Babinski Sign: Causes & Reasons

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Possible Causes for Babinski Sign

Autosomal Dominant Spastic Paraplegia Type 29

Related phenotypes are lower limb hyperreflexia and babinski sign [malacards.org]

Affiliated tissues include spinal cord and skeletal muscle, and related phenotypes are babinski sign and degeneration of the lateral corticospinal tracts Disease Ontology [malacards.org]

Affiliated tissues include spinal cord, skeletal muscle and skin, and related phenotypes are babinski sign and degeneration of the lateral corticospinal tracts Disease Ontology [malacards.org]

Autosomal Dominant Spastic Paraplegia Type 6

Related phenotypes are babinski sign and talipes equinovarus Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in mutation in the ZFYVE27 gene [malacards.org]

Showing of 26 | 80%-99% of people have these symptoms Babinski sign 0003487 Gait disturbance Abnormal gait Abnormal walk Impaired gait [ more ] 0001288 Impaired vibratory [rarediseases.info.nih.gov]

Autosomal Dominant Spastic Paraplegia Type 9A

Hoffmann's sign and Babinski's sign also can be seen. [explainmedicine.com]

Figure 6.2 Babinski sign. Babinski sign. A classic neurological test for corticospinal tract damage is the Babinski test. [nba.uth.tmc.edu]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Autosomal Dominant Spastic Paraplegia Type 42

Affiliated tissues include spinal cord and skeletal muscle, and related phenotypes are babinski sign and degeneration of the lateral corticospinal tracts Disease Ontology [malacards.org]

Affiliated tissues include spinal cord, skeletal muscle and skin, and related phenotypes are babinski sign and degeneration of the lateral corticospinal tracts Disease Ontology [malacards.org]

Affiliated tissues include skin, bone and eye, and related phenotypes are babinski sign and talipes equinovarus Disease Ontology : 12 A hereditary spastic paraplegia that [malacards.org]

Autosomal Dominant Spastic Paraplegia Type 31

sign 0003487 Lower limb muscle weakness Lower extremity weakness Lower limb weakness Muscle weakness in lower limbs [ more ] 0007340 Skeletal muscle atrophy Muscle degeneration [rarediseases.info.nih.gov]

0000012 Percent of people who have these symptoms is not available through HPO Ankle clonus Abnormal rhythmic movements of ankle 0011448 Autosomal dominant inheritance 0000006 Babinski [rarediseases.info.nih.gov]

Autosomal Dominant Spastic Paraplegia Type 10

sign 0003487 Distal sensory impairment Decreased sensation in extremities 0002936 Hyperreflexia in upper limbs 0007350 Impaired distal vibration sensation 0006886 Leg muscle [rarediseases.info.nih.gov]

99% of people have these symptoms Distal lower limb amyotrophy 0008944 Lower limb hyperreflexia Overactive lower leg reflex 0002395 30%-79% of people have these symptoms Babinski [rarediseases.info.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 32

sign 32 HP:0003487 10 lower limb muscle weakness 32 HP:0007340 11 ankle clonus 32 HP:0011448 Drugs & Therapeutics for Spastic Paraplegia 32, Autosomal Recessive Genetic Tests [malacards.org]

sign 60 33 Frequent (79-30%) HP:0003487 3 pes cavus 60 33 Obligate (100%) HP:0001761 4 difficulty walking 60 33 Obligate (100%) HP:0002355 5 hypoplasia of the corpus callosum [malacards.org]

The deep tendon reflexes were increased in all four limbs, but Babinski sign was not elicited bilaterally. Neither ankle nor knee clonus was observed. [nature.com]

Autosomal Recessive Spastic Paraplegia Type 18

The pyramidal syndrome is characterised by brisk patellar tendon reflexes and the Babinski sign. [orpha.net]

Showing of 42 | 30%-79% of people have these symptoms Abnormality of jaw muscles 0045037 Ankle contracture 0006466 Babinski sign 0003487 Cough Coughing 0012735 Delayed gross [rarediseases.info.nih.gov]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Autosomal Dominant Spastic Paraplegia Type 4

Neurological examination disclosed mild spasticity and weakness in the legs, hyperreflexia in all limbs, and bilateral Babinski sign. [bmcmedgenet.biomedcentral.com]

sign 0003487 Distal sensory impairment Decreased sensation in extremities 0002936 Hyperreflexia Increased reflexes 0001347 Impaired vibration sensation in the lower limbs [rarediseases.info.nih.gov]

