Base Deficit: Causes & Reasons

Possible Causes for Base Deficit

Base deficit > 4 mEq/L Note: amylase and lipase not prognostic WBC > 16,000/μL AST > 250 IU/dL LDH > 350 IU/L Blood glucose > 200 mg/dL Risk of Mortality 3-4 signs 20% 5- [medbullets.com]

[…] diagnosis Age – WBC count – 3 (16.0x10 9 /L) Blood glucose – Serum lactate dehydrogenase – AST – During initial 48 hrs Hematocrit decrease – BUN increase – Serum calcium – Base [arupconsult.com]

deficit > 4 Fluid sequestration > 6 L Mortality based on score < 3 = 1% 3-4 = 15% 5-6 = 40% > 6 = 100% Glasgow criteria or Imrie score On admission age > 55 years WCC > 16 [lifeinthefastlane.com]

Hyperchloremia

These associations were independent of base deficit, cumulative fluid balance, acute kidney injury, and other critical illness parameters. [ncbi.nlm.nih.gov]

Those with Cl 0 greater than or equal to 110 mEq/L were older and had higher cumulative fluid balance, base deficit, and Sequential Organ Failure Assessment scores. [doi.org]

Those with Cl0 greater than or equal to 110 mEq/L were older and had higher cumulative fluid balance, base deficit, and Sequential Organ Failure Assessment scores. [ncbi.nlm.nih.gov]

Hypovolemic Shock

The aim of this study was to introduce and validate a new classification of hypovolemic shock based upon base deficit (BD) at emergency department (ED) arrival. [ncbi.nlm.nih.gov]

Based on these findings, base-deficit measurement should be strongly considered during the initial trauma evaluation to identify the presence of hypovolemic shock and to guide [ncbi.nlm.nih.gov]

BACKGROUND: Recently, our group has proposed a new classification of hypovolemic shock based on the physiological shock marker base deficit (BD). [ncbi.nlm.nih.gov]

Cerebral Small Vessel Disease

In this study, we examined a cohort of 25 SVCD patients and 19 healthy controls using video-oculographic eye movement recording in a laboratory environment, computer-based [ncbi.nlm.nih.gov]

MRI assessment of white matter lesion load (WMLL), assessment of extrapyramidal motor deficits, and psychometric testing. [ncbi.nlm.nih.gov]

[…] vascular lesion load in specific brain regions affects oculomotor function independent of cognitive decline in SVCD patients or whether the effect of higher brain function deficits [ncbi.nlm.nih.gov]

Subgaleal Hemorrhage

The cord blood pH was 7.26, with a base deficit of 7.2 mmol/L. The baby required bag and mask ventilation for a short time. [ncbi.nlm.nih.gov]

Associative Agnosia

Behavioral deficits and cortical damage loci in cerebral achromatopsia. Cerebral Cortex, 16 (2), 183-191. Branch Coslett, H. y Saffran, E. (1991). [cv.uoc.edu]

Neuroanatomical Correlates of Musicianship as Revealed by Cortical Thickness and Voxel-Based Morphometry. Cerebral Cortex Bouvier, S. E. y Engel, S. A. (2009). [cv.uoc.edu]

Time Agnosia

Behavioral deficits and cortical damage loci in cerebral achromatopsia. Cerebral Cortex, 16 (2), 183-191. Branch Coslett, H. y Saffran, E. (1991). [cv.uoc.edu]

Neuroanatomical Correlates of Musicianship as Revealed by Cortical Thickness and Voxel-Based Morphometry. Cerebral Cortex Bouvier, S. E. y Engel, S. A. (2009). [cv.uoc.edu]

Abdominal Injury

A negative number is called a base deficit and indicates metabolic acidosis. Clinical Features Seat-belt sign after motor vehicle collision. [wikem.org]

deficit < -6 mEq/L b 18 (11-30) 0.12 (0.06-0.24) Aspartate transaminase or alanine transaminase > 130 U/L 5.2 (3.5-7.9) 0.46 (0.33-0.65) Hematuria, > 25 red blood cells per [jamaevidence.mhmedical.com]

Base deficit from the first peripheral venous sample: a surrogate for arterial base deficit in the trauma bay. [dynamed.com]

Metabolic Acidosis

[…] decreased base deficits and increased pH though produced no discernible effects or benefits on cardiopulmonary parameters including rSO2 and FTOE. [ncbi.nlm.nih.gov]

Furthermore, creatinine was associated with a 1.57 mEq/L (95% CI: 0.14, 2.99) increase in the base deficit. [ncbi.nlm.nih.gov]

RESULTS: Base deficit and pH have been criticized as the standard criteria to predict outcome. [ncbi.nlm.nih.gov]

