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100 Possible Causes for Bicarbonate Decreased, Dysphagia, Failure to Thrive

  • Cystinosis

    Cystinosis is the major cause of inherited Fanconi syndrome, and should be suspected in young children with a failure to thrive and with signs of renal proximal tubular damage[ncbi.nlm.nih.gov] Slow eating and dysphagia are common. Heterozygotes may have elevated levels of free cystine in leukocytes.[disorders.eyes.arizona.edu] A subset of patients may also suffer from dysphagia, malnutrition and frequent aspiration. These patients are usually treated with an implantation of a gastrostomy tube.[symptoma.com]

  • Gastroesophageal Reflux Disease

    Cigarette smoking can reduce the LES pressure[ 117 – 119 ] and decrease salivary bicarbonate secretion, thus reducing the physiological neutralizing effect of saliva on intraesophageal[doi.org] In pediatrics, the presentation is often non-specific, with vomiting, upper and lower respiratory symptoms, irritability, aversion to food, and failure to thrive 2.[radiopaedia.org] Outcomes selected were recurrent or persistent postoperative dysphagia and an abnormal 24-hour pH test result.[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 2

    Progressive respiratory insufficiency Chronic CO 2 retention (elevated arterial pCO 2 and serum bicarbonate concentration) and hypoxemia (decreased arterial pO 2 and oxygen[dx.doi.org] Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and[genedx.com] Oropharyngeal dysphagia in infants and children with infantile Pompe disease. Dysphagia. 2009 Sep 10. [Medline]. Musumeci O, la Marca G, Spada M, et al.[emedicine.medscape.com]

  • Peptic Esophagitis

    […] may show a decreased salivary bicarbonate response to acid perfusion challenge to the distal esophagus.[nature.com] […] to thrive, or difficulty gaining adequate weight.[medicalnewstoday.com] Typical symptoms include pyrosis, dysphagia and regurgitation.[symptoma.com]

  • Diaphragmatic Hernia

    Hypoxia (oxygen saturation Treatment includes increased oxygen delivery (100% oxygen), decreasing the PCO2 and treating acidosis with sodium bicarbonate (0.5-1 mEq/kg) for[clinicalpainadvisor.com] Failure to thrive: Children with the most serious lung problems are most likely to have growth problems.[childrenshospital.org] Granderath FA, Schweiger UM, Kamolz T, Pointner R (2005) Dysphagia after laparoscopic antireflux surgery: a problem of hiatal closure more than a problem of the wrap.[link.springer.com]

  • Distal Renal Tubular Acidosis

    The nephrons, when bathed in an acidic solution, demonstrated an acid-induced adaptive decrease in bicarbonate secretion.[derangedphysiology.com] We suggest that RTA be considered a diagnostic possibility in all children with failure to thrive and nephrocalcinosis.[ncbi.nlm.nih.gov] These include sicca symptoms (dryness and irritation of eyes, dysphagia, dental caries, hoarseness of voice), musculoskeletal symptoms (fatigue, arthralgia), nephrocalcinosis[mjdrdypu.org]

  • Gastropathy

    Thus, inhibition of COX by NSAIDs reduces prostaglandin synthesis, thereby diminishing mucosal blood flow and decreasing mucus and bicarbonate secretion.[emedicine.medscape.com] Eosinophilic gastritis Eosinophilic gastritis and gastroenteritis may affect all age groups and present with failure to thrive (in children), abdominal pain, irritability,[cmej.org.za] Decreased blood flow and decreased mucosa decrease the healing ability and leave the stomach more exposed to injury from pepsin and gastric acid.[physio-pedia.com]

  • Glycogen Storage Disease due to Glucose-6-Phosphat Transport Defect

    (decreased due to acidosis), uric acid (increased due to acidosis), plasma lipids (increased cholesterol and triglycerides), anemia, serum alpha-fetoprotein (to look for[quizlet.com] Synopsis hepatomegaly failure to thrive renal dysfunction recurrent infections Short stature Delayed puberty ’Doll-like’ facies Lipemia retinalis Hypertension Protuberant[humpath.com] Dysphagia increases the risk of silent and nonsilent aspirations and lung infections [ 23 ].[err.ersjournals.com]

  • Glycogen Storage Disease due to GLUT2 Deficiency

    Renal bicarbonate threshold was decreased to 18-20 mmol/1 (cases 4 and 5). In case 5 it became normal at the age of 11 years.[slideheaven.com] Mutations were also found in patients with atypical clinical signs such as intestinal malabsorption, failure to thrive, the absence of hepatomegaly, or renal hyperfiltration[ncbi.nlm.nih.gov] […] ventilation 16 Axial: Abdominal & Paraspinal muscles Proximal Distal Legs Arms: Hip flexors & extensors, adductors & abductors Paraspinous muscles (Atrophy) Bulbar: Tongue; Dysphagia[neuromuscular.wustl.edu]

  • Congenital Intrinsic Factor Deficiency

    Decreased bicarbonate ion Which of the following applies to the act of swallowing?[quizlet.com] Due to pernicious anemia and megaloblastic anemia, there is failure to thrive and poor nutrition.[symptoma.com] […] sites D49.9 Neoplasm of unspecified behavior of unspecified site D50 Iron deficiency anemia D50.0 Iron deficiency anemia secondary to blood loss (chronic) D50.1 Sideropenic dysphagia[icd10data.com]

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