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37 Possible Causes for Auer Rods Present

  • Acute Myelocytic Leukemia

    The patient is referred to an oncologist, and a bone marrow aspiration is performed, demonstrating 20% myeloblasts with Auer rods that are myeloperoxidase positive.[step1.medbullets.com] Auer rods are infrequent. Staining: Relatively few blasts (5-10%) are MPO (myeloperoxidase) positive. A minimum of 3% MPO positive blasts are required for diagnosis.[med-ed.virginia.edu] What is the most likely chromosomal translocation that is responsible for this patient's clinical presentation and lab results?[step1.medbullets.com]

  • Refractory Anemia with Excess Blasts in Transformation

    rod present in blast, 6 - 8% myeloblasts, neutrophils show nuclear hypolobulation RAEB-2: 47 year old woman with 12% myeloblasts and occasional Auer rods: Normocellular biopsy[pathologyoutlines.com] rods Refractory Anemia with Excess Blasts is characterized by elevated numbers of myeloid stem cells inside the bone marrow; the Auer rods may also be present The prognosis[dovemed.com] rods in myeloblasts or other cells of the neutrophil cell line Auer rods present in 70% of cases Ringed sideroblasts may be numerous Hypercellular marrow in 80-90% of cases[thedoctorsdoctor.com]

  • Refractory Anemia with Excess Blasts

    rod present in blast, 6 - 8% myeloblasts, neutrophils show nuclear hypolobulation RAEB-2: 47 year old woman with 12% myeloblasts and occasional Auer rods: Normocellular biopsy[pathologyoutlines.com] rods Refractory Anemia with Excess Blasts is characterized by elevated numbers of myeloid stem cells inside the bone marrow; the Auer rods may also be present The prognosis[dovemed.com] rods, if present, advance MDS case to RAEB-2 ETIOLOGY/PATHOGENESIS Hematopoietic Stem Cell Disorder Clonal hematopoietic stem cell disorder CLINICAL ISSUES Epidemiology Incidence[basicmedicalkey.com]

  • Refractory Anemia

    rods Refractory Anemia with Excess Blasts is characterized by elevated numbers of myeloid stem cells inside the bone marrow; the Auer rods may also be present The prognosis[dovemed.com] rods, if present, advance MDS case to RAEB-2 ETIOLOGY/PATHOGENESIS Hematopoietic Stem Cell Disorder Clonal hematopoietic stem cell disorder CLINICAL ISSUES Epidemiology Incidence[basicmedicalkey.com] Auer rods may be present in blast cells. Dysmorphic changes that occur in abnormal marrow precursor cells are described in “Laboratory Features” above.[patient-help.com]

  • Myelodysplasia

    Auer rods have never been reported in JMML.[ncbi.nlm.nih.gov] rods in blasts, ringed sideroblasts present, normal karyotype or -Y, 5q- or 20q- alone Microscopic (histologic) description Peripheral blood smear (general MDS findings)[pathologyoutlines.com] rods.[en.wikipedia.org]

  • Agranulocytosis

    rods.[en.wikipedia.org] However, occasional cases are difficult to classify into defined categories because of one or more unusual features: Rare cases with less than 5% blast will present with Auer[en.wikipedia.org] Occasionally, cases of MDS present with isolated neutropenia or thrombocytopenia without anemia and with dysplastic changes confined to the single lineage.[en.wikipedia.org]

  • Chronic Myelomonocytic Leukemia

    rods present in blood or marrow CMML with eosinophilia may be diagnosed if blood eosinophils 1.5 x 10 3 /μL All other CMML criteria must be fulfilled, including lack of PDGFRA[surgpathcriteria.stanford.edu] rods present; also 20% blasts in blood or marrow; poorer prognosis If blasts promonocytes are 20% of more of bone marrow differential count, classify as AML Diagnosis Persistent[pathologyoutlines.com] : (i) more than 5% of blasts in the PB, (ii) 20-30% in the BM, and (iii) the presence of Auer rods in granulocyte precursors in BM or PB.[ncbi.nlm.nih.gov]

  • Acute Panmyelosis with Myelofibrosis

    Auer rods were not identified. On the touch preparations, numerous megakaryocytes are present.[gpec.ubc.ca] Auer rod bodies may be found within the neoplastic cells. Genetics : No unique chromosomal abnormalities are associated with acute megakaryoblastic leukemia in adults.[wiki.clinicalflow.com] rods · Epidemiology o 10% of cases of AML o Adults (median age 46 y/o), but can occur at any age · Clinical o Present with marrow failure: anemia, neutropenia, thrombocytopenia[hemepathreview.com]

  • Granulocytic Sarcoma

    […] white cell count lack of Auer rods poor nutrition (1) Diagnosis is established through cytochemical and/or immunohistochemical analyses (1).[gpnotebook.co.uk] […] leukocyte count, and decreased blast Auer rods, have been associated with a higher incidence of EML.[ncbi.nlm.nih.gov] Systemic antileukaemic chemotherapy should be given to patients who present with de novo or in relapse with extramedullary leukaemia.[gpnotebook.co.uk]

  • Leukopenia

    M3v blasts often have folded nuclei, but unlike traditional APL blasts, they often possess faint granules without Auer rods.[ncbi.nlm.nih.gov] The microgranular variant (M3v) of acute promyelocytic leukemia (APL) is rare, and the diagnosis can be delayed due to variability in how this condition presents.[ncbi.nlm.nih.gov] In addition, microgranular APL often presents with an elevated or normal white blood cell count in contrast with the leukopenia seen in traditional APL.[ncbi.nlm.nih.gov]

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