Fetal Hypoxia

There were poor correlations between hypoxanthine concentrations and those of hydrogen ion, base deficit and lactate. [ncbi.nlm.nih.gov]

deficit (taua=-0.36, taub=0.-0.36, p = 0.0002). [ncbi.nlm.nih.gov]

The median erythropoietin concentration increased significantly with decreasing pH and with increasing base deficit in umbilical arterial blood. [ncbi.nlm.nih.gov]

CD45 Deficiency

deficit. [ncbi.nlm.nih.gov]

The serum levels of globulin, total bilirubin (TBIL), alkaline phosphatase, alanine transaminase, standard base deficit, potassium, and sodium in COVID-19 patients were not [ncbi.nlm.nih.gov]

0(0%) normal 153(96.2%) 52(89.7%) 61(93.8%) 18(78.3.0%) 284(93.1%) 15(57.7%) TBIL, total bilirubin; ALP, alkaline phosphatase; ALT, alanine transaminase; SBD, standard base [ncbi.nlm.nih.gov]

Prostatic Atrophy

(HGPIN) and to the CaP, fundamentally deficit in GSTP1 expression and overexpression of AGR2. [elsevier.es]

This hypothesis is based on its frequent association to cancer lesions (CaP) and on some genetic alterations that are common to the high grade prostatic intraepithelial neoplasia [elsevier.es]

Pelvic Fracture

Inclusion criteria included shock on admission (systolic blood pressure 120 beats/min and base deficit >5, and the ability to review pelvic imaging). [ncbi.nlm.nih.gov]

Transfusions were triggered by abnormal TEG/PM results and/or the presence of active hemorrhage, persistent hemorrhagic shock, and abnormal base deficit levels. [ncbi.nlm.nih.gov]

Hemorrhagic shock (HS) patients had a systolic blood pressure ≤ 90 mmHg or base deficit of ≥ 6 mEq/L on admission. [ncbi.nlm.nih.gov]

Acid-Base Imbalance

There will be a base deficit in state of partially or fully compensated respiratory alkalosis. [quizlet.com]

(base deficit) Term A patient with severe diarrhea would be at risk for what acid-base imbalance? why? [flashcardmachine.com]

BASE EXCESS/DEFICIT• Base excess and base deficit are terms applied to an analytical method for determination of the appropriateness of responses to disorders of acid-base [slideshare.net]

Topographical Agnosia

Behavioral deficits and cortical damage loci in cerebral achromatopsia. Cerebral Cortex, 16 (2), 183-191. Branch Coslett, H. y Saffran, E. (1991). [cv.uoc.edu]

Neuroanatomical Correlates of Musicianship as Revealed by Cortical Thickness and Voxel-Based Morphometry. Cerebral Cortex Bouvier, S. E. y Engel, S. A. (2009). [cv.uoc.edu]

Refsum Disease Type 2

Essa è caratterizzata da ipoacusia congenita associata a retinite pigmentosa che inizialmente comporta deficit visivo e poi progredisce verso la cecità nell'arco di qualche [med2000eco.it]

In base alla sordità, ai problemi di equilibrio ed all'età di insorgenza della retinite pigmentosa si distinguono tre forme di S. di Usher: La patologia è trasmessa con carattere [med2000eco.it]

Alcoholic Ketoacidosis

The clinical presentation included an arterial pH of 7.15, a base deficit of 23 mEq/liter, a bicarbonate of less than 10 m Eq/liter, larger serum and urinary ketone levels [ncbi.nlm.nih.gov]

The clinical presentation included an arterial pH of 7.15, a base deficit of 23 mEq/liter, a bicarbonate of less than 10 mEq/liter, large serum and urinary ketone levels, [journals.lww.com]

The wide anion gap and base deficit indicate that he has metabolic acidosis. [pulmonarychronicles.com]

Acid Base Disorder

Initial pH, base deficit, lactate, anion gap, strong ion différence and strong ion gap predict outcome from major vascular surgery. [jpmiss2.free.fr]

The magnitude of the metabolic acidosis is generally quantified by the base deficit or base excess, which is defined as the amount of base (or acid) that must be added to [intechopen.com]

Kaplan LJ, Kellum JA (2004) Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. [journals.plos.org]

Abdominal Injury

We sought to assess the diagnostic performance of base deficit (BD) in identifying intra-abdominal injury in patients with blunt abdominal trauma. [ncbi.nlm.nih.gov]

Test results increasing the likelihood of intra-abdominal injury include a base deficit less than -6 mEq/L (LR, 18; 95% CI, 11-30), elevated liver transaminases (LR range, [ncbi.nlm.nih.gov]

A moderate base deficit indicates the need for aggressive resuscitation and determination of the aetiology. [patient.info]

