 of 21 patients showed FFI typical neuropathological findings with prominent thalamo-olivaric pathology. 27 Severe astrocytic gliosis and nerve cell loss but weak[jnnp.bmj.com] C : Immunohistochemistry for glial fibrillary acidic protein (GFAP) reveals reactive astrocytic gliosis in the mediodorsal thalamic nucleus of the present case but not in[doi.org]

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