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38 Possible Causes for Bicarbonate Decreased, Cognitive Defect, Metabolic Encephalopathy

  • Acidosis

    Labs: General Arterial Blood Gas Arterial pH decreased Serum bicarbonate decreased PaCO2 decreased PaCO2 drops 1.2 mmHg per 1 meq/L bicarbonate fall Calculated PaCO2 1.5 x[fpnotebook.com] A persistent decrease in the rate of renal bicarbonate reabsorption that maintains the decreased plasma bicarbonate level. c.[slideshare.net] Decreased in increased Anion Gap Metabolic Acidosis Bicarbonate decrease matches Anion Gap increase Urinalysis with Urine pH Urine pH 6: Suggests Renal cause Urine pH Urine[fpnotebook.com]

  • Hyponatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] Arieff AI et al . (1995) Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy . Am J Physiol 268 : R1143–R1152 16.[nature.com] Bryan Young, Metabolic Encephalopathies, Disorders of Consciousness, 10.1016/S0072-9752(07)01707-1, (115-166), (2008).[doi.org]

  • Chronic Kidney Insufficiency

    Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium; so, doctors[nutritionfacts.org] encephalopathy).[merckmanuals.com] While this is not an all-inclusive list, some of the common conditions are: Anemia Hypertension Electrolyte imbalance, hyperparathyroidism Metabolic acidosis and alkalosis[library.ahima.org]

  • Hypercapnia

    The increase in PaCO 2 , in turn, decreases the bicarbonate (HCO 3 – )/PaCO 2 ratio, thereby decreasing the pH.[emedicine.medscape.com] Asterixis is the inability to maintain posture due to a metabolic encephalopathy.[en.wikipedia.org] The renal system participates in acid-base regulation by increasing or decreasing levels of bicarbonate (HCO3-).[rtmagazine.com]

  • Drug-induced Hypoglycemia

    Drugs leading to loss of bicarbonate in the gastrointestinal (GI) tract or kidney 3. Drugs causing increased endogenous acid production 4.[f1000research.com] Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 1994;43:1426–34. Fanelli C, Pampanelli S, Epifano L, et al.[guidelines.diabetes.ca] Drugs that decrease renal acid excretion Some medications cannot be placed into one single category, as they possess multiple mechanisms that can cause metabolic acidosis.[f1000research.com]

  • Cerebral Edema

    In addition, bicarbonate therapy causes central nervous system hypoxia in laboratory animals with diabetic ketoacidosis. 33 Hyperglycemia superimposed on an ischemic insult[nejm.org] G93.40 Encephalopathy, unspecified G93.41 Metabolic encephalopathy G93.49 Other encephalopathy G93.5 Compression of brain G93.6 Cerebral edema G93.7 Reye's syndrome G93.8[icd10data.com] Theories include osmotic disequilibrium between brain and plasma as glucose is rapidly lowered, decreased plasma oncotic pressure due to infusion of large amounts of saline[ncbi.nlm.nih.gov]

  • Hypernatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] Bryan Young, Metabolic Encephalopathies, Neurologic Clinics, 10.1016/j.ncl.2011.08.002, 29, 4, (837-882), (2011).[oadoi.org] Lastly, rarer causes of hypernatremia in the elderly population include sodium overload from iatrogenic excessive administration of sodium bicarbonate or hypertonic saline[dovepress.com]

  • Acute Alcohol Intoxication

    […] in serum bicarbonate concentration.[cjasn.asnjournals.org] , sepsis, hypothermia, profound acidosis and hypoactive delirium or encephalopathy from a variety of toxic, metabolic, and infectious etiologies including viral and bacterial[clinicaladvisor.com] Accumulation of the alcohols in the blood can cause an increment in the osmolality, and accumulation of their metabolites can cause an increase in the anion gap and a decrease[cjasn.asnjournals.org]

  • Acute Renal Failure

    […] buildup of potassium Sodium bicarbonate is used to decrease acid buildup Acute Kidney Failure Follow-up The doctor will arrange follow-up visits as needed for the underlying[emedicinehealth.com] ., diarrhea and vomiting) should be given intravenous fluid Complications Hyperkalemia Metabolic acidosis Uremic encephalopathy and platelet dysfunction Anemia Chronic kidney[step2.medbullets.com] The individual's ability to live with multisystem diseases, cope with ensuing problems, and care for himself are markedly diminished. failure of artificial pacemaker A defect[medical-dictionary.thefreedictionary.com]

  • Renal Tubular Acidosis

    […] resorption Decrease in aldosterone secretion or activity Plasma bicarbonate (mEq/L or mmol/L) Frequently 15, occasionally 10 Usually 12–20 Usually 17 Plasma potassium Usually[msdmanuals.com] Other features include developmental delay, short stature, cognitive defects, and a history of multiple fractures by adolescence.[doi.org] A decrease in proximal tubular bicarbonate resorptive capacity results in proximal (type 2) RTA.[clinicaladvisor.com]

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