Ataxia Telangiectasia & Immunoglobulin M Decreased: Causes & Reasons

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Possible Causes for Ataxia Telangiectasia & Immunoglobulin M Decreased

Ataxia Telangiectasia

Bar syndrome ataxia telangiectasia syndrome AT At, Complementation Group C ATAXIA-TELANGIECTASIA ATAXIA-TELANGIECTASIA; AT Ataxia Telangiectasia Louis-Bar Syndrome At, Complementation [wikidata.org]

Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. [emedicine.medscape.com]

telangiectasia syndrome AT At, Complementation Group C ATAXIA-TELANGIECTASIA ATAXIA-TELANGIECTASIA; AT Ataxia Telangiectasia Louis-Bar Syndrome At, Complementation Group [wikidata.org]

Hypogammaglobulinemia

Hypogammaglobulinemia Drug Induced Antimalarial agents Captopril Carbamazepine Glucocorticoids Fenclofenac Gold salts Penicillamine Phenytoin Sulfasalazine Genetic Disorders Ataxia [esid.org]

Serum immunoglobulin determination at Walter Reed General Hospital revealed an immunoglobulin G level of 150 mg per 100 ml and absence of immunoglobulins A and M. [pubs.rsna.org]

[…] chest (with fewer cuts as appropriate); frequency of scanning as clinically indicated, and balanced against lifetime radiation risk as some PIDs are radiosensitive (e.g., ataxia-telangiectasia [online.epocrates.com]

Common Variable Immunodeficiency

Hypogammaglobulinemia Drug Induced Antimalarial agents Captopril Carbamazepine Glucocorticoids Fenclofenac Gold salts Penicillamine Phenytoin Sulfasalazine Genetic Disorders Ataxia [esid.org]

[…] serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) are characteristic of the disorder, about 50% of CVID patients also have decreased immunoglobulin M (IgM [medigoo.com]

Dysgammaglobulinemia

Hyper IgM syndrome ( 2, 3, 4, 5 ) Common variable immunodeficiency Cell-mediated ( T ) DiGeorge syndrome · Nezelof syndrome · Purine nucleoside phosphorylase deficiency · Ataxia [wikidoc.org]

Isolated primary immunoglobulin M deficiency (or selective IgM immunodeficiency (SIgMD)) is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM [diki.pl]

Isolated primary immunoglobulin M deficiency Isolated primary immunoglobulin M deficiency (or selective IgM immunodeficiency (SIgMD)) is a poorly defined dysgammaglobulinemia [howlingpixel.com]

Congenital Agammaglobulinemia

What is the earliest site of telangiectasia in ataxia-telangiectasia? Chronic mucocutaneous candidiasis Def'n: T-Cell disorder. [quizlet.com]

telangiectasia See ataxia telangiectasia. [amboss.com]

The following conditions and diseases can lead to an immunodeficiency disorder: Ataxia-telangiectasia Complement deficiencies DiGeorge syndrome Hypogammaglobulinemia Job syndrome [stlukes-stl.com]

X-Linked Syndromic Mental Retardation Type Chudley-Schwartz

Some causes may include: 1 Causes of Unsteady Gait : 7q11.23 Microduplication Syndrome AL-Raqad Syndrome Ataxia-Pancytopenia Syndrome Ataxia-Telangiectasia-Like Disorder 2 [familydiagnosis.com]

[…] type 1 Ataxia-pancytopenia syndrome Ataxia-tapetoretinal degeneration syndrome Ataxia-telangiectasia Ataxia-telangiectasia variant Ataxia-telangiectasia-like disorder Atelosteogenesis [se-atlas.de]

+ isolated vitamin E deficiency (AVED) Neurological Ataxia and oculomotor apraxia Neurological Ataxia-telangiectasia-like disorder Neurological Ataxia, spastic, autosomal [genomediagnosticsnijmegen.nl]

Immune System Disorder

Telangiectasia Common Variable Immunodeficiency Deltaretrovirus Infections + Dysgammaglobulinemia + HIV Infections + Leukocyte-Adhesion Deficiency Syndrome Lymphopenia + [ncbi.nlm.nih.gov]

X-linked lymphoproliferative disease (XLP) Ataxia–telangiectasia Secondary immune deficiencies AIDS Allergies[edit] An allergy is an abnormal immune reaction to a harmless [en.wikipedia.org]

Partial T-cell function occurs in conditions such as acquired immune deficiency syndrome (AIDS) and genetic conditions such as DiGeorge Syndrome, Ataxia Telangiectasia and [columbiadoctors.org]

Severe Combined Immunodeficiency

These cutaneous granulomas are primarily seen in combined variable immunodeficiency, ataxia-telangiectasia, and severe combined immunodeficiency (SCID) and can emulate the [ncbi.nlm.nih.gov]

telangiectasia will not meet the inclusion criteria for Stratum A, B, or C above However, a patient with one of the above may meet the inclusion criteria for Stratum B and [mayo.edu]

