Atrophy: Causes & Reasons

Possible Causes for Atrophy

Steroid-induced skin atrophy Skin atrophy Specialty Dermatology Steroid-induced skin atrophy is thinning of the skin as a result of prolonged exposure to steroids. [en.wikipedia.org]

Steroid atrophy is often permanent although the degree of atrophy may improve if topical corticosteroids are discontinued as soon as cutaneous changes are noticed. [medscape.com]

It is likely that the detailed mechanisms of GC-induced skin atrophy will be discovered and in vitro models for the reliable prediction of atrophy will be established in the [ncbi.nlm.nih.gov]

Elastosis perforans serpiginosa

[…] perforans serpiginosa", abstract = "A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy [scholars.northwestern.edu]

A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy on the bilateral neck. [ncbi.nlm.nih.gov]

The plaque measured 3.5 × 1.5 cm and was skin colored with well-defined serpiginous border with crateriform appearance, the center of which showed atrophy [Figure 1]. [e-ijd.org]

Atrophic Patchy Alopecia

Fig. 3 Vascular changes in steroid-induced atrophy. [karger.com]

Abstract We report a case of the Hallermann-Strieff syndrome with focal scalp atrophy and associated patchy hair loss. [ncbi.nlm.nih.gov]

The affected muscles may be stiff, sore, and/or tender and, eventually, may show signs of degeneration and muscle wasting (atrophy). [rarediseases.org]

Steroid Rosacea

The appearance is of a flaming red, scaly, papule-covered face (red face syndrome).[11] If left untreated, permanent skin atrophy and telangiectasia can result. [ncbi.nlm.nih.gov]

If steroid use continues or the condition is left untreated, the skin may become atrophied and permanently damaged. [news-medical.net]

Most of them had history of exacerbation of symptoms after sun exposure, probably due to atrophy and vasodilatation of the facial skin, caused by the prolonged use of topical [ijdvl.com]

Atrophic Vaginitis

The major universal change is vaginal atrophy. [ncbi.nlm.nih.gov]

What is vaginal atrophy? [hormone.org]

Key Topics Covered: Vaginal Atrophy (Atrophic Vaginitis) Overview Vaginal Atrophy (Atrophic Vaginitis) Pipeline Therapeutics Vaginal Atrophy (Atrophic Vaginitis) Therapeutics [businesswire.com]

Orthostatic Hypotension

The disorder may be associated with Addison's disease, diabetes, and certain neurological disorders including Multiple System Atrophy with Orthostatic Hypotension (formerly [ninds.nih.gov]

A patient suffering from multiple system atrophy (Shy-Drager syndrome) with severe symptomatic postprandial orthostatic hypotension was treated. [ncbi.nlm.nih.gov]

Phase Biomarkers in Parkinsonian Syndromes The differential diagnosis between Parkinson's disease, multiple system atrophy and progressive supranuclear palsy can be very difficult [centerwatch.com]

Autoimmune Gastritis

Abstract To date, autoimmune gastritis has been diagnosed for the most part only when total atrophy of the oxyntic glands is detected. [ncbi.nlm.nih.gov]

Antrum atrophy was present in 39% of H. pylori-negative AIG patients. [ncbi.nlm.nih.gov]

[…] and to determine the relationship of Helicobacter pylori with oxyntic gastric atrophy. [ncbi.nlm.nih.gov]

Orthostatic Syncope

MRI findings include atrophy of putamen and middle cerebellar peduncles, as well as putaminal and cerebellar hypometabolism on [18F]-fluorodeoxyglucose positron emission tomography [orpha.net]

Multiple system atrophy is known to cause neurogenic orthostatic hypotension by damaging the autonomic nervous system. [multiplesystematrophy.org]

Multiple system atrophy Autonomic manifestations are similar to those observed in AAN and PAF. [emedicine.medscape.com]

