Atrophy: Causes & Reasons

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Possible Causes for Atrophy

Skin Atrophy

Steroid-induced skin atrophy is the most frequent and perhaps most important cutaneous side effect of topical glucocorticoid therapy. [ncbi.nlm.nih.gov]

Steroid-induced skin atrophy Skin atrophy Specialty Dermatology Steroid-induced skin atrophy is thinning of the skin as a result of prolonged exposure to steroids. [en.wikipedia.org]

It is well known that topical steroids cause atrophy of the skin. However few people recognize that there are two kinds of atrophy. [mototsugufukaya.blogspot.com]

Elastosis perforans serpiginosa

[…] perforans serpiginosa", abstract = "A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy [scholars.northwestern.edu]

A 17-year-old white boy with no underlying connective tissue disorders presented with flat-topped annular plaques, with slight central atrophy on the bilateral neck. [ncbi.nlm.nih.gov]

The wide differential for the dermatologic features of OI includes chronologic aging, photoaging, steroid-induced atrophy and other connective tissue diseases. [jhu.pure.elsevier.com]

Atrophic Patchy Alopecia

Fig. 3 Vascular changes in steroid-induced atrophy. [karger.com]

Abstract We report a case of the Hallermann-Strieff syndrome with focal scalp atrophy and associated patchy hair loss. [ncbi.nlm.nih.gov]

The affected muscles may be stiff, sore, and/or tender and, eventually, may show signs of degeneration and muscle wasting (atrophy). [rarediseases.org]

Steroid Rosacea

The appearance is of a flaming red, scaly, papule-covered face (red face syndrome).[11] If left untreated, permanent skin atrophy and telangiectasia can result. [ncbi.nlm.nih.gov]

Most of them had history of exacerbation of symptoms after sun exposure, probably due to atrophy and vasodilatation of the facial skin, caused by the prolonged use of topical [ijdvl.com]

If steroid use continues or the condition is left untreated, the skin may become atrophied and permanently damaged. [news-medical.net]

Atrophic Vaginitis

The major universal change is vaginal atrophy. [ncbi.nlm.nih.gov]

What is vaginal atrophy? [hormone.org]

Vaginal atrophy, atrophic vaginitis, and urogenital atrophy are other terms used to describe this constellation of symptoms associated with decreased estrogenization of the [ncbi.nlm.nih.gov]

Orthostatic Hypotension

The disorder may be associated with Addison's disease, diabetes, and certain neurological disorders including Multiple System Atrophy with Orthostatic Hypotension (formerly [ninds.nih.gov]

Multiple system atrophy is known to cause neurogenic orthostatic hypotension by damaging the autonomic nervous system. [multiplesystematrophy.org]

A patient suffering from multiple system atrophy (Shy-Drager syndrome) with severe symptomatic postprandial orthostatic hypotension was treated. [ncbi.nlm.nih.gov]

Autoimmune Gastritis

Abstract To date, autoimmune gastritis has been diagnosed for the most part only when total atrophy of the oxyntic glands is detected. [ncbi.nlm.nih.gov]

Antrum atrophy was present in 39% of H. pylori-negative AIG patients. [ncbi.nlm.nih.gov]

[…] and to determine the relationship of Helicobacter pylori with oxyntic gastric atrophy. [ncbi.nlm.nih.gov]

Orchitis

As mumps orchitis seem to induce testicular atrophy, periodic check up may be required after the acute stage. [synapse.koreamed.org]

The biopsies showed total atrophy of the seminiferous tubules in 39%, 10% atrophy in 16%, and no apparent histological alterations, except an arrest in spermatogenesis, in [ncbi.nlm.nih.gov]

Among patients with orchitis, 6 in every 10 patients have unilateral testicular atrophy. [symptoma.com]

Myopic Macular Degeneration

To investigate the retinal sensitivity of highly myopic eyes with chorioretinal patchy atrophy (PA) using microperimetry. [physiciansweekly.com]

Bottom row (C1–C3) shows the photographs of eyes with Meta-PM Category 4 (myopic macular atrophy). Peripapillary atrophy was present in all eyes. [iovs.arvojournals.org]

[…] can coalesce and result in geographic atrophy (GA). [aao.org]

X-Linked Parkinsonism with Spasticity

Optic atrophy develops around the same time or slightly later. Severity is variable, and some patients lose independent ambulation. [mendelian.co]

atrophy is symmetric in the other 50%. [neuroweb.us]

The hyperintense MCP sign is not specific for FXTAS and can also be seen in multiple system atrophy. [neurology.org]

Progressive Myoclonic Epilepsy Type 3

A new study by an international research team characterized three new cases of a rare medical condition where spinal muscular atrophy (SMA) is associated with progressive [smanewstoday.com]

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Figure 1: Diffused atrophy in cerebral cortex in magnetic resonance imaging (MRI). [journals.lww.com]

