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89 Possible Causes for Astrocytic Gliosis, Psychiatric Manifestation

  • Alzheimer Disease

    Dementias with prominent psychiatric-behavioral manifestations and gait impairment have a faster progression compared to AD.[ncbi.nlm.nih.gov] Multifocal spongiform encephalopathic changes, mononuclear perivascular infiltrates, subcortical demyelination and gliosis were also found.[ncbi.nlm.nih.gov] Behavioral and psychiatric manifestations in dementia patients in a community: caregiver burden and outcome.[dx.doi.org]

  • Chronic Fatigue Syndrome

    Manifestations that were commonly reported included neurological manifestations (84.2 %), musculoskeletal (78.9 %), psychiatric (63.1 %), fatigue (63.1 %), gastrointestinal[ncbi.nlm.nih.gov] PubMed Google Scholar Hwang SY, Jung JS, Kim TH, Lim SJ, Oh ES, Kim JY, Ji KA, Joe EH, Cho KH, Han IO: Ionizing radiation induces astrocyte gliosis through microglia activation[doi.org] In a typical severe case the early manifestations included localized muscular weakness, stiffness of the neck and back, headache, diarrhea and temperature elevation.[doi.org]

  • Primary Progressive Multiple Sclerosis

    As lesions evolve, there is prominent astrocytic proliferation (gliosis) [ 11 ].[omicsonline.org]

  • McLeod Neuroacanthocytosis Syndrome

    manifestations, and distinct striatal imaging findings.[research-projects.uzh.ch] Marked neuronal loss and astrocytic gliosis were observed on histologic examination.[ncbi.nlm.nih.gov] A cell loss of 90% in the striatum with astrocytic gliosis has been reported.[emedicine.medscape.com]

  • Hypoxia

    After 20 weeks' gestation, hypoxic-ischemic insults result in astrocyte activation with subsequent gliosis.[emedicine.medscape.com] GFAP is a useful marker to study astrocytic response to injury.[emedicine.medscape.com] The 3 major features of status marmoratus include neuronal loss, gliosis and hypermyelination.[emedicine.medscape.com]

  • Multiple Sclerosis

    Psychiatric manifestations of multiple sclerosis: A review. Can J Psychiatry 1996 ; 41: 441 – 445. Google Scholar SAGE Journals ISI 5. Patten, SB, Svenson, LW, Metz, LM.[dx.doi.org] Multiple sclerosis (MS) is characterised by inflammation, demyelination, axonal or neuronal loss, and astrocytic gliosis in the central nervous system (CNS), which can result[ncbi.nlm.nih.gov] Fatigue and psychiatric symptoms, such as depression or euphoria, can also be manifestations of MS. Symptoms (attacks) of MS need disseminated in “time and space.”[clinicaladvisor.com]

  • Huntington's Disease

    Huntington's disease (HD) is an autosomal dominant and progressive neurodegenerative syndrome characterized by motor, cognitive and psychiatric manifestations.[ncbi.nlm.nih.gov] Proliferation of reactive astrocytes causes the affected nuclei to appear more cellular than normal.[neuropathology-web.org] Although noncompliance to oral antipsychotic drugs can be a practical problem, especially when significant psychiatric manifestations of HD are present, the effect of depot[ncbi.nlm.nih.gov]

  • Boxer's Dementia

    Pathophysiology Although the details remain to be elucidated, there is mounting evidence that reactive gliosis and redistribution of aquaporin 4 molecules, leading to disruption[radiopaedia.org] There is severe neuronal loss and gliosis (A) with neurofibrillary tangles (NFTs) (white arrow, B ) in the SN.[actaneurocomms.biomedcentral.com] […] traumatic encephalopathy is characterized by the presence of neurofibrillary tangles and TDP-43 binding protein in subcortical and perivascular regions, often with reactive astrocytes[radiopaedia.org]

  • Subacute Sclerosing Panencephalitis

    Psychiatric manifestation of SSPE. J Neuropsychiatry Clin Neurosci 2006;18:560. [ PUBMED ] 3. Kartal A, Kurt AN, Gürkas E, Aydin K, Serdaroglu A.[ijpm.info] There is often evidence of neuronal degeneration, gliosis, proliferation of astrocytes, perivascular cuffing, lymphocytic and plasma cell infiltration, and demyelination.[doi.org] In the earlier stages of the disease, psychiatric manifestations, such as behavioral changes, mood swings, depression, and cognitive decline, are noted.[cureus.com]

  • Anti-NMDA Receptor Encephalitis

    OBJECTIVE: Anti-N-methyl-d-aspartate receptor (NMDA-R) encephalitis is a recently discovered disorder with prominent psychiatric manifestations that is often misdiagnosed.[ncbi.nlm.nih.gov] […] of various serum proteins and the reactivity of proximal microglia and astrocytes in the uninjured brainstem and spinal cord enlargements after 1-4 weeks.[ncbi.nlm.nih.gov] Acute neurological and psychiatric manifestations are the common presenting symptoms.[ncbi.nlm.nih.gov]

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