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21 Possible Causes for Asymmetric Nipples, Developmental Delay, Malignant Melanoma

  • Congenital Nevus

    Large CMNs over the head or axial skeleton should alert the physician to assess for neurocutaneous involvement (developmental delays, seizures, hydrocephalous, increased intracranial[] More than a half of the patients in which malignant melanoma developed in giant congenital nevi were under the age of 10.[] We report a 26-year-old male with a 4 mm diameter, asymmetric, irregularly pigmented and bordered, brown maculopapular lesion on the right nipple present since childhood with[]

  • Noonan Syndrome

    This degree of developmental delay was atypical for an individual with Noonan syndrome, raising concerns for a chromosomal abnormality.[] […] tumour samples: p.G248R (glioma, large intestine carcinoma and melanoma) and p.R284C (endometrium carcinoma) in the catalogue of somatic mutations in cancer (COSMIC database[] In addition, nipples were wide-spaced and appeared to be low-set. On genital examination, testicles appeared to be small.[]

  • Monosomy 1p36 Syndrome

    Developmental delay/intellectual disability of variable degree are present in all, and hypotonia in 95%. Seizures occur in 44%-58% of affected individuals.[] Furthermore, chromosome Ip36 deletions have also been reported to occur in various neoplasms, including neuroblastoma, prostate cancer, lung cancer, malignant melanoma, hepatoma[] […] rotated ears Low-set ears Small mouth Down turned corners of the mouth Long philtrum Pointed chin Micro/retrognathia High arched palate Webbed neck Short neck Hypoplastic nipples[]

  • Ring Chromosome 19

    A careful examination for dysmorphic features should be done in all children with developmental delay.[] melanoma pter qter 8428043 Edit 37 10594874_2 46, XY [293]/ 47, XY, 7 [56]/ 46, XY, r(7) [60]/ 47, XY, 7, r(7)[2] intrauterine growth retardation, short stature, moderate[] […] and dysmorphic ears with prominent helix, spaced nipples, and tapering fingers (Fig. 1).[]

  • Central Precocious Puberty

    delay.[] Critical thinking a statement of expert consensus ul adha Eid festival essay argumentative essay topics on animals not criminally responsible essay case study malignant melanoma[] Initially, breast budding may be unilateral or asymmetric.[]

  • Aprosencephaly and Cerebellar Dysgenesis

    Delay Trisomy 13 Trisomy 18p Trisomy 1q Vici Syndrome Weyers Acrofacial Dysostosis Weyers Ulnar Ray/ Oligodactyly Syndrome Williams-Beuren Syndrome X-Linked Intellectual[] Mesothelioma: 0.49, 0.78, 7.50, 8.00, 15.43, 62.50, 325.00, 434.00, 515.70, 655.20 Cancer: Melanoma: 0.49, 0.70, 32.80, 102.25, 212.75, 321.20, 434.00, 545.68, 795.61, 857.77[] Stevenson ; Introduction ; 33.1 Amastia-Hypomastia ; 33.2 Enlarged Breasts ; 33.3 Supernumerary Nipples ; 33.4 Widely Spaced Nipples ; 33.5 Gynecomastia ; Chapter 34 Asymmetric[]

  • Familial Neutropenia

    delay, facial dysmorphisms JAGN1 deficiency JAGN1 AR Myeloid maturation arrest, osteopenia 3-methylglutaconic aciduria CLPB AR Neurocognitive developmental abnormalities,[] (See Melanoma ) Esophageal and Esophagogastric Junction Cancers Gestational Trophoblastic Neoplasia Malignant Pleural Mesothelioma Melanoma Multiple Myeloma/Other Plasma[] […] proximaldistal2 Neutropenia with decreased marrow reserve20 Neutropenia with normal marrow reserve20 Neutrophilia20 Nipple lesions Nodules painful Nystagmus Nystagmus monocular[]

  • Supernumerary Nipples

    delay Gastrointestinal peptic ulcer pyloric stenosis Ear, nose, throat and lung laryngeal web ear abnormalities accessory lung lobe Skeletal hand malformation vertebral anomaly[] melanoma, lymphangioma, osteoma cutis, and hypohidrosis.[] Third nipple is found unilaterally and it can be symmetric or asymmetric. In some people it is found above the normal nipples and in other cases below.[]

  • Rapp-Hodgkin Syndrome

    One showed growth retardation, craniofacial dysmorphism, syndactyly, developmental delay and a de novo deletion ( 8.5Mb) on chromosome 7q21.13-q21.3, including DLX5 and DLX6[] , cutaneous malignant, Renal cell carcinoma with or without malignant melanoma, Tietz albinism-deafness syndrome, Waardenburg syndrome MYO5A Griscelli syndrome OCA2 Albinism[] Breast and/or nipple hypoplasia that may be symmetric or asymmetric is typically seen in ADULT syndrome and limb-mammary syndrome and not in other TP63- related disorders.[]

  • Frontoocular Syndrome

    delay.[] Vitreous metastasis of malignant cutaneous melanoma during treatment with ipilimumab]. Ophthalmologe. 2016 Jun 3. [Epub ahead of print] German.[] nipples and volume, webbed neck, hand or foot abnormalities such as clinodactyly (most common is a curved 5th finger) and cutaneous syndactyly (webbed fingers / toes). [3[]

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