Progressive Myoclonic Epilepsy Type 7

 Presence of optic atrophy and retinal degeneration has been documented but normal retina is usually noted.  Lafora disease is caused by mutations in one of two genes, [slideshare.net]

Abnormality of movement Cerebellar atrophy Dystonia Gait disturbance Amaurosis fugax Gait ataxia Cerebellar hypoplasia Babinski sign Dysarthria Peripheral neuropathy Loss [mendelian.co]

Figure 1: Diffused atrophy in cerebral cortex in magnetic resonance imaging (MRI). [journals.lww.com]

Pallidopyramidal Syndrome

Whilst this eponym has stuck, ‘progressive pallidal atrophy’ has not done so well. [academic.oup.com]

Neuronal atrophy and synaptic alteration in a mouse model of dentatorubral-pallidoluysian atrophy. Brain 2006 ; 129 : 2353 –62. 44. [cambridge.org]

In the present study, we screened entire exons of FBXO7 from 271 patients (231 PD and 40 multiple system atrophy [MSA]), of which 221 samples were of Japanese origin. [ncbi.nlm.nih.gov]

Orthostatic Syncope

MRI findings include atrophy of putamen and middle cerebellar peduncles, as well as putaminal and cerebellar hypometabolism on [18F]-fluorodeoxyglucose positron emission tomography [orpha.net]

Multiple system atrophy is known to cause neurogenic orthostatic hypotension by damaging the autonomic nervous system. [multiplesystematrophy.org]

Multiple system atrophy Autonomic manifestations are similar to those observed in AAN and PAF. [emedicine.medscape.com]

Progressive Myoclonic Epilepsy Type 8

Sagittal T1‐weighted brain MRI showing brainstem atrophy, particularly in the pons. [onlinelibrary.wiley.com]

Brain magnetic resonance imaging revealed brainstem atrophy, particularly in the pons (Figure 1). [onlinelibrary.wiley.com]

Friedreich's ataxia, spinocerebellar ataxias types 1, 2, 3, 6, 7, 12, 17 and dentatorubropallidoluysian atrophy molecular analysis came out negative. [onlinelibrary.wiley.com]

Geographic Tongue

[…] ge·o·graph·ic tongue idiopathic, asymptomatic erythematous circinate macules, often bounded peripherally by a white band, as a result of atrophy of the filiform papillae; [medical-dictionary.thefreedictionary.com]

The classic manifestation is a maplike distribution of erythema caused by atrophy of the filiform papillae of the tongue, surrounded by a white hyperkeratotic rim. [nejm.org]

One review reported overall prevalence ranges of 0.1-14.3% for geographic tongue, 1.3-9.0% for "atrophy tongue" (atrophic glossitis), and 0.0-3.35% for median rhomboid glossitis [omicsonline.org]

Macular Degeneration

atrophy occurrence in one eye. [ncbi.nlm.nih.gov]

Purpose: To assess the impact of distinct atrophy border characteristics based on spectral-domain optical coherence tomography (SD-OCT) imaging on local atrophy progression [ncbi.nlm.nih.gov]

KEYWORDS: Age-related macular degeneration; Choroidal thickness; Macular atrophy; Neovascular age-related macular degeneration; Treat-and-extend [ncbi.nlm.nih.gov]

Pancreatic Atrophy

25.7-36.7 mo) among patients who did not develop pancreatic atrophy (P = 0.009). [ncbi.nlm.nih.gov]

We have observed four cases of pancreatic atrophy following single episodes of acute pancreatitis. [ncbi.nlm.nih.gov]

We report a case of pancreatic atrophy following blunt injury in an 8 year old boy who presented 3 years later with diabetes mellitus. [ncbi.nlm.nih.gov]

Progressive Muscular Atrophy

The name "spinal muscular atrophy" is ambiguous as it refers to any of various spinal muscular atrophies, including the autosomal recessive spinal muscular atrophy caused [en.wikipedia.org]

KEYWORDS: Lower motor neuron syndrome; Lower motor neuron-onset ALS; PMA; Progressive muscular atrophy [ncbi.nlm.nih.gov]

What Is Progressive Muscular Atrophy? Progressive muscular atrophy is an inherited form of motor neuron disease. [healthcare.utah.edu]

Primary Progressive Multiple Sclerosis

We investigated the relationship between regional brain atrophy and physical disability in patients with PPMS. [ncbi.nlm.nih.gov]

[…] longitudinal study was designed to assess the frequency, extent, and rate of formation of CLs in PPMS and their relationship with T2 lesion volume (LV), gray matter (GM) atrophy [ncbi.nlm.nih.gov]

Although patients did not show significant cord atrophy when compared with healthy controls, they had significantly lower total N-acetyl-aspartate (mean 4.01 versus 5.31 mmol [ncbi.nlm.nih.gov]

Wolfram Syndrome

Wolfram syndrome was originally described as a combination of familial juvenile-onset diabetes mellitus and optic atrophy. [ncbi.nlm.nih.gov]

