Basophilia: Causes & Reasons

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Possible Causes for Basophilia

Leukoerythroblastic Anemia

[…] absolute basophil count >100 etiology of basophilia chronic myeloproliferative disorders lymphocytosis absolute lymphocyte count >4000 in adults or >8000 in children etiology [memorize.com]

PV Cellular Phase PMF ET RBC Normal or ↓ Normal, ↑ or ↓, may be hypochromatic or polychromatic ↓, teardrop cells Normal or ↓ (iron deficient anemia) WBC ↑, left shifted, basophilia [surgpathcriteria.stanford.edu]

Basophilia is also reported in hypothyroidism. [med-ed.virginia.edu]

Chronic Phase of Chronic Myeloid Leukemia

Increasing basophilia is a sign of acceleration! [amboss.com]

[…] characterized by leukocytosis and hypercellular marrow Peripheral blood leukocytosis Granulocytes at all stages of maturation Two peaks: segmented neutrophils and myelocytes Basophilia [surgpathcriteria.stanford.edu]

In CML, the peripheral smear frequently shows immature granulocytes as well as absolute eosinophilia and basophilia. [merckmanuals.com]

Leukemoid Reaction

In general, in a leukemoid reaction, circulating blasts or pro-myelocytes are not seen and basophilia is absent. The leukocyte alkaline phosphatase score is high. [tcd.ie]

Historically, various clues including the leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction. [en.wikipedia.org]

( Basophil s >100/mm3) See Basophilia for causes Consider malignancy Consider allergic condition Images: Related links to external sites (from Bing) Ontology: Leukemoid Reaction [fpnotebook.com]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant. [ncbi.nlm.nih.gov]

[…] multivariate analyses, a diagnosis-to-treatment interval of 3 years or more, splenomegaly, and peripheral blasts predicted poor major cytogenetic response; age >60 years, marrow basophilia [ncbi.nlm.nih.gov]

[…] demonstrating chromosomal translocation involving the BCR-ABL genes: t(9;22).1 Typical presentations of CML include high white count dominated by mature myeloid cells, with basophilia [archivesofpathology.org]

Chronic Myeloid Leukemia

A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia. [ncbi.nlm.nih.gov]

Patients with Ph+ AML were less likely to have splenomegaly or peripheral basophilia and had lower bone marrow cellularity and myeloid/erythroid ratios than patients with [ncbi.nlm.nih.gov]

In CML, the peripheral smear frequently shows immature granulocytes as well as absolute eosinophilia and basophilia. [merckmanuals.com]

Myeloproliferative Disease

Other criteria for the diagnosis of accelerated phase include: Peripheral basophilia greater than 20% Persistent thrombocytopenia (<100 x 109/L) unrelated to therapy or persistent [clinlabnavigator.com]

[…] gradual increase in leukocyte count See too many neutrophils at various stages of maturation, granulocytosis with all granulocytic precursors, and there is characteristic basophilia [quizlet.com]

Splenomegaly isthe myeloblast, and basophilia). [slideshare.net]

Polycythemia Vera

Generalized pruritus, especially following a warm shower or bath, is related to histamine release from the basophilia. [accessmedicine.mhmedical.com]

Med 2007;356:459, Haematologica 2017;102:1511 Differential diagnosis Chronic myelogenous leukemia (CML): leukocytosis (WBC ranges from 12k/L to 1,000k/L, median 100k/L), basophilia [pathologyoutlines.com]

Myelodysplasia

Cytoplasmic characteristics include variable cytoplasmic basophilia; there may or may not be granules or Auer rods but no Golgi zone is detected (Figure 1). [haematologica.org]

[…] leukemia ( C94.3- ) Type 1 Excludes: D72 ICD-10-CM Diagnosis Code D72 Other disorders of white blood cells 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes basophilia [icd10data.com]

Abnormal features that lead to recognition of promyelocytes as being dysplastic include reduced or irregular cytoplasmic basophilia, a poorly developed Golgi zone, hypergranularity [haematologica.org]

Paraneoplastic Syndrome

Patients with cancer may develop pure RBC aplasia, anemia of chronic disease, leukocytosis (leukemoid reaction), thrombocytosis, eosinophilia, basophilia, and disseminated [merckmanuals.com]

