Basophilia: Causes & Reasons

Possible Causes for Basophilia

[…] absolute basophil count >100 etiology of basophilia chronic myeloproliferative disorders lymphocytosis absolute lymphocyte count >4000 in adults or >8000 in children etiology [memorize.com]

PV Cellular Phase PMF ET RBC Normal or ↓ Normal, ↑ or ↓, may be hypochromatic or polychromatic ↓, teardrop cells Normal or ↓ (iron deficient anemia) WBC ↑, left shifted, basophilia [surgpathcriteria.stanford.edu]

Basophilia is also reported in hypothyroidism. [med-ed.virginia.edu]

Chronic Phase of Chronic Myeloid Leukemia

Increasing basophilia is a sign of acceleration! [amboss.com]

[…] characterized by leukocytosis and hypercellular marrow Peripheral blood leukocytosis Granulocytes at all stages of maturation Two peaks: segmented neutrophils and myelocytes Basophilia [surgpathcriteria.stanford.edu]

In addition, both the peripheral blood and bone marrow showed absolute basophilia (98.7 × 10 9 /L), including numerous basophilic precursors such as myelocytes and metamyelocytes [bloodjournal.org]

Leukemoid Reaction

In general, in a leukemoid reaction, circulating blasts or pro-myelocytes are not seen and basophilia is absent. The leukocyte alkaline phosphatase score is high. [tcd.ie]

( Basophil s >100/mm3) See Basophilia for causes Consider malignancy Consider allergic condition Images: Related links to external sites (from Bing) Ontology: Leukemoid Reaction [fpnotebook.com]

Less 3% are Myeloblast Eosinophilia & Basophilia 8.  Absolute basophilia is seen.  Hypogranular basophils were also seen. 9.  Platelets showed variation in size.  Few [slideshare.net]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant. [ncbi.nlm.nih.gov]

[…] multivariate analyses, a diagnosis-to-treatment interval of 3 years or more, splenomegaly, and peripheral blasts predicted poor major cytogenetic response; age >60 years, marrow basophilia [ncbi.nlm.nih.gov]

[…] demonstrating chromosomal translocation involving the BCR-ABL genes: t(9;22).1 Typical presentations of CML include high white count dominated by mature myeloid cells, with basophilia [archivesofpathology.org]

Chronic Myeloid Leukemia

A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia. [ncbi.nlm.nih.gov]

Patients with Ph+ AML were less likely to have splenomegaly or peripheral basophilia and had lower bone marrow cellularity and myeloid/erythroid ratios than patients with [ncbi.nlm.nih.gov]

In CML, the peripheral smear frequently shows immature granulocytes as well as absolute eosinophilia and basophilia. [merckmanuals.com]

Myeloproliferative Disease

Other criteria for the diagnosis of accelerated phase include: Peripheral basophilia greater than 20% Persistent thrombocytopenia (<100 x 109/L) unrelated to therapy or persistent [clinlabnavigator.com]

[…] gradual increase in leukocyte count See too many neutrophils at various stages of maturation, granulocytosis with all granulocytic precursors, and there is characteristic basophilia [quizlet.com]

U-BCR (p230) ABL: सामान्य neutrophilia और basophilia के साथ CML जाता है. b. [helpebookhindi.wikifoundry.com]

Polycythemia Vera

Generalized pruritus, especially following a warm shower or bath, is related to histamine release from the basophilia. [accessmedicine.mhmedical.com]

Med 2007;356:459, Haematologica 2017;102:1511 Differential diagnosis Chronic myelogenous leukemia (CML): leukocytosis (WBC ranges from 12k/L to 1,000k/L, median 100k/L), basophilia [pathologyoutlines.com]

Hypereosinophilic Syndrome

[…] filgrastim can also induce a minor increase in the number of circulating eosinophils and basophils relative to baseline; some of these patients may present with eosinophilia or basophilia [sk.glosbe.com]

[…] disorders involving the immune mechanism D72 ICD-10-CM Diagnosis Code D72 Other disorders of white blood cells 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes basophilia [icd10data.com]

[…] characteristics: elevated B12 level, abnormal leukocyte alkaline phosphatase score, splenomegaly, cytogenetic abnormalities, myelofibrosis anaemia, myeloid dysplasia and basophilia [nature.com]

Myelodysplasia

Cytoplasmic characteristics include variable cytoplasmic basophilia; there may or may not be granules or Auer rods but no Golgi zone is detected (Figure 1). [haematologica.org]

