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20 Possible Causes for Asymmetric Nipples, Hypertelorism, Malignant Melanoma

  • Congenital Nevus

    LEOPARD is an acronym for lentigines, electrocardiographic abnormalities, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth, and[journals.lww.com] More than a half of the patients in which malignant melanoma developed in giant congenital nevi were under the age of 10.[ncbi.nlm.nih.gov] We report a 26-year-old male with a 4 mm diameter, asymmetric, irregularly pigmented and bordered, brown maculopapular lesion on the right nipple present since childhood with[ncbi.nlm.nih.gov]

  • Noonan Syndrome

    Craniofacial anomalies in affected patients include hypertelorism and severe open bite associated with masticatory dysfunction.[ncbi.nlm.nih.gov] […] tumour samples: p.G248R (glioma, large intestine carcinoma and melanoma) and p.R284C (endometrium carcinoma) in the catalogue of somatic mutations in cancer (COSMIC database[jmg.bmj.com] In addition, nipples were wide-spaced and appeared to be low-set. On genital examination, testicles appeared to be small.[jiaomr.in]

  • Central Precocious Puberty

    We describe a 7.4 year-old Brazilian girl with CPP who also presented hypertelorism, limitation of lateral neck rotation and synkinesis of the hands.[ncbi.nlm.nih.gov] Critical thinking a statement of expert consensus ul adha Eid festival essay argumentative essay topics on animals not criminally responsible essay case study malignant melanoma[eventi.nerobold.com] Initially, breast budding may be unilateral or asymmetric.[emedicine.medscape.com]

  • Ring Chromosome 19

    […] infant evaluated for severe hypotonia, psychomotor retardation, and facial dysmorphisms, including round face, high prominent forehead, downward slanted palpebral fissures, hypertelorism[karger.com] melanoma pter qter 8428043 Edit 37 10594874_2 46, XY [293]/ 47, XY, 7 [56]/ 46, XY, r(7) [60]/ 47, XY, 7, r(7)[2] intrauterine growth retardation, short stature, moderate[chr7.org] […] and dysmorphic ears with prominent helix, spaced nipples, and tapering fingers (Fig. 1).[ssmc-tl.com]

  • Aprosencephaly and Cerebellar Dysgenesis

    Note the broad nasal cleft and extreme hypertelorism ( a ) and the presence of an occipital cephalocele ( b ) The association between open neural tube defects and facial anomalies[radiologykey.com] Mesothelioma: 0.49, 0.78, 7.50, 8.00, 15.43, 62.50, 325.00, 434.00, 515.70, 655.20 Cancer: Melanoma: 0.49, 0.70, 32.80, 102.25, 212.75, 321.20, 434.00, 545.68, 795.61, 857.77[drhuldaclarkzappers.wordpress.com] Stevenson ; Introduction ; 33.1 Amastia-Hypomastia ; 33.2 Enlarged Breasts ; 33.3 Supernumerary Nipples ; 33.4 Widely Spaced Nipples ; 33.5 Gynecomastia ; Chapter 34 Asymmetric[geneeskundeboek.nl]

  • Neurofibromatosis-Noonan Syndrome

    NS is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis.[uniprot.org] Anal malignant melanoma and soft-tissue malignant fibrous histiocytoma in neurofibromatosis type 1.[familialcancerdatabase.nl] At age 10.5 months, she was noted to have plagiocephaly, facial asymmetry with left side smaller than the right, webbed neck, asymmetric chest with widely spaced nipples,[genome.jp]

  • Monosomy 1p36 Syndrome

    The dysmorphic features of the proband included microcephaly, straight eyebrows, deep-set eyes, hypertelorism, asymmetric and low-set ears, a high-arched palate, clinodactyly[enlivenarchive.org] Furthermore, chromosome Ip36 deletions have also been reported to occur in various neoplasms, including neuroblastoma, prostate cancer, lung cancer, malignant melanoma, hepatoma[google.ch] […] growth Retarded growth [ more ] 0001510 High palate Elevated palate Increased palatal height [ more ] 0000218 Hydrocephalus Too much cerebrospinal fluid in the brain 0000238 Hypertelorism[rarediseases.info.nih.gov]

  • Poland Syndrome

    The syndrome is characterized by Widely spaced eyes or ocular hypertelorism Broad nose and small mouth Cleft palate Micrognathia – small jaw Facial nerve paralysis in some[boneandspine.com] The definite risk of developing melanoma in Blaschkolinear CMN remains unclear because of its rarity.[jamanetwork.com] Last updated Dec. 26, 2018 NIH Image of a 55-year-old male with Poland Syndrome showing asymmetric appearance of the nipples.[dovemed.com]

  • Curry Hall Syndrome

    Figure 1: Intraoral view of the patient showed Figure supernumerary tooth and hyperplastic labial frenulum Click here to view On general examination, the patient had hypertelorism[amhsjournal.org] , cutaneous malignant, 9 TERT Melanoma, desmoplastic neurotrophic (DNM) NF1 del Melanoma, malignant sporadic STK11 Melanoma, malignant, somatic BRAF, PTEN del Meningioma PTEN[uniklinik-freiburg.de] At age 10.5 months, she was noted to have plagiocephaly, facial asymmetry with left side smaller than the right, webbed neck, asymmetric chest with widely spaced nipples,[genome.jp]

  • Ulnar Mammary Syndrome

    Note the rather coarse face with tall forehead, widely patent metopic suture, hypertelorism, shallow orbits, infraorbital folds and anteverted nares.[atlasgeneticsoncology.org] It is overexpressed in several cancers and may contributor to malignant melanoma.[sigmaaldrich.com] […] hypoplasia, asymmetrical features including unilateral ulnar or renal abnormalities).[ncbi.nlm.nih.gov]

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