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2,880 Possible Causes for Autoantibodies

  • Hashimoto's Thyroiditis

    High thyroid autoantibodies against thyroid peroxidase (TPOAb) levels are present in 90% of patients with HT and serve as a clinical marker for the detection of early AITD[] The aim of the study was to analyze the clinical course of 6 cases of hyperthyroid girls with GD in whom a normalization of previously increased autoantibodies against thyrotropin[] The common characteristic of all these disorders is the production of different autoantibodies against various autoantigens along with inflammation.[]

  • Acquired Angioedema

    The autoantibodies were directed against the Cl-INH active center.[] Acquired Angioedema (AAE) is a rare condition classified into two subtypes: Type I, which is associated with lymphoproliferative disorders, and Type II, which is linked with autoantibodies[] Abstract We describe a mechanism of action of autoantibodies reactive with the C1 esterase inhibitor (C1EI) molecule found in three patients with acquired angioedema without[]

  • Acquired Thrombotic Thrombocytopenic Purpura

    […] inhibitory autoantibody titer in TTP patient plasma.[] However, 15/43 patients had autoantibodies with no detectable inhibitory action and as many as 32/43 patients had autoantibodies with inhibitory function that was insufficient[] Thrombotic thrombocytopenic purpura (TTP) either occurs in a congenital form caused by ADAMTS13 gene mutations or it is acquired and most often due to ADAMTS13 inhibitory autoantibodies[]

  • Stiff-Person Syndrome

    Autoantibodies to GAD might be the causative agent or a disease marker.[] Both subsets represent only a fraction of anti-GAD65 autoantibody secreting cells.[] Symptoms consistent with reduced inhibition such as stiffness, spasms and anxiety occur in paraneoplastic stiff person syndrome with autoantibodies against the intracellular[]

  • Bullous Pemphigoid

    Autoantibody titres are markers for disease activity.[] In conclusion, higher serum IgE autoantibody levels are associated with more severe clinical manifestations of BP.[] Abstract Bullous pemphigoid (BP) and herpes gestationis (HG) are skin diseases characterized by subepidermal blisters and autoantibodies against two hemidesmosomal Ag, i.e[]

  • Systemic Lupus Erythematosus

    At entry into the cohort, a standardized medical history and extensive laboratory tests profile, including autoantibodies were completed.[] These data suggest that molecular mimicry may play a role in the induction of anti-SmD autoantibodies.[] There is also new recognition that most pathogenic autoantibodies are produced by B cells that have matured within the germinal center and that immune complexes in both diseases[]

  • Mucous Membrane Pemphigoid

    IgG autoantibodies against laminin-332 in patients with MMP are well documented; however, IgA and IgE autoantibodies against laminin-332 have not yet been described.[] Serologically, IgA and IgG class autoantibodies directed against COL17 or IgG autoantibodies directed against laminin-332 in patients with MMP have been well documented.[] By immunoblot analyses, immunoglobulin G autoantibodies in the patient's sera reacted with full-length BP180 and the 120-kDa ectodomain of BP180 (LAD-1).[]

  • Lupus Erythematosus

    Autoantibodies were positively correlated to the number of CD5 B-cells in LE-patients.[] There is also new recognition that most pathogenic autoantibodies are produced by B cells that have matured within the germinal center and that immune complexes in both diseases[] Mechanisms for photosensitivity might include: modulation of autoantibody location, cytotoxic effects, apoptosis induction with autoantigens in apoptotic blebs, upregulation[]

  • Paraneoplastic Syndrome

    Neurofascin as target of autoantibodies in Guillain–Barré syndrome. Brain 134, e173 (2011). 48. Uncini, A. & Kuwabara, S.[] autoantibodies: antineuronal nuclear autoantibody type 1 (ANNA‐1), ANNA‐2, ANNA‐3; Purkinje cell cytoplasmic autoantibody type 1 (PCA‐1), PCA‐2; and CRMP‐5–immunoglobulin[] Paraneoplastic Autoantibodies Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors.[]

  • Drug-induced Lupus Erythematosus

    These theories hold that in SLE, the immune system generates autoantibodies to foreign antigens, and these autoantibodies, in turn, attack the patient’s own tissues.[] The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies.[] In DILE, autoantibodies are thought to be generated by a mechanism other than molecular mimicry.[]

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