[…] leukemia ( C94.3- ) Type 1 Excludes: D72 ICD-10-CM Diagnosis Code D72 Other disorders of white blood cells 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes basophilia [icd10data.com]

Abnormal features that lead to recognition of promyelocytes as being dysplastic include reduced or irregular cytoplasmic basophilia, a poorly developed Golgi zone, hypergranularity [haematologica.org]

Paraneoplastic Syndrome

Patients with cancer may develop pure RBC aplasia, anemia of chronic disease, leukocytosis (leukemoid reaction), thrombocytosis, eosinophilia, basophilia, and disseminated [merckmanuals.com]

Acute Myeloid Leukemia

Blasts were smaller, with a predominance of small cells, scanty cytoplasm, moderate cytoplasmic basophilia, and variable cytoplasmic vacuolation. Wright stain, 1000×. [casesjournal.biomedcentral.com]

Blast crisis of CML • Presence of marked splenomegaly, basophilia and Philadelphia chromosome are suggestive of CML. [slideshare.net]

Acute myeloid leukemia with t(6;9) (p23;q34): association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype. [northshore.org]

Influenza

Vaccine. 2018 Jun 27;36(28):4095-4101. doi: 10.1016/j.vaccine.2018.05.086. Epub 2018 May 31. Author information 1 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. 2 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI,[…] [ncbi.nlm.nih.gov]

Chronic Sinusitis

BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory diseases of the nasal and paranasal cavities, either accompanied by polyp formation (CRSwNP) or without polyps (CRSsNP). The etiology and pathophysiology is unknown; some specialists define rhinitis and sinusitis as one clinical entity,[…] [ncbi.nlm.nih.gov]

Subcutaneous Abscess

Extraintestinal infestation by Enterobius vermicularis is uncommon. It has been reported to occur in the peritoneal cavity, ovary, fallopian tube, endometrium, lung, liver and urinary tract. Fine needle aspiration diagnosis was made in a case of enterobiasis presenting with a subcutaneous abscess in the natal cleft.[…] [ncbi.nlm.nih.gov]

Herpes Zoster

Vaccine. 2002 Jun 7;20(19-20):2500-7. Author information 1 Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, UK. mbrisson@phls.org.uk Abstract We present data to confirm that exposure to varicella boosts immunity to herpes-zoster. We show that exposure to varicella is greater in adults[…] [ncbi.nlm.nih.gov]

Hereditary Spherocytosis

In HS, intrinsic defects in erythrocyte membrane proteins result in RBC cytoskeleton instability. Loss of erythrocyte surface area leads to the production of spherical RBCs (spherocytes), which are culled rapidly from the circulation by the spleen. [6] Hemolysis primarily is confined to the spleen and, therefore, is[…] [emedicine.medscape.com]

Ulcerative Colitis

Although extraintestinal manifestations of inflammatory bowel diseases are not uncommon, few reports have described concurrent idiopathic thrombocytopenic purpura (ITP). Spontaneous pneumomediastinum is also a rare complication of ulcerative colitis (UC). This report describes the case of a 14-year-old boy who[…] [ncbi.nlm.nih.gov]

Minimal Change Nephropathy

From Wikidata Jump to navigation Jump to search Human disease Minimal Change Glomerulonephritis Minimal change disease (disorder) Nephrotic syndrome with Lesion of Minimal Change Glomerulonephritis Nephrotic syndrome with lesion of minimal change glomerulonephritis Nephrotic syndrome with lesion of minimal change[…] [wikidata.org]

Nephrotic Syndrome

Kimura disease is a rare benign, chronic inflammatory disorder that typically presents with slowly enlarging, nontender, subcutaneous swellings in the head and neck region. The occurrence of Kimura disease in the oral cavity is extremely rare. A 16-year-old boy presented with a complaint of a right painless buccal[…] [ncbi.nlm.nih.gov]

Hodgkin Lymphoma

The endobronchial localization of Hodgkin's disease is a rare entity which is often confused with endobronchial tuberculosis in our setting. We report the case of a 16 years old female who presented with 6 months history of dry cough, hemoptysis, dyspnea, dysphagia and dysphonia. The chest radiography showed a[…] [ncbi.nlm.nih.gov]