Abstract Wolfram syndrome is the constellation of juvenile onset diabetes mellitus and optic atrophy, known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy [ncbi.nlm.nih.gov]

[…] with diabetes mellitus and optic atrophy [ 1 ]. [doi.org]

Entrapment Neuropathy

Neuromuscular examination revealed severe atrophy in the thenar, hypothenar, and interossei muscles on the right side, as well as moderate atrophy in the left interossei and [touchneurology.com]

[…] images superimposed on muscle atrophy indicates an ongoing, partly reversible process. [musculoskeletalkey.com]

The patient developed atrophy in some muscles, possibly a result of the surgery, which resulted in significant motor disability. [touchneurology.com]

Spinal and Bulbar Muscular Atrophy

We report on a case of genetically proven X-linked spinal and bulbar muscular atrophy (X-SBMA) with prominent distal muscle atrophy and without proximal muscle involvement [ncbi.nlm.nih.gov]

Abstract Spinal and bulbar muscular atrophy (SBMA) is an adult-onset degenerative disorder of the neuromuscular system resulting in slowly progressive weakness and atrophy [ncbi.nlm.nih.gov]

Spinal and bulbar muscular atrophy mainly affects males and is characterized by muscle weakness and wasting (atrophy) that usually begins in adulthood and worsens slowly over [ghr.nlm.nih.gov]

Progressive Bulbar Paralysis

[…] motor neuron disease G12.8 Other spinal muscular atrophies and related syndromes G12.9 Spinal muscular atrophy, unspecified G13 Systemic atrophies primarily affecting central [icd10data.com]

[…] term(s): Adult form spinal muscular atrophy Childhood form, type II spinal muscular atrophy Distal spinal muscular atrophy Juvenile form, type III spinal muscular atrophy [icd10coded.com]

Progressive muscular atrophy is a variety of ALS in which the neuron degeneration is most pronounced in the spinal cord. [britannica.com]

Arthrogryposis due to Muscular Dystrophy

Type 2 atrophy Type 2 atrophy Immobilization or disuse of muscle causes atrophy of type 2 fibers. [neuropathology-web.org]

Fast facts on spinal muscular atrophy: Here are some key points about spinal muscular atrophy (SMA). More detail is in the main article. [medicalnewstoday.com]

Kennedy syndrome (progressive spinobulbar muscular atrophy) This form of spinal muscular atrophy only affects men; it is an X-linked recessive disorder, meaning that the defective [healthofchildren.com]

Upper Motor Neuron Disease

No muscle atrophy is seen initially but later on some disuse atrophy may occur. 2. [medicalopedia.org]

Progressive muscular atrophy A rare subtype of MND is which you get atrophy, fasiculation and muscle weakness in the arms only A rare subtype of MND is which you get atrophy [brainscape.com]

Spinal muscular atrophy In type I spinal muscular atrophy (SMA), atrophy of the anterior spinal nerve roots is seen in the spinal cord, whereas the posterior nerve roots are [emedicine.medscape.com]

Distal Spinal Muscular Atrophy Type 5

Treatment for spinal muscular atrophy Unfortunately, there is currently no specific treatment for SMA. [betterhealth.vic.gov.au]

[…] spinal muscular atrophy Adult onset. [en.wikipedia.org]

Keywords : Motor neuropathy, Lower motor neuron syndrome, Motor neuronopathy, ALS, Spinal muscular atrophy, Benign monomelic amyotrophy [em-consulte.com]

Distal Spinal Muscular Atrophy Type 4

[…] that are not associated with a defect in the SMN1 gene on chromosome 5q X-linked spinal muscular atrophy X-linked spinal muscular atrophy is seen only among males! [amboss.com]

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

What is spinal muscular atrophy? [christopherreeve.org]

Distal Hereditary Motor Neuropathy Type 1

PubMed Search : neurogenic atrophy[title] muscle Advertisement Page views in 2018: 3,076 Page views in 2019 to date: 1,444 Cite this page: Walsh M. Neurogenic atrophy. [pathologyoutlines.com]

These conditions include: Spinal muscular atrophy with respiratory distress (SMARD) —SMARD has similar symptoms to infant-onset spinal muscular atrophy, though it affects [togetherinsma.com]

Spinal muscular atrophy with respiratory distress type 1 (SMARD1), also known as distal spinal muscular atrophy Tpe 1 (DSMA1) or distal hereditary motor neuropathy Type 6 [mda.org.nz]

Distal Spinal Muscular Atrophy Type 1

atrophy of body muscles. [en.wikipedia.org]

Homepage Rare diseases Search Search for a rare disease Spinal muscular atrophy with respiratory distress type 1 Disease definition Spinal muscular atrophy with respiratory [orpha.net]

Hardart MK, Truog RD (2003) Spinal muscular atrophy-type I. [doi.org]