Base Deficit: Causes & Reasons

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Possible Causes for Base Deficit

Acute Pancreatitis

Base deficit > 4 mEq/L Note: amylase and lipase not prognostic WBC > 16,000/μL AST > 250 IU/dL LDH > 350 IU/L Blood glucose > 200 mg/dL Risk of Mortality 3-4 signs 20% 5- [medbullets.com]

[…] diagnosis Age – WBC count – 3 (16.0x10 9 /L) Blood glucose – Serum lactate dehydrogenase – AST – During initial 48 hrs Hematocrit decrease – BUN increase – Serum calcium – Base [arupconsult.com]

deficit > 4 Fluid sequestration > 6 L Mortality based on score < 3 = 1% 3-4 = 15% 5-6 = 40% > 6 = 100% Glasgow criteria or Imrie score On admission age > 55 years WCC > 16 [lifeinthefastlane.com]

Hyperchloremia

These associations were independent of base deficit, cumulative fluid balance, acute kidney injury, and other critical illness parameters. [ncbi.nlm.nih.gov]

Those with Cl 0 greater than or equal to 110 mEq/L were older and had higher cumulative fluid balance, base deficit, and Sequential Organ Failure Assessment scores. [doi.org]

Those with Cl0 greater than or equal to 110 mEq/L were older and had higher cumulative fluid balance, base deficit, and Sequential Organ Failure Assessment scores. [ncbi.nlm.nih.gov]

Hypovolemic Shock

Based on these findings, base-deficit measurement should be strongly considered during the initial trauma evaluation to identify the presence of hypovolemic shock and to guide [ncbi.nlm.nih.gov]

Vital signs, shock index (SI), the lactic acid value and the base deficit were compared before and after NASG application. [ncbi.nlm.nih.gov]

The aim of this study was to introduce and validate a new classification of hypovolemic shock based upon base deficit (BD) at emergency department (ED) arrival. [ncbi.nlm.nih.gov]

Metabolic Acidosis

[…] decreased base deficits and increased pH though produced no discernible effects or benefits on cardiopulmonary parameters including rSO2 and FTOE. [ncbi.nlm.nih.gov]

Furthermore, creatinine was associated with a 1.57 mEq/L (95% CI: 0.14, 2.99) increase in the base deficit. [ncbi.nlm.nih.gov]

RESULTS: Base deficit and pH have been criticized as the standard criteria to predict outcome. [ncbi.nlm.nih.gov]

Fetal Hypoxia

There were poor correlations between hypoxanthine concentrations and those of hydrogen ion, base deficit and lactate. [ncbi.nlm.nih.gov]

deficit (taua=-0.36, taub=0.-0.36, p = 0.0002). [ncbi.nlm.nih.gov]

The median erythropoietin concentration increased significantly with decreasing pH and with increasing base deficit in umbilical arterial blood. [ncbi.nlm.nih.gov]

Cerebral Small Vessel Disease

In this study, we examined a cohort of 25 SVCD patients and 19 healthy controls using video-oculographic eye movement recording in a laboratory environment, computer-based [ncbi.nlm.nih.gov]

MRI assessment of white matter lesion load (WMLL), assessment of extrapyramidal motor deficits, and psychometric testing. [ncbi.nlm.nih.gov]

[…] vascular lesion load in specific brain regions affects oculomotor function independent of cognitive decline in SVCD patients or whether the effect of higher brain function deficits [ncbi.nlm.nih.gov]

Abdominal Injury

A negative number is called a base deficit and indicates metabolic acidosis. Clinical Features Seat-belt sign after motor vehicle collision. [wikem.org]

deficit < -6 mEq/L b 18 (11-30) 0.12 (0.06-0.24) Aspartate transaminase or alanine transaminase > 130 U/L 5.2 (3.5-7.9) 0.46 (0.33-0.65) Hematuria, > 25 red blood cells per [jamaevidence.mhmedical.com]

Base deficit from the first peripheral venous sample: a surrogate for arterial base deficit in the trauma bay. [dynamed.com]

Pelvic Fracture

Inclusion criteria included shock on admission (systolic blood pressure 120 beats/min and base deficit >5, and the ability to review pelvic imaging). [ncbi.nlm.nih.gov]

Transfusions were triggered by abnormal TEG/PM results and/or the presence of active hemorrhage, persistent hemorrhagic shock, and abnormal base deficit levels. [ncbi.nlm.nih.gov]

Hemorrhagic shock (HS) patients had a systolic blood pressure ≤ 90 mmHg or base deficit of ≥ 6 mEq/L on admission. [ncbi.nlm.nih.gov]

Malouf Syndrome

[…] mild intellectual deficit metabolic abnormalities thyroid hemiagenisis: a rare congenital abnormality of the thyroid gland characterized by the absence of one lobe [9] aged [en.wikipedia.org]

