Possible Causes for Autonomic Instability Malignant Catatonia Malignant catatonia is a severe form of catatonia which is acute in onset, and is systemically devastating, as it is associated with fever and autonomic instability. [ncbi.nlm.nih.gov] Malignant catatonia is defined as a life-threatening febrile neuropsychiatric disorder, characterized by psychosis with autonomic instability, hyperactivity, mutism, and stuperous [ncbi.nlm.nih.gov] After brief exposure to haloperidol and olanzapine, she developed fever, rigidity, waxy flexibility, autonomic instability, and elevated creatinine phosphokinase enzyme. [ncbi.nlm.nih.gov] Anti-NMDA Receptor Encephalitis Elevated intracranial pressure may also be associated with anti-NMDA receptor encephalitis, and might contribute to the autonomic instability. [ncbi.nlm.nih.gov] Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis usually presents with psychiatric symptoms, behavioural changes, impaired consciousness, seizures and autonomic instability [ncbi.nlm.nih.gov] instability. [ncbi.nlm.nih.gov] Autoimmune Encephalopathy instability and respiratory failures. [ci.nii.ac.jp] receptor antibodies, which are the most common in autoimmune encephalopathy, often cause psychiatric manifestation, memory impairment, seizures, dyskinesia, catatonia, autonomic [ci.nii.ac.jp] Hyperpyrexia The patient's preoperative symptoms of fever, rigidity, altered consciousness, and autonomic instability presented a dilemma whether to proceed with battery exchange to treat [ncbi.nlm.nih.gov] On presentation, he was noted to be febrile with autonomic instability, diaphoresis and marked rigidity. He was disoriented and responding to visual hallucinations. [ncbi.nlm.nih.gov] […] en Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia [sl.glosbe.com] Classic Paraneoplastic Limbic Encephalitis Patients with this syndrome may present as limbic encephalitis but more frequently manifest severe psychiatric symptoms, seizures, dyskinesias, autonomic instability or hypoventilation [jstage.jst.go.jp] instability... [readbyqxmd.com] instability (fluctuations in BP, temp, and cardiac rhythm), orofacial dyskinesias, limb choreoathetosis, and dystonia. [sites.google.com] Tetanus Cardiovascular arrest from severe autonomic instability remains an important cause of mortality in tetanus despite artificial ventilation. [ncbi.nlm.nih.gov] Tetanus is an infectious disease caused by Clostridium tetani, which manifests systemic convulsion and autonomic instability associated with high case fatality. [ncbi.nlm.nih.gov] Tetanus is a life-threatening clinical syndrome that commonly presents with muscular spasms, rigidity, and autonomic instability. [ncbi.nlm.nih.gov] Catatonia The malignant subtype, consisting of motor symptoms, autonomic instability and fever, is associated with high mortality rates, though exact current mortality rates are unknown [ncbi.nlm.nih.gov] Hospital admission is required as most patients refuse to eat, are unable to care for themselves and have autonomic instability. [symptoma.com] The third progressed to severe immobility, muscular rigidity, catalepsy, mutism, and autonomic instability, and was transferred to a general hospital for emergency medical [doi.org] Monoamine Oxidase Inhibitor Poisoning instability (hypo and hypertension) Rapidly followed by: Decline in GCS Muscle rigidity and respiratory compromise Hypoxia, hypercapnia, respiratory acidosis Hyperthermia [lifeinthefastlane.com] This disease entity is similar to an adrenergic crisis from MAOI toxicity, but also features hyperreflexia and autonomic instability when severe. [emedicine.medscape.com] instability and muscle spasms and rigidity. 