Asymmetric Overgrowth: Causes & Reasons

Possible Causes for Asymmetric Overgrowth

Trevor disease is more commonly known as hemimelic epiphyseal dysplasia (HED) and is characterized by unilateral asymmetric overgrowth of the epiphyseal cartilage. [symptoma.com]

Abstract Dysplasia epiphysealis hemimelica is a rare skeletal disease characterized by asymmetric overgrowth of cartilage. [ispub.com]

DEH is a rare disease characterized by asymmetric overgrowth of cartilage. [joas.in]

Proteus Syndrome

We report the first case of ductal carcinoma in situ (DCIS) in a 28-yr-old woman with PS who underwent a mastectomy for asymmetric overgrowth. [ncbi.nlm.nih.gov]

The affected 9-year-old boy showed progressive postnatal overgrowth of his right leg and foot and asymmetric progressive overgrowth of single toes with a small cerebriform [ncbi.nlm.nih.gov]

Onset usually occurs from 6-18 months of age with asymmetric overgrowth seen mainly in the hands or feet. [orpha.net]

Congenital Hemihypertrophy

overgrowth typically manifesting as left-sided hemihypertrophy and recurrent, severe hypoinsulinemic or hypoketotic hypo-fatty-acidemic hypoglycemia in infancy, which results [766766.pw]

Hypoinsulinemic hypoglycemia and body hemihypertrophy is a rare, genetic, endocrine disease characterized by neonatal macrosomia, asymmetrical overgrowth typically manifesting [teren.mobi]

overgrowth of unknown aetiology may involve the whole of one side of the body or it may be limited in extent to one limb or a side of the face. [adc.bmj.com]

Klippel-Trenaunay-Weber Syndrome

overgrowth. [doi.org]

In 1900 the French physicians Maurice Klippel and Paul Trènaunay reported the case of a patient with a port-wine stain, asymmetrical overgrowth (hypertrophy) of soft tissue [rxlist.com]

KTS, Klippel-Trenaunay syndrome Klippel-Trenaunay syndrome VG5Q asymmetric overgrowth Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of [doi.org]

Schimmelpenning-Feuerstein-Mims Syndrome

[Article in French] Affiliations PMID: 33058640 [Schimmelpenning-Feuerstein-Mims syndrome] [Article in French] Sabah Bazouti et al. Rev Prat. 2020 May. No abstract available Keywords: Jadassohn's Sebaceous Nevus. Conflict of interest statement Les auteurs déclarent n’avoir aucun lien d’intérêts. Similar articles[…] [pubmed.ncbi.nlm.nih.gov]

Fairbank Disease

[…] osteochondral overgrowth of the epiphyseal cartilage. [pesquisa.bvsalud.org]

ID: biblio-1129245 Biblioteca responsável: AR337.1 RESUMEN ABSTRACT ABSTRACT Dysplasia epiphysealis hemimelica, also known as Trevor Fairbank disease, is characterized by asymmetrical [pesquisa.bvsalud.org]

CLOVES Syndrome

The predominant areas of overgrowth include the brain, limbs (including fingers and toes), trunk (including abdomen and chest), and face, all usually in an asymmetric distribution [ncbi.nlm.nih.gov]

Showing of 16 | Medical Terms Other Names Learn More: HPO ID 100% of people have these symptoms Hemihypertrophy Asymmetric overgrowth 0001528 30%-79% of people have these [rarediseases.info.nih.gov]

[…] syndrome Presentation Overgrowth features mostly present at birth and are asymmetric, disproportionate, and less progressive Overgrowth features mostly present at 6-18 months [ncbi.nlm.nih.gov]

Epidermal Nevus

Disproportionate, asymmetric overgrowth occurs in a mosaic pattern (i.e., a random “patchy” pattern of affected and unaffected areas). [rarediseases.org]

PROTEUS SYNDROME The characteristic finding of Proteus syndrome is overgrowth of various tissues of the body. The cause of the disorder is unknown. [rarediseases.org]

Benign Hypopharyngeal Neoplasm

overgrowth of various body parts, adipose tissue dysregulation, cystadenomas, adenomas, vascular malformation. [18] [19] Familial adenomatous polyposis [ edit ] Familial [en.wikipedia.org]

[…] characterised by hamartomatous intestinal polyposis, macrocephaly, lipomatosis, hemangiomatosis and glans penis macules. [14] [17] Proteus syndrome is characterised by nevi, asymmetric [en.wikipedia.org]

Nevus Sebaceous

Proteus syndrome is a complex hamartomatous disorder characterized by disproportionate, asymmetrical overgrowth of any tissue of the body, particularly the skeleton, cerebriform [medlink.com]

overgrowth 0001528 Hemimegalencephaly 0007206 Horseshoe kidney Horseshoe kidneys 0000085 Hypophosphatemic rickets 0004912 Hypopigmentation of the skin Patchy lightened skin [rarediseases.info.nih.gov]

