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59 Possible Causes for Atrophy of Intrinsic Hand Muscles, Tongue Weakness, Vacuolization

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] She had symmetrical atrophy of intrinsic hand muscles and distal leg muscles.[jnnp.bmj.com] […] muscles Bulbar Dysphagia: Oropharyngeal Dysarthria: Hoarse & Nasal voice Tongue weakness Limbs Legs Arms Distal: Anterior tibial; Finger extensors Onset: 5 years after disease[neuromuscular.wustl.edu]

  • Distal Myopathy Type 3

    Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[neuroweb.us] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    TDP43 immunoreactivity was observed adjacent to rimmed vacuoles and in areas around cytoplasmic bodies.[bmcneurol.biomedcentral.com] […] discomfort Weakness Symmetric Distal Arms Legs Arms: Forearm pronators, Finger flexors, Intrinsic hand muscles Legs: Ankle evertors, Plantar-flexors (Calf atrophy) Differential[neuromuscular.wustl.edu] ; DMRV; Nonaka myopathy; Rimmed vacuole myopathy; Quadriceps Sparing Myopathy; GNE myopathy "OMIM Entry # 605820 - Nonaka Myopathy".[en.wikipedia.org]

  • Secondary Myopathy

    Sensorimotor neuropathy Hypothyroid (amiodarone) Elevated serum CK EMG: fibs, PSWs, myotonia (choroquine), myopathic MUAPs NCS: axonal sensorimotor neuropathy Autophagic vacuoles[neurology.mhmedical.com] Weakness and atrophy of the intrinsic hand muscles is common.[dartmouth.edu] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com]

  • Polyglucosan Body Myopathy Type 2

    ; DMRV; Nonaka myopathy; Rimmed vacuole myopathy; Quadriceps Sparing Myopathy; GNE myopathy "OMIM Entry # 605820 - Nonaka Myopathy" .[en.wikipedia.org] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[neuroweb.us] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com]

  • Limb-Girdle Muscular Dystrophy Type 1H

    While young patients show minor pathological changes in muscle, the middle-aged and old patients show rimmed vacuoles and inclusions of filaments measuring 15–18 nm in diameter[scinapse.io] […] disorder characterized by onset in young adulthood of distal muscle weakness affecting the upper and lower limbs but sparing the intrinsic hand muscles.[mendelian.co] LGMD2G (telethoninopathy) This form of LGMD usually becomes apparent during childhood or adolescence and presents with muscle weakness of the upper and lower legs.[rarediseases.org]

  • Acquired Amyloid Myopathy

    Vacuoles rimmed with basophilic granules. Inclusion body myositis IBM. Vacuole filled with granules. Modified Gomori trichrome stain. Inclusion body myositis IBM.[neuropathology-web.org] Weakness and atrophy of the intrinsic hand muscles is common.[dartmouth.edu] Symptoms can include: Swelling of ankles and legs Weakness Weight loss Shortness of breath Numbness or tingling in the hands or feet Diarrhea Severe fatigue Enlarged tongue[sinoemedicalassociation.org]

  • Glycogen Storage Disease due to Phosphoglycerate Mutase Deficiency

    […] recurrent episodes after exercise Treatment: Low carbohydrate diet; Regular exercise Skeletal muscle Abnormal glycogen accumulation: Coarse granular, Amylase-resistant, Cytoplasmic[neuromuscular.wustl.edu] .  Patients with distal myopathy develop atrophy of leg and intrinsic hand muscles, often leading to the diagnosis of motor neurone disease or peripheral neuropathy.  The[slideshare.net] Episodic attacks of weakness are also common, resembling those seen with hyperKPP, and they are accompanied by myotonia.[what-when-how.com]

  • Glycogen Storage Disease

    Histopathologic examination of the placental tissue showed intracytoplasmic inclusion vacuoles with a strong reaction in Periodic acid-Schiff staining and a slightly pallor[ncbi.nlm.nih.gov] On examination, there was atrophy of the right left intrinsic hand muscles and reduced muscle bulk throughout the upper and lower extremities.[nature.com] An enlarged tongue and hypertrophic cardiomyopathy are characteristic.[doi.org]

  • Upper Motor Neuron Disease

    There is a characteristic rimmed vacuole within a muscle fibre histopathologically (with acknowledgement to Dr Waney Squier).[pn.bmj.com] […] of the intrinsic hand muscles, pyramidal signs and lower limb spasticity. 14 The upper limb-onset phenotype (dHMN V) may also result from mutations in GARS with most cases[jnnp.bmj.com] […] movement of the facial muscles and tongue; and weak palatal movement.[msdmanuals.com]

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