[…] and cardiomyopathy, whose coexistence is extremely rare. [7] symptoms [8] hypergonadotropic hypogonadism cardiomyopathy dilated cardiomyopathy blepharoptosis broad nasal base [en.wikipedia.org]

Acid-Base Imbalance

There will be a base deficit in state of partially or fully compensated respiratory alkalosis. [quizlet.com]

(base deficit) Term A patient with severe diarrhea would be at risk for what acid-base imbalance? why? [flashcardmachine.com]

BASE EXCESS/DEFICIT• Base excess and base deficit are terms applied to an analytical method for determination of the appropriateness of responses to disorders of acid-base [slideshare.net]

Alcoholic Ketoacidosis

The clinical presentation included an arterial pH of 7.15, a base deficit of 23 mEq/liter, a bicarbonate of less than 10 m Eq/liter, larger serum and urinary ketone levels [ncbi.nlm.nih.gov]

The clinical presentation included an arterial pH of 7.15, a base deficit of 23 mEq/liter, a bicarbonate of less than 10 mEq/liter, large serum and urinary ketone levels, [journals.lww.com]

The wide anion gap and base deficit indicate that he has metabolic acidosis. [pulmonarychronicles.com]

Ureteroenterostomy

Presence of an increased anion gap signifies a base deficit and a metabolic acidosis. Normal anion gap is 12 ± 2-4 mEq/L. [calsprogram.org]

EXCESS/BASE DEFICIT 13. [slideshare.net]

Despite the compensatory mechanisms, the pH may not return all the way to normal • What may appear to be a compensatory process may not actually represent true compensation • BASE [slideshare.net]

Acid Base Disorder

Initial pH, base deficit, lactate, anion gap, strong ion différence and strong ion gap predict outcome from major vascular surgery. [jpmiss2.free.fr]

The magnitude of the metabolic acidosis is generally quantified by the base deficit or base excess, which is defined as the amount of base (or acid) that must be added to [intechopen.com]

Kaplan LJ, Kellum JA (2004) Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. [journals.plos.org]

Rudd-Klimek Syndrome

The phenotypes of these mutant mice suggest that sirenomelia in humans is associated with an excess of RA signaling and a deficit in Bmp signaling in the caudal body. [scienceopen.com]

The first hypothesis, based on the aberrant abdominal and umbilical vascular pattern of affected individuals, postulates a primary vascular defect that leaves the caudal part [scienceopen.com]

Methanol Poisoning

Methanol-poisoned patients on fomepizole treatment may be separated into two categories: 1) The critically ill patient, with severe metabolic acidosis (base deficit >15 mM [ncbi.nlm.nih.gov]

RESULTS: The median pH upon admission was 6.9 (range 6.6 - 7.5) and median base deficit 20.4 mmol/l (range 5.1 - 30.0). [ncbi.nlm.nih.gov]

The patients with haemorrhagic brain lesions were more acidemic (lower arterial blood pH, higher base deficit) and had higher glycaemia and lactacidaemia on admission than [ncbi.nlm.nih.gov]

48,XXXY Syndrome

These individuals may face difficulties in communicating with others due to their language-based deficits. [en.wikipedia.org]

Abdominal Injury

We sought to assess the diagnostic performance of base deficit (BD) in identifying intra-abdominal injury in patients with blunt abdominal trauma. [ncbi.nlm.nih.gov]

Test results increasing the likelihood of intra-abdominal injury include a base deficit less than -6 mEq/L (LR, 18; 95% CI, 11-30), elevated liver transaminases (LR range, [ncbi.nlm.nih.gov]

A moderate base deficit indicates the need for aggressive resuscitation and determination of the aetiology. [patient.info]

Attention Deficit Disorder

Furthermore, optimal management continues to gain evidence-based support. [doi.org]

Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184 – 214. [doi.org]

Evidence-based psychosocial treatments for Attention-Deficit/Hyperactivity Disorder. [ncbi.nlm.nih.gov]

Adult Attention Deficit-Hyperactivity Disorder

Furthermore, optimal management continues to gain evidence-based support. [doi.org]

Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184 – 214. [doi.org]

Abstract The Wender-Reimherr adult attention deficit disorder scale (WRAADDS; Wender, 1995) is a clinician-rated scale based on the Utah Criteria for attention-deficit/hyperactivity [ncbi.nlm.nih.gov]

Massive Trauma

Markers of hypoperfusion such as base deficit or lactate should guide therapy; however, these too have their limitations. [academic.oup.com]

Assess the response to resuscitation by monitoring vital signs, clinical status, base deficit, and serum lactate levels. [emedicine.medscape.com]

Buffers are avoided where possible since they will mask the reversal of base deficit and or lactate as an indicator of adequacy of resuscitation. [academic.oup.com]

Glycogen Storage Disease Type 12

Englehart et al., Measurement of acid-base resuscitation endpoints: lactate, base deficit, bicarbonate or what? Curr Opin Crit Care. 12, 569 (2006) H.J. [charite.de]