[…] aorta Narrowing of aorta Narrowing of the aorta [ more ] 0001680 Coloboma Notched pupil 0000589 Cranial asymmetry 0000267 Hemangioma Strawberry mark 0001028 Hemihypertrophy Asymmetric [rarediseases.info.nih.gov]

Nevus Sebaceous

overgrowth * Advanced bone age * Nevus sebaceous * Hyperpigmented nevus sebaceous * Hyperkeratosis * Trunk lesions * Limb lesions * Midfacial linear lesions * Seizures * [checkorphan.org]

Proteus syndrome is a complex hamartomatous disorder characterized by disproportionate, asymmetrical overgrowth of any tissue of the body, particularly the skeleton, cerebriform [medlink.com]

Symptoms - Nevus sebaceus of Jadassohn The list of signs and symptoms mentioned in various sources for Nevus sebaceous of Jadassohn includes the 13 symptoms listed below: * Asymmetric [checkorphan.org]

Congenital Generalized Hypertrichosis

It is characterized by hair overgrowth on the entire body in males, and mild and asymmetric hair overgrowth in females. [malacards.org]

Patchy or asymmetric overgrowth of the affected tissues and organs, along with the liability to the development of tumors are characteristics of this disease [ 17 ]. [omicsonline.org]

Beckwith-Wiedemann Syndrome

Hemihyperplasia (HH) "Asymmetric overgrowth of one or more of the cranium, face, trunk and limbs, with or without visceral involvement" (13). [starship.org.nz]

overgrowth of one or more regions of the body) May affect segmental regions of body or selected organs and tissues Milder phenotypes may develop tumors associated with BWS [pathologyoutlines.com]

Paisley was born with Beckwith-Wiedemann syndrome, a genetic pediatric overgrowth disorder characterized by macroglossia (enlarged tongue), asymmetric overgrowth of limbs, [cnn.com]

Epiphyseal Chondrodysplasia Type Miura

Abnormal asymmetric growth and hemihypertrophy are its typical clinical manifestations, though overgrowth of the long bones, macrodactyly, asymmetric macrocephaly, plantar [deepdyve.com]

Importantly, disproportionate asymmetric overgrowth can be a clue to the differential diagnosis of other diseases of osseous overgrowth in which the enlarged bones retain [deepdyve.com]

The T12 vertebra shows disproportionate asymmetric overgrowth which is characteristic for the Proteus syndrome. [deepdyve.com]

Lymphedema - Cerebral Arteriovenous Anomaly Syndrome

Because of the many deformities characterized by asymmetric overgrowth of the extremities and soft tissue masses, the syndrome is named after the Greek god Proteus, who could [chop.edu]

This congenital (C) disease is linked to a somatic activating mutation in the PIK3CA gene [ 4 ] that causes asymmetrical lipomatous overgrowth (LO), vascular malformations [omicsonline.org]

[…] that can affect any organ or tissue in the body. (1) The overgrowth observed in individuals with Proteus syndrome is typically asymmetric, begins postnatally, progresses [k-t.org]

Hypoinsulinemic Hypoglycemia and Body Hemihypertrophy

overgrowth (typically manifesting as left-sided hemihypertrophy) and recurrent, severe hypoinsulinemic (or hypoketotic hypo-fatty-acidemic) hypoglycemia in infancy, which [orpha.net]

Major findings associated with BWS [1] Macrosomia (traditionally defined as weight and length/height >97th centile) Macroglossia Hemihyperplasia (asymmetric overgrowth of [en.wikipedia.org]

Overgrowth may manifest in a symmetric or asymmetric pattern, and may include additional features such as developmental delay, intellectual disability, seizures, behavioral [invitae.com]

Arteriovenous Fistula

These malformations are frequently associated with dilated capillary vessels in the dermis, asymmetric overgrowth of the involved limbs, and sometimes multiple soft tissue [emedicine.com]

Spondyloepimetaphyseal Dysplasia Type Bieganski

CLOVES (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined‐type Vascular malformations, Epidermal naevi, Scoliosis/Skeletal [infona.pl]

[…] spectrum (PROS) Overgrowth syndromes are characterized by global or localized disproportionate growth associated with other anomalies, including vascular malformations and [infona.pl]

[…] variable modes of inheritance, including autosomal dominant and X‐linked inheritance, but relatively few responsible... article CLOVES syndrome: review of a PIK3CA‐related overgrowth [infona.pl]

Proteus

The overgrowth is usually asymmetric, which means it affects the right and left sides of the body differently. [ghr.nlm.nih.gov]

Onset usually occurs from 6-18 months of age with asymmetric overgrowth seen mainly in the hands or feet. [orpha.net]

Proteus syndrome is a rare congenital, multisystemic, hamartomatous condition characterized by asymmetrical overgrowth of almost any part of the body and a broad spectrum [radiopaedia.org]