[…] radiography with no thymic shadow Flow cytometry absent T-cells abnormal function of B-cells Differential Diagnosis Hypogammaglobulinemia DiGeorge syndrome Hyper-IgM syndrome Ataxia-telangiectasia [medbullets.com]

Wiskott-Aldrich Syndrome

Ataxia-telangiectasia associated with hypogammaglobulinemia. Arch Neurol. 1963 Mar;8:318–327. [ncbi.nlm.nih.gov]

telangiectasia [Louis-Bar] ( G11.3 ) Immunodeficiency associated with other major defects Approximate Synonyms Wiskott aldrich syndrome Clinical Information A rare, x-linked [icd10data.com]

[…] immune mechanism D82 ICD-10-CM Diagnosis Code D82 Immunodeficiency associated with other major defects 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes ataxia [icd10data.com]

Hyper-IgM Syndrome Type 4

In addition, ataxia-telangiectasia can present as a hyper-IgM syndrome in infancy with the neurological symptoms and telangiectasia developing later in childhood. [dermnetnz.org]

Abnormalities in the CD40L gene were associated with an X-linked immunodeficiency in humans [hyper-IgM (immunoglobulin M) syndrome]. [science.sciencemag.org]

Ataxia-telangiectasia: Immunodeficiency and survival. Clin Immunol. 2017 Jan 24. [Medline]. Jain A, Atkinson TP, Lipsky PE, et al. [medscape.com]

Persistent Polyclonal B-cell Lymphocytosis

The genetic predisposition (8), the persistent viral infection, the chromosomal instability (9) or genetic alterations of ataxia-telangiectasia-mutated and Rad3-related gene [mafiadoc.com]

Datta U, Sehgal S, Kumar L, et al: Immune status in ataxia telangiectasia. Indian J Med Res 94:252, 1991. 156. [medtextfree.wordpress.com]

Chronic Lymphocytic Leukemia

Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet 1999 ;353: 26 - 29 25. Bullrich F, Rasio D, Kitada S, et al. [doi.org]

These include: ataxia-telangiectasia Bloom syndrome Schwachman-Diamond syndrome Wiskott-Aldrich syndrome Immune suppression: Childhood leukemia may develop due to the deliberate [medicalnewstoday.com]

telangiectasia gene mutations, and interphase cytogenetic abnormalities including del(17p13)] have been associated with poor response to fludarabine-based therapy. 42-50 [dx.doi.org]

Transient Hypogammaglobulinemia of Infancy

Ataxia-telangiectasia I. Common variable immunodeficiency J. Immunoglobulin G subclass deficiency K. Wiskott-Aldrich syndrome 3. [proprofs.com]

(A, G or M) can be decreased in this condition. [symptoma.com]

THI is characterized by decreased serum IgG with or without decreased immunoglobulin A (IgA) and immunoglobulin M (IgM) levels less than 2 standard deviations (SDs) from age-adjusted [emedicine.medscape.com]

Chronic Myeloid Leukemia

telangiectasia, and Fanconi anemia. [doi.org]

Other hereditary conditions that can increase the risk of developing leukemia include Down syndrome, neurofibromatosis type 1, ataxia telangiectasia, and Noonan syndrome. [medicinenet.com]

Hyper-IgM Syndrome

In addition, ataxia-telangiectasia can present as a hyper-IgM syndrome in infancy with the neurological symptoms and telangiectasia developing later in childhood. [dermnetnz.org]

Abnormalities in the CD40L gene were associated with an X-linked immunodeficiency in humans [hyper-IgM (immunoglobulin M) syndrome]. [science.sciencemag.org]

Of note, two patients (P1 and P2) developed ataxia-telangiectasia during follow-up. [nature.com]

Adenosine Deaminase Deficiency

Malignant Melanoma of the Skin

Abstract TIP60 (HTATIP) is a histone acetyltransferase (HAT) whose function is critical in regulating ataxia-telangiectasia mutated (ATM) activation, gene expression, and [doi.org]

Hepatocellular Carcinoma

[…] alcohol or are long-time users of androgenic anabolic steroids They have the following congenital (present at birth) diseases and conditions: Alpha-1 antitrypsin deficiency Ataxia [stjude.org]

telangiectasia Budd-Chiari syndrome Galactosemia Hemochromatosis Hereditary tyrosinemia Type 1 glycogen storage disease Wilson’s disease Only about a third of children diagnosed [stjude.org]

Bloom Syndrome

DNA-damaging agents that cause double strand breaks and a G2 delay induced BLM by a p53- and ataxia-telangiectasia mutated independent mechanism. [jcb.rupress.org]

Patients with Bloom syndrome have decreased immunoglobulin A and M. [dermnetnz.org]

Bulbar telangiectasia are frequently described in other genodermatoses such as ataxia telangiectasia and hereditary hemorrhagic telangiectasia, but are infrequently noted [ncbi.nlm.nih.gov]

