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12 Possible Causes for Bicytopenia, Complete Blood Count Abnormal, Haptoglobin Decreased

  • Paroxysmal Nocturnal Hemoglobinuria

    Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[] : Decreased Bilirubin: Elevated unconjugated Urine: Positive for hemosiderin and hemoglobin In addition, further hemolysis parameters, renal function, folic acid and vitamin[] Haptoglobin: usually undetectable Increased Lactate Dehydrogenase (LDH): may be in the thousands Indirect (Unconjugated) Hyperbilirubinemia: usually mildly-moderately elevated[]

  • Disseminated Intravascular Coagulation

    To determine the accuracy of disseminated intravascular coagulation (DIC) and sustained systemic inflammatory response syndrome (SIRS) in predicting posttrauma multiple organ dysfunction syndrome (MODS) and to find a simple laboratory test for detecting MODS. In trauma patients, the duration of SIRS is the main[…][]

  • Autoimmune Hemolytic Anemia

    Often, anemia caused by chronic diseases goes undetected until a routine test such as a complete blood count (CBC) reveals abnormal results.[] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[] , and haptoglobin decreased to less than 8 mg/dL.[]

  • Acute Leukemia

    A 1-year-old boy presented with abnormal complete blood count findings, and was found to have blasts and mild dysgranulopoiesis.[] A 43-year-old female presented with leukocytosis and bicytopenia.[] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[]

  • Acute Erythroblastic Leukemia

    Diagnosis & Treatment Erythroleukemia is usually diagnosed by one of the following tests: Blood tests : A CBC (complete blood count) can indicate the presence of certain substances[] The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[] Abnormally high levels of chemical substances in the blood can indicate the presence of cancerous cells.[]

  • Acute Myelocytic Leukemia

    It has not been treated except to relieve signs and symptoms such as fever, bleeding, or pain, and the following are true: The complete blood count is abnormal.[] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[] haptoglobin).[]

  • Acquired Sideroblastic Anemia

    Complete blood count with differential will show variable severity of anemia, with usually normal leukocytes and platelets.[] RCMD-RS shows cytopenias (bicytopenia or pancytopenia) in the peripheral blood plus dysplasia in more than 10% of the cells in 2 or more myeloid lineages and no Auer rods.[] Decreased in hemolysis (decrease in haptoglobin is more likely in intravascular hemolysis than in extravascular hemolysis) However, haptoglobin is an acute phase reactant[]

  • Refractory Megaloblastic Anemia

    CLASSIFICATION OF MDS (2008) SUBTYPE BLOOD BONE MARROWREFRACTORY ANEMIA; UNILINEAGECYTOPENIA WITH NO OR RARE BLASTS DYSPLASIA 10%UNILINEAGE UNICYTOPENIA CELLS IN ONEDYSPLASIA (RCUD) BICYTOPENIA[] Lab features of hemolysis Decreased haptoglobin Increased LDH and bilirubin Urine hemosiderin may be elevated in some Plasma hemoglobin may be elevated if hemolysis severe[] Decreased yield of RBCs Anemia Ineffective erythropoiesis also results in · Unconjugated hyperbilirubinemia · Raised urobilinogen · Reduced haptoglobins · Positive urine hemosiderin[]

  • Chronic Myelomonocytic Leukemia

    In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[] Total protein was decreased along with albumin (2.0 g/dL). Alkaline phosphatase was elevated (149 U/L). Haptoglobin was normal.[]

  • Evan's Syndrome

    Diagnostic methods Diagnosis is based on a complete blood count showing anemia (hemoglobin level Differential diagnosis Differential diagnosis mainly includes microangiopathies[] The pattern of occurrence of bicytopenia can delay the diagnosis since it may be coincidental, sequential, or separate, and the time frame between episodes can range from[] Serum Fe was 77μg/d l , and haptoglobin was markedly decreased (5mg/d l ). Both direct and indirect Coombs' tests were continuously negative.[]