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28 Possible Causes for Bicytopenia, Complete Blood Count Abnormal, Generalized Lymphadenopathy

  • Gaucher Disease

    Protein-losing enteropathy due to massive mesenteric lymphadenopathy is a rare complication of Gaucher disease which is generally refractory to treatment with enzyme replacement[]

  • Follicular Lymphoma

    This patient was a 58 years old with generalized lymphadenopathy and Ann Arbor Stage III disease.[] A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal.[] In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient.[]

  • Acute Leukemia

    Some individuals with ALL and AML may develop localized or generalized lymphadenopathy, or even shortness of breath as a result of enlarged mediastinal nodes.[] A 1-year-old boy presented with abnormal complete blood count findings, and was found to have blasts and mild dysgranulopoiesis.[] A 43-year-old female presented with leukocytosis and bicytopenia.[]

  • Acute Myelocytic Leukemia

    On exam, he has bilateral submandibular lymphadenopathy and hepatosplenomegaly. CBC demonstrates decreased RBCs and mature WBCs.[] It has not been treated except to relieve signs and symptoms such as fever, bleeding, or pain, and the following are true: The complete blood count is abnormal.[] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[]

  • Autoimmune Hemolytic Anemia

    lymphadenopathy, splenomegaly and mild hepatitis.[] Often, anemia caused by chronic diseases goes undetected until a routine test such as a complete blood count (CBC) reveals abnormal results.[] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[]

  • Castleman Disease

    CD can present with localized (unicentric CD or UCD) or generalized lymphadenopathy (multicentric CD or MCD).[] Investigations showed bicytopenia, nephrotic range proteinuria with hypoalbuminemia, hypogammaglobulinemia, and features of hyaline-vascular type Castleman disease in a lymph[] Case Report: We present a case of a 63-year-old woman with multicentric CD who was admitted with weight loss, night sweat, fever, and generalized lymphadenopathy.[]

  • Systemic Mastocytosis

    On examination, splenomegaly occurs in 50% to 60% of patients, hepatomegaly in 50% to 70%, generalized lymphadenopathy in 40% and skin lesions are apparent in 60%.[] The doctor may want the patient to have a bone scan performed in adults or in children with an abnormal complete blood count (CBC).[] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[]

  • Disseminated Tuberculosis

    Physical examination reveals cough, splenomegaly, hepatomegaly, generalized lymphadenopathy and signs of multiorgan dysfunction. Genitourinary involvement is common.[] (Blood cultures reports and sensitivity tests in second and third week of admission at secondary hospital in appendix B) Her full blood count remained normal in follow-up[] Patients and Methods 312 bone marrow aspirates from patients with the diagnosis of anaemia, severe granulocytopenia, thrombocytopenia, bicytopenia or pancytopenia, referred[]

  • Brucellosis

    One patient presented with generalized lymphadenopathy, and 1 patient presented with meningitis.[] In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia.[] The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[]

  • Chronic Myeloid Leukemia

    Blood tests Chromosome analysis The diagnosis of CML is suspected when the results of a complete blood count show an abnormally high white blood cell count.[] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[] The diagnosis of chronic myelogenous leukemia is usually via a blood test called a complete blood count ( CBC ).[]