Possible Causes for bicytopenia Gaucher Disease Gaucher disease is the commonest lysosomal storage disease seen in India and worldwide. It should be considered in any child or adult with an unexplained splenohepatomegaly and cytopenia which are seen in the three types of Gaucher disease. Type 1 is the non-neuronopathic form and type 2 and 3 are the[…] [ncbi.nlm.nih.gov] Severe Aplastic Anemia Ann Hematol. 2015 Jul;94(7):1105-10. doi: 10.1007/s00277-015-2348-5. Epub 2015 Mar 19. Zhao X 1, Zhang L, Jing L, Zhou K, Li Y, Peng G, Ye L, Li Y, Li J, Fan H, Song L, Yang W, Zhang F. Author information 1 Department of Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of[…] [ncbi.nlm.nih.gov] Pancytopenia […] of bicytopenia and pancytopenia. [ijpmonline.org] Of the BM examinations for bicytopenia (n 1,731), 1,580 were performed on adults and 151 were performed on pediatric patients. [ashpublications.org] If more than one of the blood cells is low then the condition is called as bicytopenia. [ncbi.nlm.nih.gov] Adenovirus Infection […] encephalopathy, myocarditis, rash) was diagnosed with adenovirus-associated macrophage activation syndrome according to clinical and laboratory parameters (fever, hepatosplenomegaly, bicytopenia [ncbi.nlm.nih.gov] Vitamin B12 Deficiency Laboratory data revealed bicytopenia with macrocytic anemia and methylmalonic acid in the urine, consistent with vitamin B12 deficient anemia. [ncbi.nlm.nih.gov] Refractory Anemia with Excess Blasts in Transformation Anemia Blasts 1% Erythroid dysplasia only Blasts 5% Ringsideroblasts ³ 15% (count on erythroblasts) Refractory cytopenia with multilineage dysplasia (RCMD) Cytopenias (bicytopenia [w1.uzleuven.be] […] abnormalities (%) Marrow blasts (%) Disease Anaemia ‒ isolated 25 5 RA 15% ringed sideroblasts 5 - 20 5 RARS ‒ with ring sideroblasts Anaemia ‒ normal platelets 100 5 5q-syndrome Bicytopenia [cmej.org.za] […] results of both blood tests and bone marrow biopsy results. 2016 WHO Classification of MDS Subtype Blood Bone Marrow MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia [oncolink.org] Bone Lymphoma We report a unique case of PBNHL with bicytopenia as the initial clinical manifestation in a Chinese. [caribbean.scielo.org] This patient had bicytopenia which was consistent with the previous cases of primary bone marrow lymphoma (3–8). [caribbean.scielo.org] Here, we report a case of PBNHL associated with bicytopenia. CASE REPORT A 55-year old woman was hospitalized with a febrile illness for 10 months. [caribbean.scielo.org] Thrombocytopenia HIV post exposure prophylaxis induced bicytopenia: a case report. AIDS Res Ther. 2014; 11 :11. [ PubMed ] [ DOI ] 8. Visentin GP, Liu CY. Drug-induced thrombocytopenia. [wjgnet.com] Refractory Anemia Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia). [gpec.ubc.ca] RCMD shows cytopenias (bicytopenia or pancytopenia) in the peripheral blood plus dysplasia in more than 10% of the cells in 2 or more myeloid lineages. [atlasgeneticsoncology.org] MDS Type Blood Marrow Refractory cytopenia with unilineage dysplasia (RCUD) Refractory anemia (RA) Refractory neutropenia (RN) Refractory thrombocytopenia (RT) Uni- or bicytopenia [slideshare.net] Febrile Neutropenia The blood tests revealed bicytopenia with iron deficiency anemia, leucopoenia with neutropenia, and elevated C-reactive protein. [ncbi.nlm.nih.gov] Calcium Pyrophosphate Arthropathy Minor adverse events (AE) did not differ in frequency between the groups, but the only serious AE occurred on MTX (bicytopenia). [arthritis-research.biomedcentral.com] One serious AE was observed on a patient on methotrexate: an acute bicytopenia, which imposed hospitalization, fortunately without permanent damage. [arthritis-research.biomedcentral.com] Heavy Chain Disease The patient had an autoimmune bicytopenia. [biochemia-medica.com] In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient. [hrcak.srce.hr] These data introduced the possibility that the origin of bicytopenia was autoimmune. [biochemia-medica.com] Leukoerythroblastic Anemia Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients. [jahjournal.org] Out of 70 cases 32 were reported as pancytopenia, 17 were microcytic hypochromic anemia, 10 normocytic normochromic blood picture, 3 dimorphic anemia ,2 bicytopenia, 2 CML [ispub.com] Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients. Only eight cases had bone marrow correlation. [jahjournal.org] Refractory Anemia with Excess Blasts Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia). [gpec.ubc.ca] Refractory cytopenia with multilineage dysplasia is characterized by bicytopenia or pancytopenia. [businessandleadership.com] […] results of both blood tests and bone marrow biopsy results. 