Acute Myeloid Leukemia

Blasts were smaller, with a predominance of small cells, scanty cytoplasm, moderate cytoplasmic basophilia, and variable cytoplasmic vacuolation. Wright stain, 1000×. [casesjournal.biomedcentral.com]

Blast crisis of CML • Presence of marked splenomegaly, basophilia and Philadelphia chromosome are suggestive of CML. [slideshare.net]

Acute myeloid leukemia with t(6;9) (p23;q34): association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype. [northshore.org]

Influenza

OBJECTIVE: To determine the clinical effectiveness of influenza vaccination in patients with rheumatoid arthritis (RA). METHODS: The present study was conducted by using the Taiwan National Health Insurance Research Database. In this retrospective nationwide study, we included 3748 RA patients who received[…] [ncbi.nlm.nih.gov]

Chronic Sinusitis

BACKGROUND: Chronic rhinosinusitis (CRS) is a commonly observed sequela after radiation therapy to the paranasal sinuses. The histopathologic features of radiation-induced CRS have yet to be determined and may have major implications in disease management. METHODS: A structured histopathology report was utilized[…] [ncbi.nlm.nih.gov]

Subcutaneous Abscess

Extraintestinal infestation by Enterobius vermicularis is uncommon. It has been reported to occur in the peritoneal cavity, ovary, fallopian tube, endometrium, lung, liver and urinary tract. Fine needle aspiration diagnosis was made in a case of enterobiasis presenting with a subcutaneous abscess in the natal cleft.[…] [ncbi.nlm.nih.gov]

Herpes Zoster

Nurs Womens Health. 2018 Oct;22(5):417-422. doi: 10.1016/j.nwh.2018.07.004. Epub 2018 Aug 24. Abstract Women ages 50 years and older are at risk for herpes zoster, a reactivated virus from varicella zoster virus (chickenpox) that causes a painful vesicular rash and can result in postherpetic neuralgia. It is[…] [ncbi.nlm.nih.gov]

Hereditary Spherocytosis

A 16-year-old male patient with known hereditary spherocytosis presented with a 4-day history of chest pain and lethargy. On admission, he had a low-grade fever and was grossly anaemic; examination revealed splenomegaly. An ultrasound scan confirmed splenomegaly with areas of splenic infarction. Subsequent tests[…] [ncbi.nlm.nih.gov]

Ulcerative Colitis

Abstract A 40-year-old man with a history of ulcerative colitis over 20 years was admitted to our hospital because of bloody diarrhea. Barium enema and endoscopic examination revealed two nodular tumors and many flat elevations surrounding tumors in the rectum. Total coloproctectomy was performed. H istological[…] [doi.org]

Minimal Change Nephropathy

2015 ICD-9-CM Diagnosis Code 581.3 Nephrotic syndrome with lesion of minimal change glomerulonephritis 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 581.3 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 581.3 should only be used for claims[…] [icd9data.com]

Nephrotic Syndrome

2015 ICD-9-CM Diagnosis Code 581.9 Nephrotic syndrome with unspecified pathological lesion in kidney 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 581.9 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 581.9 should only be used for claims with[…] [icd9data.com]

Hodgkin Lymphoma

The endobronchial localization of Hodgkin's disease is a rare entity which is often confused with endobronchial tuberculosis in our setting. We report the case of a 16 years old female who presented with 6 months history of dry cough, hemoptysis, dyspnea, dysphagia and dysphonia. The chest radiography showed a[…] [ncbi.nlm.nih.gov]

Varicella

Abstract Neonatal varicella is mostly caused by maternal chickenpox acquired during the last 3 weeks of pregnancy. Transplacentally transmitted infections occur in the first 10 to 12 days of life, whereas chickenpox after that time is most likely acquired by postnatal infection. If the mother develops rash between[…] [doi.org]

Myxedema

Myxedema coma occurs as a result of long-standing, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness. Myxedema coma can result from any of the causes of hypothyroidism, most commonly chronic autoimmune thyroiditis. It can also occur in patients who had thyroidectomy or[…] [emedicine.com]

Hereditary Neutrophilia

[…] leukocytosis [ loo″ko-si-to´sis ] a transient increase in the number of leukocytes in the blood, due to various causes. basophilic leukocytosis basophilia (def. 1). pathologic [medical-dictionary.thefreedictionary.com]

