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100 Possible Causes for Bicarbonate Decreased, Dysphagia, Failure to Thrive

  • Cystinosis

    Cystinosis is the major cause of inherited Fanconi syndrome, and should be suspected in young children with a failure to thrive and with signs of renal proximal tubular damage[] Slow eating and dysphagia are common. Heterozygotes may have elevated levels of free cystine in leukocytes.[] A subset of patients may also suffer from dysphagia, malnutrition and frequent aspiration. These patients are usually treated with an implantation of a gastrostomy tube.[]

  • Gastroesophageal Reflux Disease

    Cigarette smoking can reduce the LES pressure[ 117 – 119 ] and decrease salivary bicarbonate secretion, thus reducing the physiological neutralizing effect of saliva on intraesophageal[] In pediatrics, the presentation is often non-specific, with vomiting, upper and lower respiratory symptoms, irritability, aversion to food, and failure to thrive 2.[] Outcomes selected were recurrent or persistent postoperative dysphagia and an abnormal 24-hour pH test result.[]

  • Glycogen Storage Disease Type 2

    Progressive respiratory insufficiency Chronic CO 2 retention (elevated arterial pCO 2 and serum bicarbonate concentration) and hypoxemia (decreased arterial pO 2 and oxygen[] Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and[] Oropharyngeal dysphagia in infants and children with infantile Pompe disease. Dysphagia. 2009 Sep 10. [Medline]. Musumeci O, la Marca G, Spada M, et al.[]

  • Peptic Esophagitis

    […] may show a decreased salivary bicarbonate response to acid perfusion challenge to the distal esophagus.[] […] to thrive, or difficulty gaining adequate weight.[] Typical symptoms include pyrosis, dysphagia and regurgitation.[]

  • Diaphragmatic Hernia

    Hypoxia (oxygen saturation Treatment includes increased oxygen delivery (100% oxygen), decreasing the PCO2 and treating acidosis with sodium bicarbonate (0.5-1 mEq/kg) for[] Failure to thrive: Children with the most serious lung problems are most likely to have growth problems.[] Granderath FA, Schweiger UM, Kamolz T, Pointner R (2005) Dysphagia after laparoscopic antireflux surgery: a problem of hiatal closure more than a problem of the wrap.[]

  • Distal Renal Tubular Acidosis

    The nephrons, when bathed in an acidic solution, demonstrated an acid-induced adaptive decrease in bicarbonate secretion.[] We suggest that RTA be considered a diagnostic possibility in all children with failure to thrive and nephrocalcinosis.[] These include sicca symptoms (dryness and irritation of eyes, dysphagia, dental caries, hoarseness of voice), musculoskeletal symptoms (fatigue, arthralgia), nephrocalcinosis[]

  • Gastropathy

    Thus, inhibition of COX by NSAIDs reduces prostaglandin synthesis, thereby diminishing mucosal blood flow and decreasing mucus and bicarbonate secretion.[] Eosinophilic gastritis Eosinophilic gastritis and gastroenteritis may affect all age groups and present with failure to thrive (in children), abdominal pain, irritability,[] Decreased blood flow and decreased mucosa decrease the healing ability and leave the stomach more exposed to injury from pepsin and gastric acid.[]

  • Glycogen Storage Disease due to Glucose-6-Phosphat Transport Defect

    (decreased due to acidosis), uric acid (increased due to acidosis), plasma lipids (increased cholesterol and triglycerides), anemia, serum alpha-fetoprotein (to look for[] Synopsis hepatomegaly failure to thrive renal dysfunction recurrent infections Short stature Delayed puberty ’Doll-like’ facies Lipemia retinalis Hypertension Protuberant[] Dysphagia increases the risk of silent and nonsilent aspirations and lung infections [ 23 ].[]

  • Glycogen Storage Disease due to GLUT2 Deficiency

    Renal bicarbonate threshold was decreased to 18-20 mmol/1 (cases 4 and 5). In case 5 it became normal at the age of 11 years.[] Mutations were also found in patients with atypical clinical signs such as intestinal malabsorption, failure to thrive, the absence of hepatomegaly, or renal hyperfiltration[] […] ventilation 16 Axial: Abdominal & Paraspinal muscles Proximal Distal Legs Arms: Hip flexors & extensors, adductors & abductors Paraspinous muscles (Atrophy) Bulbar: Tongue; Dysphagia[]

  • Congenital Intrinsic Factor Deficiency

    Decreased bicarbonate ion Which of the following applies to the act of swallowing?[] Due to pernicious anemia and megaloblastic anemia, there is failure to thrive and poor nutrition.[] […] sites D49.9 Neoplasm of unspecified behavior of unspecified site D50 Iron deficiency anemia D50.0 Iron deficiency anemia secondary to blood loss (chronic) D50.1 Sideropenic dysphagia[]

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