Atrophy: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for atrophy

Atrophic Vaginitis

The major universal change is vaginal atrophy. [ncbi.nlm.nih.gov]

Key Topics Covered: Vaginal Atrophy (Atrophic Vaginitis) Overview Vaginal Atrophy (Atrophic Vaginitis) Pipeline Therapeutics Vaginal Atrophy (Atrophic Vaginitis) Therapeutics [businesswire.com]

Treatment Vaginal atrophy can be treated with estrogen therapy. [drugs.com]

Orthostatic Hypotension

The disorder may be associated with Addison's disease, diabetes, and certain neurological disorders including Multiple System Atrophy with Orthostatic Hypotension (formerly [ninds.nih.gov]

A patient suffering from multiple system atrophy (Shy-Drager syndrome) with severe symptomatic postprandial orthostatic hypotension was treated. [ncbi.nlm.nih.gov]

[…] long-term safety of droxidopa for the treatment of symptomatic neurogenic orthostatic hypotension in patients with Parkinson disease, pure autonomic failure, multiple system atrophy [ncbi.nlm.nih.gov]

Menopause

[…] intravaginal prasterone obtained in the three randomized clinical studies performed in postmenopausal women suffering from moderate to severe (MS) dyspareunia due to vulvovaginal atrophy [ncbi.nlm.nih.gov]

RESULTS: Vaginal atrophy symptoms and signs as well as the overactive bladder subjective symptom parameter improved significantly. [ncbi.nlm.nih.gov]

KEYWORDS: atrophic vaginitis; dyspareunia; genitourinary syndrome of menopause; menopause; vaginal atrophy; vaginal estrogen [ncbi.nlm.nih.gov]

Vaginitis

AV is typically marked by either an increased inflammatory response or by prominent signs of epithelial atrophy or both. [ncbi.nlm.nih.gov]

In breast-feeding and postmenopausal women with vaginal atrophy, additional treatment with local estriol may be necessary to prevent recurrence. [ncbi.nlm.nih.gov]

INTRODUCTION: Vaginal atrophy results from a decrease in circulating estrogen and is experienced by approximately 50% of postmenopausal women. [ncbi.nlm.nih.gov]

Autoimmune Gastritis

Abstract To date, autoimmune gastritis has been diagnosed for the most part only when total atrophy of the oxyntic glands is detected. [ncbi.nlm.nih.gov]

Antrum atrophy was present in 39% of H. pylori-negative AIG patients. [ncbi.nlm.nih.gov]

[…] and to determine the relationship of Helicobacter pylori with oxyntic gastric atrophy. [ncbi.nlm.nih.gov]

Skin Atrophy

Steroid-induced skin atrophy is the most frequent and perhaps most important cutaneous side effect of topical glucocorticoid therapy. [ncbi.nlm.nih.gov]

This study aims to review clinical data on skin atrophy induced by TCs. [ncbi.nlm.nih.gov]

To our knowledge, this is the first report of skin atrophy in this association. [ncbi.nlm.nih.gov]

Vulvitis

Vaginal Dryness, Vaginal Atrophy & Vulvitis During Menopause Decreased function of estrogens can specifically result in vaginal dryness and vaginal atrophy which can bring [yourhormones.com]

When the percentage was 25-50%, hemosiderin deposition and epithelial atrophy were additional histologic features helpful in diagnosing PCV. [ncbi.nlm.nih.gov]

The most common causes of secondary vulvitis are: urinary incontinence vaginal discharge The barrier is reduced in cases of vulval atrophy or degeneration resulting from: [gpnotebook.com]

Patulous Eustachian Tube

The MRI of the three patients when they developed pET demonstrated atrophy and fat infiltration of the muscles innervated by the mandibular branch of the trigeminal nerve. [ncbi.nlm.nih.gov]

It is frequently associated with peritubal atrophy, and usually responds to conservative measures such as weight gain or mucus-producing agents. [ncbi.nlm.nih.gov]

The right ear showed similar mobility of the tympanic membrane on respiration but without the associated chronic tympanic changes and atrophy. [nejm.org]

Orchitis

As mumps orchitis seem to induce testicular atrophy, periodic check up may be required after the acute stage. [synapse.koreamed.org]

The biopsies showed total atrophy of the seminiferous tubules in 39%, 10% atrophy in 16%, and no apparent histological alterations, except an arrest in spermatogenesis, in [ncbi.nlm.nih.gov]

The most common forms of brucellosis are epididymo-orchitis, testicular abscess and atrophy. [ncbi.nlm.nih.gov]

Gastritis

RESULTS: A total of 177 non-atrophic gastritis and 154 atrophic gastritis were analyzed, among which 40 were antrum atrophy, 32 were corpus atrophy and 82 were pan-atrophy [ncbi.nlm.nih.gov]

Hp, chronic inactive gastritis, atrophy, and intestinal metaplasia were also more common among East-Asians, Hp and atrophy decreasing with rising income but remaining unaffected [ncbi.nlm.nih.gov]