What Is the Clinical Utility of Obtaining Serum Lactate and Arterial Base Deficit Values in Patients With Early Signs of Sepsis and Septic Shock? Medscape Today. [labtestsonline.it]

A lactose-free diet prevents acute toxicity and reverses some manifestations but may not prevent neurocognitive deficits Resources - Aldolase A deficiency [checkorphan.org]

Attention Deficit Hyperactivity Disorder

Furthermore, optimal management continues to gain evidence-based support. [ncbi.nlm.nih.gov]

Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184 – 214. [doi.org]

Attention deficit/hyperactivity disorder is a subject of great interest to families, providers, researchers, and public forums. [ncbi.nlm.nih.gov]

Ventriculomegaly with Defects of the Radius and Kidney

[…] excess / deficit Birth (Child) FAN0101 Venous cord blood pH Birth (Child) FAN0102 Arterial cord blood base excess / deficit Birth (Child) FAN0103 Arterial Cord Blood pH Birth [datadictionary.bornontario.ca]

Child) N0202 Forceps/Vacuum (Child) Birth (Child) N0200 Delayed Cord Clamping Birth (Child) FAN0029 Neonatal Transfer Hospital To Birth (Child) FAN0100 Venous cord blood base [datadictionary.bornontario.ca]

Neonatal Seizures

METHODS: Neonates were categorized depending on the presence of metabolic acidemia at birth by umbilical artery pH < 7.00, base deficit ≥12 mmol/L. [ncbi.nlm.nih.gov]

Infants enrolled were at risk for seizures based on various historical factors, including an Apgar score of less than 5 at five minutes with a base deficit of more than 10 [aafp.org]

Penetrating Abdominal Trauma

deficit less than -15 mEq/L HCO 3, core temperature less than 35° C, and development of coagulopathy have a dramatically increased mortality rate mandating "damage control [emedicine.medscape.com]

A moderate base deficit indicates the need for aggressive resuscitation and determination of the aetiology. [patient.info]

Serum lactate level or base deficit calculation (from arterial blood gas testing) may help identify occult shock. [merckmanuals.com]

Amusia

Some indications for timbral, as well as pitch-based deficits come from the comments of several amusics, who report that music sounds like ‘banging’ or ‘noise’. [thepsychologist.bps.org.uk]

A harmonicity-based deficit would likely extend outside of music. [pnas.org]

Because a pitch-based deficit could affect the Scale test or the Off-key test, scores below cutoff on both tests was considered as indicative of amusia (prevalence and distribution [ncbi.nlm.nih.gov]

Ethylene Glycol Poisoning

Her admission data revealed a median pH of 7.31 (range 6.87-7.49), pCO(2): 4.2 kPa (1.2-6.7) (32 mmHg [9-50]), HCO-3: 15 mmol/L (4-26) (15 mEq/L [4-26]), base deficit (BD) [ncbi.nlm.nih.gov]

Mean base deficit on admission was 18.6 ± 10.9 (range –27.7 to 0.9) ( Table 2 ). Five of six patients had an acidosis in the blood gas analysis on admission. [ckj.oxfordjournals.org]

Laboratory test results on admission in intoxicated patients Case Na + (mmol/L) K + (mmol/L) Cl − (mmol/L) Anion gap (mmol/L) Osmolal gap (mOsm/L pH PCO 2 (mmHg) Base deficit [ckj.oxfordjournals.org]

Metabolic Alkalosis

Excess[ 5 ] (BD alb, base deficit due to albumin; BD Cl, base deficit due to chloride; BD tot, total base deficit; BD UMA, base deficit due to unmeasured anions; SID, Strong [ncbi.nlm.nih.gov]

Synonyms base deficit bicarbonate deficit This is a preview of subscription content, log in to check access. Preview Unable to display preview. Download preview PDF. [link.springer.com]

The base excess indicates the amount of excess or insufficient level of bicarbonate in the system. (A negative base excess indicates a base deficit in the blood.) [globalrph.com]

Hypoxic-Ischemic Brain Injury

In the overcooled infants, Apgar scores, pH, base deficit, and eventual death rate (7/16; 43.8%) indicated more severe asphyxia suggesting poor temperature control in this [ncbi.nlm.nih.gov]

This can cause medical staff to calculate a different value (base excess or base deficit) (5). [hiehelpcenter.org]

Clinical variables such as sex, gestational age at birth, birth weight, cord blood pH and base deficit, Apgar scores, and degree of encephalopathy at presentation were ascribed [ncbi.nlm.nih.gov]

Neonatal Acute Respiratory Distress due to SP-B Deficiency

At 4 hours of age, the infant is in 50% oxygen in a head hood, and his initial capillary blood gas is pH 7.28, P0O2 54, P02 46, and base deficit 4.2. [healio.com]

A follow-up capillary blood gas shows a pH of 7.26, PCO7 of 58, and a P02 of 48 with a base deficit of 3.Í Arrangements are made to transfer the infant to a level III neonatal [healio.com]