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95 Possible Causes for Bicytopenia

  • Familial Hemophagocytic Lymphohistiocytosis

    Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis.[] […] guidelines of the Histiocyte Society, diagnosis of Hemophagocytic Lympho-histiocytosis (HLH) requires fulfillment of 5 out of 8 criteria – prolonged fever, splenomegaly, bicytopenia[] As for bicytopenia, only the platelet count was low at admission; anemia developed later but was attributed to severe bleeding.[]

  • Refractory Anemia with Excess Blasts

    Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia).[] Refractory cytopenia with multilineage dysplasia is characterized by bicytopenia or pancytopenia.[] […] count No or rare blasts ( Normal to increased megakaryocytes with hypolobated nuclei Isolated del(5q) cytogenetic abnormality No Auer rods MDS, myelodysplastic syndrome. * Bicytopenia[]

  • Hypocupremia

    Copper deficiency usually presents with bicytopenia (neutropenia and anemia), but severe pancytopenia has been observed in some cases, especially those patients on TPN.[]

  • Griscelli Syndrome, Type 2

    Figure 1: Note the silvery discoloration of the scalp hair and the eyebrows Click here to view Investigation revealed bicytopenia, with hemoglobin of 5.8 gm/dl and platelets[] […] mL) and the triglycerides was 279 mg/dL (normal values: In view of sudden onset of high grade fever with no foci of infection with lymphadenopathy, hepatosplenomegaly and bicytopenia[]

  • Autosomal Recessive Dyskeratosis Congenita Type 5

    , hypothyroidism, dry skin, dystrophic nails (Figure 1A), skin pigmentations, tooth abnormality, scoliosis, omnibus sign and saddle nose (Figure 1B, C), lung disease and bicytopenia[]

  • Hodgkin Lymphoma, Lymphocyte Predominance, Nodular

    […] criteria used in the HLH-2004 trial by the Histiocyte Society are described in the Table . 5 In our case, diagnosis of HLH was delayed at least 6 weeks following development of bicytopenia[]

  • Evan's Syndrome

    The pattern of occurrence of bicytopenia can delay the diagnosis since it may be coincidental, sequential, or separate, and the time frame between episodes can range from[]

  • Acute Panmyelosis with Myelofibrosis

    ) Anemia Blasts 1% Erythroid dysplasia only Blasts 5% Ringsideroblasts ³ 15% (count on erythroblasts) Refractory cytopenia with multilineage dysplasia (RCMD) Cytopenias (bicytopenia[] […] in two or more myeloid cell lines Blasts 5% No Auer rods Ringed sideroblasts Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD) Cytopenias (bicytopenia[]

  • Hepatosplenic T-cell Lymphoma

    There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1][] It can be easily misdiagnosed as acute leukemia on morphology as well as flow-cytometry, though massive hepatosplenomegaly with bicytopenia and no lymphadenopathy is highly[]

  • Severe Aplastic Anemia

    Severe aplastic anemia is a rare hematological disorder characterized by pancytopenia due to bone marrow failure, whereby depletion of pluripotent stem cells is commonly mediated by an autoimmune response. Accordingly, immunosuppression and hematopoietic stem cell transplantation constitute treatment options, with[…][]

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