13, 14 The clinical features are difficult to distinguish from serotonin toxicity, but this rare diagnosis need only be considered [mja.com.au] Triple A Syndrome instability (making it 4A syndrome). [ajol.info] Triple-A syndrome (Allgrove syndrome) is an autosomal recessive disorder characterized by adrenal insufficiency, alacrima, achalasia, and - occasionally - autonomic instability [ncbi.nlm.nih.gov] Allgrove syndrome (triple A syndrome) is a rare autosomal recessive disorder characterized by achalasia, alacrima, adrenal insufficiency, and--occasionally--autonomic instability [ncbi.nlm.nih.gov] Serotonin Syndrome The syndrome can potentially be life-threatening and presents with a triad of autonomic instability, neuromuscular excitation and changes of mental status. [infona.pl] Alcohol Withdrawal Delirium instability Disorientation Hallucinations Agitation Management Thiamine Folate Multivitamin Dextrose IV Fluids Begin benzodiazepine taper to avoid seizures Benzodiazepine [medbullets.com] Early recognition and treatment of Delirium Tremens – a rapid onset of severe alcohol withdrawal accompanied by delirium and autonomic instability about 3-10 days after the [emergencymedicinecases.com] Alcohol withdrawal manifests as a continuum, ranging from tremor to seizures, hallucinations, and life-threatening autonomic instability in severe withdrawal (delirium tremens [msdmanuals.com] Micturition Syncope Tilt table testing can be used to determine the extent of the autonomic instability. Often the diagnosis may be made with a careful history, examination and normal ECG. [patient.co.uk] Acute Porphyria Term Name: acute porphyria Search Ontology: Synonyms: hepatic porphyria Definition: A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic [zfin.org] Autonomic instability with tachycardia and hypertension may be present, and seizures commonly occur [ 4, 5 ]. [karger.com] Untreated hypovolaemia and autonomic instability in the presence of central neuroaxial block may precipitate severe cardiovascular instability. [academic.oup.com] Phenothiazine Poisoning Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia [rxlist.com] Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia [home.intekom.com] instability), and tardive dyskinesia (involuntary movements of the tongue, face, jaw, or mouth) (Rosenberg & Green 1989). [inchem.org] Extrapyramidal Disorder Muscle rigidity, akinesia, tremor Hyperthermia Autonomic instability ( tachycardia, labile blood pressure, tachypnea, diaphoresis, dysrhythmias) Mental status change: confusion [amboss.com] instability. [medicalnewstoday.com] If dystonia occurs in the presence of fever, generalized rigidity, altered level of consciousness, and autonomic instability, a diagnosis of neuroleptic malignant syndrome [uspharmacist.com] Drug-Induced Dystonia instability Medication-induced acute dystonia Involuntary contractions of major muscle groups, characterized by symptoms such as torticollis, retrocollis, oculogyric crisis [hopkinsguides.com] instability and obtundation lead to pulmonary embolism, myocardial infarction and disseminated intravascular coagulation. [benzosupport.org] If dystonia occurs in the presence of fever, generalized rigidity, altered level of consciousness, and autonomic instability, a diagnosis of neuroleptic malignant syndrome [uspharmacist.com] Haldol Basically what Neuroleptic Malignant Syndrome is, is it’s muscle rigidity, fever, autonomic instability and cognitive changes including delirium and it can cause some lab [nrsng.com] Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia [reference.medscape.com] instability; neuroleptic malignant syndrome may occur Motor instability, somnolence, and orthostatic hypotension reported, which may lead to falls and, consequently, fractures [reference.medscape.com] Labile Hypertension The patient's hospital course was complicated by episodes of autonomic instability. [clinmedjournals.org] Paroxysmal autonomic instability with dystonia appears to accomplish this. [jamanetwork.com] Autonomic neuropathy might have caused labile blood pressure as well. [signavitae.com] Familial Dysautonomia The autonomic instability is of greatest importance for the anaesthetist although the sensory defect is the most dramatic symptom of the disease. [ncbi.nlm.nih.gov] The major causes of death are the result of pulmonary complications or sudden death due to autonomic instability. [familialdysautonomia.org] BACKGROUND AND OBJECTIVE: Familial dysautonomia (FD), a rare genetic disorder, is characterized by autonomic instability, pulmonary infections, oesophageal dysmotility, spinal [ncbi.nlm.nih.gov] Teratoma of the Brain Clinical presentation usually includes psychiatric