Autoantibodies: Causes & Reasons

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Possible Causes for Autoantibodies

Infantile-Onset Multisystem Autoimmune Disease Type 1

Certain CTDs are characterized by specific autoantibodies. [thermofisher.com]

Connective tissue disease diagnosis: Testing for differential diagnosis Serological tests reveal that connective tissue diseases (CTDs) are associated with a variety of autoantibodies [thermofisher.com]

Hemolytic Anemia

Acquired hemolytic anemia due to the presence of autoantibodies which agglutinate or lyse the patient's own red blood cells. [icd9data.com]

CLINICAL FEATURES Clinically, AIHA and RBC autoantibodies present with signs and symptoms that reflect the activity and thermal reactivity of the autoantibody. [archivesofpathology.org]

Since in most WAIHA cases, the autoantibody shows no RBC antigen specificity, the autoantibodies should be eluted from RBC after their detection by the DAT to potentially [dovepress.com]

Hashimoto Thyroiditis

[…] http://www.ebi.ac.uk/efo/EFO_0003779 An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. [ebi.ac.uk]

Hashimoto’s autoantibodies decrease precursors necessary for thyroid hormone production, thereby causing hypothyroidism. [actforlibraries.org]

The aim of the study was to analyze the clinical course of 6 cases of hyperthyroid girls with GD in whom a normalization of previously increased autoantibodies against thyrotropin [ncbi.nlm.nih.gov]

Autoimmune Gastritis

Pernicious anemia (53.6%), iron deficiency anemia (34.8%), gastric autoantibodies (68.8%), and autoimmune disorders (41.7%) were present. [ncbi.nlm.nih.gov]

ATP4A antibody prevalence increased with age of onset of T1DM, which is atypical of other T1DM autoantibodies. [ncbi.nlm.nih.gov]

Taken together with the logistic advantages these blots are a good alternative for autoantibody detection in the respective diseases. [pubag.nal.usda.gov]

Thrombocytopenia

In childhood ITP, the autoantibody may be triggered by viral antigens. [msdmanuals.com]

HIV treatment can also help calm down the immune system, which may slow or stop the production of autoantibodies that cause the thrombocytopenia. [poz.com]

[…] factor deficiencies Vitamin B12 deficiency Folic acid deficiency Reduced life expectancy Antibody reactions Alloantibodies Transfusion incident Morbus haemolyticus neonatorum Autoantibodies [flexikon.doccheck.com]

Diabetes Mellitus

Although the presence of any one of these autoantibodies in LADA predicts inevitable β cell failure, multiple autoantibodies in circulation or a high titre correlate with [dx.doi.org]

[…] period, from the last islet-autoantibody-negative sample to the first islet-autoantibody-positive sample; and (3) the progression period, from the first islet-autoantibody-positive [ncbi.nlm.nih.gov]

Interestingly, a frozen blood sample obtained prior to treatment with nivolumab tested positive for three of the four diabetes related (islet) autoantibodies despite no prior [ncbi.nlm.nih.gov]

Diabetes Mellitus Type 1

One or more of these autoantibodies are detected in 93% to 96% of patients with type 1 diabetes, both adults and children. [mayomedicallaboratories.com]

Interpretation Seropositivity for 1 or more islet cell autoantibodies is supportive of: -A diagnosis of type 1 diabetes. [pediatric.testcatalog.org]

Patients with gestational diabetes can also be stratified for future diabetes risk by detection of 1 or more islet autoantibodies. [mayomedicallaboratories.com]

Graves Disease

Graves' disease (GD) is an autoimmune disorder involving the thyroid gland, typically characterized by the presence of circulating autoantibodies that bind to and stimulate [ncbi.nlm.nih.gov]

Measurement of anti-TSHR autoantibodies Two types of tests are available for clinical laboratories to measure anti-TSHR autoantibodies. [quidel.com]

Paraneoplastic Syndrome

Paraneoplastic Autoantibodies Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. [clinlabnavigator.com]

[…] on the malignancy and carries some autoantibody specificity. [eyewiki.aao.org]

Autoantibodies directed against the central neurons and brain often are present in the serum and cerebrospinal fluid (CSF) of patients with sensory and mixed neuropathies. [emedicine.medscape.com]

Systemic Vasculitis

For this reason, we focus here on anti-neutrophil cytoplasmic autoantibody-associated vasculitides. [uncch.pure.elsevier.com]

Considerable progress has been made in understanding the role of autoantibodies in systemic vasculitides (SV), and consequently testing for anti-neutrophil cytoplasmic antibodies [mdpi.com]

Herein, the main autoantibodies and their clinical associations in systemic vasculitis are reviewed. Table 1. Autoantibodies in primary systemic vasculitides. [journal.frontiersin.org]

