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71 Possible Causes for Bicarbonate Decreased, Cognitive Defect

  • Acidosis

    Labs: General Arterial Blood Gas Arterial pH decreased Serum bicarbonate decreased PaCO2 decreased PaCO2 drops 1.2 mmHg per 1 meq/L bicarbonate fall Calculated PaCO2 1.5 x[fpnotebook.com] A persistent decrease in the rate of renal bicarbonate reabsorption that maintains the decreased plasma bicarbonate level. c.[slideshare.net] Decreased in increased Anion Gap Metabolic Acidosis Bicarbonate decrease matches Anion Gap increase Urinalysis with Urine pH Urine pH 6: Suggests Renal cause Urine pH Urine[fpnotebook.com]

  • Acute Alcohol Intoxication

    […] in serum bicarbonate concentration.[cjasn.asnjournals.org] Accumulation of the alcohols in the blood can cause an increment in the osmolality, and accumulation of their metabolites can cause an increase in the anion gap and a decrease[cjasn.asnjournals.org]

  • Hyponatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] […] mannitol use Correct glucose level, stop mannitol use Renal tubular acidosis Urinary osmolar gap, increased urinary pH, urinary sodium 25 mEq per L, fractional excretion of bicarbonate[aafp.org]

  • Chronic Kidney Insufficiency

    Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium; so, doctors[nutritionfacts.org] Moderate metabolic acidosis (plasma bicarbonate content 15 to 20 mmol/L) is characteristic.[merckmanuals.com] Potassium may be high and bicarbonate levels may be low if you have CKD. There may also be an increase of acid in the blood.[healthline.com]

  • Hypercapnia

    The increase in PaCO 2 , in turn, decreases the bicarbonate (HCO 3 – )/PaCO 2 ratio, thereby decreasing the pH.[emedicine.medscape.com] The renal system participates in acid-base regulation by increasing or decreasing levels of bicarbonate (HCO3-).[rtmagazine.com] Bicarbonate does indeed cause a transient elevation in pCO2, but this will be blown off over time (with a decrease back to the previous equilibrium pCO2 levels).[emcrit.org]

  • Drug-induced Hypoglycemia

    Drugs leading to loss of bicarbonate in the gastrointestinal (GI) tract or kidney 3. Drugs causing increased endogenous acid production 4.[f1000research.com] Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 1994;43:1426–34. Fanelli C, Pampanelli S, Epifano L, et al.[guidelines.diabetes.ca] Drugs that decrease renal acid excretion Some medications cannot be placed into one single category, as they possess multiple mechanisms that can cause metabolic acidosis.[f1000research.com]

  • Hypercalcemia

    Ionized calcium Albumin Creatinine Serum bicarbonate (milk-alkali syndrome) Serum phosphorous (decreased in primary hyperparathyroidism) Intact PTH: If laboratory evidence[clinicaladvisor.com]

  • Diabetic Ketotic Coma

    Indeed this is much higher then expected given the relatively modest decrease in bicarbonate.[anaesthesiamcq.com] Moreover, several deleterious effects of bicarbonate therapy have been reported, such as increased risk of hypokalemia, decreased tissue oxygen uptake, and cerebral edema.[endocrinologyadvisor.com] Nine small studies have evaluated the effect of alkalinization in a total of 434 patients with DKA, 217 treated with bicarbonate, and 178 patients without alkali therapy.[endocrinologyadvisor.com]

  • Heat Stroke

    Alkalinizing agents: These medicines, such as potassium and sodium bicarbonate, decrease the amount of acid in your blood and urine. This helps prevent organ damage.[drugs.com]

  • Cerebral Edema

    In addition, bicarbonate therapy causes central nervous system hypoxia in laboratory animals with diabetic ketoacidosis. 33 Hyperglycemia superimposed on an ischemic insult[nejm.org] Theories include osmotic disequilibrium between brain and plasma as glucose is rapidly lowered, decreased plasma oncotic pressure due to infusion of large amounts of saline[ncbi.nlm.nih.gov] […] children with diabetic ketoacidosis is related to brain ischemia. 24,32 Both hypocapnia, which causes cerebral vasoconstriction, and extreme dehydration would be expected to decrease[nejm.org]

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