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47 Possible Causes for Bicytopenia, Bone Marrow Biopsy Abnormal, Hepatosplenomegaly

  • Pancytopenia

    We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.[ncbi.nlm.nih.gov] […] of bicytopenia and pancytopenia.[ijpmonline.org] Bone Marrow Examination Almost always indicated in case pancytopenia unless cause is apparent. Both aspiration and biopsy are indicated.[slideshare.net]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] The diagnosis of leukemia requires confirmation of leukemic cells in the bone marrow by bone marrow biopsy and aspiration.[medical-dictionary.thefreedictionary.com]

  • Mantle Cell Lymphoma

    Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement.[icd9data.com] Further investigation revealed bicytopenia with splenomegaly and elevated serum creatinine.[ncbi.nlm.nih.gov] MCL manisfests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement.[codes.iarc.fr]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity.[leukaemia.org.au]

  • Acute Myelocytic Leukemia

    In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org] A bone marrow biopsy or a bone marrow aspiration may be done if the results of the blood tests are abnormal.[medicinenet.com]

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] Plain radiography and magnetic resonance imaging (MRI) revealed a lytic lesion in the acetabulum, with abnormal serum electrophoresis and bone marrow biopsy.[ncbi.nlm.nih.gov] marrow analysis Spleen biopsy Genetic tests and analysis Prenatal test to detect any abnormal mutations (if there is a family history of Gaucher Disease) Many clinical conditions[dovemed.com]

  • Systemic Mastocytosis

    We report the case of a 48-year old male patient who presented with hepatosplenomegaly for 12 years, yellow-brown colored maculopapular pigmentation on the skin and pancytopenia[sciforschenonline.org] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov] marrow (BM) biopsy (1) MCs are derived from CD34 /KIT pluripotent hematopoietic cells in the bone marrow; its neoplastic counterparts are morphologically atypical (spindled[gpnotebook.co.uk]

  • Chronic Myeloid Leukemia

    Due to presenting complaint of bleeding diathesis and absence of hepatosplenomegaly, the case was undiagnosed for CML until the patient reported to us.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] […] counts Tests of previous bone marrow studies to look for specific chromosome abnormalities Needle aspiration or biopsy (if necessary) for a new sample of bone marrow Molecular[rush.edu]

  • Chronic Myelomonocytic Leukemia

    Affected individuals present with monocytosis, cytopenias, and extramedullary manifestations like lymphadenopathy and hepatosplenomegaly.[symptoma.com] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] marrow studies to look for specific chromosome abnormalities Needle aspiration or biopsy (if necessary) for a new bone marrow sample Molecular test to look for certain markers[rush.edu]

  • Severe Aplastic Anemia

    […] with aplastic anemia present with jaundice and evidence of clinical hepatitis. [1, 2] Findings of adenopathy or organomegaly should suggest an alternative diagnosis (eg, hepatosplenomegaly[emedicine.medscape.com] A bone marrow biopsy is usually done at the same time, especially if an aspiration was not productive.[daviddarling.info] The peripheral blood smear shows no abnormal cells. The diagnosis is confirmed by a bone marrow biopsy with an assessment of cellularity.[med.uth.edu]

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