ACE Inhibitor-Induced Angioedema

The autoantibodies were directed against the Cl-INH active center. [ncbi.nlm.nih.gov]

We also measured complement parameters, autoantibody titer, and cleaved C1-inhibitor (relative molecular mass = 96,000), because autoantibodies to C1-inhibitor are known to [ncbi.nlm.nih.gov]

Patients with acquired angioedema type I may initially present with autoantibodies to C1-INH, or the autoantibodies may develop as the disease progresses. [emedicine.medscape.com]

Vasculitis

It is caused by autoantibodies called ANCAs, or Anti-Neutrophilic Cytoplasmic Autoantibodies. [unckidneycenter.org]

Therefore, in order to make early diagnosis and treatment, we suggest checking autoantibodies and abdominal CT scans with contrast when children present with gastrointestinal [ncbi.nlm.nih.gov]

The PTU was discontinued and she was treated with immunosuppressants and plasmapheresis for reducing pathogenic autoantibodies. [ncbi.nlm.nih.gov]

Urticaria

Autoantibody-induced cross-linking of IgE receptors may be an important mechanism in the pathogenesis of chronic urticaria and other diseases mediated by mast cells. [ncbi.nlm.nih.gov]

Besides, the occurrence of autoantibodies against IgE or its receptor, FcεRI, and the therapeutic efficacy of anti-IgE antibodies imply that IgE-mediated mechanisms also play [ncbi.nlm.nih.gov]

Finding autoantibodies in children does not impact a disease prognosis, unlike in adult patients, where the presence of autoantibodies is associated with a more prolonged [doi.org]

Connective Tissue Disease

Laboratory analysis and autoantibody screening was negative. [ncbi.nlm.nih.gov]

Homburger HA: Cascade testing for autoantibodies in connective tissue diseases. [mayocliniclabs.com]

[…] case series describes three children who were initially diagnosed as having severe pulmonary arterial hypertension (PAH) and subsequently found to be positive for specific autoantibodies [ncbi.nlm.nih.gov]

Addison Disease

Inhibin chains do not appear to be likely candidate targets of autoantibodies in human POI. [ncbi.nlm.nih.gov]

METHODS: Adrenal cortex autoantibodies, presence of other autoimmune and nonautoimmune diseases, nonadrenal autoantibodies, adrenal imaging, and genetic profile for HLA-DRB1 [ncbi.nlm.nih.gov]

Analysis of ZnT8A enabled to identify autoimmunity in two (14.3 %) T1D individuals previously classified as autoantibody-negative. [ncbi.nlm.nih.gov]

Lupus Erythematosus

Neonatal lupus erythematosus is an uncommon acquired autoimmune disease caused by the passive transfer of autoantibodies, especially anti-Ro and anti-La autoantibodies, across [cmaj.ca]

Mechanisms for photosensitivity might include: modulation of autoantibody location, cytotoxic effects, apoptosis induction with autoantigens in apoptotic blebs, upregulation [ncbi.nlm.nih.gov]

The reason why these damaging autoantibodies develop is not entirely understood. [britannica.com]

Myositis

[…] conjunction with another autoantibody. [ncbi.nlm.nih.gov]

autoantibodies (MSAs). [ncbi.nlm.nih.gov]

How accurate are the different autoantibody tests for myositis? [aruplab.com]

Systemic Scleroderma

[…] these autoantibodies, the severity of the disease, and the presence of other autoantibodies. [ncbi.nlm.nih.gov]

The coexistence of SSc-associated and other autoantibodies was common (43% of patients). [ncbi.nlm.nih.gov]

Presence of such procoagulant autoantibodies might predict future complications and should influence treatment strategy. [ncbi.nlm.nih.gov]

Diffuse Cutaneous Systemic Scleroderma

Wikidata Jump to navigation Jump to search scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies [wikidata.org]

[…] lacked RPC1 autoantibodies. [doi.org]

The presence of autoantibodies against an 86,000-mol wt marker antigen for diffuse scleroderma (Scl-86) was found in 14 out of 33 patients with scleroderma. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus

At entry into the cohort, a standardized medical history and extensive laboratory tests profile, including autoantibodies were completed. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. [dx.doi.org]

The U1 small nuclear RNPs are common targets of autoantibodies in lupus and other autoimmune diseases. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus with Organ/System Involvement

Active nephritis was more prevalent (60% vs 24%) in MAGE-B2 autoantibody-positive than autoantibody-negative SLE patients. [ncbi.nlm.nih.gov]

Over 100 different autoantibodies have been described in SLE patients, highlighting the need for comprehensive autoantibody profiling. [ncbi.nlm.nih.gov]

