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13 Possible Causes for Average Intelligence, Congenital Heart Disease, Wide Space Between the First and Second Toe

  • Down Syndrome

    heart disease and Down syndrome.[ncbi.nlm.nih.gov] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] The intelligence quotient (IQ) among children with Down syndrome varies but averages about 50, compared with normal children, whose average IQ is 100.[merckmanuals.com]

  • Craniofrontonasal Dysplasia

    heart disease NGS panel CHD7, ELN, GATA4, GATA6, GDF1, JAG1, NKX2-5, NKX2-6, NOTCH1, NOTCH2, NR2F2, TAB2, TBX1, TBX20, TBX5, ZIC3 Del Dup NGS Connective tissue disorder NGS[ctgt.net] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] In conclusion, individuals diagnosed with frontonasal dysplasia usually are of average intelligence and can expect a normal life span.[ruralneuropractice.com]

  • Ring Chromosome 10

    In some of the cases congenital heart disease was present.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Prenatal diagnosis of a female carrier of a familial r(Jeny21) who was of above average intelligence with a normal phenotype; revealed a twin pregnancy with a 46,XX,r(21)[tp.amegroups.com]

  • Russell-Silver Syndrome

    , etc.) motor, speech, and/or cognitive delay Rare cases have been associated with: cardiac defects (congenital heart disease, pericarditis, etc.) underlying malignant conditions[healthline.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] heart disease, pericarditis, etc.[syndromespedia.com]

  • Seckel Syndrome

    Tricuspid atresia is a rare and life threatening cyanotic congenital heart diseases, with an incidence of 1% to 3%.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] is considered lower than average Can affect boys and girls equally Genetics of Seckel Syndrome Autosomal recessive pattern Additional reading about Seckel Syndrome National[littlepeopleuk.org]

  • Dubowitz Syndrome

    For example, echocardiography is needed in the setting of congenital heart diseases (CHDs), whereas a complete laboratory workup with an immunological profile in case frequent[symptoma.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Results indicate that the level of intellectual functioning among children with Dubowitz syndrome varies from severe retardation to average intelligence.[ncbi.nlm.nih.gov]

  • Familial Congenital Nasolacrimal Duct Obstruction

    The genetic basis of congenital heart disease . Ped Annals 2000; 19 : 469–480. 2. Goldmuntz E . The epidemiology and genetics of congenital heart disease .[nature.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] […] is often subnormal and, in one study of 15 patients with Apert syndrome, the average IQ was 72.5. 66 Development may be adversely affected by progression of increased intracranial[entokey.com]

  • Meningomyelocele

    NTDs are the most common congenital abnormalities of the CNS and, overall, the second most common type of congenital abnormality after congenital heart disease.[neuropathology-web.org] space between first and second toes 11. ability to assume unusual positions Intracranial hemorrhage interventions 1. observation of increased intracranial pressure 2. head[quizlet.com] Discourse after early-onset hydrocephalus: Core deficits in children of average intelligence . Brain and Language , 61 , 309 – 334 .[cambridge.org]

  • Atelosteogenesis

    Genetics of congenital heart diseases in syndromic and non-syndromic patients: new advances and clinical implications . J Cardiovasc Med (Hagerstown) 2007; 8 : 7–11. 27.[nature.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] They are usually of normal intelligence. Dwarfism most often does happen in families where both parents are of average height.[medlineplus.gov]

  • Genee-Wiedemann Syndrome

    When congenital heart disease is present, there is a 30 % risk of mortality in first 2 years of life.[radiologykey.com] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] They typically have normal intelligence and normal lifespans.[chop.edu]

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