2016 WHO Classification of MDS Subtype Blood Bone Marrow MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia [oncolink.org] Sepsis DIAGNOSIS: The present patient met 5 of the HLH criteria: fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hyperferritinemia. [ncbi.nlm.nih.gov] Kikuchi-Fujimoto Disease Laboratory analysis showed bicytopenia, and radiological studies showed systemic lymphadenopathy accompanied by splenomegaly. [ncbi.nlm.nih.gov] Case 2 was a 47-year-old male with KFD and bone marrow involvement and presented with severe bicytopenia. [ncbi.nlm.nih.gov] Pseudogout Minor adverse events (AE) did not differ in frequency between the groups, but the only serious AE occurred on MTX (bicytopenia). [dx.doi.org] One serious AE was observed on a patient on methotrexate: an acute bicytopenia, which imposed hospitalization, fortunately without permanent damage. [dx.doi.org] Evans Syndrome The pattern of occurrence of bicytopenia can delay the diagnosis since it may be coincidental, sequential, or separate, and the time frame between episodes can range from [symptoma.com] The patient presented bicytopenia, defined by normocytic, normochromic regenerative anemia with broad red blood cell distribution width and reticulocytosis. [elsevier.es] It presents with bicytopenia, which can coincide or occur separately or sequentially. [scielo.br] Drug-induced Bone Marrow Suppression Early forms of myelodysplastic syndrome initially can manifest as a single cytopenia or, more often, as a bicytopenia. [emedicine.medscape.com] Interstitial Nephritis HPS could be diagnosed with the presence of six criteria: fever, splenomegaly, bicytopenia, high ferritin, hypertriglyceridemia, and high levels of soluble CD25. [ncbi.nlm.nih.gov] Paroxysmal Nocturnal Hemoglobinuria Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia [bloodjournal.hematologylibrary.org] The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line). [bcmj.org] The cumulative incidence of bicytopenia or pancytopenia ( Figure 2 B) was similar in patients with classic and intermediate disease ( P .63). [bloodjournal.hematologylibrary.org] Paraneoplastic Syndrome More on polymyalgia rheumatica (PMR) as a paraneoplastic rheumatic syndrome in the elderly (bicytopenia and PMR preceding acute myeloid leukemia). [ncbi.nlm.nih.gov] Autosomal Dominant Aplasia and Myelodysplasia Early forms of myelodysplastic syndrome initially can manifest as a single cytopenia or, more often, as a bicytopenia. [emedicine.medscape.com] Drug-induced Neutropenia Bicytopenia: adverse effect of risperidone. Current Psychiatry. 2014;13(4):E1. 5. Meylan C, Bondolfi G, Aubert AC, Baumann P. [dovepress.com] Review was limited to articles focusing on leukopenia, neutropenia, agranulocytosis, bicytopenia, and underlying pathophysiological mechanisms. [dovepress.com] Hepatosplenic Lymphoma There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1] [ijpmonline.org] It can be easily misdiagnosed as acute leukemia on morphology as well as flow-cytometry, though massive hepatosplenomegaly with bicytopenia and no lymphadenopathy is highly [ijpmonline.org] Diffuse Lymphoma He also met criteria for HLH with fever, bicytopenia, splenomegaly, ferritin level, and hypertriglyceridemia. [acgcasereports.gi.org] Myelodysplasia Subtype Blood Bone marrow (1) MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia Dysplasia in 10 of one cell line, 5% blasts (2) MDS with ring sideroblasts [intechopen.com] 2017) Age – median is 65-70 Sex – M F Classification Classification of MDS, Subtypes Subtype Blood Bone Marrow MDS cytopenias with single lineage dysplasia Unicytopenia or bicytopenia [arupconsult.com] […] ringed sideroblasts in erythroid precursors 5 Refractory anemia with sideroblasts 100 Anemia, normal platelets 5 Myelodysplasias with isolated del (5q) (5q syndrome) 50 Bicytopenia [lecturio.com] Disseminated Intravascular Coagulation A 78-year-old woman was admitted to our hospital complaining of anorexia and purpura of the extremities. She presented with prominent peripheral eosinophilia and disseminated intravascular coagulation (DIC). Despite receiving intensive therapy for DIC, her illness worsened. Esophagogastroduodenoscopy revealed[…] [ncbi.nlm.nih.gov] ACE Inhibitor-Induced Angioedema In view of bicytopenia with lymphopenia, ANA positive and hypocomplementemia, diagnosis of systemic lupus erythematosus was suspected. [ijcasereportsandimages.com] Laboratory investigation showed bicytopenia with hemoglobin of 11.4 g/dL (normal range 10.7–14.9), a white blood cell count of 2.88x10 3 /µL (normal range 3.30x10 3 –9.66x10 [ijcasereportsandimages.com] Acute Panmyelosis with Myelofibrosis Anemia Blasts 1% Erythroid dysplasia only Blasts 5% Ringsideroblasts ³ 15% (count on erythroblasts) Refractory cytopenia with multilineage dysplasia (RCMD) Cytopenias (bicytopenia [w1.uzleuven.be] […] in two or more myeloid cell lines Blasts 5% No Auer rods Ringed sideroblasts Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD) Cytopenias (bicytopenia [w1.uzleuven.be]
