Bicytopenia: Causes & Reasons

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Possible Causes for Bicytopenia

Gaucher Disease

Summary Epidemiology The prevalence is approximately 1/100,000. The annual incidence of GD in the general population is about 1/60,000, but it can reach up to 1/1,000 in Ashkenazi Jewish populations. Clinical description The clinical manifestations of this disease are highly variable. GD type 1 (90% of cases) is the chronic[…] [orpha.net]

Severe Aplastic Anemia

Ann Hematol. 2015 Jul;94(7):1105-10. doi: 10.1007/s00277-015-2348-5. Epub 2015 Mar 19. Zhao X 1, Zhang L, Jing L, Zhou K, Li Y, Peng G, Ye L, Li Y, Li J, Fan H, Song L, Yang W, Zhang F. Author information 1 Department of Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of[…] [ncbi.nlm.nih.gov]

Pancytopenia

[…] of bicytopenia and pancytopenia. [ijpmonline.org]

Of the BM examinations for bicytopenia (n = 1,731), 1,580 were performed on adults and 151 were performed on pediatric patients. [ashpublications.org]

The presence of severe congenital bicytopenia (thrombocytopenia and anemia) at birth should be a clue to consider investigation for IBMFS. [ncbi.nlm.nih.gov]

Shapiro Syndrome

Mathur S...Ram C 24640213 2013 14 Insights into thermoregulation: a clinico-radiological description of Shapiro syndrome. 61 Pazderska A...O'Dowd S 23578790 2013 15 Cyclic bicytopenia [malacards.org]

Tang Hsi Ryu Syndrome

Serial blood counts continued to show bicytopenia. His growth progressed steadily around the fifteenth centile, and he was achieving normal milestones for age. [karger.com]

The child’s bicytopenia persisted and at 7 months of age the parents were then strongly encouraged to proceed to bone marrow aspiration as the next step of investigation; [karger.com]

Investigations for common etiologies of neonatal bicytopenia and heart failure including TORCH screening, karyotyping, echocardiography, blood film, and brain ultrasound were [karger.com]

Refractory Anemia with Excess Blasts in Transformation

[…] in two or more myeloid cell lines Blasts < 5% No Auer rods Ringed sideroblasts Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD) Cytopenias (bicytopenia [w1.uzleuven.be]

(%) Marrow blasts (%) Disease Anaemia ‒ isolated 25 <5 RA ≥15% ringed sideroblasts 5 - 20 <5 RARS ‒ with ring sideroblasts Anaemia ‒ normal platelets 100 <5 5q-syndrome Bicytopenia [cmej.org.za]

[…] results of both blood tests and bone marrow biopsy results. 2016 WHO Classification of MDS Subtype Blood Bone Marrow MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia [oncolink.org]

Acute Myeloid Leukemia with Multilineage Dysplasia

No or rare blasts Platelets usually normal or increased Normal to increased megakaryocytes with hypolobulated nuclei < 5% blasts No Auer rods Isolated del(5q) Notes: (1) Bicytopenia [bloodref.com]

[…] cytopenia with multilineage dysplasia 29 Refractory cytopenia with multilineage dysplasia 30 Refractory cytopenia with multilineage dysplasia and ringed sideroblasts PB Bicytopenia [slideplayer.com]

[…] type Blood Bone marrow 9 RCUD (refractory cytopenia with unilineage dysplasia) RA (refractory anaemia) RT (refractory thrombocytopenia) RN (refractory neutropenia) Uni- or bicytopenia [docmh.net]

Refractory Anemia with Excess Blasts

Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia). [gpec.ubc.ca]

Refractory cytopenia with multilineage dysplasia is characterized by bicytopenia or pancytopenia. [businessandleadership.com]

Autosomal Dominant Aplasia and Myelodysplasia

Early forms of myelodysplastic syndrome initially can manifest as a single cytopenia or, more often, as a bicytopenia. [emedicine.medscape.com]

Heavy Chain Disease

The patient had an autoimmune bicytopenia. [biochemia-medica.com]

In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient. [hrcak.srce.hr]

These data introduced the possibility that the origin of bicytopenia was autoimmune. [biochemia-medica.com]

Leukoerythroblastic Anemia

Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients. [jahjournal.org]

Out of 70 cases 32 were reported as pancytopenia, 17 were microcytic hypochromic anemia, 10 normocytic normochromic blood picture, 3 dimorphic anemia ,2 bicytopenia, 2 CML [ispub.com]

Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients. Only eight cases had bone marrow correlation. [jahjournal.org]

Bone Lymphoma

We report a unique case of PBNHL with bicytopenia as the initial clinical manifestation in a Chinese. [caribbean.scielo.org]

This patient had bicytopenia which was consistent with the previous cases of primary bone marrow lymphoma (3–8). [caribbean.scielo.org]

Here, we report a case of PBNHL associated with bicytopenia. CASE REPORT A 55-year old woman was hospitalized with a febrile illness for 10 months. [caribbean.scielo.org]

Bilineal Acute Leukemia

A 43-year-old female presented with leukocytosis and bicytopenia. [pubtransformer.com]

Finally, an M7 case persisted with severe bicytopenia (anemia and leukopenia) and moderate thrombocytosis for several months without receiving antineoplastic treatment, who [elsevier.es]

Drug-Induced Bone Marrow Suppression

Early forms of myelodysplastic syndrome initially can manifest as a single cytopenia or, more often, as a bicytopenia. [emedicine.medscape.com]

Poor Response to Eculizumab

Our patient had features of classical PNH-bicytopenia, hemolysis and venous thrombosis at three sites intraabdominal cerebral and retinal with no marrow involvement. [ijcasereportsandimages.com]

