Atrophy: Causes & Reasons

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Possible Causes for Atrophy

Skin Atrophy

Steroid-induced skin atrophy is the most frequent and perhaps most important cutaneous side effect of topical glucocorticoid therapy. [ncbi.nlm.nih.gov]

The aim of this study was to establish an in vitro skin atrophy model. [ncbi.nlm.nih.gov]

This study aims to review clinical data on skin atrophy induced by TCs. [ncbi.nlm.nih.gov]

Elastosis perforans serpiginosa

[…] perforans serpiginosa", abstract = "A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy [scholars.northwestern.edu]

A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy on the bilateral neck. [ncbi.nlm.nih.gov]

The wide differential for the dermatologic features of OI includes chronologic aging, photoaging, steroid-induced atrophy and other connective tissue diseases. [jhu.pure.elsevier.com]

Atrophic Patchy Alopecia

Fig. 3 Vascular changes in steroid-induced atrophy. [karger.com]

Abstract We report a case of the Hallermann-Strieff syndrome with focal scalp atrophy and associated patchy hair loss. [ncbi.nlm.nih.gov]

The affected muscles may be stiff, sore, and/or tender and, eventually, may show signs of degeneration and muscle wasting (atrophy). [rarediseases.org]

Atrophic Vaginitis

A significant decrease in epithelial atrophy and vaginal pH were detected in both the groups (P < 0.01) after treatment. [ncbi.nlm.nih.gov]

The major universal change is vaginal atrophy. [ncbi.nlm.nih.gov]

Atrophic Vaginitis - Introduction Atrophic vaginitis (also known as vaginal atrophy, senile vaginal atrophy or urogenital atrophy) is inflammation of the vagina due to the [2womenshealth.com]

Orthostatic Hypotension

The disorder may be associated with Addison's disease, diabetes, and certain neurological disorders including Multiple System Atrophy with Orthostatic Hypotension (formerly [ninds.nih.gov]

Multiple system atrophy is known to cause neurogenic orthostatic hypotension by damaging the autonomic nervous system. [multiplesystematrophy.org]

A patient suffering from multiple system atrophy (Shy-Drager syndrome) with severe symptomatic postprandial orthostatic hypotension was treated. [ncbi.nlm.nih.gov]

Geographic Tongue

[…] ge·o·graph·ic tongue idiopathic, asymptomatic erythematous circinate macules, often bounded peripherally by a white band, as a result of atrophy of the filiform papillae; [medical-dictionary.thefreedictionary.com]

The classic manifestation is a maplike distribution of erythema caused by atrophy of the filiform papillae of the tongue, surrounded by a white hyperkeratotic rim. [nejm.org]

One review reported overall prevalence ranges of 0.1-14.3% for geographic tongue, 1.3-9.0% for "atrophy tongue" (atrophic glossitis), and 0.0-3.35% for median rhomboid glossitis [omicsonline.org]

Patulous Eustachian Tube

The right ear showed similar mobility of the tympanic membrane on respiration but without the associated chronic tympanic changes and atrophy. [nejm.org]

It is frequently associated with peritubal atrophy, and usually responds to conservative measures such as weight gain or mucus-producing agents. [ncbi.nlm.nih.gov]

Key words: Kennedy disease, Spinobulbar muscular atrophy, Eustachian tube [e-acn.org]

Vaginitis

AV is typically marked by either an increased inflammatory response or by prominent signs of epithelial atrophy or both. [ncbi.nlm.nih.gov]

It also increases the risk of urinary system atrophy (genitourinary atrophy). [healthline.com]

Atrophy causes changes in the acidic environment of the vagina, making it easier for bacteria, yeast, and other organisms to thrive. [healthline.com]

Polyneuropathy

Neuronal Peroneal Muscular Atrophy (HMSN II) Autosomal dominant inheritance is also the case with HMSN II. [lecturio.com]

[…] accompanied by neuropathic pain, paresthesias, and motor weakness Burning-foot syndrome: burning pain, tingling, pins-and-needles sensation, or formication. hyperhidrosis Atrophy [amboss.com]

MRIs of the brain may reveal cerebellar atrophy. Mild cognitive problems have been reported in a few individuals. [disorders.eyes.arizona.edu]

Entrapment Neuropathy

Neuromuscular examination revealed severe atrophy in the thenar, hypothenar, and interossei muscles on the right side, as well as moderate atrophy in the left interossei and [touchneurology.com]

[…] images superimposed on muscle atrophy indicates an ongoing, partly reversible process. [musculoskeletalkey.com]

The patient developed atrophy in some muscles, possibly a result of the surgery, which resulted in significant motor disability. [touchneurology.com]

Autoimmune Gastritis

[…] and to determine the relationship of Helicobacter pylori with oxyntic gastric atrophy. [ncbi.nlm.nih.gov]

