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236 Possible Causes for Ataxia, Deep White Matter Changes

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] If narrowing of the cerebral aqueduct occurs, many neurological symptoms may exist, including headaches, vertigo, nausea, muscle fasciculations, eye sensitivity, and ataxia[en.wikipedia.org] Less frequently, patients present with ataxia, motor and sensory impairment, mental and emotional disturbances, epilepsy, circadian rhythm disturbances, hypothalamic dysfunction[ncbi.nlm.nih.gov]

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org] Moderate - personality change, muscle cramps and weakness, confusion, ataxia. Severe - drowsiness.[patient.info] 24 Hours: 6-8 mEq/L ( Sterns 2010 ) DANGER : Rapid Overcorrection Rapid overcorrection of serum sodium can cause osmotic demyelination syndrome (ODS) ODS can manifest as ataxia[coreem.net]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] The first patient (female, 50 years old) had dysarthria, nystagmus and trunk ataxia on admission. Her blood alcohol level was 2.3‰.[ncbi.nlm.nih.gov] Dysarthria and right-sided limb ataxia were newly developed before DWI (after p-CTA).[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] Spastic paraparesis and progressive ataxia are principal symptoms in this subset of patients.[symptoma.com] Abstract HDLS (Hereditary Diffuse Leukodystrophy with Spheroids) is a hereditary leukodystrophy whose main clinical manifestations include parkinsonism, spasticity, and ataxia[ncbi.nlm.nih.gov]

  • Susac Syndrome

    In addition, high-signal-intensity changes are usually seen in the periventricular white matter and the deep gray matter [ 1 ].[ajronline.org] The encephalopathy, ataxia, and urinary incontinence resolved, and the hearing loss stabilized.[onlinelibrary.wiley.com] Though most commonly involving white matter, many patients also had lesions in deep grey matter structures, as well as leptomeningeal enhancement.[en.wikipedia.org]

  • Normal Pressure Hydrocephalus

    White matter changes (WMC) INPH is known to be associated with deep white matter changes (DWMC) and smooth periventricular hyperintensity (PVH) [ 51 ] on MRI ( Figure 2B )[intechopen.com] Our patient's gait disturbance was unassociated with muscle weakness, spasticity, cerebellar ataxia, or Romberg's sign, and, therefore, was consistent with a frontal gait[ncbi.nlm.nih.gov] White-matter changes: A distinction is drawn between periventricular and “deepwhite matter changes ( e49, e50 ); only the former are considered a sign of NPH.[ncbi.nlm.nih.gov]

  • Olivopontocerebellar Atrophy

    Evaluation of Postmortem MR Imaging Findings The presence of atrophy and signal-intensity change of cerebellar cortices, deep white matter and dentate nucleus regions was[ajnr.org] Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant, slowly progressive cerebellar ataxia without multisystem involvement.[ncbi.nlm.nih.gov] […] of 'idiopathic' late onset cerebellar ataxia.[ncbi.nlm.nih.gov]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] The patient presented with a slowly progressive illness with seizures, extrapyramidal symptoms, cerebellar ataxia, dementia, spasticity, myoclonic movements and a severe demyelinating[ncbi.nlm.nih.gov] Although rare, cerebellar ataxia, behavioural abnormalities, parkinsonism and apraxia of eyelid opening were exclusively seen in late onset patients.[ncbi.nlm.nih.gov]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] Cerebellar Ataxia Rehabilitation Trialists Collaboration. Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.[ncbi.nlm.nih.gov] Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia.[ncbi.nlm.nih.gov]

  • AMACR Deficiency

    References Clarke CE, Alger S, Preece MA et al (2004) Tremor and deep white matter changes in alpha-methylacyl-CoA racemase deficiency.[link.springer.com] AMACR mutations cause late-onset autosomal recessive cerebellar ataxia. Neurology. 2011 May 17;76(20):1768-70. doi: 10.1212/WNL.0b013e31821a4484.[ghr.nlm.nih.gov] Tremor and deep white matter changes in alpha-methylacyl-CoA racemase deficiency. Neurology 2004; 63 : 188–9 [ PubMed ] [ Google Scholar ] 3.[ncbi.nlm.nih.gov]

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