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16 Possible Causes for Bicarbonate Decreased, Cognitive Defect, Hyperpnea

  • Acidosis

    Labs: General Arterial Blood Gas Arterial pH decreased Serum bicarbonate decreased PaCO2 decreased PaCO2 drops 1.2 mmHg per 1 meq/L bicarbonate fall Calculated PaCO2 1.5 x[] The most characteristic sign is hyperpnea (long, deep breaths at a normal rate), reflecting a compensatory increase in alveolar ventilation; this hyperpnea is not accompanied[] A persistent decrease in the rate of renal bicarbonate reabsorption that maintains the decreased plasma bicarbonate level. c.[]

  • Chronic Kidney Insufficiency

    Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium; so, doctors[] Moderate metabolic acidosis (plasma bicarbonate content 15 to 20 mmol/L) is characteristic.[] Potassium may be high and bicarbonate levels may be low if you have CKD. There may also be an increase of acid in the blood.[]

  • Diabetic Ketotic Coma

    Indeed this is much higher then expected given the relatively modest decrease in bicarbonate.[] […] ketoacidosis is the same as for diabetes mellitus. diabetic ketoacidosis A hyperglycemia-induced clinical crisis most common in type 1 DM Clinical N&V, thirst, diaphoresis, hyperpnea[] Many clinicians have observed worsening of acidemia, as evidenced by decreased serum bicarbonate concentration, after aggressive resuscitation with normal saline.[]

  • Hyponatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[] 65 mEq/L. 49 In the stool, average sodium concentration is 40 mEq/L, and potassium, 90 mEq/L. 50 Water and solute losses increase in sweating, vomiting, or diarrhea and hyperpnea[] […] mannitol use Correct glucose level, stop mannitol use Renal tubular acidosis Urinary osmolar gap, increased urinary pH, urinary sodium 25 mEq per L, fractional excretion of bicarbonate[]

  • Acute Renal Failure

    […] buildup of potassium Sodium bicarbonate is used to decrease acid buildup Acute Kidney Failure Follow-up The doctor will arrange follow-up visits as needed for the underlying[] The individual's ability to live with multisystem diseases, cope with ensuing problems, and care for himself are markedly diminished. failure of artificial pacemaker A defect[] Sodium bicarbonate hydration improves urinary alkalinization, as opposed to normal saline hydration, which presumably works by decreasing the concentration of contrast media[]

  • Hypernatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[] Common symptoms in infants include hyperpnea, muscle weakness, restlessness, a characteristic high-pitched cry, insomnia, lethargy, and even coma.[] Lastly, rarer causes of hypernatremia in the elderly population include sodium overload from iatrogenic excessive administration of sodium bicarbonate or hypertonic saline[]

  • High Altitude Cerebral Edema

    It is a carbonic anhydrase inhibitor that causes a bicarbonate diuresis and metabolic acidosis.[] It is characterized by periods of hyperpnea followed by apnea. Apneic duration is commonly 3-10 seconds, but may be up to 15 seconds.[] It increases the hypoxic ventilatory response, decreases CSF production and may also have effects on the perripheral chemoreceptors. It is usually well tolerated.[]

  • Tetralogy of Fallot

    (increases venous return and may decrease heart rate) Correction of acidosis: sodium bicarbonate 1–2 mmol/kg IV (ensure adequate ventilation) Beta-blockers , (decreases heart[] These spells are characterized by a paroxysm of hyperpnea, irritability or agitation, and prolonged crying, leading to worsening cyanosis.[] , vertebral and ocular anomalies, cognitive deficits, characteristic facies and right-sided heart defects, predominantly peripheral pulmonic stenosis (PPS) ( 3 ).[]

  • Hypoventilation

    Renal function adapts by an increased reabsorption of bicarbonate, but this is necessarily accompanied by retention of sodium [ 18 ] and, thus, fluid retention and eventual[] In the first cycle, the interevent hyperpnea is sufficient to excrete the carbon dioxide accumulated during hypopnea.[] Of note, other known genetic defects of pituitary development are frequently associated with mental retardation (such as FOXE-1 / FKHL15 and NKX2.1 ( 13 )).[]

  • Organic Aciduria

    -oxoprolinuria; 266130, 231900) Glutathione synthetase GSS (20q11.2)* Biochemical profile: Elevated urinary, plasma, and CSF 5-oxoproline; increased γ -glutamylcysteine; decreased[] Physical ExaminationThe physical exam of patients with IEM is usually normal except for nonspecific findings such as lethargy, coma, apnea or hyperpnea, seizures, hypotonia[] PubMed Google Scholar Gropman AL, Batshaw ML: Cognitive outcome in urea cycle disorders. Mol Genet Metab. 2004, 81 (Suppl 1): S58-S62.[]

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