Conclusion In this presentation, a young girl who presented to us with bicytopenia and hemorrhagic cerebral infarct with recent history of jaundice was found to have coombs [ijcasereportsandimages.com]

Discussion We report a young girl who presented with headache, abdominal pain and distension with past history of jaundice was found to have bicytopenia and venous thrombosis [ijcasereportsandimages.com]

Refractory Anemia

Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia). [gpec.ubc.ca]

RCMD shows cytopenias (bicytopenia or pancytopenia) in the peripheral blood plus dysplasia in more than 10% of the cells in 2 or more myeloid lineages. [atlasgeneticsoncology.org]

MDS Type Blood Marrow Refractory cytopenia with unilineage dysplasia (RCUD) Refractory anemia (RA) Refractory neutropenia (RN) Refractory thrombocytopenia (RT) Uni- or bicytopenia [slideshare.net]

Hemophagocytic Lymphohistiocytosis

Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis. [link.springer.com]

[…] guidelines of the Histiocyte Society, diagnosis of Hemophagocytic Lympho-histiocytosis (HLH) requires fulfillment of 5 out of 8 criteria – prolonged fever, splenomegaly, bicytopenia [indianpediatrics.net]

As for bicytopenia, only the platelet count was low at admission; anemia developed later but was attributed to severe bleeding. [bloodjournal.org]

Ring Chromosome 19

Hemogram showed bicytopenia with hemoglobin 4.9 g%; total leukocyte count 9600/cu.mm; and platelet 60,000/cu.mm. [cancerjournal.net]

The present case with bicytopenia detected with highly complex chromosome rearrangements with variability in numerical and structural combinations. [cancerjournal.net]

Hairy Cell Leukemia Variant

It is characterized by persistent bicytopenia and splenomegaly. [medical-case-reports.imedpub.com]

Nevertheless, an abnormal blood count that indicates bicytopenia, associated to unspecific symptoms such as fatigue, splenomegaly, must bring suspicion of this type of clinical [medical-case-reports.imedpub.com]

[…] soap factory, with a history of fatigue, weight loss and diagnosed with Non Hodgkin lymphoma, who had received chemotherapy, presented recurrent pneumonia and persistent bicytopenia [medical-case-reports.imedpub.com]

Evans Syndrome

The pattern of occurrence of bicytopenia can delay the diagnosis since it may be coincidental, sequential, or separate, and the time frame between episodes can range from [symptoma.com]

The patient presented bicytopenia, defined by normocytic, normochromic regenerative anemia with broad red blood cell distribution width and reticulocytosis. [elsevier.es]

It presents with bicytopenia, which can coincide or occur separately or sequentially. [scielo.br]

Chronic Lymphadenitis except Mesenteric

Laboratory analysis showed bicytopenia, and radiological studies showed systemic lymphadenopathy accompanied by splenomegaly. [ncbi.nlm.nih.gov]

Case 2 was a 47-year-old male with KFD and bone marrow involvement and presented with severe bicytopenia. [ncbi.nlm.nih.gov]

Gamma-Heavy Chain Disease

In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient. [ncbi.nlm.nih.gov]

Idiopathic Refractory Anemia

My Response Distinguishing Cases of Immune-Mediated BM failure Diagnosing MDS is often challenging in patients with pancytopenia or bicytopenia who do not show definitive [hematology.org]

The terms “ICUS-anemia, ICUS-neutropenia, ICUS-thrombocytopenia, ICUS-bicytopenia, or bi/pancytopenia” were also proposed in which the cut-off levels of cytopenia were the [intechopen.com]

Drug-induced Neutropenia

Bicytopenia: adverse effect of risperidone. Current Psychiatry. 2014;13(4):E1. 5. Meylan C, Bondolfi G, Aubert AC, Baumann P. [dovepress.com]

Review was limited to articles focusing on leukopenia, neutropenia, agranulocytosis, bicytopenia, and underlying pathophysiological mechanisms. [dovepress.com]

Paroxysmal Nocturnal Hemoglobinuria

Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia [bloodjournal.hematologylibrary.org]

The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line). [bcmj.org]

The cumulative incidence of bicytopenia or pancytopenia ( Figure 2 B) was similar in patients with classic and intermediate disease ( P = .63). [bloodjournal.hematologylibrary.org]

Acute Panmyelosis with Myelofibrosis

Anemia Blasts < 1% Erythroid dysplasia only Blasts < 5% Ringsideroblasts ³ 15% (count on erythroblasts) Refractory cytopenia with multilineage dysplasia (RCMD) Cytopenias (bicytopenia [w1.uzleuven.be]

Febrile Neutropenia

The blood tests revealed bicytopenia with iron deficiency anemia, leucopoenia with neutropenia, and elevated C-reactive protein. [ncbi.nlm.nih.gov]

Lymphoproliferative Syndrome 1

A complete hematological workup revealed bicytopenia with hemoglobin of 8.8 gm/dl and platelet count of 80000 cells/mm 3, total leucocyte count being 11300 cells/mm 3 with [jpgmonline.com]

[…] the male Pt. 1 presented with failure to thrive, mild fever, extensive splenomegaly (12 cm in length, as assessed with ultrasound imaging), generalized lymphadenopathy, bicytopenia [bloodadvances.org]

Autoimmune Lymphoproliferative Syndrome Type 3

A complete hematological workup revealed bicytopenia with hemoglobin of 8.8 gm/dl and platelet count of 80000 cells/mm 3, total leucocyte count being 11300 cells/mm 3 with [jpgmonline.com]

Brucellosis

In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia. [ncbi.nlm.nih.gov]

The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high [ncbi.nlm.nih.gov]

Finally, a case of brucellosis with acute hepatitis and bicytopenia was treated with a successful outcome. [ncbi.nlm.nih.gov]