Primary Immune Deficiency Disorder

Ataxia 22. telangiectasia 23. [slideshare.net]

Although decreased serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) are characteristic, approximately 50% of patients with the deficiency also have diminished [emedicine.medscape.com]

Ataxia-Telangiectasia Leman Yel Martin F. Lavin and Yosef Shiloh 48. Chromosomal Instability Syndromes Other than Ataxia-Telangiectasia Rolf-Dieter Wegner, James J. [oxfordmedicine.com]

Hyper-IgM Syndrome Type 5

In addition, ataxia-telangiectasia can present as a hyper-IgM syndrome in infancy with the neurological symptoms and telangiectasia developing later in childhood. [dermnetnz.org]

Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins [owlapps.net]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections. [owlapps.net]

Neutrophil Immunodeficiency Syndrome

Ataxia telangiectasia - AR - Mutated gene on Chr 11 Ataxia (cerebellar ataxia is 1st neuro sign) Telangiectasia of eyes and skin Chronic sinopulmonary disease Endocrine abnormalities [brainscape.com]

Ataxia-telangiectasia is a deficiency of T cells associated with a lack of coordination of movement (ataxis) and dilation of small blood vessels of the facial area (telangiectasis [microbiologybook.org]

Immunodeficiency

Indexing: Immunity (1966-1967) See Also: Immunocompromised Host All MeSH Categories Diseases Category Immune System Diseases Immunologic Deficiency Syndromes Agammaglobulinemia Ataxia [ncbi.nlm.nih.gov]

telangiectasia See ataxia telangiectasia for details. [amboss.com]

Common Variable Immunodeficiency Type 4

Some of the more commonly seen primary immunodeficiencies we treat are: Ataxia telangiectasia Chronic granulomatous disease Common variable immune deficiency Complement deficiencies [uchicagokidshospital.org]

[…] serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) are characteristic of the disorder, about 50% of CVID patients also have decreased immunoglobulin M (IgM [medigoo.com]

The following diseases and conditions are linked to primary immunodeficiency disorders: ataxia-telangiectasia Chediak-Higashi syndrome combined immunodeficiency disease complement [healthline.com]

Autosomal Recessive Agammaglobulinemia Type 3

Ataxia-telangiectasia Petechiae and/or purpura Pigmentary dilution/silvery hair Pyoderma gangrenosum-like ulcerations Chédiak–Higashi syndrome Griscelli syndrome Wiskott–Aldrich [mhmedical.com]

Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins [en.wikipedia.org]

Examples: Albinism (except ocular albinism which is X-linked recessive) ARPKD Ataxia Telangiectasia Barter syndrome Bloom syndrome Congenital adrenal hyperplasia Criggler [epomedicine.com]

Chemotherapy

The dispersal of replication proteins after etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. [doi.org]

Gonda Oncogene (2019) GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells Laura Pintado-Berninches, Beatriz Fernandez-Varas, [doi.org]

Autosomal Recessive Agammaglobulinemia Type 4

Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins [en.wikipedia.org]

Examples: Albinism (except ocular albinism which is X-linked recessive) ARPKD Ataxia Telangiectasia Barter syndrome Bloom syndrome Congenital adrenal hyperplasia Criggler [epomedicine.com]

Hyper-IgM Syndrome Type 3

In addition, ataxia-telangiectasia can present as a hyper-IgM syndrome in infancy with the neurological symptoms and telangiectasia developing later in childhood. [dermnetnz.org]

Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins [en.wikipedia.org]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections.[8][7][ [en.wikipedia.org]

IgE Myeloma

Low IgE levels have been reported in severe combined immunodeficiency, hyper-IgM syndrome, ataxia telangiectasia, X-linked recessive Bruton agammaglobulinemia, and common [clinlabnavigator.com]

Elevations of immunoglobulin G (IgG), immunoglobulin A (IgA), or immunoglobulin M (IgM) may occur in monoclonal gammopathies such as multiple myeloma (IgG, IgA), macroglobulinemia [mayomedicallaboratories.com]

Low levels of IgE can occur in a rare inherited disease that affects muscle coordination (ataxia-telangiectasia). [healthy.kaiserpermanente.org]

Generalized Amyoplasia

Meckel-Gruber Syndrome Pallister-Hall Syndrome X-Linked Hydrocephalus Spectrum Hydrolethalus Syndrome Walker-Warburg Syndrome Miller-Dieker Syndrome Smith-Magenis Syndrome Ataxia-Telangiectasia [leaderbook.com.tw]

Immunoglobulin M levels and specific viral titers (eg, coxsackievirus, enterovirus, Akabane virus) in the newborn may reveal intrauterine infection. [emedicine.medscape.com]

ataxy, ataxic R27.0 Ataxia-telangiectasia (Louis-Bar) G11.3 Atelectasis (massive) (partial) (pressure) (pulmonary) J98.11 Atelocardia Q24.9 Atelomyelia Q06.1 Atheroembolism [icd.codes]