( > 0.2 103/uL) or basopenia Term Clinical conditions associated with change in basophils Definition basophilia associated with thyroid insufficiency, inflammatory reactions [flashcardmachine.com]

Causes of Basophilia Hypersensitivity reactions Drug and food hypersensitivity Urticaria Inflammation and infection Ulcerative colitis Rheumatoid arthritis Influenza Chickenpox [arthritisresearch.us]

Transfusion Reaction

BACKGROUND: Kpa antigen is a low incidence red blood cell antigen within the Kell system. Anti-Kpa alloantibody may be associated with acute and delayed hemolytic transfusion reactions. CASE STUDY: We report a case of a clinically significant acute extravascular hemolytic transfusion reaction mediated by previously[…] [ncbi.nlm.nih.gov]

Aggressive Systemic Mastocytosis

Summary Epidemiology It represents less than 10% of cases of SM and the global prevalence is estimated in the order of between 1/400,000 and 1/250,000. Clinical description ASM doesn't usually develop in children. Cutaneous involvement is normally absent. Patients present with severe symptoms related to mast cell[…] [orpha.net]

Atypical Chronic Myeloid Leukemia

Differs from CML due to lack of BCR-ABL by cytogenetics or RT-PCR, presence of marked granulocytic and multilineage dysplasia; anemia and thrombocytopenia are common, basophilia [pathologyoutlines.com]

We report a case of atypical chronic myeloid leukemia (aCML) who showed marked neutrophilia without dysplastic features, basophilia or monocytosis. [ncbi.nlm.nih.gov]

The hematologic features were partly myeloproliferative, partly myelodysplastic, and included myeloid hyperplasia, neutrophilia without basophilia, a relatively high number [ncbi.nlm.nih.gov]

Acute Basophilic Leukemia

Review of pre-therapy slides showed features consistent with AML-M2 with basophilia. There were no basophilic blasts. [ncbi.nlm.nih.gov]

At a Glance Basophilia is defined as an absolute increase in the number of basophils. [clinicaladvisor.com]

Earlier observations have linked bone marrow basophilia either to a deletion of the short arm of chromosome 12 (p11-13), to translocations involving the long arm of chomosome [ncbi.nlm.nih.gov]

Philadelphia Chromosome Negative Chronic Myeloid Leukemia

[…] years, respectively; P = .001), leukocytosis (153.4 +/- 135.1 v 58.5 +/- 37.7 10(9)/L, P = .002), relative monocytosis (1.8% +/- 1.2% v 5.6% +/- 1.4%, P = .048), absolute basophilia [ashpublications.org]

These patients presented with high white blood cell counts, neutrophilia, occasional basophilia, splenomegaly, and a hypercellular bone marrow with granulocytic hyperplasia [ncbi.nlm.nih.gov]

[…] patients in general are older and more often have thrombocytopenia, lower white blood cell counts, greater monocytosis, lower bone marrow myeloid:erythroid ratio, and less basophilia [medscape.com]

Hookworm Infection

Hookworm infection is a relatively common cause of anemia in endemic areas. The most common hookworm species are Ancylostoma duodenale and Necator americanus. In this report we present a case of overt gastrointestinal bleeding because of hookworm infection. Capsule endoscopy revealed many hookworms in the lumen[…] [ncbi.nlm.nih.gov]

Splenectomy

Splenic cysts are a rare pathology, which can be classified as true (25%) or pseudocysts (75%). Total splenectomy has been the treatment of choice, particularly in recent times with the advent of the laparoscopic approach. However, as the spleen is an organ with multiple immunological functions, the laparoscopic[…] [ncbi.nlm.nih.gov]

Myeloid Neoplasm Associated with FGFR1 Rearrangement

Patients with t(8;22)(p11;q11)/ BCR-FGFR1 have a higher median age (61 years) and often have neutrophilia and basophilia mimicking CML. [ajcp.oxfordjournals.org]

There was no peripheral blood monocytosis or basophilia and neither increase in bone marrow mast cells. [actamedicainternational.com]

Atypical CML • Rare, 13x109/L) with Prominent dysplasia of granulocytes (may show abnormal chromatin clumping) • No or minimal basophilia ( 28. Atypical CML 29. [slideshare.net]