Orchitis

Key terms Atrophy — A wasting away or withering. [medical-dictionary.thefreedictionary.com]

As mumps orchitis seem to induce testicular atrophy, periodic check up may be required after the acute stage. [synapse.koreamed.org]

Sixty percent of patients with mumps orchitis develop testicular atrophy in at least one testis. Atrophy is unrelated to fertility or to the severity of the orchitis. [msdmanuals.com]

Entrapment Neuropathy

Only patients classified with grade IV atrophy of ADQ muscle (complete fatty muscle atrophy) were considered for evaluation. [scielo.br]

Neuromuscular examination revealed severe atrophy in the thenar, hypothenar, and interossei muscles on the right side, as well as moderate atrophy in the left interossei and [touchneurology.com]

[…] images superimposed on muscle atrophy indicates an ongoing, partly reversible process. [musculoskeletalkey.com]

Pallidopyramidal Syndrome

Whilst this eponym has stuck, ‘progressive pallidal atrophy’ has not done so well. [academic.oup.com]

Neuronal atrophy and synaptic alteration in a mouse model of dentatorubral-pallidoluysian atrophy. Brain 2006 ; 129 : 2353 –62. 44. [cambridge.org]

In the present study, we screened entire exons of FBXO7 from 271 patients (231 PD and 40 multiple system atrophy [MSA]), of which 221 samples were of Japanese origin. [ncbi.nlm.nih.gov]

X-Linked Parkinsonism with Spasticity

Optic atrophy develops around the same time or slightly later. Severity is variable, and some patients lose independent ambulation. [mendelian.co]

atrophy is symmetric in the other 50%. [neuroweb.us]

Parkinsonisms include multiple system atrophy, progressive supranuclear palsy and cortiobasal degeneration. [rush.edu]

Myopic Macular Degeneration

To investigate the retinal sensitivity of highly myopic eyes with chorioretinal patchy atrophy (PA) using microperimetry. [physiciansweekly.com]

Bottom row (C1–C3) shows the photographs of eyes with Meta-PM Category 4 (myopic macular atrophy). Peripapillary atrophy was present in all eyes. [iovs.arvojournals.org]

Click here for an explanation of how the atrophy can occur as well as how the blood vessels grow into the macula. The symptoms are similar to AMD & JMD as well. [mymacularjournal.com]

Progressive Myoclonic Epilepsy Type 7

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Abnormality of movement Cerebellar atrophy Dystonia Gait disturbance Amaurosis fugax Gait ataxia Cerebellar hypoplasia Babinski sign Dysarthria Peripheral neuropathy Loss [mendelian.co]

・淡蒼球ルイ体萎縮症（dentatorubural pallidoluysian atrophy, DRPLA、別名内藤・小柳病）の原因遺伝子である DRPLA （別名CTG-B37）の遺伝子産物である。 [tmig.or.jp]

Progressive Myoclonic Epilepsy Type 3

A new study by an international research team characterized three new cases of a rare medical condition where spinal muscular atrophy (SMA) is associated with progressive [smanewstoday.com]

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Panel and their clinical significance Gene Associated phenotypes Inheritance ClinVar HGMD AFG3L2 * Spastic ataxia, Spinocerebellar ataxia AD/AR 22 40 ASAH1 Spinal muscular atrophy [blueprintgenetics.com]

Primary Progressive Multiple Sclerosis

We investigated the relationship between regional brain atrophy and physical disability in patients with PPMS. [ncbi.nlm.nih.gov]

[…] longitudinal study was designed to assess the frequency, extent, and rate of formation of CLs in PPMS and their relationship with T2 lesion volume (LV), gray matter (GM) atrophy [ncbi.nlm.nih.gov]

Although patients did not show significant cord atrophy when compared with healthy controls, they had significantly lower total N-acetyl-aspartate (mean 4.01 versus 5.31 mmol [ncbi.nlm.nih.gov]