Gastric atrophy: Atrophy of gastric glands may follow in gastritis, most often long-standing antral (sometimes referred to as type B) gastritis. [web.archive.org]

Entrapment Neuropathy

[…] line-art representation of the radiographs, showed a significant (P less than .0001) correlation between decrease in the area of the cubital tunnel and ulnar innervated muscle atrophy [ncbi.nlm.nih.gov]

Neuromuscular examination revealed severe atrophy in the thenar, hypothenar, and interossei muscles on the right side, as well as moderate atrophy in the left interossei and [touchneurology.com]

The patient developed atrophy in some muscles, possibly a result of the surgery, which resulted in significant motor disability. [touchneurology.com]

Myopic Macular Degeneration

To investigate the retinal sensitivity of highly myopic eyes with chorioretinal patchy atrophy (PA) using microperimetry. [physiciansweekly.com]

Bottom row (C1–C3) shows the photographs of eyes with Meta-PM Category 4 (myopic macular atrophy). Peripapillary atrophy was present in all eyes. [iovs.arvojournals.org]

[…] can coalesce and result in geographic atrophy (GA). [aao.org]

Polyneuropathy

MRIs of the brain may reveal cerebellar atrophy. Mild cognitive problems have been reported in a few individuals. [disorders.eyes.arizona.edu]

Neuronal Peroneal Muscular Atrophy (HMSN II) Autosomal dominant inheritance is also the case with HMSN II. [lecturio.com]

In general, neuropathies with extensive axonal loss, denervation and atrophy have a poor prognosis for full recovery. [now.aapmr.org]

Orthostatic Syncope

MRI findings include atrophy of putamen and middle cerebellar peduncles, as well as putaminal and cerebellar hypometabolism on [18F]-fluorodeoxyglucose positron emission tomography [orpha.net]

[…] sinus sensitivity *"36 % elderly NH pop. had orthostatic hypotension postprandially BUT: only 2 % had symptoms from it. d) Primary Autonomic Disease Idiopathic Multi-System Atrophy [unmc.edu]

The relationship of multiple system atrophy to sporadic olivopontocerebellar atrophy and other forms of late onset cerebellar atrophy. [ahajournals.org]

Primary Progressive Multiple Sclerosis

We investigated the relationship between regional brain atrophy and physical disability in patients with PPMS. [ncbi.nlm.nih.gov]

[…] longitudinal study was designed to assess the frequency, extent, and rate of formation of CLs in PPMS and their relationship with T2 lesion volume (LV), gray matter (GM) atrophy [ncbi.nlm.nih.gov]

Although patients did not show significant cord atrophy when compared with healthy controls, they had significantly lower total N-acetyl-aspartate (mean 4.01 versus 5.31 mmol [ncbi.nlm.nih.gov]

Pancreatic Atrophy

25.7-36.7 mo) among patients who did not develop pancreatic atrophy (P 0.009). [ncbi.nlm.nih.gov]

We have observed four cases of pancreatic atrophy following single episodes of acute pancreatitis. [ncbi.nlm.nih.gov]

We report a case of pancreatic atrophy following blunt injury in an 8 year old boy who presented 3 years later with diabetes mellitus. [ncbi.nlm.nih.gov]

Macular Degeneration

Purpose: To assess the impact of distinct atrophy border characteristics based on spectral-domain optical coherence tomography (SD-OCT) imaging on local atrophy progression [ncbi.nlm.nih.gov]

atrophy occurrence in one eye. [ncbi.nlm.nih.gov]

KEYWORDS: Age-related macular degeneration; Choroidal thickness; Macular atrophy; Neovascular age-related macular degeneration; Treat-and-extend [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 3

A new study by an international research team characterized three new cases of a rare medical condition where spinal muscular atrophy (SMA) is associated with progressive [smanewstoday.com]

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Figure 1: Diffused atrophy in cerebral cortex in magnetic resonance imaging (MRI). [journals.lww.com]

Geographic Tongue

[…] ge·o·graph·ic tongue idiopathic, asymptomatic erythematous circinate macules, often bounded peripherally by a white band, as a result of atrophy of the filiform papillae; [medical-dictionary.thefreedictionary.com]

One review reported overall prevalence ranges of 0.1-14.3% for geographic tongue, 1.3-9.0% for "atrophy tongue" (atrophic glossitis), and 0.0-3.35% for median rhomboid glossitis [omicsonline.org]

In this condition, the papillae will atrophy (shrink) and cause irregular shaped smooth areas.The patches vary in size, shape and location- hence the name benign migratory [healthtap.com]

Vitamin B12 Deficiency

The results showed significant gray matter atrophy of the right middle occipital gyrus and the opercular part of the inferior frontal gyrus in subjects with a simultaneous [ncbi.nlm.nih.gov]

MRI revealed cerebral atrophy and delayed myelination. [ncbi.nlm.nih.gov]

Preferential atrophy in frontal regions is the main neuroimaging feature. [ncbi.nlm.nih.gov]