symptoms and/or neurological symptoms often accompanied by decreased responsiveness and autonomic instabilities during the [theses.fr] This is followed by autonomic instability (heart rate, blood pressure and temperature instability, incontinence), alternating periods of agitation and catatonia, oral/facial [hormonesmatter.com] […] and breathing instability. [31] Testicular teratomas present as a palpable mass in the testis ; mediastinal teratomas often cause compression of the lungs or the airways [en.wikipedia.org] Limbic Encephalitis instability Sweating attacks Hyperventilation Urinary retention Movement disorder Dystonia Coarse tremor aggravated by stressful stimuli Hyponatraemia is more common than [ganfyd.org] The next stage is hypoventilation (inadequate breathing) requiring intubation, orofacial dyskinesia and autonomic instability (dramatic fluctuations in blood pressure, temperature [en.wikipedia.org] instability AMPA R 15 70% Thymoma, lung, breast Limbic Encephalitis, Psychiatric GAD 65 60% of SPS 8% Stiff person syndrome, Cerebellar degeneration, Limbic encephalitis, [wieslab.se] Alcohol Withdrawal Seizures Is it delirium tremens basically alcohol withdrawal + delirium + severe autonomic instability? [learningext.com] It is important to trend vital signs for autonomic instability. [clinicaladvisor.com] Delirium tremens is a rapid-onset fluctuating disturbance of attention and cognition (sometimes with hallucinations) plus alcohol withdrawal symptoms and often autonomic instability [emdocs.net] Distal Spinal Muscular Atrophy Type 5 Additionally, it can result in autonomic instability and may be life-threatening. [dartmouth.edu] instability (in up to 65 % of patients); monophasic evolution pattern with recovery beginning 2–4 weeks after progression ceases. [neupsykey.com] It is critical to recognize this condition since it can progress rapidly to respiratory paralysis and life-threatening autonomic instability. [dartmouth.edu] Hypothermia due to Anesthesia Signs include rigidity (ex. elevated ETCO2), temperature, depressed consciousness, and autonomic instability. [openanesthesia.org] Neuroleptic Malignant Syndrome Signs include rigidity, temperature, depressed consciousness, and autonomic instability. [openanesthesia.org] Neuromuscular Junction Disorder Autonomic instability, mostly hypersympathetic state, may occur in severe cases. [slideshare.net] Additionally, it can result in autonomic instability and may be life-threatening. [dartmouth.edu] […] nervous system leading to cardiovascular instability, GI dysfunction, and urinary retention. [academic.oup.com] Substance Withdrawal Syndrome With GHB withdrawal, however, autonomic instability and prolonged psychotic symptoms are the dominant withdrawal symptoms. [withdrawal.net] instability. [en.wikipedia.org] instability Disorientation Hallucinations Agitation Management Thiamine Folate Multivitamin Dextrose IV Fluids Begin benzodiazepine taper to avoid seizures Benzodiazepine [medbullets.com] Parkinsonism PHS occurred eventually and was characterized by hyperthermia, extreme muscle rigidity, autonomic instability, and altered consciousness. [cnjournal.biomedcentral.com] instability; depression; and personality changes Drugs Antipsychotics Can cause reversible† parkinsonism (drug-induced or pharmacologic parkinsonism) Meperidine analog (N-MPTP [merckmanuals.com] instability. [cnjournal.biomedcentral.com] Paraneoplastic Neurologic Syndrome cerebellar degeneration, myelitis, and autonomic dysfunction. [emedicine.medscape.com] instability. [questdiagnostics.com] instability with frequent hypoventilation. 47 The antibodies are directed against the NR1 subunit of the NMDA receptor that is highly enriched in the hippocampus ( Fig. 39 [clinicalgate.com] Dystonia with Cerebellar Atrophy (DYTCA) Clinical features include psychiatric and neurological disturbances, central hypoventilation, autonomic instability, and cardiac dysrhythmias. [biomedsearch.com] Carbon Monoxide-Induced Parkinsonism Causes Idiopathic Parkinson disease (77%) Parkinson-plus syndromes (12%) — Multiple system atrophy(MSA): autonomic instability — Corticobasal ganglionic degeneration (CBGD [lifeinthefastlane.com]