Geographic Tongue

The classic manifestation is a maplike distribution of erythema caused by atrophy of the filiform papillae of the tongue, surrounded by a white hyperkeratotic rim. [nejm.org]

[…] ge·o·graph·ic tongue idiopathic, asymptomatic erythematous circinate macules, often bounded peripherally by a white band, as a result of atrophy of the filiform papillae; [medical-dictionary.thefreedictionary.com]

One review reported overall prevalence ranges of 0.1-14.3% for geographic tongue, 1.3-9.0% for "atrophy tongue" (atrophic glossitis), and 0.0-3.35% for median rhomboid glossitis [omicsonline.org]

Progressive Myoclonic Epilepsy Type 8

Sagittal T1‐weighted brain MRI showing brainstem atrophy, particularly in the pons. [onlinelibrary.wiley.com]

Brain magnetic resonance imaging revealed brainstem atrophy, particularly in the pons (Figure 1). [onlinelibrary.wiley.com]

Friedreich's ataxia, spinocerebellar ataxias types 1, 2, 3, 6, 7, 12, 17 and dentatorubropallidoluysian atrophy molecular analysis came out negative. [onlinelibrary.wiley.com]

Macular Degeneration

Purpose: To assess the impact of distinct atrophy border characteristics based on spectral-domain optical coherence tomography (SD-OCT) imaging on local atrophy progression [ncbi.nlm.nih.gov]

atrophy occurrence in one eye. [ncbi.nlm.nih.gov]

KEYWORDS: Age-related macular degeneration; Choroidal thickness; Macular atrophy; Neovascular age-related macular degeneration; Treat-and-extend [ncbi.nlm.nih.gov]

Cronkhite-Canada Syndrome

Endoscopic exam and biopsies revealed severe atrophy and diffuse marked edema of mucosa of stomach and duodenum. [ncbi.nlm.nih.gov]

Patients typically present with watery diarrhea and protein losing enteropathy and associated nail atrophy, brownish skin pigmentation, and alopecia 3. [radiopaedia.org]

[…] syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis, chronic diarrhea, ectodermal dysplasia, skin hyperpigmentation, hair loss and nail atrophy [ncbi.nlm.nih.gov]

Pancreatic Atrophy

25.7-36.7 mo) among patients who did not develop pancreatic atrophy (P = 0.009). [ncbi.nlm.nih.gov]

We have observed four cases of pancreatic atrophy following single episodes of acute pancreatitis. [ncbi.nlm.nih.gov]

What Is Pancreatic Atrophy? Pancreatic atrophy is the irreversible degeneration of the pancreas that is often associated with chronic pancreatitis. [reference.com]

Polyneuropathy

Neuronal Peroneal Muscular Atrophy (HMSN II) Autosomal dominant inheritance is also the case with HMSN II. [lecturio.com]

MRIs of the brain may reveal cerebellar atrophy. Mild cognitive problems have been reported in a few individuals. [disorders.eyes.arizona.edu]

In general, neuropathies with extensive axonal loss, denervation and atrophy have a poor prognosis for full recovery. [now.aapmr.org]

Non-Syndromic Ocular Stickler Syndrome Type 1

+ hereditary night blindness + Hereditary Optic Atrophies + hereditary retinal dystrophy + high hyperopia Histiocytic Dermatoarthritis Iris Pigment Epithelium Anomalies Joubert [rgd.mcw.edu]

[…] anomalies - Ulnar / cubital anomaly / absence / agenesis / hypoplasia / abnormal ulnar / cubital ray Frequent - Abnormal gait - Metaphyseal anomaly - Muscle hypotrophy / atrophy [csbg.cnb.csic.es]

Epicanthus Blindness Retrognathia Epiphora Rhegmatogenous retinal detachment Posterior vitreous detachment Membranous vitreous appearance Ptosis Enlarged epiphyses Optic atrophy [mendelian.co]