Malouf Syndrome

[…] mild intellectual deficit metabolic abnormalities thyroid hemiagenisis: a rare congenital abnormality of the thyroid gland characterized by the absence of one lobe [7] aged [en.wikipedia.org]

[…] and cardiomyopathy, whose coexistence is extremely rare.[3] symptoms [5] hypergonadotropic hypogonadism cardiomyopathy dilated cardiomyopathy blepharoptosis broad nasal base [en.wikipedia.org]

Klinefelter Syndrome with Male Phenotype with more than Two X Chromosomes

These individuals may face difficulties in communicating with others due to their language-based deficits. [en.wikipedia.org]

Methanol Poisoning

Methanol-poisoned patients on fomepizole treatment may be separated into two categories: 1) The critically ill patient, with severe metabolic acidosis (base deficit >15 mM [ncbi.nlm.nih.gov]

RESULTS: The median pH upon admission was 6.9 (range 6.6 - 7.5) and median base deficit 20.4 mmol/l (range 5.1 - 30.0). [ncbi.nlm.nih.gov]

The patients with haemorrhagic brain lesions were more acidemic (lower arterial blood pH, higher base deficit) and had higher glycaemia and lactacidaemia on admission than [ncbi.nlm.nih.gov]

Ureteroenterostomy

Presence of an increased anion gap signifies a base deficit and a metabolic acidosis. Normal anion gap is 12 ± 2-4 mEq/L. [calsprogram.org]

EXCESS/BASE DEFICIT 13. [slideshare.net]

Despite the compensatory mechanisms, the pH may not return all the way to normal • What may appear to be a compensatory process may not actually represent true compensation • BASE [slideshare.net]

Attention Deficit Hyperactivity Disorder

Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184 – 214. [doi.org]

Furthermore, optimal management continues to gain evidence-based support. [ncbi.nlm.nih.gov]

[Taylor & Francis Online], [Web of Science ®], [Google Scholar] ) review of evidence-based practices for children and adolescents with attention-deficit/hyperactivity disorder [doi.org]

Adult Attention Deficit-Hyperactivity Disorder

Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184 – 214. [doi.org]

Furthermore, optimal management continues to gain evidence-based support. [doi.org]

Abstract The Wender-Reimherr adult attention deficit disorder scale (WRAADDS; Wender, 1995) is a clinician-rated scale based on the Utah Criteria for attention-deficit/hyperactivity [ncbi.nlm.nih.gov]

Rhizomelic Skeletal Dysplasia with Retinitis Pigmentosa

Essa è caratterizzata da ipoacusia congenita associata a retinite pigmentosa che inizialmente comporta deficit visivo e poi progredisce verso la cecità nell'arco di qualche [med2000eco.it]

In base alla sordità, ai problemi di equilibrio ed all'età di insorgenza della retinite pigmentosa si distinguono tre forme di S. di Usher: La patologia è trasmessa con carattere [med2000eco.it]

Glycogen Storage Disease Type 12

Englehart et al., Measurement of acid-base resuscitation endpoints: lactate, base deficit, bicarbonate or what? Curr Opin Crit Care. 12, 569 (2006) H.J. [charite.de]

What Is the Clinical Utility of Obtaining Serum Lactate and Arterial Base Deficit Values in Patients With Early Signs of Sepsis and Septic Shock? Medscape Today. [labtestsonline.it]

A lactose-free diet prevents acute toxicity and reverses some manifestations but may not prevent neurocognitive deficits Resources - Aldolase A deficiency [checkorphan.org]

Tune Deafness

Considering amusics can exhibit a normal priming effect of note expectancy (faster response to expected notes) based on the musical pitch context (Omigie et al., 2012) and [jneurosci.org]

Peretz and colleagues (Peretz et al., 2008; Peretz and Vuvan, 2017) report that amusia and visuo-spatial deficits are associated, though this is solely based on self-report [frontiersin.org]

Based on previous findings (Albouy et al., 2013), Schaal et al. (2015) demonstrated that modulating the right DLPFC with transracial alternating current stimulation (tACS) [jneurosci.org]

Massive Trauma

Markers of hypoperfusion such as base deficit or lactate should guide therapy; however, these too have their limitations. [academic.oup.com]

Assess the response to resuscitation by monitoring vital signs, clinical status, base deficit, and serum lactate levels. [emedicine.medscape.com]

Buffers are avoided where possible since they will mask the reversal of base deficit and or lactate as an indicator of adequacy of resuscitation. [academic.oup.com]

Neonatal Seizures

METHODS: Neonates were categorized depending on the presence of metabolic acidemia at birth by umbilical artery pH < 7.00, base deficit ≥12 mmol/L. [ncbi.nlm.nih.gov]

Infants enrolled were at risk for seizures based on various historical factors, including an Apgar score of less than 5 at five minutes with a base deficit of more than 10 [aafp.org]