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137 Possible Causes for Basophils Increased, Hypercellular Bone Marrow

  • Chronic Myeloid Leukemia

    Basophils may increase, and granulocyte maturation may be defective. The proportion of immature cells and the leukocyte alkaline phosphatase score may increase.[merckmanuals.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Megakaryocytes are prominent and may be increased Mild reticulin fibrosis The goals of treatment of chronic myeloid leukemia are to achieve hematologic, cytogenetic, and[symptoma.com]

  • Myeloproliferative Disease

    .  Elevated granulocyte count, mostly mature but with some left shift  Increased basophils  Splenomegaly  Increased platelets  Single genetic change 26.[slideshare.net] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] […] counts increased -Absolute lymphocytes & monocytes may be normal.[quizlet.com]

  • Polycythemia Vera

    Pruritus results from increased histamine levels released from increased basophils and mast cells and can be exacerbated by a warm bath or shower.[emedicine.medscape.com] bone marrow 5.[slideshare.net] Pruritus also results from increased histamine levels due to increased basophils and mast cells. This occurs in up to 40% of patients with polycythemia vera.[symptoma.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    Differential showed neutrophilia with increased basophils (2%), eosinophils (1.5%), and left shift including myeloblasts (3%).[ncbi.nlm.nih.gov] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Increased numbers of basophils and eosinophils in the blood—Patients with an increase in these types of white blood cells have a less favorable prognosis.[lls.org]

  • Secondary Polycythemia

    Increased leucocytosis is seen in more than half of the patients and even may see increased basophils. Increased neutrophil alkaline phosphatase score (NAP).[labpedia.net] The renal biopsy revealed membranous nephropathy, and the bone marrow biopsy disclosed hypercellular marrow with mild panhyperplasia.[ncbi.nlm.nih.gov] Bone marrow is hypercellular with prominent megakaryocytes. Serum erythropoietin level is usually low. Blood viscosity is increased.[labpedia.net]

  • Hereditary Spherocytosis

    […] and basophils are commonly seen, neutrophil alkaline phosphatase positive rate is 1%, score 2.[degruyter.com] Bone marrow test shows extremely active proliferation, Myeloid: erythroid ratio is 8:1, all stages of myeloid cells are increased, especially late promyelocytes, eosinophils[degruyter.com]

  • Myelodysplasia

    basophils or monocytes; rarely monocytic nodules ( Am J Clin Pathol 2003;120:874 ); myeloid cells are myeloperoxidase negative; note that in ALIP, aggregates (3 - 5) or clusters[pathologyoutlines.com] The myelodysplastic syndrome (MDS) is group of disorders typified by peripheral cytopenia, dysplastic hematopoietic progenitors, a hypercellular bone marrow, and a high risk[msdmanuals.com] The bone marrow can be hypocellular or hypercellular.[merckmanuals.com]

  • Chronic Neutrophilic Leukemia

    Increased Not increased Not increased Not increased Blood monocytes Variable,** 3 /μL Variable, 3 /μL Always 1x10 3 /μL 3 /μL Blood immature granulocytes 20% 10-20% Usually[surgpathcriteria.stanford.edu] bone marrow with predominant neutrophilic granulopoiesis (M:E is 20:1 or more), the number of myeloblasts and promyelocytes is not increased, myelocytes and mature neutrophils[atlases.muni.cz] Basophils and monocytes are not typically increased. The bone marrow is hypercellular with CNL. However, dysplasia and fibrosis are usually not present.[labce.com]

  • Acute Myelocytic Leukemia

    The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow.[lecturio.com] marrow biopsy: Markedly hypercellular marrow with heterogeneous cells, including immature monocytes (irregular nuclei and prominent nucleoli) and neutrophils Stains: Chloroacetate[pathologyoutlines.com] When the bone marrow is hypercellular or normocellular and easy to aspirate, bone marrow biopsy is usually not essential and cytological examination of smears is sufficient[atlasgeneticsoncology.org]

  • Chronic Eosinophilic Leukemia

    Peripheral blood (PB) smear also showed increased number of eosinophils ( Fig. 1A ). Blood urine nitrogen (BUN) and creatinine levels were within reference ranges.[synapse.koreamed.org] Histology Hypercellular bone marrow with predominatnt eosinophilic proliferation, the number of myeloblasts may be increased between 5 – 19%, Charcot-Leyden crystals are often[atlases.muni.cz] […] their precursors (c) Bone marrow core biopsy showing hypercellularity with a greater than 90% cell to fat ratio (d) Bone marrow core biopsy demonstrating sheets of eosinophils[sciforschenonline.org]

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