Abstract To date, autoimmune gastritis has been diagnosed for the most part only when total atrophy of the oxyntic glands is detected. [ncbi.nlm.nih.gov]

Corpus atrophy may be complicated by gastric carcinoids and gastric cancer. [ncbi.nlm.nih.gov]

Orthostatic Syncope

Multiple system atrophy is known to cause neurogenic orthostatic hypotension by damaging the autonomic nervous system. [multiplesystematrophy.org]

Multiple system atrophy Autonomic manifestations are similar to those observed in AAN and PAF. [emedicine.medscape.com]

[…] sinus sensitivity *"36 % elderly NH pop. had orthostatic hypotension postprandially BUT: only 2 % had symptoms from it. d) Primary Autonomic Disease Idiopathic Multi-System Atrophy [unmc.edu]

Orchitis

As mumps orchitis seem to induce testicular atrophy, periodic check up may be required after the acute stage. [synapse.koreamed.org]

The biopsies showed total atrophy of the seminiferous tubules in 39%, 10% atrophy in 16%, and no apparent histological alterations, except an arrest in spermatogenesis, in [ncbi.nlm.nih.gov]

Among patients with orchitis, 6 in every 10 patients have unilateral testicular atrophy. [symptoma.com]

Gastritis

RESULTS: A total of 177 non-atrophic gastritis and 154 atrophic gastritis were analyzed, among which 40 were antrum atrophy, 32 were corpus atrophy and 82 were pan-atrophy [ncbi.nlm.nih.gov]

Gastric atrophy: Atrophy of gastric glands may follow in gastritis, most often long-standing antral (sometimes referred to as type B) gastritis. [web.archive.org]

Hp, chronic inactive gastritis, atrophy, and intestinal metaplasia were also more common among East-Asians, Hp and atrophy decreasing with rising income but remaining unaffected [ncbi.nlm.nih.gov]

Primary Progressive Multiple Sclerosis

We investigated the relationship between regional brain atrophy and physical disability in patients with PPMS. [ncbi.nlm.nih.gov]

[…] longitudinal study was designed to assess the frequency, extent, and rate of formation of CLs in PPMS and their relationship with T2 lesion volume (LV), gray matter (GM) atrophy [ncbi.nlm.nih.gov]

Although patients did not show significant cord atrophy when compared with healthy controls, they had significantly lower total N-acetyl-aspartate (mean 4.01 versus 5.31 mmol [ncbi.nlm.nih.gov]

X-Linked Parkinsonism with Spasticity

Optic atrophy develops around the same time or slightly later. Severity is variable, and some patients lose independent ambulation. [mendelian.co]

atrophy is symmetric in the other 50%. [neuroweb.us]

The hyperintense MCP sign is not specific for FXTAS and can also be seen in multiple system atrophy. [neurology.org]

Pallidopyramidal Syndrome

Brain scans show atrophy of the globus pallidus and pyramids and, later, widespread cerebral atrophy. [research.manchester.ac.uk]

Multiple system atrophy, cerebellar predominant Multiple system atrophy, cerebellar variant Multiple system atrophy, Parkinson variant Multiple system atrophy, Parkinson's [icd9data.com]

[…] variant Olivopontocerebellar atrophy Olivopontocerebellar atrophy with blindness Olivopontocerebellar atrophy with slow eye movement Olivopontocerebellar degeneration Pallidal [icd9data.com]

Median Neuropathy

Chronic injuries to the nerve result in atrophy of median nerve innervated muscles while acute injuries do not have this feature. [amboss.com]

The patient may also have pain at rest (especially at night), weakness in the thumb, and thenar atrophy. [mitchmedical.us]

Atrophy of thenar muscles was present in half the cases. [jamanetwork.com]

Cronkhite-Canada Syndrome

Endoscopic exam and biopsies revealed severe atrophy and diffuse marked edema of mucosa of stomach and duodenum. [ncbi.nlm.nih.gov]

One case was Type II, which was mainly characterized by abnormal salt and sweet taste, accompanied by tongue atrophy. [wjgnet.com]

[…] of alopecic lesions in two female CCS patients with severe hair loss revealed a marked increase in telogen hair follicles with no sign of loss or of the minaturisation or atrophy [ncbi.nlm.nih.gov]

Carpal Tunnel Syndrome

[…] may occur Applies To Median nerve entrapment Partial thenar atrophy ICD-9-CM Volume 2 Index entries containing back-references to 354.0 : [icd9data.com]

At the six-month follow-up examination, the patient experienced relief from numbness and improvement in thenar muscle atrophy was noted. [ncbi.nlm.nih.gov]

We recommended surgery to those outpatients who presented with difficulty in pinching due to severe thenar atrophy and/ or showing poor response to conservative treatment. [ncbi.nlm.nih.gov]