Other common symptoms of HSP are urinary urgency and frequency, hyperactive reflexes, difficulty with balance, clonus, Babinski’s sign, diminished vibration sense in the feet [sp-foundationorg.presencehost.net]

Behr Syndrome

sign, and incoordination. [whonamedit.com]

Unusual foot reflexes (a positive Babinski sign) may also be experienced by the patient when the sole is stimulated. [medigest.uk]

sign). [the-medical-dictionary.com]

Amyotrophic Lateral Sclerosis Type 4

Typical symptoms include distal muscle weakness and atrophy, brisk deep-tendon reflexes and a positive Babinski sign (Chen et al. Am J Hum Genet 74:1128-1135, 2004). [preventiongenetics.com]

There are no standard laboratory tests for upper motor neuron disease, but spasticity (a specific type of stiffness), abnormally brisk tendon reflexes, Babinski’s sign and [memory.ucsf.edu]

[…] of upper motor neuron dysfunction include the Babinski sign, muscle spasms, and overactive reflexes (hyperreflexia). [rarediseases.info.nih.gov]

Pallidopyramidal Syndrome

sign 0003487 Bradykinesia Slow movements Slowness of movements [ more ] 0002067 Dysphagia Poor swallowing Swallowing difficulties Swallowing difficulty [ more ] 0002015 Dystonia [rarediseases.info.nih.gov]

Names Learn More: HPO ID 100% of people have these symptoms Parkinsonism 0001300 30%-79% of people have these symptoms Abnormal autonomic nervous system physiology 0012332 Babinski [rarediseases.info.nih.gov]

Autosomal Dominant Spastic Paraplegia Type 37

SPASTIC PARAPLEGIA 19, AUTOSOMAL DOMINANT; SPG19 Is also known as ;spg19 Related symptoms: Autosomal dominant inheritance Spasticity Hyperreflexia Babinski sign Slow progression [mendelian.co]

Affiliated tissues include globus pallidus, skin and bone, and related phenotypes are babinski sign and lower limb hyperreflexia Disease Ontology : 12 A hereditary spastic [malacards.org]

sign 0003487 Cerebellar atrophy Degeneration of cerebellum 0001272 Impaired vibration sensation in the lower limbs Decreased lower limb vibratory sense Decreased vibratory [rarediseases.info.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 56

Affiliated tissues include globus pallidus, and related phenotypes are lower limb hyperreflexia and babinski sign Disease Ontology : 12 A hereditary spastic paraplegia that [malacards.org]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Babinski sign was negative. Video gait analysis was performed, which showed internal rotation of the hips and feet while walking and running. [omicsonline.org]

Autosomal Recessive Spastic Paraplegia Type 27

sign 59 32 hallmark (90%) Very frequent (99-80%) HP:0003487 4 dysdiadochokinesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002075 5 spastic paraplegia 59 32 hallmark [malacards.org]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

HPO Source Accession 1 dysarthria 59 32 occasional (7.5%) Occasional (29-5%) HP:0001260 2 sensorineural hearing impairment 59 32 very rare (1%) Very rare ( HP:0000407 3 babinski [malacards.org]

Autosomal Recessive Spastic Paraplegia Type 7

The deep tendon reflexes were increased in all four limbs, but Babinski sign was not elicited bilaterally. Neither ankle nor knee clonus was observed. [nature.com]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

X-Linked Spastic Paraplegia Type 34

Hoffmann's sign and Babinski's sign also can be seen. [explainmedicine.com]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

sign + + Vibration sense Normal Normal Sphincter involvement − − Mini-Mental State Examination (MMSE) 16/30 25/30 Lower limb NCV FWCV decreased Decreased Sural nerve biopsy [intechopen.com]

Autosomal Recessive Spastic Paraplegia Type 46

Showing of 36 | 80%-99% of people have these symptoms Babinski sign 0003487 Impaired vibratory sensation Decreased vibration sense Decreased vibratory sense Diminished vibratory [rarediseases.info.nih.gov]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Detailed neurological examination showed predominantly bilateral proximal pronounced paresis (3/4) of the lower limbs with hyperreflexia and positive bilateral Babinski sign [omicsonline.org]

Juvenile Primary Lateral Sclerosis

Hyperreflexia is another key feature of PLS as seen in patients presenting with the Babinski's sign. [en.wikipedia.org]

sign 0003487 Cerebral cortical atrophy Decrease in size of the outer layer of the brain due to loss of brain cells 0002120 Childhood onset Symptoms begin in childhood 0011463 [rarediseases.info.nih.gov]

signs. [neuropathology-web.org]

