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434 Possible Causes for Beta Thalassemia, Hepatomegaly

  • Thalassemia

    Figure 1 Probability of OS by age and hepatomegaly. Figure 2 Probability of DFS by age and hepatomegaly.[doi.org] Other forms include BT associated with Hb anomalies (HbE - beta-thalassemia resulting in BTI or less frequently BT-major, HbC - beta-thalassemia, delta-beta-thalassemia and[orpha.net] Beta-thalassemias can be classified into: Thalassemia intermedia Thalassemia minor Beta-thalassemia with associated Hb anomalies HbC/Beta-thalassemia HbE/Beta-thalassemia[doi.org]

  • Cooley's Anemia

    Abdominal imaging such as ultrasound scanning, MRI, or CT may show gallstones, liver cirrhosis, and hepatomegaly.[symptoma.com] How is beta thalassemia treated?[hopkinsmedicine.org] Hepatomegaly can result from a number of mechanisms; extramedullary erthyropoiesis, hepatitis due to chronic transfusion associated infections, and iron overload.[pathophys.org]

  • Alpha Thalassemia

    Concurrent alpha thalassemia might be a protective trait against significant hepatomegaly in sickle cell anaemia patients more than 60 months of age at Mulago hospital.[ncbi.nlm.nih.gov] beta-thalassemia minor.[ncbi.nlm.nih.gov] He also had moderate anemia, hepatomegaly and hypospadias.[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    Additional autopsy findings included cardiomegaly with a heart weight of 450 gm (312 78), right atrial and right ventricular chamber dilatation, and hepatomegaly with a liver[ncbi.nlm.nih.gov] Although PXE tissue changes are thought to develop in the absence of ABCC6 mutations in patients with beta-thalassemia, ABCC6 mutations have not been well evaluated among[ncbi.nlm.nih.gov] Hepatomegaly was seen in 28.6% of the subjects.[doi.org]

  • Hemochromatosis

    […] transferrin saturation (TS); ALT; AST; GGT; elevated C-reactive protein; ß-thalassemia; neutrophils; lymphocytes; monocytes; platelets; metacarpophalangeal joint hypertrophy; hepatomegaly[ncbi.nlm.nih.gov] RESULTS: In case 1, we detected heterozygosity for a novel HJV mutation (g.3659_3660insG), which was inherited together with the beta thalassemia trait from the father, who[ncbi.nlm.nih.gov] Eight of the 16 homozygous subjects had clinical findings that were consistent with the presence of hereditary hemochromatosis, such as hepatomegaly, skin pigmentation, and[ncbi.nlm.nih.gov]

  • Cholelithiasis

    Abstract Sickle cell intrahepatic cholestasis (SCIC) is a rare complication seen in sickle cell patients who present with sudden onset of RUQ pain, progressive hepatomegaly[ncbi.nlm.nih.gov] […] fever Right upper quadrant pain There may be Yang jaundice that is bright and sometimes itches Anorexia Tendency toward Liver enlargement Dry stools Yellow urine Jaundice Hepatomegaly[americandragon.com]

  • Heart Failure

    A physical examination revealed a systolic murmur, which was best audible in the right parasternal side, ascites, and hepatomegaly.[ncbi.nlm.nih.gov] […] to increased deposition of iron in the heart and occurs with common genetic disorders such as primary hemochromatosis or with lifetime transfusion requirements as seen in beta-thalassemia[doi.org] We report the case of a 41-year-old female patient admitted to the Department of Cardiology with clinical signs of right heart failure: congested jugular veins, hepatomegaly[ncbi.nlm.nih.gov]

  • Congestive Heart Failure

    Right upper quadrant sonogram revealed hepatomegaly of 15 cm, trace amount of perihepatic ascites, pericholecystic fluid, and also thickened edematous gallbladder wall with[ncbi.nlm.nih.gov] […] to increased deposition of iron in the heart and occurs with common genetic disorders such as primary hemochromatosis or with lifetime transfusion requirements as seen in beta-thalassemia[doi.org] Cardiac examination at the age of 6 years revealed constrictive pericarditis with significant elevation of atrial filling pressures, consecutive hepatomegaly, and protein[ncbi.nlm.nih.gov]

  • Cardiomyopathy

    Additional symptoms may include fluid collection in the abdomen (ascites) and feet due to accumulation of fluid, congestion of the lungs, and an abnormally large liver (hepatomegaly[rarediseases.org] Mavrogeni SI, Markussis V, Kaklamanis L et al (2005) A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with beta-thalassemia[link.springer.com]

  • Liver Cirrhosis

    Cardinal symptoms include fasting hypoglycemia, lactic acidosis and hepatomegaly as well as neutropenia.[ncbi.nlm.nih.gov] Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia.[ncbi.nlm.nih.gov] […] aminotransferase, and prothrombin international normalized ratio; LR, 0.09; 95% CI, 0.03-0.31); a platelet count 160 x 10(3)/μL (LR, 0.29; 95% CI, 0.20-0.39); or the absence of hepatomegaly[ncbi.nlm.nih.gov]

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