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26 Possible Causes for Bicarbonate Decreased, Cognitive Defect, Hyporeflexia

  • Acute Alcohol Intoxication

    […] in serum bicarbonate concentration.[cjasn.asnjournals.org] Accumulation of the alcohols in the blood can cause an increment in the osmolality, and accumulation of their metabolites can cause an increase in the anion gap and a decrease[cjasn.asnjournals.org]

  • Hyponatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] Apart from reduced muscle power (4/5) and hyporeflexia, the neurological examination was normal.[ncbi.nlm.nih.gov] […] mannitol use Correct glucose level, stop mannitol use Renal tubular acidosis Urinary osmolar gap, increased urinary pH, urinary sodium 25 mEq per L, fractional excretion of bicarbonate[aafp.org]

  • Chronic Kidney Insufficiency

    Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium; so, doctors[nutritionfacts.org] Moderate metabolic acidosis (plasma bicarbonate content 15 to 20 mmol/L) is characteristic.[merckmanuals.com] Potassium may be high and bicarbonate levels may be low if you have CKD. There may also be an increase of acid in the blood.[healthline.com]

  • Hypercalcemia

    Ionized calcium Albumin Creatinine Serum bicarbonate (milk-alkali syndrome) Serum phosphorous (decreased in primary hyperparathyroidism) Intact PTH: If laboratory evidence[clinicaladvisor.com] Anxiety Psychotic symptoms: hallucination CNS depression, somnolence and eventually coma do occur at high levels Hypotonia and hyporeflexia Can mimic focal neurological lesions[broomedocs.com] This results in diminished deep tendon reflexes (hyporeflexia), and skeletal muscle weakness.[en.wikipedia.org]

  • Oculocerebrorenal Syndrome

    Low bicarbonate levels Compensatory decrease in PCO2 levels Raised serum creatinine levels Serum markers: Rise in AST LDH Creatinine kinase Acid phosphatase T4, TSH levels[wikidoc.org] Neurological features Hyporeflexia and hypotonia are usual features. 'Ragged red fibre' muscle pathology has been described.[patient.info] None of the patients we examined were institutionalized, but the group had a broad range of cognitive defects.[doi.org]

  • Renal Tubular Acidosis

    […] resorption Decrease in aldosterone secretion or activity Plasma bicarbonate (mEq/L or mmol/L) Frequently 15, occasionally 10 Usually 12–20 Usually 17 Plasma potassium Usually[msdmanuals.com] The signs and symptoms of hypokalemia, such as muscle weakening, hyporeflexia, and paralysis, are evident, especially in the already mentioned Type 1 and Type 2 RTA.[symptoma.com] Other features include developmental delay, short stature, cognitive defects, and a history of multiple fractures by adolescence.[doi.org]

  • Combined Oxidative Phosphorylation Defect Type 11

    Metabolic acidosis Metabolic acidosis is defined as a state of decreased systemic pH resulting from either a primary increase in hydrogen ion (H ) or a reduction in bicarbonate[emedicine.medscape.com] Clinical features Neonatal forms present with severe hypotonia, weakness and hyporeflexia. Respiratory failure develops.[mrineonatalbrain.com] Treatment: See Beta-oxidation Defects . Links: OMIM Long Name: Mitochondrial Encephalomyopathy Lactic Acidosis and Strokelike Episodes.[umdf.org]

  • Hypocalcemia

    RESULTS: Among controls, hypocalcemia elicited a major rise in intact PTH (iPTH) levels 4 minutes after bicarbonate infusion.[ncbi.nlm.nih.gov] […] include: -Poor feeding -Vomiting -Constipation -Abdominal Pain -Hypertension -Altered mental status In more severe cases of hypercalcemia, findings can include: -Hypotonia -Hyporeflexia[clinicaladvisor.com] Cognitive defects such as mental retardation and memory impairment have been encountered.[web.archive.org]

  • Hyperalaninemia

    -oxoprolinuria; 266130, 231900) Glutathione synthetase GSS (20q11.2)* Biochemical profile: Elevated urinary, plasma, and CSF 5-oxoproline; increased γ -glutamylcysteine; decreased[merckmanuals.com] Macrocephaly,peripheral neuropathy,hyporeflexia. Adult syndrome consists of leukodysrophy, cortical blindness, and spasticity. Peripheral neuropathy is rare.[cmdg.org] Clinically, affected individuals show an L-DOPA-responsive, diurnally fluctuating movement disorder usually associated with cognitive delay and severe neurologic dysfunction[mendelian.co]

  • Combined Oxidative Phosphorylation Defect Type 13

    Metabolic acidosis Metabolic acidosis is defined as a state of decreased systemic pH resulting from either a primary increase in hydrogen ion (H ) or a reduction in bicarbonate[emedicine.medscape.com] Treatment: See Beta-oxidation Defects . Links: OMIM Long Name: Mitochondrial Encephalomyopathy Lactic Acidosis and Strokelike Episodes.[umdf.org] Symptoms: Short statue, seizures, stroke-like episodes with focused neurological deficits, recurrent headaches, cognitive regression, disease progression, ragged-red fibers[umdf.org]

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