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48 Possible Causes for Bicytopenia, Complete Blood Count Abnormal, Hepatomegaly

  • Gaucher Disease

    A physical examination revealed obvious hypoevolutism and hepatomegaly, and laboratory tests and imaging examinations showed severe pulmonary interstitial fibrosis, infection[ncbi.nlm.nih.gov] After 4years of ERT, therapeutic goals for thrombocytopenia and splenomegaly had been achieved in 100% of patients; goals for anemia and hepatomegaly had been achieved in[ncbi.nlm.nih.gov] Hematologic changes, bone pain, hepatomegaly, splenomegaly, and fatigue were the most recurrent signs and symptoms.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Primary myelofibrosis is diagnosed using the following procedures: Blood testing: Complete blood count (CBC) looking for abnormal amounts of red and white blood cells and[patientworthy.com] The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com]

  • Acute Leukemia

    A 1-year-old boy presented with abnormal complete blood count findings, and was found to have blasts and mild dysgranulopoiesis.[ncbi.nlm.nih.gov] Hepatomegaly and/or splenomegaly resulting from leukemic infiltration are present in many patients at diagnosis but are often overlooked.[clinicaladvisor.com] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov]

  • Follicular Lymphoma

    A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal.[emedicine.com] An abdominal ultrasound showed inferior vena cava suprahepatic veins dilation without hepatomegaly.[sponcologia.pt] In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Pathological findings include systemic venous or portal thrombosis, normoblastic bone marrow hyperplasia, hepatomegaly with necrosis, hemosiderosis, and massive iron deposits[whonamedit.com] Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[bloodjournal.hematologylibrary.org] […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com]

  • Acute Myelocytic Leukemia

    It has not been treated except to relieve signs and symptoms such as fever, bleeding, or pain, and the following are true: The complete blood count is abnormal.[cancer.gov] Multivariate analysis showed that grades 1 or 2 GVHD (P .008) and no hepatomegaly at diagnosis (P .014) were associated with improved relapse-free survival (RFS).[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org]

  • Autoimmune Hemolytic Anemia

    Often, anemia caused by chronic diseases goes undetected until a routine test such as a complete blood count (CBC) reveals abnormal results.[labtestsonline.org] […] hepatitis B virus, drug usage or cholestatic syndrome and in around 40% of cases its etiology will be defined as autoimmune. 22 One patient from the present sample developed hepatomegaly[scielo.br] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[jahjournal.org]

  • Castleman Disease

    Examination revealed pallor; generalized edema; axillary, cervical, and inguinal lymphadenopathy; hypertension; and hepatomegaly.[ncbi.nlm.nih.gov] […] lymphadenopathy (128/128), anaemia (79/91), elevated C-reactive protein (65/79), hypergammaglobulinaemia (63/82), hypoalbuminaemia (57/63), elevated interleukin 6 (57/63), hepatomegaly[ncbi.nlm.nih.gov] […] accompanied by systemic manifestations of the disease, consisting of fever, fatigue, abundant nocturnal sweating, inappetence, nausea, vomiting, cough, and dyspnea, as well as hepatomegaly[symptoma.com]

  • Chronic Myeloid Leukemia

    Blood tests Chromosome analysis The diagnosis of CML is suspected when the results of a complete blood count show an abnormally high white blood cell count.[merck.com] Low-grade fever and excessive sweating Elevated white blood cell (WBC) count Splenomegaly Decreased appetite and food intake Left upper quadrant abdominal pain from splenomegaly Hepatomegaly[symptoma.com] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org]

  • Systemic Mastocytosis

    The doctor may want the patient to have a bone scan performed in adults or in children with an abnormal complete blood count (CBC).[medfriendly.com] […] without impairment of liver function, and/or palpable splenomegaly without hypersplenism, and/or palpable visceral lymphadenopathy Palpable hepatomegaly with impairment of[bloodref.com] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov]

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