Autosomal Dominant Spastic Paraplegia Type 17

Affiliated tissues include globus pallidus, skin and bone, and related phenotypes are babinski sign and lower limb hyperreflexia Disease Ontology : 12 A hereditary spastic [malacards.org]

Showing of 25 | 30%-79% of people have these symptoms Babinski sign 0003487 Foot dorsiflexor weakness Foot drop 0009027 Hand muscle atrophy Hand muscle degeneration 0009130 [rarediseases.info.nih.gov]

Showing of 39 | 30%-79% of people have these symptoms Ankle clonus Abnormal rhythmic movements of ankle 0011448 Babinski sign 0003487 Brisk reflexes 0001348 Functional motor [rarediseases.info.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 39

Neurological examination disclosed mild spasticity and weakness in the legs, hyperreflexia in all limbs, and bilateral Babinski sign. [bmcmedgenet.biomedcentral.com]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Detailed neurological examination showed predominantly bilateral proximal pronounced paresis (3/4) of the lower limbs with hyperreflexia and positive bilateral Babinski sign [omicsonline.org]

Autosomal Dominant Spastic Paraplegia Type 13

sign 60 33 occasional (7.5%) Frequent (79-30%) HP:0003487 4 lower limb muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0007340 5 impaired vibration sensation in [malacards.org]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Autosomal Recessive Spastic Paraplegia Type 14

Detailed neurological examination showed predominantly bilateral proximal pronounced paresis (3/4) of the lower limbs with hyperreflexia and positive bilateral Babinski sign [omicsonline.org]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

sign 34 Clinical presentation Symptoms typically begin sometime between the ages of 5 to 15 years, scoliosis Diabetes (about 20% of people with Friedreich's ataxia develop [slideplayer.com]

Autosomal Recessive Spastic Paraplegia Type 26

Showing of 37 | 30%-79% of people have these symptoms Babinski sign 0003487 Cerebral cortical atrophy Decrease in size of the outer layer of the brain due to loss of brain [rarediseases.info.nih.gov]

Achilles and brachioradialis reflexes were absent, but Babinski sign was present. Distal muscles in the lower limbs were atrophic, and gait was spastic ataxic. [docplayer.net]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Autosomal Recessive Spastic Paraplegia Type 55

The deep tendon reflexes were increased in all four limbs, but Babinski sign was not elicited bilaterally. Neither ankle nor knee clonus was observed. [nature.com]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

sign + + Vibration sense Normal Normal Sphincter involvement − − Mini-Mental State Examination (MMSE) 16/30 25/30 Lower limb NCV FWCV decreased Decreased Sural nerve biopsy [intechopen.com]

Autosomal Dominant Spastic Paraplegia Type 19

Related phenotypes are babinski sign and talipes equinovarus Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in mutation in the ZFYVE27 gene [malacards.org]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Deep tendon reflexes were increased in all patients with clonus in 3 and bilateral Babinski sign in 4. [bmcneurol.biomedcentral.com]

Autosomal Recessive Spastic Paraplegia Type 21

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

’s sign). [medschool.lsuhsc.edu]

Detailed neurological examination showed predominantly bilateral proximal pronounced paresis (3/4) of the lower limbs with hyperreflexia and positive bilateral Babinski sign [omicsonline.org]

Autosomal Dominant Spastic Paraplegia Type 8

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

Babinski sign was negative. Video gait analysis was performed, which showed internal rotation of the hips and feet while walking and running. [omicsonline.org]

Autosomal Recessive Spastic Paraplegia Type 57

Reflexes were brisk, and he showed ankle clonus and a Babinski sign on the left. [ng.neurology.org]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

sign, and scoliosis; within 10 to 15 years of onset, patients have to use wheelchairs. 22 In addition to axonal sensory polyneuropathy, auditory and optic neuropathy are [elsevier.es]

Autosomal Recessive Spastic Paraplegia Type 43

Bilateral Babinski sign and ankle clonus were elicited. The patient tended to walk on his toes and the legs scissored. The motor nerve velocities were less than normal. [jlc.jst.go.jp]

There was hyperreflexia in both upper and lower limbs and spastic paraplegia with a bilateral Babinski sign. [journals.plos.org]

sign + + Vibration sense Normal Normal Sphincter involvement − − Mini-Mental State Examination (MMSE) 16/30 25/30 Lower limb NCV FWCV decreased Decreased Sural nerve biopsy [intechopen.com]