Progressive Muscular Atrophy

The name "spinal muscular atrophy" is ambiguous as it refers to any of various spinal muscular atrophies, including the autosomal recessive spinal muscular atrophy caused [en.wikipedia.org]

KEYWORDS: Lower motor neuron syndrome; Lower motor neuron-onset ALS; PMA; Progressive muscular atrophy [ncbi.nlm.nih.gov]

What Is Progressive Muscular Atrophy? Progressive muscular atrophy is an inherited form of motor neuron disease. [healthcare.utah.edu]

Ulnar Nerve Entrapment

Symptoms: Pain or numbness in the elbow, hand, or wrist Weakening hand grip Atrophy of the muscles of the hand How is it diagnosed? [sportsandortho.com]

Alternatively, subcutaneous transposition is frequently used in the case of athletes (gymnasts) whose activity involves throwing and who do not present muscular atrophy. [symptoma.com]

Symptoms of ulnar nerve entrapment include tingling in fingers 4 and 5, weak grip strength, pain and sensitivity on the ulnar side of the forearm, wrist and hand, muscle atrophy [physio-pedia.com]

Muscular Dystrophy

Distal muscular dystrophies are a group of inherited primary muscle disorders showing progressive weakness and atrophy preferentially in the hands, forearm, lower legs, or [ncbi.nlm.nih.gov]

Spinal muscular atrophies: Amyotrophic lateral sclerosis (ALS), or motor neuron disease Infantile progressive spinal muscular atrophy Intermediate spinal muscular atrophy [urmc.rochester.edu]

Spinal muscular atrophies Amyotrophic lateral sclerosis (ALS), or motor neuron disease Infantile progressive spinal muscular atrophy Intermediate spinal muscular atrophy Juvenile [hopkinsmedicine.org]

Wolfram Syndrome

Abstract Wolfram syndrome is the association of diabetes mellitus and optic atrophy, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness [nature.com]

Wolfram syndrome was originally described as a combination of familial juvenile-onset diabetes mellitus and optic atrophy. [ncbi.nlm.nih.gov]

Abstract Wolfram syndrome is the constellation of juvenile onset diabetes mellitus and optic atrophy, known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy [ncbi.nlm.nih.gov]

Plummer-Vinson Syndrome

It leads to degeneration of muscles of pharynx, leading to mucosal atrophy and development of webs. [medicaljoyworks.com]

Histopathology Histologically, webs in patients with Plummer-Vinson syndrome show fibrosis, epithelial atrophy, epithelial hyperplasia, hyperkeratosis, basal cell hyperplasia [statpearls.com]

Deficiency of iron-dependent oxidative enzymes causes gradual degradation of the pharyngeal muscles which lead to mucosal atrophy and formation of webs. [ncbi.nlm.nih.gov]

Antral G-Cell Hyperplasia

During active phase, there is a lymphocytic and plasma cell infiltrate Centered in the deep lamina propria of the body Typically sparse in cases with advanced atrophy In [surgpathcriteria.stanford.edu]

Atrophy Gastric atrophy is defined as a loss of gastric glands. 10, 47 Atrophy is a histologic finding, not a nosologic entity. [clinicalgate.com]

The degree of parietal and chief cell loss and atrophy varies with disease stage. [humpath.com]

Normal-Tension Glaucoma

We found that LTGL patients had a significantly greater mean area of peripapillary atrophy inferior to the optic disc (0.65 +/- 0.38 mm2) than LTGH (0.40 +/- 0.38 mm2) or [ncbi.nlm.nih.gov]

CONCLUSION: This study suggests a greater extent of cerebral infarcts and corpus callosum atrophy in patients with low-tension glaucoma. [ncbi.nlm.nih.gov]

Chandler, is that after the optic discs have developed cupping and atrophy from elevated intraocular pressure they tend to become abnormally vulnerable and, in some cases, [ncbi.nlm.nih.gov]