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21 Possible Causes for Bicarbonate Decreased, Cognitive Defect, Uric Acid Increased

  • Acute Alcohol Intoxication

    […] in serum bicarbonate concentration.[cjasn.asnjournals.org] Accumulation of the alcohols in the blood can cause an increment in the osmolality, and accumulation of their metabolites can cause an increase in the anion gap and a decrease[cjasn.asnjournals.org]

  • Chronic Kidney Insufficiency

    Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium; so, doctors[nutritionfacts.org] Moderate metabolic acidosis (plasma bicarbonate content 15 to 20 mmol/L) is characteristic.[merckmanuals.com] Potassium may be high and bicarbonate levels may be low if you have CKD. There may also be an increase of acid in the blood.[healthline.com]

  • Diabetic Ketotic Coma

    Indeed this is much higher then expected given the relatively modest decrease in bicarbonate.[anaesthesiamcq.com] These biochemical changes are frequently associated with increased anion gap, increased serum osmolarity and increased serum uric acid. (See Clinical Presentation.)[emedicine.medscape.com] Many clinicians have observed worsening of acidemia, as evidenced by decreased serum bicarbonate concentration, after aggressive resuscitation with normal saline.[ahcmedia.com]

  • Heat Stroke

    Alkalinizing agents: These medicines, such as potassium and sodium bicarbonate, decrease the amount of acid in your blood and urine. This helps prevent organ damage.[drugs.com] Within 24 hrs, the levels of serum uric acid in both patients decreased dramatically, and their creatinine levels decreased and urine output increased concurrently.[ncbi.nlm.nih.gov] Excretion of uric acid is also reduced in the presence of lactic acidaemia.[bja.oxfordjournals.org]

  • Acidosis

    Labs: General Arterial Blood Gas Arterial pH decreased Serum bicarbonate decreased PaCO2 decreased PaCO2 drops 1.2 mmHg per 1 meq/L bicarbonate fall Calculated PaCO2 1.5 x[fpnotebook.com] […] anion gap metabolic acidosis M M ethanol (formic acid), metformin U U raemia (including aminoglycosides) R R enal failure (Uric acid) K K etoacidosis (alcohol, diabetes ([lifeinthefastlane.com] A persistent decrease in the rate of renal bicarbonate reabsorption that maintains the decreased plasma bicarbonate level. c.[slideshare.net]

  • Diabetes Mellitus

    Bicarbonate therapy The use of bicarbonate in DKA is controversial ( 62 ) because most experts believe that during the treatment, as ketone bodies decrease there will be adequate[web.archive.org] […] lowering uric acid levels prevented the increase in mean arterial blood pressure ( 40 ).[doi.org] 'cognition', 'mixed depression and dementia', 'presenile dementia', 'frontotemporal dementia', 'dementia' or 'multiinfarct dementia', 'senile dementia', 'cognitive defect'[doi.org]

  • Hyponatremia

    15% to 20%, hyperchloremic acidosis, decreased serum bicarbonate level, potassium abnormalities (type dependent) Correct acidosis, sodium bicarbonate Salt-wasting nephropathies[aafp.org] […] exhibit increased serum uric acid levels (greater than 0.3 mmol/L). 25 In contrast, in patients with SIADH, serum uric acid levels are actually depressed (less than 0.24[ncbi.nlm.nih.gov] […] syndrome of inappropriate antidiuretic hormone secretion (SIADH) (low to normal serum creatinine and urea, decreased uric acid levels, increased urine Na ). [35] However,[ncbi.nlm.nih.gov]

  • Precursor-Cell Lymphoblastic Leukemia

    Allopurinol is a xanthine oxidase inhibitor that decreases the production of uric acid.[lecturio.com] defects Patient Education Ensure that the patient's parents and guardians understand that ALL usually does not have a known cause, that accurate stratification helps guide[emedicine.medscape.com] This is done to maintain good flow through the kidneys to prevent renal damage from tumor lysis and to increase the solubility of uric acid that is excreted in the urine.[clinicaladvisor.com]

  • Renal Tubular Acidosis

    […] resorption Decrease in aldosterone secretion or activity Plasma bicarbonate (mEq/L or mmol/L) Frequently 15, occasionally 10 Usually 12–20 Usually 17 Plasma potassium Usually[msdmanuals.com] It may occur secondary to generalized dysfunction of the proximal tubules and can be associated with increased urinary excretion of glucose, uric acid, phosphate, amino-acid[sjkdt.org] Other features include developmental delay, short stature, cognitive defects, and a history of multiple fractures by adolescence.[doi.org]

  • Long QT Syndrome 13

    This acidemia causes a decrease in serum bicarbonate concentration and a high anion gap acidosis (see the Anion Gap calculator).[emedicine.medscape.com] The disease usually manifests with acute and potentially fatal episodes of metabolic decompensation and delays in cognitive development.[analesdepediatria.org] However, uric acid is less soluble in renal tubular and collecting duct fluid due to normally acidic media, thus increasing the possibility of uric acid crystal formation[emedicine.medscape.com]

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