Varicella

Does the use of calamine or antihistamine provide symptomatic relief from pruritus in children with varicella zoster infection? Marc Tebruegge, Specialist Registrar 1, Minju Kuruvilla, Specialist Registrar 2, Isabel Margarson, Consultant Paediatrician 3 1 London Deanery, Department of Paediatrics, Southend University[…] [adc.bmj.com]

Myxedema

Ureteral myxedema is exceptionally rare. We describe computed tomography and magnetic resonance imaging findings in a case of ureteral myxedema. The demonstration of water-like hyperintensity around the ureteral lumen on heavily T2-weighted sequences should be considered a strongly suggestive sign for ureteral[…] [ncbi.nlm.nih.gov]

Hereditary Neutrophilia

[…] leukocytosis [ loo″ko-si-to´sis ] a transient increase in the number of leukocytes in the blood, due to various causes. basophilic leukocytosis basophilia (def. 1). pathologic [medical-dictionary.thefreedictionary.com]

( > 0.2 103/uL) or basopenia Term Clinical conditions associated with change in basophils Definition basophilia associated with thyroid insufficiency, inflammatory reactions [flashcardmachine.com]

Causes of Basophilia Hypersensitivity reactions Drug and food hypersensitivity Urticaria Inflammation and infection Ulcerative colitis Rheumatoid arthritis Influenza Chickenpox [arthritisresearch.us]

Transfusion Reaction

Transfusion reaction is a general term to describe any adverse reaction of the immune system of a patient after receiving blood products. The clinical picture varies with the underlying TR. While acute hemolytic TR are often characterized by fever and chills, flushing, hypotension, in severe cases dyspnea and[…] [symptoma.com]

Aggressive Systemic Mastocytosis

Abstract Systemic mastocytosis is a rare and occasionally aggressive condition that raises major diagnostic challenges. We report a case in a 72-year-old patient in whom the diagnosis of malignant mastocytosis required two bone marrow smears and three bone marrow biopsies examined using specific staining[…] [ncbi.nlm.nih.gov]

Atypical Chronic Myeloid Leukemia

Differs from CML due to lack of BCR-ABL by cytogenetics or RT-PCR, presence of marked granulocytic and multilineage dysplasia; anemia and thrombocytopenia are common, basophilia [pathologyoutlines.com]

We report a case of atypical chronic myeloid leukemia (aCML) who showed marked neutrophilia without dysplastic features, basophilia or monocytosis. [ncbi.nlm.nih.gov]

The hematologic features were partly myeloproliferative, partly myelodysplastic, and included myeloid hyperplasia, neutrophilia without basophilia, a relatively high number [ncbi.nlm.nih.gov]

Acute Basophilic Leukemia

At a Glance Basophilia is defined as an absolute increase in the number of basophils. [clinicaladvisor.com]

Review of pre-therapy slides showed features consistent with AML-M2 with basophilia. There were no basophilic blasts. [ncbi.nlm.nih.gov]

Earlier observations have linked bone marrow basophilia either to a deletion of the short arm of chromosome 12 (p11-13), to translocations involving the long arm of chomosome [ncbi.nlm.nih.gov]

Philadelphia Chromosome Negative Chronic Myeloid Leukemia

[…] years, respectively; P = .001), leukocytosis (153.4 +/- 135.1 v 58.5 +/- 37.7 10(9)/L, P = .002), relative monocytosis (1.8% +/- 1.2% v 5.6% +/- 1.4%, P = .048), absolute basophilia [ashpublications.org]

These patients presented with high white blood cell counts, neutrophilia, occasional basophilia, splenomegaly, and a hypercellular bone marrow with granulocytic hyperplasia [ncbi.nlm.nih.gov]

Ph-negative BCR-positive CML and Ph-positive CML were significantly younger, had a significantly higher incidence of leukocytosis, thrombocytosis, and peripheral and marrow basophilia [ncbi.nlm.nih.gov]

Hookworm Infection

Summary This study extended the association between hookworm transmission in KwaZulu‐Natal and the sandy coastal plain by investigating the parasite's occurrence in isolated areas of sandy soils further inland. A school‐based prevalence survey was carried out in selected inland sandy areas and in surrounding[…] [doi.org]

Splenectomy

The traumatic rupture of an accessory spleen is a very rare condition and only few cases have been reported in the literature. We describe the case of a 51-year-old man undergone splenectomy for trauma several years before, who developed hemoperitoneum due to a laceration of a voluminous accessory spleen,[…] [ncbi.nlm.nih.gov]