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91 Possible Causes for Basophilia, Eosinophils Increased, Thrombocytosis

  • Myeloproliferative Disease

    & basophil counts increased -Absolute lymphocytes & monocytes may be normal.[] One patient clearly represents a case of RARS with reactive thrombocytosis.[] Other criteria for the diagnosis of accelerated phase include: Peripheral basophilia greater than 20% Persistent thrombocytopenia ( 1000 x 109/L) unresponsive to therapy;[]

  • Chronic Myeloid Leukemia

    Basophils and eosinophils are also elevated. Hematocrit is usually normal with normal RBC morphology. Platelets are usually increased.[] Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[] 36.22 (normal 2.0 - 6.8) Basophils (2%) 1.68 (normal 0.2) The peripheral smear demonstrated increased numbers of neutrophils and neutrophil precursors (Images 1 and 2 ), basophilia[]

  • Polycythemia Vera

    To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[] Blood CML PV Cellular Phase PMF ET RBC Normal or Normal, or , may be hypochromatic or polychromatic , teardrop cells Normal or (iron deficient anemia) WBC , left shifted, basophilia[] Polycythemia vera (PV) and essential thrombocytosis (ET) are hematological disorders characterized by excessive production of mature and functional blood cells.[]

  • Acute Myelocytic Leukemia

    Variant: M4e variant in which eosinophils ( 5%) are increased in number and abnormal associated with abnormalities of chromosome 16 .[] Here we report a case of AML with thrombocytosis arising in a patient with this syndrome.[] Blasts were smaller, with a predominance of small cells, scanty cytoplasm, moderate cytoplasmic basophilia, and variable cytoplasmic vacuolation. Wright stain, 1000 .[]

  • Chronic Phase of Chronic Myeloid Leukemia

    Increased numbers of basophils and eosinophils in the blood—Patients with an increase in these types of white blood cells have a less favorable prognosis.[] Extreme thrombocytosis was present, although no evidence of acquired von Willebrand disorder was found.[] […] hematological disturbances manifest in dyspnea, transient ischemic attacks, or cerebrovascular accidents (related to leukostasis), gastrointestinal bleedings (related to basophilia[]

  • Paraneoplastic Syndrome

    Lymphoma may be a cause of secondary thrombocytosis. Renal Paraneoplastic Syndrome About 10% patinets with idiopathic nephrotic syndrome have an underlying maligancy.[] […] paraneoplastic syndromes Patients with cancer may develop pure RBC aplasia , anemia of chronic disease , leukocytosis (leukemoid reaction), thrombocytosis, eosinophilia, basophilia[] Many haematologic conditions, including anaemia, leucocytosis, thrombocytopenia or thrombocytosis, coagulapathy have been reported in association with cancer.[]

  • Eosinophilia Myalgia Syndrome

    Further studies of the interaction of eosinophils, inflammatory cells, and fibroblasts may increase the understanding of the pathogenesis of the eosinophilia-myalgia syndrome[] The clinical constellation of leukocytosis, thrombocytosis, and low or absent stainable neutrophil alkaline phosphatase (NAP) is considered characteristic of chronic myelogenous[] Laboratory abnormalities included peripheral eosinophilia, leukocytosis, thrombocytosis, raised erythrocyte sedimentation rate, and elevated serum levels of aldolase, lactate[]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Basophils and eosinophils are almost universally increased; this feature may help differentiate CML from a leukemoid reaction .[] Here we report a case of coexistence of BCR-ABL1 fusion gene and CALR mutation, diagnosed due to persistent thrombocytosis while the patient was in treatment-free, complete[] Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant.[]

  • Ulcerative Colitis

    A complete blood count which includes anemia (hemoglobin 14 g/dL in males and 12 g/dL in females) and thrombocytosis (platelet count 350,000/µL) should be done.[] Other possible laboratory abnormalities include leukocytosis, thrombocytosis, and elevated acute-phase reactants (eg, ESR, C-reactive protein).[]

  • Eosinophilic Leukemia

    Lynh Nguyen: Moderately degranulated eosinophils Patient with longstanding hypereosinophilia Circulating abnormal eosinophils Marked increased eosinophils Immunophenotype[] […] leukemia Other Histiocytosis CFU-Baso AML Acute basophilic CFU-Eos AML Acute eosinophilic MP Chronic eosinophilic leukemia / Hypereosinophilic syndrome MEP CFU-Meg MP Essential thrombocytosis[] Bone marrow aspirate showed severe eosinophilia and mild basophilia.[]

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