Muscular Dystrophy

Distal muscular dystrophies are a group of inherited primary muscle disorders showing progressive weakness and atrophy preferentially in the hands, forearm, lower legs, or [ncbi.nlm.nih.gov]

Spinal muscular atrophies: Amyotrophic lateral sclerosis (ALS), or motor neuron disease Infantile progressive spinal muscular atrophy Intermediate spinal muscular atrophy [urmc.rochester.edu]

Spinal muscular atrophies Amyotrophic lateral sclerosis (ALS), or motor neuron disease Infantile progressive spinal muscular atrophy Intermediate spinal muscular atrophy Juvenile [hopkinsmedicine.org]

Myopic Macular Degeneration

Bottom row (C1–C3) shows the photographs of eyes with Meta-PM Category 4 (myopic macular atrophy). Peripapillary atrophy was present in all eyes. [iovs.arvojournals.org]

[…] can coalesce and result in geographic atrophy (GA). [aao.org]

(choroidal neovascularization:CNV or macular atrophy). [iovs.arvojournals.org]

Progressive Myoclonic Epilepsy Type 7

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Abnormality of movement Cerebellar atrophy Dystonia Gait disturbance Amaurosis fugax Gait ataxia Cerebellar hypoplasia Babinski sign Dysarthria Peripheral neuropathy Loss [mendelian.co]

Figure 1: Diffused atrophy in cerebral cortex in magnetic resonance imaging (MRI). [journals.lww.com]

Progressive Myoclonic Epilepsy Type 3

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Figure 1: Diffused atrophy in cerebral cortex in magnetic resonance imaging (MRI). [journals.lww.com]

A new study by an international research team characterized three new cases of a rare medical condition where spinal muscular atrophy (SMA) is associated with progressive [smanewstoday.com]

Progressive Myoclonic Epilepsy Type 8

Sagittal T1‐weighted brain MRI showing brainstem atrophy, particularly in the pons. [onlinelibrary.wiley.com]

Brain magnetic resonance imaging revealed brainstem atrophy, particularly in the pons (Figure 1). [onlinelibrary.wiley.com]

Friedreich's ataxia, spinocerebellar ataxias types 1, 2, 3, 6, 7, 12, 17 and dentatorubropallidoluysian atrophy molecular analysis came out negative. [onlinelibrary.wiley.com]

Macular Degeneration

atrophy occurrence in one eye. [ncbi.nlm.nih.gov]

Four, seventeen and nine patients were classified as having early, intermediate and late AMD (geographic atrophy) respectively. [ncbi.nlm.nih.gov]

Odds ratios (ORs) and risk for new local atrophy onset were calculated. [ncbi.nlm.nih.gov]

Normal-Tension Glaucoma

We found that LTGL patients had a significantly greater mean area of peripapillary atrophy inferior to the optic disc (0.65 +/- 0.38 mm2) than LTGH (0.40 +/- 0.38 mm2) or [ncbi.nlm.nih.gov]

CONCLUSION: This study suggests a greater extent of cerebral infarcts and corpus callosum atrophy in patients with low-tension glaucoma. [ncbi.nlm.nih.gov]

Chandler, is that after the optic discs have developed cupping and atrophy from elevated intraocular pressure they tend to become abnormally vulnerable and, in some cases, [ncbi.nlm.nih.gov]

Subdural Hematoma

Chronic subdural hematoma Chronic subdural hematoma is commonly associated with cerebral atrophy. [emedicine.medscape.com]

In elderly persons, the bridging veins may already be stretched because of brain atrophy (shrinkage that occurs with age). [emedicine.medscape.com]

Atrophy of the brain, resulting in a space between the brain surface and the skull, increases the risk of subdural hematoma (SDH). [emedicine.medscape.com]

Ulnar Nerve Entrapment

Symptoms: Pain or numbness in the elbow, hand, or wrist Weakening hand grip Atrophy of the muscles of the hand How is it diagnosed? [sportsandortho.com]

In case cubital tunnel syndrome has caused atrophy, the improvement is often incomplete. [betaklinik.de]

Formal physical therapy Corticosteroid injections Splinting or bracing in moderate cases Surgical treatment is only pursued if conservative treatment fails or there is muscle atrophy [sportsandortho.com]

Alcohol Dementia

We describe the neuroimaging findings--diffuse cortical atrophy, ventricular dilatation, atrophy of the corpus callosum, hypothalamus, and medulla, and a probable arachnoid [ncbi.nlm.nih.gov]

Researchers said the more a person drank, the more likely they were to have hippocampal atrophy - a form of brain damage that affects memory and spatial navigation, which [express.co.uk]

This atrophy occurs due to a thiamine deficiency (vitamin B1). [alcoholrehab.com]