The frequencies of 10 selected autoantibodies among ethnic groups were compared. Cluster analysis identified groups of patients with similar autoantibody profiles. [ncbi.nlm.nih.gov]

Stiff-Person Syndrome

Autoantibodies to GAD might be the causative agent or a disease marker. [ncbi.nlm.nih.gov]

Since these findings cannot be attributed to anti-GAD65 autoantibodies alone, we propose that additional autoantibodies with so far undefined antigen specificity might affect [ncbi.nlm.nih.gov]

Stiff-person syndrome (SPS) is an autoimmune neurological disorder characterized by stiffness of the skeletal muscle with superimposed spasms and production of autoantibodies [ncbi.nlm.nih.gov]

Acquired Thrombotic Thrombocytopenic Purpura

[…] inhibitory autoantibody titer in TTP patient plasma. [ncbi.nlm.nih.gov]

However, 15/43 patients had autoantibodies with no detectable inhibitory action and as many as 32/43 patients had autoantibodies with inhibitory function that was insufficient [ncbi.nlm.nih.gov]

Improved therapies may come from understanding the diversity of pathogenic autoantibodies on a molecular or genetic level. [ncbi.nlm.nih.gov]

Sjögren Syndrome

Significant positive associations with HLA Class II markers were restricted to the formation of different autoantibodies. [ncbi.nlm.nih.gov]

The neonates have passively received IgG1 anti-SSA/Ro autoantibodies transplacentally and keep these autoantibodies for 24–32 weeks. [doi.org]

Furthermore, a range of autoantibodies can be present in Sjögren's syndrome (anti-SSA/Ro and anti-SSB/La antibodies, rheumatoid factor, cryoglobulins, antinuclear antibodies [dx.doi.org]

Chronic Immune Thrombocytopenic Purpura

Inhibition of the binding of autoantibodies from several ITP patients by either another ITP autoantibody or by a monoclonal anti-GPIIb/IIIa antibody suggests that the antigenic [ncbi.nlm.nih.gov]

We evaluated platelet-associated autoantibodies from 14 ITP patients with alphaIIb-dependent antibodies. [ncbi.nlm.nih.gov]

Thirteen of 14 ITP autoantibodies bound only to CHO cells expressing alpha(IIb)beta(3). [ncbi.nlm.nih.gov]

Autoimmune Hypophysitis

It is even more difficult to determine the mechanisms that lead to the formation of pituitary autoantibodies, or autoantibodies in general. [doi.org]

Each sample was also tested for pituitary autoantibodies using a specific indirect immunofluorescent assay; none was detected. [ncbi.nlm.nih.gov]

No correlations between hypophysitis subtype and anti-pituitary and anti-hypothalamus autoantibodies were found. [ncbi.nlm.nih.gov]

Pernicious Anemia

Eight years later, he developed gastric autoantibody-positive pernicious anemia and began methylcobalamin treatment. [ncbi.nlm.nih.gov]

If they attack your own body's cells due to a malfunction, they are called autoantibodies. Autoantibodies are proteins that attack their own master, so to speak. [study.com]

After 2 weeks of polyuria, the patient developed insulin-deficient hyperglycemia with diabetic ketoacidosis in the absence of verifiable islet-related autoantibodies and began [ncbi.nlm.nih.gov]

Insulin-Resistance Syndrome Type B

Anti-insulin receptor autoantibodies in a patient with type B insulin resistance and fasting hypoglycemia. Acta Diabetol. 2000;37:189–96. [link.springer.com]

[…] represent an anti-idiotypic response to anti-insulin autoantibodies ( 5 ). [care.diabetesjournals.org]

Type B IR syndrome is caused by autoantibodies directed against the insulin receptor. [professional.diabetes.org]

Evans Syndrome

Autoantibodies against platelets and neutrophils may be detected. [symptoma.com]

41 of these patients had both allo- and autoantibodies to RBC antigens, whereas the remainder, 80, had only autoantibodies. [jhoonline.biomedcentral.com]

Laboratory exams showed acute hemolysis due to an IgG warm autoantibody. [ncbi.nlm.nih.gov]

Acquired Hemolytic Anemia

Acquired hemolytic anemia due to the presence of autoantibodies which agglutinate or lyse the patient's own red blood cells. [icd9data.com]

[…] or the co-existence of IgM autoantibodies. 29 Specificity of IgG autoantibodies in AIHA In initial serologic testing, most warm autoantibodies are panagglutinins, meaning [clinicalgate.com]

In contrast, anti-nl, anti-pdl and anti-dl autoantibodies were frequently present in the red cell eluates. [jimmunol.org]