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22 Possible Causes for Bicarbonate Decreased, Cognitive Defect, Mild Cognitive Impairment

  • Acute Alcohol Intoxication

    […] in serum bicarbonate concentration.[cjasn.asnjournals.org] Accumulation of the alcohols in the blood can cause an increment in the osmolality, and accumulation of their metabolites can cause an increase in the anion gap and a decrease[cjasn.asnjournals.org]

  • Hyponatremia

    Abstract Hyponatremia is the most common electrolyte disorder and also a predictor of mild cognition impairment.[ncbi.nlm.nih.gov] 15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] cognition impairment.[journals.plos.org]

  • Hypercapnia

    The increase in PaCO 2 , in turn, decreases the bicarbonate (HCO 3 – )/PaCO 2 ratio, thereby decreasing the pH.[emedicine.medscape.com] The renal system participates in acid-base regulation by increasing or decreasing levels of bicarbonate (HCO3-).[rtmagazine.com] Bicarbonate does indeed cause a transient elevation in pCO2, but this will be blown off over time (with a decrease back to the previous equilibrium pCO2 levels).[emcrit.org]

  • Drug-induced Hypoglycemia

    Risk factors for hypoglycemia in people with type 2 diabetes include advancing age (18), severe cognitive impairment (19), poor health literacy (20), food insecurity (21),[guidelines.diabetes.ca] Drugs leading to loss of bicarbonate in the gastrointestinal (GI) tract or kidney 3. Drugs causing increased endogenous acid production 4.[f1000research.com] Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 1994;43:1426–34. Fanelli C, Pampanelli S, Epifano L, et al.[guidelines.diabetes.ca]

  • Hypercalcemia

    Presentation of Hypercalcaemia At levels At levels At levels 3.5 mmol/L Polyuria and polydipsia Dyspepsia - due to calcium-regulated release of gastrin Depression Mild cognitive[patient.info] Ionized calcium Albumin Creatinine Serum bicarbonate (milk-alkali syndrome) Serum phosphorous (decreased in primary hyperparathyroidism) Intact PTH: If laboratory evidence[clinicaladvisor.com] impairment All of the previous plus: Muscle weakness Constipation Anorexia and nausea Fatigue All of the previous plus: Abdominal pain Vomiting Dehydration Lethargy Cardiac[patient.info]

  • Heat Stroke

    Alkalinizing agents: These medicines, such as potassium and sodium bicarbonate, decrease the amount of acid in your blood and urine. This helps prevent organ damage.[drugs.com]

  • Diabetes Mellitus

    […] non-DM adults with mild cognitive impairment or mild Alzheimer disease ( 17, 34, 35 ).[ncbi.nlm.nih.gov] Bicarbonate therapy The use of bicarbonate in DKA is controversial ( 62 ) because most experts believe that during the treatment, as ketone bodies decrease there will be adequate[web.archive.org] 'cognition', 'mixed depression and dementia', 'presenile dementia', 'frontotemporal dementia', 'dementia' or 'multiinfarct dementia', 'senile dementia', 'cognitive defect'[doi.org]

  • Dihydrofolate Reductase Deficiency

    Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5(9):e12244.[lpi.oregonstate.edu] Increase or decrease the amount of dissociation medium needed proportionally for culture vessels of other sizes. Remove and discard culture medium.[atcc.org] […] depression Complications: Coronary artery disease, stroke Pregnancy complications include spontaneous abortion, abruption placentae, congenital malformations (neural tube defects[pathologyoutlines.com]

  • Hyperalaninemia

    Failure to thrive High pitched voice Cognitive impairment Delayed myelination Autosomal dominant inheritance Ataxia Hyperalaninemia Sinus bradycardia Gait disturbance Hyperreflexia[mendelian.co] -oxoprolinuria; 266130, 231900) Glutathione synthetase GSS (20q11.2)* Biochemical profile: Elevated urinary, plasma, and CSF 5-oxoproline; increased γ -glutamylcysteine; decreased[merckmanuals.com] Clinically, affected individuals show an L-DOPA-responsive, diurnally fluctuating movement disorder usually associated with cognitive delay and severe neurologic dysfunction[mendelian.co]

  • Autosomal Dominant Larsen Syndrome

    Williams-Gray et al., “Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis,” Neurology , vol. 75, no. 12, pp. 1062–1069, 2010.[hindawi.com] Sodium bicarbonate is given to curb metabolic acidosis. Polyuria is treated with thiazide diuretics which act on distal collecting tubule and decreases water delivery.[lecturio.com] Brain imaging has revealed a variety of defects and some patients have cognitive deficits and personality changes.[disorders.eyes.arizona.edu]

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