Faciocardiomusculoskeletal Syndrome Type Uruguay

[…] on the entire body in males, and mild and asymmetric hair overgrowth in females. [mendelian.co]

X-linked congenital generalized hypertrichosis is an extremely rare type of hypertrichosis lanuginosa congenita, a congenital skin disease, which is characterized by hair overgrowth [mendelian.co]

Phakomatosis Pigmentokeratotica

Proteus syndrome is a complex hamartomatous disorder characterized by disproportionate, asymmetrical overgrowth of any tissue of the body, particularly the skeleton, cerebriform [medlink.com]

Onset usually occurs from 6-18 months of age with asymmetric overgrowth seen mainly in the hands or feet. [ern-skin.eu]

Orpha.net Proteus syndrome (PS) Proteus syndrome (PS) is a very rare and complex hamartomatous overgrowth disorder characterised by progressive overgrowth of the skeleton, [ern-skin.eu]

Carpotarsal Osteochondromatosis

Dysplasia epiphysealis hemimelica (DEH) is a rare skeletal developmental disorder characterized by asymmetric overgrowth of cartilage in the epiphyses. [tandfonline.com]

Upper Limb Hypertrophy

Proteus syndrome is a hamartomatous disorder which is characterized by asymmetrical overgrowth of any part of the body, verrucous epidermal naevi, vascular malformations and [edoj.org.eg]

It may be asymmetrical. [congenitalhand.wustl.edu]

[…] port-wine stains and high-flow shunts, for example, are capillary malformation-arteriovenous malformation syndrome, Cobb's syndrome, and CLOVES syndrome (= Congenital Lipomatous Overgrowth [jdrntruhs.org]

Familial Multiple Lipomatosis

[…] segmental overgrowth (with soft tissue hypertrophy and ballooning effect) that develops and progresses rapidly in early childhood, arteriovenous SNOMEDCT-BE (disorder) / [wordscope.com]

Proteus syndrome and CLOVES (Congenital Lipomatous asymmetric Overgrowth, Vascular malformations, Epidermal nevi, Skeletal, and spinal anomalies) are examples of somatic mutations [dovepress.com]

[…] d'hypertrophie segmentaire-lipomatose-malformation artérioveineuse-naevus épidermique A rare genetic, poly malformative syndrome with characteristics of progressive, proportionate, asymmetric [wordscope.com]

Macrocephaly-Developmental Delay Syndrome

Additional features include variable degrees of asymmetric somatic overgrowth, distal limb malformations, and hyperelasticity. [dermnetnz.org]

Overgrowth may manifest in a symmetric or asymmetric pattern, and may include additional features such as developmental delay, intellectual disability, seizures, behavioral [invitae.com]

Major criteria : both must be present Macrocephaly (> 95th percentile) and progressive megalencephaly Capillary malformation Minor criteria : variable involvement Asymmetrical [dermnetnz.org]

Hemimegalencephaly

Abstract The authors report two cases of Brazilian children with most of the common syndromic features of Proteus syndrome, such as asymmetric overgrowth of tissues, skin [ncbi.nlm.nih.gov]

On examination, we saw asymmetrical overgrowth on the right side of her head, face, and upper and lower limbs. [idoj.in]

[10] Furthermore, MCAP can occasionally be linked with asymmetric brain overgrowth (hemimegalencephaly) as well as segmental overgrowth of the body ( hemihypertrophy ). [en.wikipedia.org]

Macrocephaly

overgrowth. [ncbi.nlm.nih.gov]

overgrowth, capillary malformation, midline facial nevus flammeus and connective tissue defects) criteria. [orpha.net]

It is characterized by marked congenital macrocephaly with dysplastic and asymmetric overgrowth of the entirety or part of one cerebral hemisphere. [ajronline.org]

Luscan-Lumish Syndrome

Skeletal malformations can be severely deforming; it includes scoliosis and asymmetric bony overgrowth. [frontiersin.org]

Typically, generalized overgrowth is symmetrical whereas segmental overgrowth is asymmetrical. [karger.com]

A very similar presentation of asymmetric overgrowth of bony, adipose, fibrous, and vascular overgrowth due to PIK3CA over-activation is called Fibroadipose hyperplasia. [frontiersin.org]

Bilateral Sensorineural Hearing Loss

overgrowth of one or more regions of the body. [mendelian.co]

More info about SCHOPF-SCHULZ-PASSARGE SYNDROME; SSPS Low match HEMIHYPERPLASIA, ISOLATED; IH Isolated hemihyperplasia is an abnormality of cell proliferation leading to asymmetric [mendelian.co]

Genee-Wiedemann Syndrome

overgrowth of one or more regions of the body) May affect segmental regions of body or selected organs and tissues Milder phenotypes may develop tumors associated with BWS [pathologyoutlines.com]

overgrowth of one or more body parts. [scielo.br]

Abnormal enlargement of one side or structure of the body (lateralized overgrowth) may occur, resulting in asymmetric growth. [rarediseases.org]