Progressive Muscular Atrophy

The name "spinal muscular atrophy" is ambiguous as it refers to any of various spinal muscular atrophies, including the autosomal recessive spinal muscular atrophy caused [en.wikipedia.org]

KEYWORDS: Lower motor neuron syndrome; Lower motor neuron-onset ALS; PMA; Progressive muscular atrophy [ncbi.nlm.nih.gov]

Muscle atrophy and weakness may be symmetrical or asymmetrical, but they are always bilateral. [ncbi.nlm.nih.gov]

Pallidopyramidal Syndrome

Brain scans show atrophy of the globus pallidus and pyramids and, later, widespread cerebral atrophy. [research.manchester.ac.uk]

Whilst this eponym has stuck, ‘progressive pallidal atrophy’ has not done so well. [academic.oup.com]

The disturbance of movement in pallidal atrophy is slowness and lack of initiation. [academic.oup.com]

Progressive Myoclonic Epilepsy Type 7

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Abnormality of movement Cerebellar atrophy Dystonia Gait disturbance Amaurosis fugax Gait ataxia Cerebellar hypoplasia Babinski sign Dysarthria Peripheral neuropathy Loss [mendelian.co]

Spinal muscular atrophy associated with progressive myoclonic epilepsy Topaloglu H, Melki J Epileptic disorders : international epilepsy journal with videotape, 2016, 18, [myobase.org]

Wolfram Syndrome

Wolfram syndrome was originally described as a combination of familial juvenile-onset diabetes mellitus and optic atrophy. [ncbi.nlm.nih.gov]

[…] with diabetes mellitus and optic atrophy [ 1 ]. [dx.doi.org]

Magnetic resonance images revealed striking brainstem atrophy affecting, in particular, the pons and midbrain. [ncbi.nlm.nih.gov]

Muscular Dystrophy

Distal muscular dystrophies are a group of inherited primary muscle disorders showing progressive weakness and atrophy preferentially in the hands, forearm, lower legs, or [ncbi.nlm.nih.gov]

Fasciculation and atrophy of the tongue with dysphagia, dysarthria, and thickened nasal speech are usually associated. [icd9data.com]

Spinal muscular atrophies: Amyotrophic lateral sclerosis (ALS), or motor neuron disease Infantile progressive spinal muscular atrophy Intermediate spinal muscular atrophy [urmc.rochester.edu]

Progressive Myoclonic Epilepsy Type 8

Sagittal T1‐weighted brain MRI showing brainstem atrophy, particularly in the pons. [onlinelibrary.wiley.com]

Brain magnetic resonance imaging revealed brainstem atrophy, particularly in the pons (Figure 1). [onlinelibrary.wiley.com]

Friedreich's ataxia, spinocerebellar ataxias types 1, 2, 3, 6, 7, 12, 17 and dentatorubropallidoluysian atrophy molecular analysis came out negative. [onlinelibrary.wiley.com]

Cronkhite-Canada Syndrome

Endoscopic exam and biopsies revealed severe atrophy and diffuse marked edema of mucosa of stomach and duodenum. [ncbi.nlm.nih.gov]

[…] of alopecic lesions in two female CCS patients with severe hair loss revealed a marked increase in telogen hair follicles with no sign of loss or of the minaturisation or atrophy [ncbi.nlm.nih.gov]

A 77-year-old man was diagnosed with sigmoid colon cancer after presenting with hypoproteinemia, nail atrophy, loss of scalp hair, hyperpigmentation, and gastrointestinal [ncbi.nlm.nih.gov]

Spinal and Bulbar Muscular Atrophy

We report on a case of genetically proven X-linked spinal and bulbar muscular atrophy (X-SBMA) with prominent distal muscle atrophy and without proximal muscle involvement [ncbi.nlm.nih.gov]

Abstract Spinal and bulbar muscular atrophy (SBMA) is an adult-onset degenerative disorder of the neuromuscular system resulting in slowly progressive weakness and atrophy [ncbi.nlm.nih.gov]

The disease is characterised by weakness, atrophy and fasciculations in the limb and bulbar muscles. [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 1

atrophy of body muscles. [en.wikipedia.org]

Homepage Rare diseases Search Search for a rare disease Spinal muscular atrophy with respiratory distress type 1 Disease definition Spinal muscular atrophy with respiratory [orpha.net]

Hardart MK, Truog RD (2003) Spinal muscular atrophy-type I. [doi.org]

Distal Spinal Muscular Atrophy Type 3

Homepage Rare diseases Search Search for a rare disease X-linked distal spinal muscular atrophy type 3 Disease definition X-linked distal spinal muscular atrophy type 3 is [orpha.net]

[…] are not associated with a defect in the SMN1 gene on chromosome 5q X-linked spinal muscular atrophy X-linked spinal muscular atrophy is seen only among males! [amboss.com]

Other forms of spinal muscular atrophy and related motor neuron diseases, such as spinal muscular atrophy with progressive myoclonic epilepsy, spinal muscular atrophy with [ghr.nlm.nih.gov]