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144 Possible Causes for Basophilia, Thrombocytosis

  • Polycythemia Vera

    To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[ncbi.nlm.nih.gov] Blood CML PV Cellular Phase PMF ET RBC Normal or Normal, or , may be hypochromatic or polychromatic , teardrop cells Normal or (iron deficient anemia) WBC , left shifted, basophilia[surgpathcriteria.stanford.edu] Polycythemia vera (PV) and essential thrombocytosis (ET) are hematological disorders characterized by excessive production of mature and functional blood cells.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    One patient clearly represents a case of RARS with reactive thrombocytosis.[ncbi.nlm.nih.gov] Other criteria for the diagnosis of accelerated phase include: Peripheral basophilia greater than 20% Persistent thrombocytopenia ( 1000 x 109/L) unresponsive to therapy;[clinlabnavigator.com] As controls we considered 61 patients with reactive thrombocytosis referred to our Department in the same period of time.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] 36.22 (normal 2.0 - 6.8) Basophils (2%) 1.68 (normal 0.2) The peripheral smear demonstrated increased numbers of neutrophils and neutrophil precursors (Images 1 and 2 ), basophilia[path.upmc.edu] In CML, the peripheral smear frequently shows immature granulocytes as well as absolute eosinophilia and basophilia.[merckmanuals.com]

  • Paraneoplastic Syndrome

    Lymphoma may be a cause of secondary thrombocytosis. Renal Paraneoplastic Syndrome About 10% patinets with idiopathic nephrotic syndrome have an underlying maligancy.[allaboutblood.com] […] paraneoplastic syndromes Patients with cancer may develop pure RBC aplasia , anemia of chronic disease , leukocytosis (leukemoid reaction), thrombocytosis, eosinophilia, basophilia[merckmanuals.com] Many haematologic conditions, including anaemia, leucocytosis, thrombocytopenia or thrombocytosis, coagulapathy have been reported in association with cancer.[jpccr.eu]

  • Acute Myelocytic Leukemia

    Here we report a case of AML with thrombocytosis arising in a patient with this syndrome.[ncbi.nlm.nih.gov] Blasts were smaller, with a predominance of small cells, scanty cytoplasm, moderate cytoplasmic basophilia, and variable cytoplasmic vacuolation. Wright stain, 1000 .[casesjournal.biomedcentral.com] Trisomy 21: Down syndrome Defective DNA repair: Bloom syndrome, Fanconi anemia , and ataxia-telangiectasia Myeloproliferative syndromes: Polycythemia Vera , and essential thrombocytosis[lecturio.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    Extreme thrombocytosis was present, although no evidence of acquired von Willebrand disorder was found.[ncbi.nlm.nih.gov] […] hematological disturbances manifest in dyspnea, transient ischemic attacks, or cerebrovascular accidents (related to leukostasis), gastrointestinal bleedings (related to basophilia[symptoma.com] An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in[ncbi.nlm.nih.gov]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Here we report a case of coexistence of BCR-ABL1 fusion gene and CALR mutation, diagnosed due to persistent thrombocytosis while the patient was in treatment-free, complete[sci.amegroups.com] Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant.[ncbi.nlm.nih.gov] Diagnostic methods A histologic analysis of a peripheral smear will display immature granulocytes as well as eosinophilia and basophilia.[symptoma.com]

  • Splenectomy

    We present a guideline about digital replantation when thrombocytosis is expected.[ncbi.nlm.nih.gov] Further investigations diagnosed pseudohyperkalaemia, one of the causes of which is thrombocytosis secondary to splenectomy.[ncbi.nlm.nih.gov] For example, Rostagno et al 12 described a patient who suffered CTEPH associated with long standing thrombocytosis but, when the thrombocytosis was treated, there was improvement[thorax.bmj.com]

  • Nephrotic Syndrome

    Antiplatelet therapy was instituted with dipyridamole to prevent thromboembolism from the combination of nephrotic syndrome and thrombocytosis.[ncbi.nlm.nih.gov] Laboratory investigations showed low hemoglobin 79 g/L, low mean corpuscular volume 53 fL, thrombocytosis 973 109/L, and marked hypochromia and microcytosis, with low iron[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[ncbi.nlm.nih.gov] Soon after splenectomy, progressive basophilia (32.3 x 10(9)/L) developed, infiltrating the skin as well as the bone marrow.[ncbi.nlm.nih.gov] Haematological investigations revealed thrombocytosis, leucocytosis and peripheral blood smear showed a leucoerythroblastic picture. JAK 2 mutation was positive.[ncbi.nlm.nih.gov]

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