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37 Possible Causes for Bicarbonate Decreased, Cognitive Defect, Somnolence

  • Acute Alcohol Intoxication

    […] in serum bicarbonate concentration.[cjasn.asnjournals.org] Somnolence, stupor, disorientation and disturbance of balance are common and well recognized symptoms of the depression of the central nervous system (CNS) related to alcohol[academic.oup.com] Patients are generally calm and somnolent," said Blatman. "Let them stay that way by avoiding arguments or provocation."[ems1.com]

  • Hyponatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] This lady’s urgent admission to hospital was prompted by somnolence following an intentional overdose (7,500 mg) of her sodium valproate medication.[acutecaretesting.org] They include: headache nausea, loss of appetite, vomiting malaise lethargy weakness poor coordination muscle cramps somnolence disorientation personality change Physical Exam[sharinginhealth.ca]

  • Chronic Kidney Insufficiency

    Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium; so, doctors[nutritionfacts.org] Moderate metabolic acidosis (plasma bicarbonate content 15 to 20 mmol/L) is characteristic.[merckmanuals.com] Potassium may be high and bicarbonate levels may be low if you have CKD. There may also be an increase of acid in the blood.[healthline.com]

  • Hypercapnia

    The increase in PaCO 2 , in turn, decreases the bicarbonate (HCO 3 – )/PaCO 2 ratio, thereby decreasing the pH.[emedicine.medscape.com] A 38-year-old patient with effort dyspnea, somnolence, cianosis and cor pulmonale is presented.[ncbi.nlm.nih.gov] The renal system participates in acid-base regulation by increasing or decreasing levels of bicarbonate (HCO3-).[rtmagazine.com]

  • Drug-induced Hypoglycemia

    Drugs leading to loss of bicarbonate in the gastrointestinal (GI) tract or kidney 3. Drugs causing increased endogenous acid production 4.[f1000research.com] […] profuse perspiration; these are caused by sympathetic stimulation (starting in patients with blood glucose levels of approximately 3.3 mmol/L [60 mg/dL]). 3) Confusion, somnolence[empendium.com] Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 1994;43:1426–34. Fanelli C, Pampanelli S, Epifano L, et al.[guidelines.diabetes.ca]

  • Diabetic Ketotic Coma

    Indeed this is much higher then expected given the relatively modest decrease in bicarbonate.[anaesthesiamcq.com] Moreover, several deleterious effects of bicarbonate therapy have been reported, such as increased risk of hypokalemia, decreased tissue oxygen uptake, and cerebral edema.[clinicaladvisor.com] Nine small studies have evaluated the effect of alkalinization in a total of 434 patients with DKA, 217 treated with bicarbonate, and 178 patients without alkali therapy.[clinicaladvisor.com]

  • Heat Stroke

    Alkalinizing agents: These medicines, such as potassium and sodium bicarbonate, decrease the amount of acid in your blood and urine. This helps prevent organ damage.[drugs.com]

  • Acidosis

    Labs: General Arterial Blood Gas Arterial pH decreased Serum bicarbonate decreased PaCO2 decreased PaCO2 drops 1.2 mmHg per 1 meq/L bicarbonate fall Calculated PaCO2 1.5 x[fpnotebook.com] As the PaCO 2 increases, the anxiety may progress to delirium, and patients become progressively more confused, somnolent, and obtunded.[web.archive.org] Plasma VPA levels above 180 mg/mL usually have some degree of lethargy or somnolence. VPA levels have little correlation with severity of intoxication and prognosis.[clinicaladvisor.com]

  • Hypernatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] In all cases, symptoms of cerebral damage such as seizures, fever and somnolence developed within hours after salt ingestion.[ncbi.nlm.nih.gov] Children present with irritability and agitation, which can progress to lethargy, somnolence, and coma.[statpearls.com]

  • Hypercalcemia

    Ionized calcium Albumin Creatinine Serum bicarbonate (milk-alkali syndrome) Serum phosphorous (decreased in primary hyperparathyroidism) Intact PTH: If laboratory evidence[clinicaladvisor.com] Anxiety Psychotic symptoms: hallucination CNS depression, somnolence and eventually coma do occur at high levels Hypotonia and hyporeflexia Can mimic focal neurological lesions[broomedocs.com] […] situation with a severe hypercalcaemia, generally above approximately 14 mg/dL (or 3.5 mmol/l).The main symptoms of a hypercalcaemic crisis are oliguria or anuria, as well as somnolence[en.wikipedia.org]

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