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44 Possible Causes for Bicytopenia, Bone Marrow Biopsy Abnormal

  • Severe Aplastic Anemia

    A bone marrow biopsy is usually done at the same time, especially if an aspiration was not productive.[] The peripheral blood smear shows no abnormal cells. The diagnosis is confirmed by a bone marrow biopsy with an assessment of cellularity.[] The doctor will take samples both of the fluid of the bone marrow (an aspirate) and of the more solid bone marrow structure (a trephine biopsy).[]

  • Pancytopenia

    If more than one of the blood cells is low then the condition is called as bicytopenia.[] Bone Marrow Examination Almost always indicated in case pancytopenia unless cause is apparent. Both aspiration and biopsy are indicated.[] If only two parameters from the complete blood count are low, the term bicytopenia can be used. The diagnostic approach is the same as for pancytopenia.[]

  • Leukoerythroblastic Anemia

    Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[] Biol Phys biopsy bleeding bleomycin bone marrow breast cancer cancer pain cancer patients cancer rehabilitation cancer treatment carcinoma chemotherapy chest chronic cisplatin[] These tests can prompt further, more invasive testing, such as a bone marrow biopsy. What are the signs of myelofibrosis?[]

  • Myelodysplasia

    2017) Age – median is 65-70 Sex – M F Classification Classification of MDS, Subtypes Subtype Blood Bone Marrow MDS cytopenias with single lineage dysplasia Unicytopenia or bicytopenia[] Fluorescence in situ hybridization performed on the gingival biopsy specimen demonstrated the same del(20q) cytogenetic abnormality present in the bone marrow, confirming[] […] results of both blood tests and bone marrow biopsy results. 2016 WHO Classification of MDS Subtype Blood Bone Marrow MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia[]

  • Drug-induced Bone Marrow Suppression

    Early forms of myelodysplastic syndrome initially can manifest as a single cytopenia or, more often, as a bicytopenia.[] Bone marrow aspiration and biopsy to look for myelodysplastic morphology or clonal cytogenic abnormalities.[] There may be dysplastic neutrophils, abnormal platelets, blasts or other abnormal cells, such as hairy cells.[]

  • Acute Leukemia

    A 43-year-old female presented with leukocytosis and bicytopenia.[] The diagnosis of leukemia requires confirmation of leukemic cells in the bone marrow by bone marrow biopsy and aspiration.[] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[] The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line).[] The cumulative incidence of bicytopenia or pancytopenia ( Figure 2 B) was similar in patients with classic and intermediate disease ( P .63).[]

  • Primary Myelofibrosis

    Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[] The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity.[] The hematologist may then test you further by doing a bone marrow biopsy. This consists of removing a small amount of bone marrow and examining it for abnormalities.[]

  • Mantle Cell Lymphoma

    Case report: A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia.[]

  • Systemic Mastocytosis

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] marrow (BM) biopsy (1) MCs are derived from CD34 /KIT pluripotent hematopoietic cells in the bone marrow; its neoplastic counterparts are morphologically atypical (spindled[] In those patients, when we do a bone marrow biopsy, we see collections of mast cells in the bone marrow in clusters, and they express abnormal markers, such as CD25, on their[]

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